iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.60e-07	30.2	210	257
E3 activity/RING/RING	3.60e-06	28.5	213	251

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpltee 53
           +f C++ + l  +Pv++p+G+t+  +++e++l++  + cP+++ +l+e 
   Q: 210  DFECALCMRLLFEPVTTPCGHTFCLKCLERCLDHAPH-CPLCKDKLSEL 257
           79***********************************.*******9875 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C+  +++ p+++pCgH+f+++Cl++          + +CPlC+
   Q: 213  CALCMRLLFE-PVTTPCGHTFCLKCLERC------LDHAPHCPLCK 251
           **********.9**************999......9*********7 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MKNYDQALQD AEAVCQREPL LTKGHHIKAQ ILSGLGRHRE VLKEFIYCLA LNPECNSAKK 60
ETQKVICEVF FSTSESEHQT STSSTETGPE ALCEGQTNPQ YPLEEAGGHA NADNPKTPSE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAAAAAAA AAAAAAAAAG GTTCAATCAG GACGCCGGCG CTGTGAGGTG GTCGCCACGC 60
TCCCACGGTC ACTTGGCTGA CGTGAGCCAC TGGGGCGCGC ACTGGGACGC GCACGGCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR011990--TPR-like_helical_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51787--LON_N
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02190--LON_substr_bdg

SMART

SM00464--LON
SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

mmu:381338

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001867	Ailuropoda melanoleuca	79.35	0.00e+00	819.00
IUUC-Apl-003355	Anas platyrhynchos	60.19	0.00e+00	650.00
IUUC-Aca-004822	Anolis carolinensis	59.85	0.00e+00	631.00
IUUC-Acl-008224	Aspergillus clavatus	30.50	5.00e-40	159.00
IUUC-Afu-008802	Aspergillus fumigatus	28.70	4.00e-37	149.00
IUUC-Ani-009473	Aspergillus nidulans	30.21	3.00e-41	163.00
IUUC-Cja-019041	Callithrix jacchus	76.88	0.00e+00	791.00
IUUC-Cfa-020025	Canis familiaris	79.11	0.00e+00	796.00
IUUC-Csa-023324	Chlorocebus sabaeus	79.00	0.00e+00	810.00
IUUC-Cne-026875	Cryptococcus neoformans	28.57	3.00e-08	53.50
IUUC-Dre-028400	Danio rerio	49.21	4.00e-143	501.00
IUUC-Dme-031919	Drosophila melanogaster	38.86	9.00e-66	245.00
IUUC-Eeu-034779	Erinaceus europaeus	61.07	4.00e-167	581.00
IUUC-Fca-036276	Felis catus	79.58	0.00e+00	820.00
IUUC-Fal-036669	Ficedula albicollis	60.19	0.00e+00	647.00
IUUC-Fso-038334	Fusarium solani	28.77	2.00e-40	160.00
IUUC-Gmo-039511	Gadus morhua	66.67	1.00e-117	416.00
IUUC-Gga-041253	Gallus gallus	60.19	0.00e+00	643.00
IUUC-Gma-042919	Glycine max	33.56	2.00e-38	153.00
IUUC-Ggo-045501	Gorilla gorilla	79.00	0.00e+00	807.00
IUUC-Hsa-046630	Homo sapiens	78.81	0.00e+00	803.00
IUUC-Itr-048224	Ictidomys tridecemlineatus	77.41	0.00e+00	784.00
IUUC-Laf-054421	Loxodonta africana	58.20	7.00e-166	577.00
IUUC-Mcc-054828	Macaca mulatta	78.42	0.00e+00	805.00
IUUC-Meu-055901	Macropus eugenii	47.62	8.00e-132	464.00
IUUC-Mtr-058075	Medicago truncatula	34.77	1.00e-42	167.00
IUUC-Mga-059760	Meleagris gallopavo	59.28	0.00e+00	652.00
IUUC-Mmr-061350	Microcebus murinus	77.41	0.00e+00	780.00
IUUC-Mdo-062203	Monodelphis domestica	61.28	0.00e+00	646.00
IUUC-Mpu-065764	Mustela putorius furo	78.82	0.00e+00	816.00
IUUC-Nfi-068337	Neosartorya fischeri	30.38	5.00e-38	152.00
IUUC-Nle-069616	Nomascus leucogenys	78.81	0.00e+00	806.00
IUUC-Ont-072142	Oreochromis niloticus	50.97	1.00e-147	516.00
IUUC-Oga-088972	Otolemur garnettii	77.99	0.00e+00	800.00
IUUC-Ptr-090992	Pan troglodytes	79.00	0.00e+00	810.00
IUUC-Pan-092180	Papio anubis	77.65	0.00e+00	793.00
IUUC-Psi-093423	Pelodiscus sinensis	60.35	0.00e+00	643.00
IUUC-Pab-097974	Pongo abelii	78.61	0.00e+00	801.00
IUUC-Pva-102269	Pteropus vampyrus	72.33	0.00e+00	723.00
IUUC-Pgr-103289	Puccinia graminis	26.50	7.00e-28	118.00
IUUC-Rno-105905	Rattus norvegicus	92.66	0.00e+00	972.00
IUUC-Spo-108344	Schizosaccharomyces pombe	30.19	2.00e-24	107.00
IUUC-Tgu-117000	Taeniopygia guttata	60.58	0.00e+00	650.00
IUUC-Tru-118016	Takifugu rubripes	49.12	1.00e-139	490.00
IUUC-Ttr-128666	Tursiops truncatus	72.33	0.00e+00	724.00
IUUC-Uma-129541	Ustilago maydis	34.77	2.00e-35	144.00
IUUC-Vpa-130334	Vicugna pacos	58.21	9.00e-152	530.00
IUUC-Vvi-130910	Vitis vinifera	33.33	2.00e-39	156.00
IUUC-Xtr-132065	Xenopus tropicalis	54.84	1.00e-163	570.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence