iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116554

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01049698

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003191.1	ENSTGUT00000003345.1	ENSTGUP00000003312.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-92	309.7	4514	4848
E3 adaptor/Cullin RING/DCX/DWD	5.70e-19	67.3	3429	3459

Active Site

Position(s)	Description	Evidence
4817	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4514 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4600
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4601 PLDLHLAPMVWKQLCCIPLILEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4687
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4688 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4772
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ i+ e+L+yAi++++++++
   Q: 4773 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQVIMAERLRYAINNCRSIDM 4848
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3429 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3459
           55416677.*9778****************97 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MAAMVPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYAK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGCTA TGGTCCCACC TGTGAAGCTG AAGTGGCTCG AACACTTAAA CAGCTCATGG 60
ATCACAGAAG ACAGTGAATC CATTGCAACA AGGGAAGGAG TTTCTGTCTT GTATGCTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	92.32	0.00e+00	8354.00
IUUC-Apl-003461	Anas platyrhynchos	96.57	0.00e+00	8695.00
IUUC-Aca-004452	Anolis carolinensis	85.74	0.00e+00	7451.00
IUUC-Aly-006545	Arabidopsis lyrata	36.84	2.00e-50	194.00
IUUC-Ame-011268	Astyanax mexicanus	60.62	0.00e+00	2227.00
IUUC-Bta-013213	Bos taurus	92.67	0.00e+00	8381.00
IUUC-Bra-017584	Brassica rapa	34.97	4.00e-51	196.00
IUUC-Cja-019298	Callithrix jacchus	92.34	0.00e+00	8371.00
IUUC-Cfa-021213	Canis familiaris	92.49	0.00e+00	8455.00
IUUC-Cpo-021674	Cavia porcellus	91.34	0.00e+00	5668.00
IUUC-Csa-023341	Chlorocebus sabaeus	92.13	0.00e+00	8356.00
IUUC-Cho-024567	Choloepus hoffmanni	90.04	0.00e+00	1704.00
IUUC-Dre-028289	Danio rerio	79.19	0.00e+00	7104.00
IUUC-Dno-029988	Dasypus novemcinctus	91.91	0.00e+00	8337.00
IUUC-Dor-030636	Dipodomys ordii	90.80	0.00e+00	2079.00
IUUC-Ete-032598	Echinops telfairi	83.31	0.00e+00	1352.00
IUUC-Eca-033754	Equus caballus	92.53	0.00e+00	8386.00
IUUC-Eeu-034702	Erinaceus europaeus	87.57	0.00e+00	1447.00
IUUC-Fca-035900	Felis catus	92.79	0.00e+00	8423.00
IUUC-Fal-037034	Ficedula albicollis	95.92	0.00e+00	7574.00
IUUC-Gmo-039260	Gadus morhua	74.95	0.00e+00	1249.00
IUUC-Gga-040321	Gallus gallus	96.24	0.00e+00	8738.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.36	0.00e+00	2231.00
IUUC-Gma-043808	Glycine max	34.03	8.00e-47	182.00
IUUC-Ggo-045134	Gorilla gorilla	87.66	0.00e+00	4497.00
IUUC-Hsa-046516	Homo sapiens	92.36	0.00e+00	8352.00
IUUC-Hvu-047529	Hordeum vulgare	36.05	1.00e-50	195.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	93.06	0.00e+00	2476.00
IUUC-Lch-049903	Latimeria chalumnae	87.31	0.00e+00	7945.00
IUUC-Lpe-051165	Leersia perrieri	33.91	1.00e-49	190.00
IUUC-Loc-052149	Lepisosteus oculatus	84.03	0.00e+00	7565.00
IUUC-Laf-053426	Loxodonta africana	92.71	0.00e+00	8440.00
IUUC-Mcc-055826	Macaca mulatta	92.46	0.00e+00	8408.00
IUUC-Meu-056521	Macropus eugenii	83.93	0.00e+00	2230.00
IUUC-Mga-059567	Meleagris gallopavo	97.84	0.00e+00	2159.00
IUUC-Mmr-061512	Microcebus murinus	92.03	0.00e+00	8289.00
IUUC-Mdo-062177	Monodelphis domestica	90.31	0.00e+00	8162.00
IUUC-Mmu-064373	Mus musculus	92.46	0.00e+00	8361.00
IUUC-Mpu-066148	Mustela putorius furo	92.34	0.00e+00	8358.00
IUUC-Mlu-067680	Myotis lucifugus	92.20	0.00e+00	8326.00
IUUC-Nle-069633	Nomascus leucogenys	91.91	0.00e+00	8298.00
IUUC-Opr-070609	Ochotona princeps	87.43	0.00e+00	1342.00
IUUC-Ont-071249	Oreochromis niloticus	81.46	0.00e+00	7484.00
IUUC-Oan-073157	Ornithorhynchus anatinus	92.45	0.00e+00	8312.00
IUUC-Ocu-074841	Oryctolagus cuniculus	92.28	0.00e+00	8429.00
IUUC-Oba-075262	Oryza barthii	33.58	6.00e-48	184.00
IUUC-Obr-076115	Oryza brachyantha	34.18	1.00e-47	183.00
IUUC-Ogl-077586	Oryza glaberrima	33.58	6.00e-48	184.00
IUUC-Ogu-078796	Oryza glumaepatula	33.33	2.00e-47	182.00
IUUC-Oin-079298	Oryza indica	33.33	2.00e-47	182.00
IUUC-Oni-082049	Oryza nivara	33.33	2.00e-47	182.00
IUUC-Opu-083608	Oryza punctata	33.00	2.00e-48	186.00
IUUC-Oru-084712	Oryza rufipogon	33.33	2.00e-47	182.00
IUUC-Osa-086078	Oryza sativa	33.33	2.00e-47	182.00
IUUC-Ola-086889	Oryzias latipes	79.99	0.00e+00	7319.00
IUUC-Oga-088459	Otolemur garnettii	91.53	0.00e+00	8301.00
IUUC-Oar-089888	Ovis aries	92.63	0.00e+00	8367.00
IUUC-Ptr-091114	Pan troglodytes	92.38	0.00e+00	8376.00
IUUC-Pan-092442	Papio anubis	92.34	0.00e+00	8385.00
IUUC-Psi-093833	Pelodiscus sinensis	93.62	0.00e+00	5588.00
IUUC-Pma-094275	Petromyzon marinus	78.15	0.00e+00	1741.00
IUUC-Ppa-095790	Physcomitrella patens	36.05	3.00e-54	205.00
IUUC-Pfo-097262	Poecilia formosa	80.02	0.00e+00	7160.00
IUUC-Pab-097760	Pongo abelii	91.52	0.00e+00	4732.00
IUUC-Pop-099121	Populus trichocarpa	37.21	4.00e-54	206.00
IUUC-Pca-100465	Procavia capensis	91.03	0.00e+00	4393.00
IUUC-Ppe-101345	Prunus persica	33.84	3.00e-52	200.00
IUUC-Pva-102950	Pteropus vampyrus	92.45	0.00e+00	3952.00
IUUC-Rno-104892	Rattus norvegicus	92.15	0.00e+00	8283.00
IUUC-Sha-106633	Sarcophilus harrisii	92.07	0.00e+00	8180.00
IUUC-Smo-108827	Selaginella moellendorffii	36.18	1.00e-53	204.00
IUUC-Sly-111155	Solanum lycopersicum	38.26	2.00e-56	213.00
IUUC-Stu-112166	Solanum tuberosum	31.81	2.00e-49	191.00
IUUC-Sar-113251	Sorex araneus	84.58	0.00e+00	2436.00
IUUC-Ssc-116391	Sus scrofa	92.40	0.00e+00	8385.00
IUUC-Tru-118695	Takifugu rubripes	80.95	0.00e+00	7437.00
IUUC-Tsy-119647	Tarsius syrichta	84.99	0.00e+00	5301.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.89	0.00e+00	7405.00
IUUC-Tur-126300	Triticum urartu	36.05	4.00e-51	196.00
IUUC-Tbe-127346	Tupaia belangeri	84.54	0.00e+00	2466.00
IUUC-Ttr-128542	Tursiops truncatus	87.64	0.00e+00	5591.00
IUUC-Vpa-130611	Vicugna pacos	93.03	0.00e+00	3841.00
IUUC-Xtr-131933	Xenopus tropicalis	85.14	0.00e+00	7680.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence