iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087928

Ensembl Protein ID

ENSOGAP00000004999.2

UniProt Accession

H0WSD9; H0WSD9_OTOGA

Genbank Protein ID

ENSOGAP00000004999

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAQR03026439

Gene Name

CSK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000005591.2	ENSOGAT00000005595.2	ENSOGAP00000004999.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.20e-10	40.4	13	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++ y+++++ d +L + kGdv++++   ++d +W k+ k+  g++G++P+n+v+k
   Q: 13   ECIAKYNFQGTADQDLPFCKGDVLTIV-AVTKDPNWYKA-KNKVGREGIIPANYVQK 67
           68999**********************.***********.6**************87 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSAIQAAWPS GTECIAKYNF QGTADQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCTACCTT TTGCCGTCCC TCCTCCCCTT TTTTTGCACC CTTACCTCTT TGTACCGCAC 60
CCCCTGGGGA CTCTTGCGCC CCTCCCCTCC CCCCTGGCCG CATGGACCGT CCTGCGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0008285--P:negative regulation of cell proliferation
GO:0042997--P:negative regulation of Golgi to plasma membrane protein transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004391	Anolis carolinensis	93.11	0.00e+00	876.00
IUUC-Cin-025513	Ciona intestinalis	54.85	2.00e-144	505.00
IUUC-Csv-025899	Ciona savignyi	51.36	6.00e-136	477.00
IUUC-Fal-037215	Ficedula albicollis	92.89	0.00e+00	869.00
IUUC-Gmo-039103	Gadus morhua	84.88	0.00e+00	803.00
IUUC-Gga-040506	Gallus gallus	92.89	0.00e+00	868.00
IUUC-Loc-052586	Lepisosteus oculatus	87.78	0.00e+00	842.00
IUUC-Meu-056387	Macropus eugenii	96.00	0.00e+00	902.00
IUUC-Mtr-058657	Medicago truncatula	28.69	2.00e-20	94.00
IUUC-Mga-060040	Meleagris gallopavo	91.48	0.00e+00	844.00
IUUC-Mdo-061871	Monodelphis domestica	95.11	0.00e+00	897.00
IUUC-Ont-072457	Oreochromis niloticus	84.20	0.00e+00	794.00
IUUC-Ola-087366	Oryzias latipes	85.01	0.00e+00	804.00
IUUC-Pfo-096126	Poecilia formosa	82.84	0.00e+00	785.00
IUUC-Sha-106987	Sarcophilus harrisii	95.78	0.00e+00	902.00
IUUC-Tru-118712	Takifugu rubripes	81.55	0.00e+00	770.00
IUUC-Tni-119856	Tetraodon nigroviridis	82.39	0.00e+00	780.00
IUUC-Xtr-132763	Xenopus tropicalis	84.00	0.00e+00	797.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence