iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20682837; 20511490

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.40e-07	30.3	10	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C++++   ++ pl+l+CgH f++dCl k++  + ss ++ +CP Cr
   Q: 10   CSVCHTRYnedERVPLLLQCGHGFCKDCLSKMF--STSSDTTLTCPRCR 56
           ********877777***************6663..666**********8 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Mediates E2-dependent protein ubiquitination. Acts as a negative regulator of abscisic acid signaling. Required for ABI5 degradation, by mediating its ubiquitination. Together with EDR1, may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses.

Protein Sequence
(Fasta)

MVGRVKVPCC SVCHTRYNED ERVPLLLQCG HGFCKDCLSK MFSTSSDTTL TCPRCRHVSV 60
VGNSVQGLRK NYAMLALIHA ASGGANFDCD YTDDEDDDDE EDGSDEDGAR AARGFHASSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAAGTGCT GACGGCACCC ACCCGTCAAA ACCGACGAAA CCAGAGAGCC CTCGAGACTC 60
AACCCCAAAT AAAATTGGAA AAAAATGAAA ATAAAAATAA AAATGATGAT ATAAAACCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0938--Abscisic acid signaling pathway
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12796--Ank_2
PF00069--Pkinase
PF14634--zf-RING_5

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00184--RING

Gene Ontology

GO:0005769--C:early endosome
GO:0005802--C:trans-Golgi network
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0043621--F:protein self-association
GO:0004674--F:protein serine/threonine kinase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0009738--P:abscisic acid-activated signaling pathway
GO:0006952--P:defense response
GO:0048589--P:developmental growth
GO:0016197--P:endosomal transport
GO:0045324--P:late endosome to vacuole transport
GO:0009788--P:negative regulation of abscisic acid-activated signaling pathway
GO:0016567--P:protein ubiquitination
GO:0009737--P:response to abscisic acid
GO:0032940--P:secretion by cell

KEGG

ath:AT5G13530

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000355	Aegilops tauschii	54.40	0.00e+00	1606.00
IUUC-Atr-002913	Amborella trichopoda	69.11	0.00e+00	1957.00
IUUC-Apl-003333	Anas platyrhynchos	27.61	2.00e-23	103.00
IUUC-Ame-010852	Astyanax mexicanus	29.19	4.00e-25	108.00
IUUC-Bdi-014301	Brachypodium distachyon	68.57	0.00e+00	2095.00
IUUC-Bol-015345	Brassica oleracea	91.69	0.00e+00	2962.00
IUUC-Bra-017946	Brassica rapa	91.82	0.00e+00	2942.00
IUUC-Cja-019653	Callithrix jacchus	26.17	1.00e-19	91.30
IUUC-Dre-028283	Danio rerio	32.04	5.00e-35	142.00
IUUC-Dor-030347	Dipodomys ordii	25.08	1.00e-13	70.90
IUUC-Dme-031775	Drosophila melanogaster	28.03	2.00e-26	114.00
IUUC-Ete-032225	Echinops telfairi	27.27	3.00e-15	77.00
IUUC-Eeu-035003	Erinaceus europaeus	26.25	6.00e-18	85.10
IUUC-Fal-036757	Ficedula albicollis	27.44	7.00e-24	105.00
IUUC-Gmo-039304	Gadus morhua	25.30	9.00e-17	82.00
IUUC-Ggr-039753	Gaeumannomyces graminis	28.19	2.00e-23	103.00
IUUC-Gga-040651	Gallus gallus	26.58	3.00e-22	100.00
IUUC-Gac-042061	Gasterosteus aculeatus	27.46	2.00e-23	103.00
IUUC-Gma-043700	Glycine max	75.14	0.00e+00	2528.00
IUUC-Hvu-047502	Hordeum vulgare	63.88	0.00e+00	1092.00
IUUC-Lch-049427	Latimeria chalumnae	26.90	8.00e-22	98.60
IUUC-Lpe-051464	Leersia perrieri	65.42	0.00e+00	2097.00
IUUC-Loc-052515	Lepisosteus oculatus	24.72	8.00e-31	128.00
IUUC-Mcc-055512	Macaca mulatta	26.71	4.00e-17	82.40
IUUC-Meu-056631	Macropus eugenii	24.34	2.00e-37	150.00
IUUC-Mtr-058673	Medicago truncatula	73.37	0.00e+00	2444.00
IUUC-Mga-059882	Meleagris gallopavo	26.90	3.00e-22	100.00
IUUC-Mdo-062495	Monodelphis domestica	25.33	2.00e-39	156.00
IUUC-Mac-065553	Musa acuminata	64.07	0.00e+00	1204.00
IUUC-Opr-070624	Ochotona princeps	26.76	4.00e-17	83.20
IUUC-Ont-072414	Oreochromis niloticus	26.27	1.00e-23	104.00
IUUC-Oba-075968	Oryza barthii	67.41	0.00e+00	2024.00
IUUC-Obr-076548	Oryza brachyantha	68.87	0.00e+00	2058.00
IUUC-Ogl-077477	Oryza glaberrima	68.26	0.00e+00	2041.00
IUUC-Ogu-079004	Oryza glumaepatula	67.35	0.00e+00	2024.00
IUUC-Oin-079705	Oryza indica	67.28	0.00e+00	2029.00
IUUC-Olo-080410	Oryza longistaminata	61.10	0.00e+00	1496.00
IUUC-Ome-081845	Oryza meridionalis	67.53	0.00e+00	2007.00
IUUC-Oni-082055	Oryza nivara	67.77	0.00e+00	2034.00
IUUC-Opu-083740	Oryza punctata	65.07	0.00e+00	2088.00
IUUC-Oru-085255	Oryza rufipogon	67.28	0.00e+00	2021.00
IUUC-Osa-086244	Oryza sativa	51.18	1.00e-29	123.00
IUUC-Ola-086715	Oryzias latipes	27.59	5.00e-22	99.40
IUUC-Psi-093964	Pelodiscus sinensis	26.52	2.00e-18	87.40
IUUC-Pfo-096821	Poecilia formosa	27.50	6.00e-23	102.00
IUUC-Pab-098233	Pongo abelii	27.04	5.00e-19	88.60
IUUC-Pop-098784	Populus trichocarpa	77.98	0.00e+00	2586.00
IUUC-Ppe-102003	Prunus persica	76.15	0.00e+00	2537.00
IUUC-Pva-102667	Pteropus vampyrus	24.14	7.00e-13	68.90
IUUC-Rno-105681	Rattus norvegicus	25.50	2.00e-18	87.80
IUUC-Sha-106932	Sarcophilus harrisii	23.27	4.00e-34	139.00
IUUC-Sit-109898	Setaria italica	66.03	0.00e+00	2201.00
IUUC-Sly-111367	Solanum lycopersicum	72.40	0.00e+00	2369.00
IUUC-Sbi-114492	Sorghum bicolor	58.33	0.00e+00	1893.00
IUUC-Tgu-116853	Taeniopygia guttata	27.69	2.00e-24	107.00
IUUC-Tru-118714	Takifugu rubripes	26.59	2.00e-22	100.00
IUUC-Tni-119764	Tetraodon nigroviridis	25.89	1.00e-22	101.00
IUUC-Tca-121711	Theobroma cacao	76.17	0.00e+00	2520.00
IUUC-Tae-124169	Triticum aestivum	69.18	0.00e+00	2022.00
IUUC-Tur-126247	Triticum urartu	63.67	0.00e+00	941.00
IUUC-Vda-129784	Verticillium dahliae	31.42	8.00e-24	105.00
IUUC-Vpa-130435	Vicugna pacos	25.07	8.00e-17	81.30
IUUC-Vvi-131705	Vitis vinifera	76.11	0.00e+00	2485.00
IUUC-Xtr-132967	Xenopus tropicalis	28.31	5.00e-23	102.00
IUUC-Xma-133473	Xiphophorus maculatus	27.50	3.00e-23	103.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence