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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064383
UUCD1 version UUC-MuM-00720
Ensembl Protein ID ENSMUSP00000014022.8
UniProt Accession Q8CBG9; A6H618; Q3U796; Q78QX6; Q8C8S1; Q8C9I0; Q8K0H6; RN170_MOUSE
Genbank Protein ID BAC29287.1; BAC31147.1; BAC31988.1; BAC37951.1; BAE31474.1; EDL32805.1; AAH31383.1; AAI14211.1; AAI38931.1; AAI45719.1
Protein Name E3 ubiquitin-protein ligase RNF170; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170
Genbank Nucleotide ID AK036051; AK042063; AK044579; AK080591; AK152760; CH466580; BC031383; BC114210; BC138930; BC145718
Gene Name Rnf170
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000013878.18 ENSMUST00000014022.14 ENSMUSP00000014022.8
ENSMUSG00000013878.18 ENSMUST00000209300.1 ENSMUSP00000147842.1
ENSMUSG00000013878.18 ENSMUST00000124757.7 ENSMUSP00000115588.1
ENSMUSG00000013878.18 ENSMUST00000153528.7 ENSMUSP00000118689.1
ENSMUSG00000013878.18 ENSMUST00000110575.7 ENSMUSP00000106204.1
ENSMUSG00000013878.18 ENSMUST00000110579.9 ENSMUSP00000106208.2
ENSMUSG00000013878.18 ENSMUST00000124867.2 ENSMUSP00000115959.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 37.06 8.00e-21 97.40 IUUC-Cel-018593
E3 activity/RING/RING 90.70 2.00e-110 396.00 IUUC-Hsa-046691
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
 E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
Protein Sequence
(Fasta)
MQRYWRFQDN KIQDICFGVL GESWIQRPVM ARYYSEGQSL QQDDSFIEGV SDQVLVAVVV 60
SLALTATLLY ALLRNVQQNI HPENQELVRV LREQFQTEQD VPAPARQQFY TEMYCPICLH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064383|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGTCCAAGGC CCGCGGGCGC GCGCCCCGGC CGGGCCCTGC GGTGGCGGCC GGTCTGTGTG 60
TCTCTCCAGT CCGCTCACCC TCGCCGGGGC TCCGCACTGC GCGTGCGCTG ACGCCGGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064383|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR010652--DUF1232
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF06803--DUF1232
PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
KEGG mmu:77733
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000837 Aegilops tauschii 34.15 3.00e-21 94.70
IUUC-Aml-002276 Ailuropoda melanoleuca 89.15 3.00e-106 377.00
IUUC-Atr-003163 Amborella trichopoda 36.93 1.00e-27 115.00
IUUC-Apl-003771 Anas platyrhynchos 73.18 3.00e-84 304.00
IUUC-Aca-004706 Anolis carolinensis 72.87 2.00e-81 295.00
IUUC-Aly-006202 Arabidopsis lyrata 39.29 1.00e-18 86.30
IUUC-Ath-007325 Arabidopsis thaliana 35.23 5.00e-25 107.00
IUUC-Ame-011453 Astyanax mexicanus 67.98 8.00e-87 313.00
IUUC-Bta-013272 Bos taurus 88.03 1.00e-105 375.00
IUUC-Bdi-014259 Brachypodium distachyon 34.88 5.00e-25 107.00
IUUC-Bol-016302 Brassica oleracea 34.66 5.00e-25 107.00
IUUC-Bra-017738 Brassica rapa 34.09 2.00e-24 105.00
IUUC-Cel-018593 Caenorhabditis elegans 34.34 3.00e-27 115.00
IUUC-Cja-019253 Callithrix jacchus 90.70 8.00e-108 382.00
IUUC-Cfa-020844 Canis familiaris 87.92 2.00e-107 383.00
IUUC-Cpo-021645 Cavia porcellus 88.89 1.00e-107 382.00
IUUC-Csa-024012 Chlorocebus sabaeus 91.09 1.00e-108 385.00
IUUC-Cho-024304 Choloepus hoffmanni 70.38 5.00e-75 273.00
IUUC-Cin-025256 Ciona intestinalis 46.40 1.00e-50 193.00
IUUC-Dre-028166 Danio rerio 68.04 2.00e-77 282.00
IUUC-Dno-029494 Dasypus novemcinctus 89.92 2.00e-107 382.00
IUUC-Dor-030259 Dipodomys ordii 87.64 2.00e-107 382.00
IUUC-Ete-032614 Echinops telfairi 72.48 7.00e-83 300.00
IUUC-Eca-033557 Equus caballus 88.37 2.00e-104 371.00
IUUC-Eeu-035324 Erinaceus europaeus 96.63 1.00e-29 124.00
IUUC-Fca-035812 Felis catus 90.31 2.00e-108 384.00
IUUC-Fal-036654 Ficedula albicollis 72.63 2.00e-93 335.00
IUUC-Gmo-039635 Gadus morhua 66.93 1.00e-85 309.00
IUUC-Gga-040345 Gallus gallus 77.13 4.00e-91 327.00
IUUC-Gac-041668 Gasterosteus aculeatus 67.06 3.00e-83 301.00
IUUC-Gma-043890 Glycine max 30.81 2.00e-25 108.00
IUUC-Ggo-045000 Gorilla gorilla 91.09 1.00e-108 385.00
IUUC-Hsa-046691 Homo sapiens 90.70 4.00e-108 384.00
IUUC-Hvu-047464 Hordeum vulgare 35.47 1.00e-25 109.00
IUUC-Itr-048988 Ictidomys tridecemlineatus 90.31 3.00e-107 381.00
IUUC-Lch-049846 Latimeria chalumnae 77.90 1.00e-60 225.00
IUUC-Loc-051785 Lepisosteus oculatus 69.23 7.00e-98 350.00
IUUC-Laf-054542 Loxodonta africana 86.59 1.00e-107 382.00
IUUC-Mcc-055234 Macaca mulatta 91.09 1.00e-108 385.00
IUUC-Meu-056544 Macropus eugenii 66.15 2.00e-68 252.00
IUUC-Mtr-057996 Medicago truncatula 35.23 2.00e-17 82.40
IUUC-Mmr-060609 Microcebus murinus 88.76 6.00e-109 386.00
IUUC-Mdo-062853 Monodelphis domestica 84.62 2.00e-105 374.00
IUUC-Mac-065250 Musa acuminata 35.43 8.00e-27 113.00
IUUC-Mlu-067410 Myotis lucifugus 87.60 3.00e-104 371.00
IUUC-Nle-069537 Nomascus leucogenys 95.98 8.00e-83 298.00
IUUC-Opr-070637 Ochotona princeps 94.67 3.00e-65 241.00
IUUC-Ont-071800 Oreochromis niloticus 70.72 6.00e-82 296.00
IUUC-Oan-073190 Ornithorhynchus anatinus 79.41 7.00e-102 363.00
IUUC-Ocu-073899 Oryctolagus cuniculus 91.86 7.00e-110 389.00
IUUC-Obr-076075 Oryza brachyantha 35.58 2.00e-23 101.00
IUUC-Oin-079850 Oryza indica 35.25 6.00e-23 100.00
IUUC-Ome-081191 Oryza meridionalis 35.25 3.00e-22 98.20
IUUC-Oni-082886 Oryza nivara 35.25 5.00e-23 100.00
IUUC-Osa-085833 Oryza sativa 35.25 6.00e-23 100.00
IUUC-Ola-086372 Oryzias latipes 68.75 5.00e-85 307.00
IUUC-Oga-087988 Otolemur garnettii 90.70 1.00e-109 389.00
IUUC-Oar-089976 Ovis aries 87.40 8.00e-107 379.00
IUUC-Ptr-091377 Pan troglodytes 90.70 1.00e-108 385.00
IUUC-Pan-092348 Papio anubis 90.70 4.00e-108 383.00
IUUC-Psi-092982 Pelodiscus sinensis 75.77 2.00e-85 308.00
IUUC-Ppa-095627 Physcomitrella patens 37.87 3.00e-22 99.00
IUUC-Pfo-096366 Poecilia formosa 66.41 2.00e-81 295.00
IUUC-Pab-098242 Pongo abelii 94.37 5.00e-104 370.00
IUUC-Pop-099622 Populus trichocarpa 28.19 5.00e-21 94.40
IUUC-Pca-100637 Procavia capensis 96.63 4.00e-29 120.00
IUUC-Ppe-101586 Prunus persica 34.09 3.00e-15 73.60
IUUC-Pva-102627 Pteropus vampyrus 87.74 6.00e-109 387.00
IUUC-Rno-105344 Rattus norvegicus 96.11 1.00e-118 418.00
IUUC-Sha-107420 Sarcophilus harrisii 83.33 1.00e-101 362.00
IUUC-Smo-109218 Selaginella moellendorffii 31.40 3.00e-25 108.00
IUUC-Sly-111612 Solanum lycopersicum 31.69 2.00e-17 83.20
IUUC-Stu-112127 Solanum tuberosum 35.75 4.00e-21 94.40
IUUC-Sar-113762 Sorex araneus 87.60 4.00e-104 370.00
IUUC-Sbi-113997 Sorghum bicolor 34.50 2.00e-24 105.00
IUUC-Ssc-115764 Sus scrofa 96.59 8.00e-29 117.00
IUUC-Tgu-116969 Taeniopygia guttata 77.78 2.00e-93 335.00
IUUC-Tru-118414 Takifugu rubripes 71.62 7.00e-79 286.00
IUUC-Tsy-119312 Tarsius syrichta 81.54 3.00e-105 374.00
IUUC-Tni-120687 Tetraodon nigroviridis 71.66 1.00e-81 295.00
IUUC-Tca-121028 Theobroma cacao 36.21 5.00e-18 84.00
IUUC-Tae-122873 Triticum aestivum 37.14 5.00e-25 107.00
IUUC-Tur-126558 Triticum urartu 35.10 1.00e-19 89.00
IUUC-Tbe-127751 Tupaia belangeri 80.77 7.00e-88 317.00
IUUC-Ttr-128731 Tursiops truncatus 79.23 1.00e-92 332.00
IUUC-Vpa-130187 Vicugna pacos 86.92 3.00e-104 370.00
IUUC-Vvi-131393 Vitis vinifera 36.63 3.00e-24 104.00
IUUC-Xtr-132512 Xenopus tropicalis 72.36 7.00e-87 313.00
IUUC-Xma-133203 Xiphophorus maculatus 66.80 6.00e-82 296.00
Created Date 25-Jun-2017

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