iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092717

Ensembl Protein ID

ENSPANP00000002215.1

UniProt Accession

A0A096MR21; A0A096MR21_PAPAN

Genbank Protein ID

ENSPANP00000002215

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01002179

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000019009.1	ENSPANT00000004511.1	ENSPANP00000002215.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.80e-115	383.4	301	922
ULD/UDP/UBQ/UBQ_Other	7.50e-18	64.3	142	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 301  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 389
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 390  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 476
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 477  TLPLPLKKDRVMEvflvpadphcrptqyrvtvplmgavsdlcealsrlcgiaaenmvvadvynhrfhkifqmdeglnhimprddifvyq 565
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 566  vcstsmdgsecvtlpvyfrerksrpsstssgsalygqplllsvpkhkltleslyqavcdrisryvkqplpddfgssplepgtcngsrns 654
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 655  cegedeeemehqeegkeqlsetegsgedelgndptkttqkkikgqpcpkrlftfslvnsygtadinslatdgkllklnsrstlaidwds 743
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 744  etrslyydeqeseayekhvsmlqpqkkkkttvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 832
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp++ L++s+f+++p+     ++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + 
   Q: 833  --WRDKLDTVVEFPIRgLNMSEFVCNPSAR---PYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KA 913
           ..567*********************8866...9**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 914  AYVLFYQRR 922
           *******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 142  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 220
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GALMRTTLQR GAQWHVIYSC QVKQCNQTVC LDWDLYKDHY 60
EINDLPIDNS GLFSGIKSLQ TLNEKLFDIL NLVLVETEPH NKFNSEYYCL SGGYPLISKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GTGGAGGCTG CCGTGAGCGA CCGGATGCGG AGACTCAGAA GTCGGAGCTT 60
GGAGCCTTAA TGAGGACCAC ACTCCAACGC GGCGCGCAGT GGTGAGCATC CGGCTCGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF14836--Ubiquitin_3
PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	40.87	1.00e-120	427.00
IUUC-Aml-001597	Ailuropoda melanoleuca	88.60	0.00e+00	1540.00
IUUC-Atr-002991	Amborella trichopoda	36.18	3.00e-130	459.00
IUUC-Apl-004068	Anas platyrhynchos	69.87	0.00e+00	1088.00
IUUC-Aca-004459	Anolis carolinensis	64.41	0.00e+00	1113.00
IUUC-Aly-006315	Arabidopsis lyrata	42.97	4.00e-130	459.00
IUUC-Ath-007288	Arabidopsis thaliana	36.02	1.00e-137	484.00
IUUC-Ang-009562	Aspergillus niger	44.80	3.00e-55	211.00
IUUC-Bta-012929	Bos taurus	89.11	0.00e+00	1585.00
IUUC-Cja-018798	Callithrix jacchus	91.39	0.00e+00	1585.00
IUUC-Cfa-020599	Canis familiaris	89.95	0.00e+00	1580.00
IUUC-Cpo-022144	Cavia porcellus	85.59	0.00e+00	1490.00
IUUC-Csa-023770	Chlorocebus sabaeus	96.88	0.00e+00	1595.00
IUUC-Cho-024595	Choloepus hoffmanni	84.43	0.00e+00	1085.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	43.75	1.00e-60	229.00
IUUC-Cne-026852	Cryptococcus neoformans	44.55	3.00e-72	267.00
IUUC-Dre-027869	Danio rerio	63.96	0.00e+00	776.00
IUUC-Dno-029316	Dasypus novemcinctus	87.36	0.00e+00	1587.00
IUUC-Ete-032970	Echinops telfairi	82.63	0.00e+00	1062.00
IUUC-Eca-034012	Equus caballus	89.64	0.00e+00	1560.00
IUUC-Eeu-035158	Erinaceus europaeus	77.13	0.00e+00	796.00
IUUC-Fca-035373	Felis catus	86.01	0.00e+00	1543.00
IUUC-Fal-037634	Ficedula albicollis	70.80	0.00e+00	1183.00
IUUC-Fox-037986	Fusarium oxysporum	44.32	6.00e-64	239.00
IUUC-Fso-038291	Fusarium solani	44.32	9.00e-64	239.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	8.00e-63	236.00
IUUC-Gga-040729	Gallus gallus	64.16	0.00e+00	1141.00
IUUC-Gac-042631	Gasterosteus aculeatus	63.20	0.00e+00	1132.00
IUUC-Ggo-045337	Gorilla gorilla	90.68	0.00e+00	1454.00
IUUC-Hsa-045669	Homo sapiens	93.15	0.00e+00	1647.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	89.33	0.00e+00	1583.00
IUUC-Lch-050533	Latimeria chalumnae	64.83	0.00e+00	1065.00
IUUC-Lpe-051424	Leersia perrieri	36.82	8.00e-137	481.00
IUUC-Laf-053803	Loxodonta africana	89.22	0.00e+00	1571.00
IUUC-Mcc-055556	Macaca mulatta	90.66	0.00e+00	1566.00
IUUC-Meu-056742	Macropus eugenii	70.49	0.00e+00	1256.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	5.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	9.00e-63	236.00
IUUC-Mtr-058138	Medicago truncatula	44.18	6.00e-139	488.00
IUUC-Mga-059300	Meleagris gallopavo	68.85	0.00e+00	1130.00
IUUC-Mdo-061848	Monodelphis domestica	79.81	0.00e+00	1429.00
IUUC-Mmu-063960	Mus musculus	85.48	0.00e+00	1521.00
IUUC-Mpu-066920	Mustela putorius furo	89.95	0.00e+00	1584.00
IUUC-Mlu-068088	Myotis lucifugus	88.19	0.00e+00	1568.00
IUUC-Ncr-068879	Neurospora crassa	45.58	1.00e-61	232.00
IUUC-Nle-070010	Nomascus leucogenys	93.26	0.00e+00	1643.00
IUUC-Opr-070740	Ochotona princeps	89.60	0.00e+00	1201.00
IUUC-Ont-072573	Oreochromis niloticus	60.53	0.00e+00	1141.00
IUUC-Oan-073363	Ornithorhynchus anatinus	72.89	0.00e+00	1293.00
IUUC-Ocu-074242	Oryctolagus cuniculus	84.45	0.00e+00	1459.00
IUUC-Oba-075553	Oryza barthii	41.62	4.00e-128	452.00
IUUC-Ogl-077583	Oryza glaberrima	41.62	4.00e-128	452.00
IUUC-Oin-079300	Oryza indica	41.77	3.00e-129	456.00
IUUC-Oru-085141	Oryza rufipogon	41.38	2.00e-125	444.00
IUUC-Osa-085641	Oryza sativa	41.77	3.00e-129	456.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.28	1.00e-123	437.00
IUUC-Oga-088562	Otolemur garnettii	81.94	0.00e+00	1370.00
IUUC-Oar-090439	Ovis aries	88.59	0.00e+00	1567.00
IUUC-Ptr-090801	Pan troglodytes	93.26	0.00e+00	1645.00
IUUC-Psi-093942	Pelodiscus sinensis	69.52	0.00e+00	1171.00
IUUC-Pab-098522	Pongo abelii	97.41	0.00e+00	1299.00
IUUC-Pca-100161	Procavia capensis	78.40	0.00e+00	1353.00
IUUC-Rno-106081	Rattus norvegicus	84.65	0.00e+00	1525.00
IUUC-Sha-106937	Sarcophilus harrisii	78.31	0.00e+00	1385.00
IUUC-Sar-113542	Sorex araneus	82.07	0.00e+00	1454.00
IUUC-Ssc-115637	Sus scrofa	89.73	0.00e+00	1570.00
IUUC-Tgu-117267	Taeniopygia guttata	67.70	0.00e+00	1181.00
IUUC-Tca-121001	Theobroma cacao	36.23	3.00e-141	496.00
IUUC-Tbe-127669	Tupaia belangeri	75.27	0.00e+00	891.00
IUUC-Ttr-128778	Tursiops truncatus	88.38	0.00e+00	1553.00
IUUC-Uma-129498	Ustilago maydis	49.04	5.00e-70	259.00
IUUC-Vda-129781	Verticillium dahliae	44.60	3.00e-65	244.00
IUUC-Vpa-130571	Vicugna pacos	88.26	0.00e+00	994.00
IUUC-Xtr-132305	Xenopus tropicalis	64.59	0.00e+00	1157.00
IUUC-Yli-134392	Yarrowia lipolytica	42.25	1.00e-61	232.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence