iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010769

Ensembl Protein ID

ENSAMXP00000019754.1

UniProt Accession

W5LIU2; W5LIU2_ASTMX

Genbank Protein ID

ENSAMXP00000019754

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01032456

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000019163.1	ENSAMXT00000019754.1	ENSAMXP00000019754.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-88	298.1	603	942

Active Site

Position(s)	Description	Evidence
910	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p  ++ +  +  +++++flGr+lgk+l    
   Q: 603  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLSELLKSGFNPNQGFFRTTNEGLLFPSPTAEMLIG-ESFTRHYYFLGRILGKVLSCFL 690
           689**********99**9******************************************999985.5********************9 PP
   S: 87   lldlplsksfykll....lgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
            + l +s++f+ +     lg++   ++l++++p+   +l+  + n+ ++++ l l+lt+s   ++l e++++eLkpgG++ipVt +N+ 
   Q: 691  SIVLLFSSFFLFTCfncgLGVDKVRDHLAKLHPKKTSNLNIFNINKWRELSSLVLHLTIS---HVLDECQVVELKPGGKDIPVTTANRI 776
           999999999987773433555655599******************999999999999986...789*********************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsse 259
           +Y++lv++yrl+++i+ ++ afr+G+ +v++le+l++F+++e+++li+G    i ++dlkk+t+y ggy++++p+i+ Fw+v+e+fs++
   Q: 777  AYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLISGAhVPICLDDLKKFTNYSGGYSATHPVIKIFWDVVENFSDD 865
           **************************************************999************************************ PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           e++++L+FvT++sr Pl Gf+el p  f+i++ ++d +rlP+++TC+n+LkLPe+  ++ +k+kLlyAie+++gFels
   Q: 866  EKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGNDlERLPTASTCMNLLKLPEFCDEQLMKSKLLYAIESSSGFELS 942
           ************************88.*****99999**************************************985 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

LCVSCRLLQL YEDDGVNVAV PMRMLEVFSS EKIYLPVLQD SSAATALTEQ ILHYMVQKGY 60
YRSLYVLVNH KLPSSLEYSD APSVPLAHTL LEHLLKPLHF TYSSCPVGAR QFVFSAFTEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTTTGCTG TTGTAACAGT TGAAATATTG AGTGGTAATA AGTGTGTGTG TGTGTGTCTG 60
TGTGTGTCCT GCAGGCTGCT GCAGCTGTAT GAGGACGATG GCGTGAATGT GGCCGTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	37.93	2.00e-66	248.00
IUUC-Aml-001355	Ailuropoda melanoleuca	62.24	0.00e+00	1073.00
IUUC-Atr-003017	Amborella trichopoda	39.19	7.00e-77	282.00
IUUC-Apl-003731	Anas platyrhynchos	62.96	0.00e+00	1103.00
IUUC-Aca-005248	Anolis carolinensis	63.81	0.00e+00	1125.00
IUUC-Aly-005768	Arabidopsis lyrata	41.92	2.00e-77	284.00
IUUC-Ath-006576	Arabidopsis thaliana	42.19	5.00e-78	286.00
IUUC-Ago-007748	Ashbya gossypii	37.93	1.00e-63	238.00
IUUC-Acl-008158	Aspergillus clavatus	35.29	3.00e-62	234.00
IUUC-Afl-008398	Aspergillus flavus	34.56	3.00e-62	233.00
IUUC-Afu-008937	Aspergillus fumigatus	35.70	2.00e-63	238.00
IUUC-Ani-009252	Aspergillus nidulans	34.41	2.00e-61	231.00
IUUC-Ang-009773	Aspergillus niger	35.05	2.00e-62	234.00
IUUC-Aor-009940	Aspergillus oryzae	34.56	3.00e-62	233.00
IUUC-Ate-010395	Aspergillus terreus	34.80	3.00e-63	237.00
IUUC-Bgr-012269	Blumeria graminis	37.37	7.00e-60	224.00
IUUC-Bta-012841	Bos taurus	62.32	0.00e+00	1076.00
IUUC-Bci-013743	Botrytis cinerea	35.34	3.00e-63	237.00
IUUC-Bdi-014123	Brachypodium distachyon	42.47	3.00e-77	283.00
IUUC-Bol-015390	Brassica oleracea	40.51	3.00e-74	273.00
IUUC-Bra-016853	Brassica rapa	41.41	4.00e-79	290.00
IUUC-Cel-018638	Caenorhabditis elegans	35.77	4.00e-71	263.00
IUUC-Cja-019743	Callithrix jacchus	62.25	0.00e+00	1073.00
IUUC-Cfa-021031	Canis familiaris	63.45	0.00e+00	1090.00
IUUC-Cpo-022401	Cavia porcellus	63.36	0.00e+00	1083.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	37.97	2.00e-67	249.00
IUUC-Csa-024107	Chlorocebus sabaeus	63.04	0.00e+00	1099.00
IUUC-Cho-024750	Choloepus hoffmanni	75.37	9.00e-149	521.00
IUUC-Cin-025750	Ciona intestinalis	35.93	1.00e-62	235.00
IUUC-Csv-026016	Ciona savignyi	36.45	1.00e-64	241.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	36.96	4.00e-67	250.00
IUUC-Cne-026841	Cryptococcus neoformans	39.90	3.00e-71	263.00
IUUC-Cme-027265	Cyanidioschyzon merolae	42.13	1.00e-82	301.00
IUUC-Dre-028196	Danio rerio	69.01	0.00e+00	1170.00
IUUC-Dno-029024	Dasypus novemcinctus	62.97	0.00e+00	1103.00
IUUC-Dor-030483	Dipodomys ordii	56.78	1.00e-101	364.00
IUUC-Dse-031416	Dothistroma septosporum	33.03	1.00e-61	231.00
IUUC-Dme-031946	Drosophila melanogaster	33.20	1.00e-126	447.00
IUUC-Ete-032240	Echinops telfairi	50.59	3.00e-84	306.00
IUUC-Eca-033828	Equus caballus	62.95	0.00e+00	1092.00
IUUC-Eeu-034604	Erinaceus europaeus	75.00	1.00e-70	261.00
IUUC-Fca-035907	Felis catus	62.66	0.00e+00	1083.00
IUUC-Fal-037389	Ficedula albicollis	63.33	0.00e+00	1115.00
IUUC-Fox-037788	Fusarium oxysporum	35.00	2.00e-63	238.00
IUUC-Fso-038088	Fusarium solani	34.73	1.00e-63	238.00
IUUC-Gmo-039254	Gadus morhua	61.66	0.00e+00	750.00
IUUC-Ggr-039941	Gaeumannomyces graminis	36.09	3.00e-62	234.00
IUUC-Gga-040310	Gallus gallus	63.71	0.00e+00	1117.00
IUUC-Gac-042054	Gasterosteus aculeatus	60.65	0.00e+00	865.00
IUUC-Gma-042836	Glycine max	42.74	2.00e-72	267.00
IUUC-Ggo-045031	Gorilla gorilla	63.04	0.00e+00	1100.00
IUUC-Hsa-045880	Homo sapiens	63.04	0.00e+00	1100.00
IUUC-Hvu-047770	Hordeum vulgare	42.19	3.00e-77	283.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	60.14	3.00e-98	351.00
IUUC-Kpa-049307	Komagataella pastoris	33.86	1.00e-53	205.00
IUUC-Lch-050403	Latimeria chalumnae	60.11	0.00e+00	986.00
IUUC-Lpe-050755	Leersia perrieri	38.42	3.00e-68	253.00
IUUC-Loc-052218	Lepisosteus oculatus	65.93	0.00e+00	1140.00
IUUC-Lma-053096	Leptosphaeria maculans	36.25	7.00e-63	236.00
IUUC-Laf-054162	Loxodonta africana	60.14	0.00e+00	917.00
IUUC-Mcc-055127	Macaca mulatta	62.83	0.00e+00	1094.00
IUUC-Meu-056187	Macropus eugenii	70.59	3.00e-51	196.00
IUUC-Mor-057021	Magnaporthe oryzae	34.42	3.00e-55	210.00
IUUC-Mpo-057570	Magnaporthe poae	35.34	7.00e-59	222.00
IUUC-Mtr-058154	Medicago truncatula	43.01	1.00e-71	265.00
IUUC-Mla-059124	Melampsora laricipopulina	42.78	9.00e-78	284.00
IUUC-Mga-059581	Meleagris gallopavo	63.71	0.00e+00	1117.00
IUUC-Mvi-060445	Microbotryum violaceum	41.90	7.00e-72	266.00
IUUC-Mmr-061360	Microcebus murinus	60.13	0.00e+00	1015.00
IUUC-Mdo-062194	Monodelphis domestica	62.89	0.00e+00	1111.00
IUUC-Mmu-064189	Mus musculus	62.83	0.00e+00	1095.00
IUUC-Mac-065275	Musa acuminata	40.10	1.00e-77	285.00
IUUC-Mpu-066439	Mustela putorius furo	63.29	0.00e+00	1093.00
IUUC-Mlu-068228	Myotis lucifugus	63.12	0.00e+00	1102.00
IUUC-Nfi-068280	Neosartorya fischeri	35.94	5.00e-64	239.00
IUUC-Ncr-068869	Neurospora crassa	36.23	7.00e-62	232.00
IUUC-Nle-069687	Nomascus leucogenys	62.94	0.00e+00	1099.00
IUUC-Opr-070592	Ochotona princeps	68.88	2.00e-70	260.00
IUUC-Ont-071836	Oreochromis niloticus	67.43	0.00e+00	1154.00
IUUC-Oan-072800	Ornithorhynchus anatinus	63.09	0.00e+00	1116.00
IUUC-Ocu-074587	Oryctolagus cuniculus	63.15	0.00e+00	1106.00
IUUC-Oba-075006	Oryza barthii	43.16	2.00e-79	290.00
IUUC-Obr-076133	Oryza brachyantha	43.43	3.00e-80	293.00
IUUC-Ogl-077003	Oryza glaberrima	43.16	2.00e-79	290.00
IUUC-Ogu-078947	Oryza glumaepatula	43.16	2.00e-79	291.00
IUUC-Oin-080058	Oryza indica	38.41	2.00e-69	258.00
IUUC-Olo-080475	Oryza longistaminata	43.16	2.00e-79	290.00
IUUC-Ome-081741	Oryza meridionalis	39.01	6.00e-69	256.00
IUUC-Oni-082385	Oryza nivara	43.16	2.00e-79	290.00
IUUC-Opu-083176	Oryza punctata	43.16	2.00e-79	290.00
IUUC-Oru-084554	Oryza rufipogon	39.78	1.00e-66	248.00
IUUC-Osa-085355	Oryza sativa	43.16	2.00e-79	290.00
IUUC-Ola-087209	Oryzias latipes	67.22	0.00e+00	1117.00
IUUC-Olu-087699	Ostreococcus lucimarinus	38.99	6.00e-69	254.00
IUUC-Oga-088776	Otolemur garnettii	59.77	0.00e+00	973.00
IUUC-Oar-089441	Ovis aries	62.25	0.00e+00	1067.00
IUUC-Ptr-091273	Pan troglodytes	63.04	0.00e+00	1100.00
IUUC-Pan-091981	Papio anubis	62.94	0.00e+00	1097.00
IUUC-Psi-093203	Pelodiscus sinensis	59.88	0.00e+00	874.00
IUUC-Pma-094738	Petromyzon marinus	52.92	0.00e+00	860.00
IUUC-Pno-095132	Phaeosphaeria nodorum	32.47	6.00e-40	159.00
IUUC-Ppa-095682	Physcomitrella patens	39.41	3.00e-80	293.00
IUUC-Pfo-097511	Poecilia formosa	67.71	0.00e+00	1156.00
IUUC-Pab-098634	Pongo abelii	59.81	0.00e+00	1019.00
IUUC-Pop-099574	Populus trichocarpa	39.55	3.00e-66	247.00
IUUC-Pca-100987	Procavia capensis	78.24	2.00e-177	616.00
IUUC-Ppe-101281	Prunus persica	39.23	4.00e-72	266.00
IUUC-Pva-103034	Pteropus vampyrus	59.92	0.00e+00	1045.00
IUUC-Pgr-103513	Puccinia graminis	38.89	4.00e-76	280.00
IUUC-Ptt-103967	Puccinia triticina	37.44	7.00e-66	245.00
IUUC-Pte-104105	Pyrenophora teres	36.70	3.00e-63	237.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	36.70	2.00e-63	238.00
IUUC-Rno-105380	Rattus norvegicus	59.93	0.00e+00	879.00
IUUC-Sce-106446	Saccharomyces cerevisiae	38.78	5.00e-54	206.00
IUUC-Sha-107108	Sarcophilus harrisii	61.39	0.00e+00	1052.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	39.91	9.00e-79	288.00
IUUC-Spo-108097	Schizosaccharomyces pombe	40.21	2.00e-74	273.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	36.00	4.00e-62	233.00
IUUC-Smo-109537	Selaginella moellendorffii	39.85	2.00e-75	277.00
IUUC-Sit-110457	Setaria italica	43.67	5.00e-72	266.00
IUUC-Sly-111362	Solanum lycopersicum	41.67	2.00e-71	264.00
IUUC-Sar-113687	Sorex araneus	52.44	2.00e-140	493.00
IUUC-Sbi-113882	Sorghum bicolor	42.47	1.00e-69	258.00
IUUC-Sre-115038	Sporisorium reilianum	40.33	9.00e-71	262.00
IUUC-Ssc-115378	Sus scrofa	62.20	3.00e-125	441.00
IUUC-Tgu-116729	Taeniopygia guttata	63.06	0.00e+00	1106.00
IUUC-Tru-118068	Takifugu rubripes	66.77	0.00e+00	1113.00
IUUC-Tsy-118942	Tarsius syrichta	73.81	3.00e-102	367.00
IUUC-Tni-120732	Tetraodon nigroviridis	63.86	0.00e+00	1082.00
IUUC-Tca-121737	Theobroma cacao	40.89	1.00e-76	281.00
IUUC-Tre-121892	Trichoderma reesei	34.19	3.00e-62	234.00
IUUC-Tvi-122354	Trichoderma virens	34.41	5.00e-64	239.00
IUUC-Tae-125580	Triticum aestivum	42.47	2.00e-77	283.00
IUUC-Tur-126086	Triticum urartu	37.75	3.00e-66	247.00
IUUC-Tme-127102	Tuber melanosporum	38.40	4.00e-74	273.00
IUUC-Tbe-127351	Tupaia belangeri	58.49	0.00e+00	865.00
IUUC-Ttr-129061	Tursiops truncatus	61.85	0.00e+00	1061.00
IUUC-Uma-129343	Ustilago maydis	40.33	6.00e-72	266.00
IUUC-Vda-129748	Verticillium dahliae	35.93	1.00e-61	231.00
IUUC-Vvi-131234	Vitis vinifera	40.45	1.00e-70	261.00
IUUC-Xtr-132094	Xenopus tropicalis	62.86	0.00e+00	1078.00
IUUC-Xma-133923	Xiphophorus maculatus	67.82	0.00e+00	1158.00
IUUC-Yli-134496	Yarrowia lipolytica	41.14	7.00e-67	248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence