iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108137

UUCD1 version

UUC-ScP-00143

Ensembl Protein ID

SPBC776.18c.1:pep

UniProt Accession

O94684; TFB3_SCHPO

Genbank Protein ID

AAF05735.1; CAA22891.1

Protein Name

RNA polymerase II transcription factor B subunit 3; CDK-activating kinase assembly factor MAT1 homolog; RING finger protein pmh1; RNA polymerase II transcription factor B 38 kDa subunit; RNA polymerase II transcription factor B p38 subunit

Genbank Nucleotide ID

AF191500; CU329671

Gene Name

pmh1; mcr1; tfb3; SPBC776.18c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC776.18c	SPBC776.18c.1	SPBC776.18c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	44.68	5.00e-32	135.00	IUUC-Hsa-045876
E3 activity/RING/RING	37.17	2.00e-46	181.00	IUUC-Sce-106405

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity).

Protein Sequence
(Fasta)

MDDEGARKVD EKCPLCQADR YLNPNMKLLI NPECYHKMCE SCVDRIFTTG PAQCPTPGCN 60
KILRKAKFRE QTFEDAQIER EVDVRKRISR IFNKGQQEFD SLQAYNDYLE EVEILTFNLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGACTACT TCTAAAAGTT TAACACCACG TATTGCGCGC TTTTTTTGTC CAAATATTAT 60
TTCTTTATAC AATCCGAAAA GTAACGTTTA CTATTCAACA TAAATTCGAT TGAAACTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015877--Cdk-activating_kinase_MAT1_cen
IPR004575--MAT1/Tfb3
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF06391--MAT1
PF17121--zf-C3HC4_5

Gene Ontology

GO:0005829--C:cytosol
GO:0000112--C:nucleotide-excision repair factor 3 complex
GO:0005634--C:nucleus
GO:0070985--C:TFIIK complex
GO:0061575--F:cyclin-dependent protein serine/threonine kinase activator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0006281--P:DNA repair
GO:0006289--P:nucleotide-excision repair
GO:0045737--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1901409--P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:0016567--P:protein ubiquitination
GO:0000079--P:regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPBC776.18c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000821	Aegilops tauschii	41.79	2.00e-08	50.80
IUUC-Aml-002414	Ailuropoda melanoleuca	44.68	2.00e-34	137.00
IUUC-Atr-002627	Amborella trichopoda	55.00	6.00e-16	75.10
IUUC-Apl-003312	Anas platyrhynchos	43.69	5.00e-23	99.40
IUUC-Aca-004731	Anolis carolinensis	44.70	3.00e-32	130.00
IUUC-Aly-006244	Arabidopsis lyrata	51.67	2.00e-14	69.70
IUUC-Ath-007136	Arabidopsis thaliana	55.00	3.00e-15	72.80
IUUC-Ago-007788	Ashbya gossypii	37.94	3.00e-51	193.00
IUUC-Acl-008179	Aspergillus clavatus	35.98	4.00e-50	189.00
IUUC-Afl-008465	Aspergillus flavus	54.01	4.00e-46	176.00
IUUC-Afu-009056	Aspergillus fumigatus	55.64	8.00e-47	179.00
IUUC-Ani-009235	Aspergillus nidulans	37.50	2.00e-05	41.20
IUUC-Ang-009677	Aspergillus niger	57.69	2.00e-47	180.00
IUUC-Aor-010017	Aspergillus oryzae	56.15	4.00e-46	176.00
IUUC-Ate-010259	Aspergillus terreus	57.69	1.00e-47	181.00
IUUC-Ame-010934	Astyanax mexicanus	39.01	9.00e-28	115.00
IUUC-Bgr-012074	Blumeria graminis	33.12	1.00e-41	162.00
IUUC-Bta-013329	Bos taurus	44.68	4.00e-34	136.00
IUUC-Bci-013704	Botrytis cinerea	33.96	9.00e-41	158.00
IUUC-Bdi-014606	Brachypodium distachyon	53.33	6.00e-15	71.60
IUUC-Bol-015807	Brassica oleracea	32.39	3.00e-05	40.00
IUUC-Bra-016949	Brassica rapa	51.67	2.00e-14	70.10
IUUC-Cel-018428	Caenorhabditis elegans	34.88	2.00e-24	104.00
IUUC-Cja-019720	Callithrix jacchus	44.68	4.00e-34	136.00
IUUC-Cfa-020319	Canis familiaris	44.68	2.00e-34	137.00
IUUC-Cpo-021652	Cavia porcellus	45.39	5.00e-35	139.00
IUUC-Cre-022749	Chlamydomonas reinhardtii	42.19	4.00e-11	58.90
IUUC-Csa-023560	Chlorocebus sabaeus	44.68	3.00e-34	136.00
IUUC-Cin-025502	Ciona intestinalis	30.95	5.00e-32	129.00
IUUC-Csv-026302	Ciona savignyi	44.88	4.00e-30	123.00
IUUC-Cgl-026541	Colletotrichum gloeosporioides	28.78	3.00e-11	60.10
IUUC-Cne-027055	Cryptococcus neoformans	53.54	1.00e-39	154.00
IUUC-Cme-027128	Cyanidioschyzon merolae	54.17	6.00e-10	55.80
IUUC-Dre-027714	Danio rerio	46.10	7.00e-34	135.00
IUUC-Dno-029232	Dasypus novemcinctus	44.68	8.00e-34	134.00
IUUC-Dor-030996	Dipodomys ordii	48.00	2.00e-15	74.30
IUUC-Dse-031359	Dothistroma septosporum	58.46	2.00e-48	183.00
IUUC-Dme-031992	Drosophila melanogaster	46.21	8.00e-33	132.00
IUUC-Ete-032973	Echinops telfairi	48.00	3.00e-10	57.40
IUUC-Eca-034116	Equus caballus	44.68	3.00e-34	136.00
IUUC-Eeu-035143	Erinaceus europaeus	33.33	2.00e-20	90.50
IUUC-Fca-035960	Felis catus	44.68	2.00e-34	137.00
IUUC-Fal-037039	Ficedula albicollis	42.72	7.00e-23	98.60
IUUC-Fox-037882	Fusarium oxysporum	47.86	8.00e-37	145.00
IUUC-Fso-038318	Fusarium solani	51.35	1.00e-35	141.00
IUUC-Gmo-038905	Gadus morhua	41.84	8.00e-31	125.00
IUUC-Ggr-039857	Gaeumannomyces graminis	48.51	3.00e-28	117.00
IUUC-Gga-041216	Gallus gallus	41.13	1.00e-30	124.00
IUUC-Gac-041987	Gasterosteus aculeatus	43.97	3.00e-31	126.00
IUUC-Gma-044312	Glycine max	53.33	3.00e-15	72.80
IUUC-Ggo-044930	Gorilla gorilla	35.46	6.00e-22	95.50
IUUC-Hsa-045876	Homo sapiens	44.68	3.00e-34	136.00
IUUC-Hvu-047088	Hordeum vulgare	51.67	8.00e-15	71.20
IUUC-Itr-048476	Ictidomys tridecemlineatus	47.22	7.00e-28	114.00
IUUC-Kpa-049202	Komagataella pastoris	36.27	2.00e-46	177.00
IUUC-Lch-049886	Latimeria chalumnae	43.18	9.00e-31	125.00
IUUC-Lpe-050952	Leersia perrieri	55.00	2.00e-15	73.60
IUUC-Loc-052556	Lepisosteus oculatus	43.97	4.00e-33	132.00
IUUC-Lma-053002	Leptosphaeria maculans	60.94	3.00e-48	183.00
IUUC-Laf-054516	Loxodonta africana	44.68	3.00e-34	137.00
IUUC-Mcc-054761	Macaca mulatta	44.68	4.00e-34	135.00
IUUC-Mor-057048	Magnaporthe oryzae	48.51	9.00e-36	142.00
IUUC-Mpo-057598	Magnaporthe poae	52.25	6.00e-24	101.00
IUUC-Mtr-058131	Medicago truncatula	53.33	1.00e-14	70.50
IUUC-Mla-059009	Melampsora laricipopulina	58.14	2.00e-43	166.00
IUUC-Mga-060199	Meleagris gallopavo	42.72	2.00e-22	96.70
IUUC-Mvi-060382	Microbotryum violaceum	46.51	6.00e-36	142.00
IUUC-Mmr-061671	Microcebus murinus	44.68	6.00e-34	135.00
IUUC-Mdo-062228	Monodelphis domestica	43.97	2.00e-33	134.00
IUUC-Mmu-064416	Mus musculus	45.39	1.00e-34	137.00
IUUC-Mac-064807	Musa acuminata	50.00	3.00e-13	65.90
IUUC-Mpu-066455	Mustela putorius furo	44.68	2.00e-34	137.00
IUUC-Mlu-067325	Myotis lucifugus	46.30	3.00e-27	112.00
IUUC-Nfi-068566	Neosartorya fischeri	33.74	1.00e-46	178.00
IUUC-Ncr-068687	Neurospora crassa	50.43	1.00e-36	145.00
IUUC-Nle-069937	Nomascus leucogenys	44.68	3.00e-34	136.00
IUUC-Opr-070321	Ochotona princeps	39.81	1.00e-20	91.70
IUUC-Ont-072636	Oreochromis niloticus	42.55	1.00e-31	128.00
IUUC-Oan-072915	Ornithorhynchus anatinus	39.81	9.00e-21	91.30
IUUC-Ocu-074547	Oryctolagus cuniculus	45.31	8.00e-31	125.00
IUUC-Oba-075269	Oryza barthii	55.00	2.00e-15	73.60
IUUC-Obr-076081	Oryza brachyantha	56.67	4.00e-16	75.90
IUUC-Ogl-077011	Oryza glaberrima	55.00	2.00e-15	73.60
IUUC-Ogu-078667	Oryza glumaepatula	55.00	2.00e-15	73.60
IUUC-Oin-079153	Oryza indica	55.00	2.00e-15	73.60
IUUC-Olo-080344	Oryza longistaminata	58.33	2.00e-11	60.10
IUUC-Ome-081805	Oryza meridionalis	55.00	2.00e-15	73.90
IUUC-Oni-082783	Oryza nivara	55.00	2.00e-15	73.20
IUUC-Opu-083247	Oryza punctata	53.33	3.00e-15	72.80
IUUC-Oru-085262	Oryza rufipogon	55.00	2.00e-15	73.60
IUUC-Osa-086250	Oryza sativa	55.00	2.00e-15	73.60
IUUC-Ola-086780	Oryzias latipes	42.55	7.00e-32	129.00
IUUC-Olu-087653	Ostreococcus lucimarinus	38.71	4.00e-11	58.90
IUUC-Oga-088012	Otolemur garnettii	44.68	9.00e-34	135.00
IUUC-Oar-090274	Ovis aries	36.88	2.00e-24	103.00
IUUC-Ptr-090780	Pan troglodytes	44.68	3.00e-34	136.00
IUUC-Pan-091815	Papio anubis	39.52	9.00e-20	88.20
IUUC-Psi-093883	Pelodiscus sinensis	45.45	4.00e-33	132.00
IUUC-Pma-094717	Petromyzon marinus	48.33	2.00e-13	67.00
IUUC-Pno-094958	Phaeosphaeria nodorum	36.42	6.00e-50	189.00
IUUC-Ppa-095445	Physcomitrella patens	46.03	5.00e-14	68.60
IUUC-Pfo-096051	Poecilia formosa	43.26	1.00e-32	131.00
IUUC-Pab-097609	Pongo abelii	43.97	1.00e-33	134.00
IUUC-Pop-099460	Populus trichocarpa	51.61	2.00e-15	73.20
IUUC-Pca-101094	Procavia capensis	46.60	1.00e-25	107.00
IUUC-Ppe-101481	Prunus persica	56.67	4.00e-15	72.40
IUUC-Pva-103219	Pteropus vampyrus	44.68	3.00e-34	136.00
IUUC-Pgr-103557	Puccinia graminis	56.59	3.00e-43	167.00
IUUC-Ptt-103719	Puccinia triticina	58.91	3.00e-44	170.00
IUUC-Pte-104301	Pyrenophora teres	49.19	4.00e-37	146.00
IUUC-Pyt-104486	Pyrenophora triticirepentis	50.00	9.00e-38	148.00
IUUC-Rno-105846	Rattus norvegicus	45.39	1.00e-34	137.00
IUUC-Sce-106405	Saccharomyces cerevisiae	37.17	8.00e-50	188.00
IUUC-Sha-107594	Sarcophilus harrisii	45.63	3.00e-24	102.00
IUUC-Sja-107951	Schizosaccharomyces japonicus	61.86	2.00e-89	320.00
IUUC-Ssl-108503	Sclerotinia sclerotiorum	32.39	2.00e-44	171.00
IUUC-Smo-108895	Selaginella moellendorffii	36.52	2.00e-14	70.10
IUUC-Sit-110672	Setaria italica	50.00	8.00e-15	71.20
IUUC-Sly-111744	Solanum lycopersicum	53.23	3.00e-15	72.80
IUUC-Stu-112343	Solanum tuberosum	53.33	1.00e-14	70.50
IUUC-Sar-113298	Sorex araneus	45.45	2.00e-33	134.00
IUUC-Sbi-113918	Sorghum bicolor	55.00	8.00e-16	74.70
IUUC-Sre-114991	Sporisorium reilianum	55.30	4.00e-37	146.00
IUUC-Ssc-116152	Sus scrofa	46.60	2.00e-25	106.00
IUUC-Tgu-116452	Taeniopygia guttata	41.84	3.00e-31	126.00
IUUC-Tru-118621	Takifugu rubripes	42.66	8.00e-31	125.00
IUUC-Tsy-119500	Tarsius syrichta	43.97	2.00e-33	134.00
IUUC-Tni-120454	Tetraodon nigroviridis	41.67	8.00e-21	92.00
IUUC-Tca-121192	Theobroma cacao	53.33	1.00e-14	70.50
IUUC-Tre-122011	Trichoderma reesei	46.62	2.00e-34	137.00
IUUC-Tvi-122317	Trichoderma virens	32.58	2.00e-37	147.00
IUUC-Tae-123854	Triticum aestivum	51.67	5.00e-15	72.00
IUUC-Tur-126556	Triticum urartu	53.33	3.00e-15	72.80
IUUC-Tme-127135	Tuber melanosporum	44.87	3.00e-48	183.00
IUUC-Tbe-127287	Tupaia belangeri	46.60	2.00e-22	97.80
IUUC-Ttr-128864	Tursiops truncatus	44.68	4.00e-34	136.00
IUUC-Uma-129539	Ustilago maydis	57.14	4.00e-41	160.00
IUUC-Vda-129713	Verticillium dahliae	56.48	4.00e-30	123.00
IUUC-Vpa-130462	Vicugna pacos	40.43	5.00e-26	109.00
IUUC-Vvi-130988	Vitis vinifera	53.33	4.00e-14	68.90
IUUC-Xtr-131830	Xenopus tropicalis	43.97	4.00e-33	132.00
IUUC-Xma-133952	Xiphophorus maculatus	43.97	6.00e-33	132.00
IUUC-Yli-134433	Yarrowia lipolytica	35.55	1.00e-49	187.00
IUUC-Zma-134867	Zea mays	56.67	3.00e-16	75.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence