iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045338

Ensembl Protein ID

ENSGGOP00000003275.2

UniProt Accession

G3QLC6; G3QLC6_GORGO

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000003332.2	ENSGGOT00000029840.1	ENSGGOP00000025919.1
ENSGGOG00000003332.2	ENSGGOT00000003349.2	ENSGGOP00000003275.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.70e-08	33.3	311	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 311  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 349
           89********************************99986 PP

Organism

Gorilla gorilla

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLAGTVRFAR HCLKFFPAQE PACVDFGASR GRAMLTFMAS DSEEEVCDER TSLMSAESPT 60
PRSCQEGRQG PEDGENTAQW RSQENEEDGE EDPDRYVCSG VPGRPPGLEE ELTLKYGAKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCCTGGG CCGGCGCCGG GTCCGGCCGG GCGCTCAGCC AGCTGCGTAA ACTCCGCTGG 60
AGCGCGGCGG TGGAGCAGGT GAGCTGGCGG GGCCGGGGGG TGCCCAGGCC AGGGCCCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	56.79	3.00e-15	77.40
IUUC-Aml-002356	Ailuropoda melanoleuca	89.23	0.00e+00	644.00
IUUC-Apl-003959	Anas platyrhynchos	77.02	1.00e-163	568.00
IUUC-Aca-005160	Anolis carolinensis	74.35	1.00e-160	559.00
IUUC-Ang-009768	Aspergillus niger	51.85	1.20e-01	31.60
IUUC-Ame-010686	Astyanax mexicanus	79.43	2.00e-147	514.00
IUUC-Bta-013097	Bos taurus	96.66	0.00e+00	728.00
IUUC-Bdi-014196	Brachypodium distachyon	38.92	8.00e-19	88.20
IUUC-Bol-015841	Brassica oleracea	61.73	2.00e-17	83.20
IUUC-Bra-017580	Brassica rapa	57.47	3.00e-17	82.80
IUUC-Cel-018553	Caenorhabditis elegans	48.91	8.00e-93	333.00
IUUC-Cja-018824	Callithrix jacchus	96.26	0.00e+00	803.00
IUUC-Cfa-020253	Canis familiaris	95.98	0.00e+00	743.00
IUUC-Cpo-021401	Cavia porcellus	95.33	0.00e+00	742.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	4.00e-30	126.00
IUUC-Csa-023369	Chlorocebus sabaeus	99.78	0.00e+00	776.00
IUUC-Cin-025780	Ciona intestinalis	60.90	2.00e-116	412.00
IUUC-Csv-025967	Ciona savignyi	59.91	2.00e-117	415.00
IUUC-Dre-028526	Danio rerio	70.29	2.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	91.76	0.00e+00	690.00
IUUC-Dme-031929	Drosophila melanogaster	65.35	2.00e-83	303.00
IUUC-Ete-033081	Echinops telfairi	84.04	4.00e-94	338.00
IUUC-Eca-034387	Equus caballus	95.82	0.00e+00	714.00
IUUC-Eeu-034846	Erinaceus europaeus	82.03	2.00e-154	538.00
IUUC-Fca-035396	Felis catus	94.92	0.00e+00	764.00
IUUC-Fal-037457	Ficedula albicollis	76.52	5.00e-161	560.00
IUUC-Gmo-038550	Gadus morhua	82.76	3.00e-105	375.00
IUUC-Gga-040706	Gallus gallus	77.46	1.00e-157	549.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.04	7.00e-130	457.00
IUUC-Gma-043822	Glycine max	36.88	2.00e-22	99.80
IUUC-Hsa-046455	Homo sapiens	99.79	0.00e+00	847.00
IUUC-Hvu-047141	Hordeum vulgare	58.02	5.00e-16	79.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	97.32	0.00e+00	756.00
IUUC-Lch-049638	Latimeria chalumnae	69.11	3.00e-147	514.00
IUUC-Lpe-051132	Leersia perrieri	37.68	2.00e-17	83.60
IUUC-Loc-052427	Lepisosteus oculatus	75.28	5.00e-158	550.00
IUUC-Laf-053758	Loxodonta africana	89.20	0.00e+00	738.00
IUUC-Mcc-054755	Macaca mulatta	98.13	0.00e+00	828.00
IUUC-Mtr-058392	Medicago truncatula	33.51	1.00e-29	123.00
IUUC-Mmr-060890	Microcebus murinus	96.43	0.00e+00	751.00
IUUC-Mdo-062197	Monodelphis domestica	81.00	8.00e-178	616.00
IUUC-Mmu-063823	Mus musculus	95.98	0.00e+00	750.00
IUUC-Mac-064858	Musa acuminata	43.27	7.00e-22	97.40
IUUC-Mpu-066181	Mustela putorius furo	95.54	0.00e+00	740.00
IUUC-Nle-069596	Nomascus leucogenys	100.00	0.00e+00	726.00
IUUC-Opr-070344	Ochotona princeps	95.15	0.00e+00	762.00
IUUC-Ont-071867	Oreochromis niloticus	70.79	2.00e-133	468.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.61	1.00e-156	545.00
IUUC-Ocu-074652	Oryctolagus cuniculus	94.73	0.00e+00	722.00
IUUC-Oba-075256	Oryza barthii	60.49	3.00e-16	79.30
IUUC-Obr-076302	Oryza brachyantha	37.68	2.00e-17	83.60
IUUC-Ogl-077097	Oryza glaberrima	37.68	5.00e-17	82.00
IUUC-Ogu-078570	Oryza glumaepatula	37.68	5.00e-17	82.00
IUUC-Oin-079244	Oryza indica	38.41	3.00e-17	82.80
IUUC-Olo-080484	Oryza longistaminata	60.49	1.00e-16	80.10
IUUC-Ome-081814	Oryza meridionalis	36.87	2.00e-17	84.00
IUUC-Oni-082057	Oryza nivara	38.41	3.00e-17	82.80
IUUC-Opu-084176	Oryza punctata	38.41	6.00e-17	82.00
IUUC-Oru-084618	Oryza rufipogon	38.41	3.00e-17	82.80
IUUC-Osa-085602	Oryza sativa	37.43	1.00e-17	84.00
IUUC-Ola-086707	Oryzias latipes	71.15	6.00e-107	380.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.44	1.00e-46	179.00
IUUC-Oga-088560	Otolemur garnettii	96.90	0.00e+00	718.00
IUUC-Oar-089200	Ovis aries	96.21	0.00e+00	706.00
IUUC-Ptr-090569	Pan troglodytes	99.78	0.00e+00	775.00
IUUC-Pan-091742	Papio anubis	99.78	0.00e+00	775.00
IUUC-Psi-093297	Pelodiscus sinensis	77.10	2.00e-133	468.00
IUUC-Pma-094612	Petromyzon marinus	77.75	2.00e-128	452.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	8.00e-28	118.00
IUUC-Pfo-097396	Poecilia formosa	67.58	2.00e-127	449.00
IUUC-Pab-098531	Pongo abelii	99.78	0.00e+00	776.00
IUUC-Pop-099661	Populus trichocarpa	32.51	8.00e-30	124.00
IUUC-Pca-101120	Procavia capensis	90.44	0.00e+00	746.00
IUUC-Pva-102934	Pteropus vampyrus	83.78	0.00e+00	717.00
IUUC-Rno-106052	Rattus norvegicus	95.31	0.00e+00	763.00
IUUC-Sha-106876	Sarcophilus harrisii	79.96	3.00e-174	604.00
IUUC-Smo-109325	Selaginella moellendorffii	36.54	2.00e-30	126.00
IUUC-Sit-110624	Setaria italica	58.02	9.00e-16	78.20
IUUC-Sbi-114305	Sorghum bicolor	47.83	4.00e-16	79.00
IUUC-Ssc-115380	Sus scrofa	97.99	0.00e+00	783.00
IUUC-Tgu-117280	Taeniopygia guttata	77.17	7.00e-162	563.00
IUUC-Tru-117732	Takifugu rubripes	68.77	1.00e-120	426.00
IUUC-Tni-119852	Tetraodon nigroviridis	64.74	4.00e-113	401.00
IUUC-Tae-125925	Triticum aestivum	58.02	5.00e-16	79.00
IUUC-Tur-126237	Triticum urartu	58.02	5.00e-16	78.60
IUUC-Tbe-127632	Tupaia belangeri	97.98	0.00e+00	650.00
IUUC-Ttr-129008	Tursiops truncatus	92.78	0.00e+00	743.00
IUUC-Xtr-132756	Xenopus tropicalis	71.86	4.00e-163	567.00
IUUC-Xma-133377	Xiphophorus maculatus	67.68	4.00e-125	441.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence