iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063140

UUCD1 version

UUC-MuM-00382

Ensembl Protein ID

ENSMUSP00000041581.5

UniProt Accession

Q3TZ87; Q8VCL1; MARH9_MOUSE

Genbank Protein ID

BAE34323.1; AAH19560.1

Protein Name

E3 ubiquitin-protein ligase MARCH9; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; RING-type E3 ubiquitin transferase MARCH9

Genbank Nucleotide ID

AK158026; BC019560

Gene Name

March9

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000040502.5	ENSMUST00000040307.5	ENSMUSP00000041581.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.11	2.00e-122	436.00	IUUC-Hsa-046250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLKSRLRMFL NELKLLVLTG GGRPRAEPQP RGGGGGGCGW APFAGCSARD GDGDEEEYYG 60
SEPRARGLAG DKEPRAGPPP PPAPPPPPPG ALDALSLSSS LDSGLRTPQC RICFQGPEQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCTACCG CCGAACGCAC GGGCCGAACC GAGCCGGATC CGGCAGTCGG AGCGGGACTG 60
GGGCCGAGAG GACGACGATG GGGGGCGGCC CCGCCGCAGG AGGACCGGGG CGCATAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005795--C:Golgi stack
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005802--C:trans-Golgi network
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

mmu:216438

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000992	Aegilops tauschii	36.62	2.00e-08	52.80
IUUC-Aml-001373	Ailuropoda melanoleuca	93.72	1.00e-109	389.00
IUUC-Aly-005700	Arabidopsis lyrata	35.62	7.00e-10	57.40
IUUC-Ath-006885	Arabidopsis thaliana	34.25	2.00e-09	56.20
IUUC-Ame-010820	Astyanax mexicanus	62.36	1.00e-114	406.00
IUUC-Bta-012719	Bos taurus	96.84	6.00e-124	436.00
IUUC-Bol-015757	Brassica oleracea	34.25	6.00e-10	57.80
IUUC-Cja-019583	Callithrix jacchus	75.21	8.00e-111	393.00
IUUC-Cfa-020701	Canis familiaris	95.78	3.00e-113	400.00
IUUC-Cpo-021311	Cavia porcellus	96.75	2.00e-139	488.00
IUUC-Cre-022732	Chlamydomonas reinhardtii	40.38	3.00e-08	50.40
IUUC-Csa-023212	Chlorocebus sabaeus	83.83	4.00e-116	410.00
IUUC-Cho-024792	Choloepus hoffmanni	95.88	7.00e-117	413.00
IUUC-Cgl-026475	Colletotrichum gloeosporioides	34.07	5.00e-07	48.50
IUUC-Cne-027028	Cryptococcus neoformans	42.62	1.00e-08	54.30
IUUC-Dre-027921	Danio rerio	65.56	6.00e-123	433.00
IUUC-Dno-029652	Dasypus novemcinctus	97.13	6.00e-129	453.00
IUUC-Dor-030811	Dipodomys ordii	96.84	5.00e-129	454.00
IUUC-Ete-032298	Echinops telfairi	95.20	3.00e-106	377.00
IUUC-Eca-034077	Equus caballus	95.88	3.00e-117	414.00
IUUC-Eeu-035277	Erinaceus europaeus	93.89	4.00e-104	370.00
IUUC-Fca-035691	Felis catus	96.61	2.00e-111	394.00
IUUC-Ggr-039944	Gaeumannomyces graminis	42.37	8.00e-09	54.70
IUUC-Gac-042171	Gasterosteus aculeatus	66.57	1.00e-107	382.00
IUUC-Ggo-044663	Gorilla gorilla	95.38	1.00e-122	432.00
IUUC-Hsa-046250	Homo sapiens	95.11	8.00e-128	449.00
IUUC-Itr-048606	Ictidomys tridecemlineatus	96.30	2.00e-110	391.00
IUUC-Lch-049563	Latimeria chalumnae	68.98	5.00e-111	394.00
IUUC-Lpe-051036	Leersia perrieri	32.91	1.00e-07	50.10
IUUC-Laf-054358	Loxodonta africana	95.98	7.00e-141	493.00
IUUC-Mcc-055132	Macaca mulatta	95.69	1.00e-129	456.00
IUUC-Meu-056776	Macropus eugenii	92.74	3.00e-109	387.00
IUUC-Mor-056968	Magnaporthe oryzae	37.50	7.00e-09	54.70
IUUC-Mpo-057421	Magnaporthe poae	42.37	1.00e-08	53.90
IUUC-Mmr-061668	Microcebus murinus	96.55	4.00e-131	461.00
IUUC-Mdo-062134	Monodelphis domestica	88.25	7.00e-122	430.00
IUUC-Mpu-065878	Mustela putorius furo	96.30	2.00e-117	414.00
IUUC-Mlu-067572	Myotis lucifugus	89.08	1.00e-115	409.00
IUUC-Nle-068993	Nomascus leucogenys	95.31	1.00e-124	439.00
IUUC-Opr-071182	Ochotona princeps	95.44	5.00e-118	417.00
IUUC-Ont-071812	Oreochromis niloticus	63.43	3.00e-105	374.00
IUUC-Ocu-074117	Oryctolagus cuniculus	95.65	3.00e-107	380.00
IUUC-Obr-076491	Oryza brachyantha	40.00	1.00e-09	57.00
IUUC-Ogl-076942	Oryza glaberrima	32.91	5.00e-09	54.30
IUUC-Oin-079184	Oryza indica	32.91	4.00e-09	54.70
IUUC-Olo-080640	Oryza longistaminata	32.91	5.00e-09	54.70
IUUC-Oru-084407	Oryza rufipogon	32.91	4.00e-09	54.70
IUUC-Ola-087504	Oryzias latipes	64.44	4.00e-108	384.00
IUUC-Oga-088000	Otolemur garnettii	96.26	2.00e-130	458.00
IUUC-Oar-089364	Ovis aries	95.65	1.00e-101	362.00
IUUC-Ptr-090674	Pan troglodytes	95.69	3.00e-130	457.00
IUUC-Pan-092400	Papio anubis	95.40	9.00e-128	449.00
IUUC-Pfo-097278	Poecilia formosa	67.13	8.00e-108	383.00
IUUC-Pab-098565	Pongo abelii	94.32	2.00e-106	377.00
IUUC-Pop-099515	Populus trichocarpa	36.84	2.00e-08	53.50
IUUC-Pca-100354	Procavia capensis	95.63	6.00e-108	384.00
IUUC-Pva-102716	Pteropus vampyrus	95.20	1.00e-107	382.00
IUUC-Rno-105711	Rattus norvegicus	94.26	2.00e-97	348.00
IUUC-Sha-106546	Sarcophilus harrisii	88.35	1.00e-124	439.00
IUUC-Smo-109144	Selaginella moellendorffii	34.25	5.00e-10	57.40
IUUC-Sit-110567	Setaria italica	40.38	6.00e-09	54.70
IUUC-Sbi-114552	Sorghum bicolor	40.38	5.00e-09	54.70
IUUC-Tru-118357	Takifugu rubripes	66.57	3.00e-106	378.00
IUUC-Tni-120712	Tetraodon nigroviridis	64.69	1.00e-109	389.00
IUUC-Tbe-128092	Tupaia belangeri	96.30	3.00e-118	417.00
IUUC-Ttr-128915	Tursiops truncatus	95.63	9.00e-100	355.00
IUUC-Vpa-130151	Vicugna pacos	96.07	2.00e-108	385.00
IUUC-Xtr-131868	Xenopus tropicalis	72.44	8.00e-110	390.00
IUUC-Xma-134247	Xiphophorus maculatus	67.42	6.00e-111	393.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence