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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105514
Ensembl Protein ID ENSRNOP00000062034.2
UniProt Accession Q5XIS7; UBAP1_RAT
Genbank Protein ID AAH83594.1
Protein Name Ubiquitin-associated protein 1
Genbank Nucleotide ID BC083594
Gene Name Ubap1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000012004.6 ENSRNOT00000063849.2 ENSRNOP00000062034.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBA 1.90e-14 53.7 459 496
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLl 39
           e+ +++ +++eMGF+ +++++ L+ +nn+ + A+e+L+
   Q: 459  EFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLM 496
           667899******************************97 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).
Protein Sequence
(Fasta)
MASKKLGTDF HGTFSYLDDV PFKIGDKFKT PAKVGLPIGF SLPDCLQVVR EMQYDFSLEK 60
KAIEWAEDIR LIQEAQQEAE RKSEEAEAKV NSKSGPEGDS KVSFSKTHSP ATMPPPINPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105514|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGGAGGAG GGAAGTAGGC CTTCAACATG GCGGCTGTGG TACTGGCGGT GGCTACGGTG 60
ACGGTCTGGT TCGGGGCGGG TAGAGTTGGA AGAGGTGGTG TTCGCTCTCC CTAGGGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105514|UBD,UBA|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR023340--UMA
PROSITE

PS50030--UBA
PS51497--UMA
Gene Ontology

GO:0005829--C:cytosol
GO:0000813--C:ESCRT I complex
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0043130--F:ubiquitin binding
GO:0015031--P:protein transport
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG rno:362502
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001255 Ailuropoda melanoleuca 90.08 0.00e+00 853.00
IUUC-Atr-003026 Amborella trichopoda 28.77 2.00e-04 39.30
IUUC-Apl-003392 Anas platyrhynchos 71.68 0.00e+00 666.00
IUUC-Aca-004360 Anolis carolinensis 67.84 5.00e-180 624.00
IUUC-Aly-006147 Arabidopsis lyrata 26.15 4.00e-04 38.10
IUUC-Ame-010979 Astyanax mexicanus 41.26 9.00e-81 293.00
IUUC-Bta-012720 Bos taurus 90.24 0.00e+00 844.00
IUUC-Bdi-014208 Brachypodium distachyon 33.33 7.00e-04 37.40
IUUC-Bol-015914 Brassica oleracea 30.38 5.00e-02 32.70
IUUC-Bra-016839 Brassica rapa 41.86 1.40e-02 34.30
IUUC-Cja-019955 Callithrix jacchus 91.04 0.00e+00 891.00
IUUC-Cfa-020433 Canis familiaris 87.38 5.00e-147 513.00
IUUC-Cpo-022043 Cavia porcellus 91.43 0.00e+00 889.00
IUUC-Csa-023905 Chlorocebus sabaeus 91.24 0.00e+00 860.00
IUUC-Cho-025098 Choloepus hoffmanni 88.87 0.00e+00 865.00
IUUC-Cin-025370 Ciona intestinalis 27.86 2.00e-09 57.00
IUUC-Dre-027667 Danio rerio 66.67 6.00e-48 185.00
IUUC-Dno-028980 Dasypus novemcinctus 88.87 0.00e+00 887.00
IUUC-Dor-030380 Dipodomys ordii 92.03 0.00e+00 895.00
IUUC-Dme-031880 Drosophila melanogaster 40.91 5.00e-03 35.80
IUUC-Ete-032657 Echinops telfairi 80.75 0.00e+00 762.00
IUUC-Eca-034094 Equus caballus 90.91 0.00e+00 877.00
IUUC-Eeu-034842 Erinaceus europaeus 89.33 0.00e+00 830.00
IUUC-Fca-036237 Felis catus 90.84 0.00e+00 851.00
IUUC-Fal-037011 Ficedula albicollis 70.99 0.00e+00 674.00
IUUC-Gmo-038530 Gadus morhua 72.41 6.00e-49 188.00
IUUC-Gga-040947 Gallus gallus 70.04 0.00e+00 660.00
IUUC-Gac-042101 Gasterosteus aculeatus 41.06 3.00e-86 312.00
IUUC-Gma-043886 Glycine max 28.26 1.00e-03 35.80
IUUC-Ggo-045459 Gorilla gorilla 90.74 0.00e+00 839.00
IUUC-Hsa-045873 Homo sapiens 91.24 0.00e+00 860.00
IUUC-Itr-048313 Ictidomys tridecemlineatus 93.43 0.00e+00 895.00
IUUC-Lch-050450 Latimeria chalumnae 53.77 4.00e-134 471.00
IUUC-Loc-052519 Lepisosteus oculatus 43.24 9.00e-84 303.00
IUUC-Laf-054397 Loxodonta africana 91.07 0.00e+00 879.00
IUUC-Mcc-055651 Macaca mulatta 89.87 0.00e+00 777.00
IUUC-Meu-056233 Macropus eugenii 84.45 0.00e+00 851.00
IUUC-Mtr-058776 Medicago truncatula 27.37 3.00e-04 38.50
IUUC-Mga-059888 Meleagris gallopavo 68.71 0.00e+00 651.00
IUUC-Mmr-061166 Microcebus murinus 91.85 0.00e+00 889.00
IUUC-Mdo-062565 Monodelphis domestica 81.73 0.00e+00 764.00
IUUC-Mmu-063850 Mus musculus 95.22 0.00e+00 915.00
IUUC-Mpu-066241 Mustela putorius furo 91.30 0.00e+00 876.00
IUUC-Mlu-068065 Myotis lucifugus 88.48 0.00e+00 855.00
IUUC-Nle-069682 Nomascus leucogenys 91.24 0.00e+00 861.00
IUUC-Opr-070846 Ochotona princeps 89.24 0.00e+00 880.00
IUUC-Ont-071429 Oreochromis niloticus 42.83 3.00e-81 295.00
IUUC-Oan-073014 Ornithorhynchus anatinus 94.23 2.00e-23 99.80
IUUC-Ocu-073955 Oryctolagus cuniculus 90.04 0.00e+00 890.00
IUUC-Obr-076832 Oryza brachyantha 34.09 6.00e-04 37.40
IUUC-Oin-080129 Oryza indica 33.33 1.00e-03 37.00
IUUC-Ola-087056 Oryzias latipes 39.81 2.00e-76 279.00
IUUC-Oga-088447 Otolemur garnettii 90.04 0.00e+00 867.00
IUUC-Oar-089849 Ovis aries 90.04 0.00e+00 843.00
IUUC-Ptr-091574 Pan troglodytes 91.04 0.00e+00 835.00
IUUC-Pan-092584 Papio anubis 91.04 0.00e+00 881.00
IUUC-Psi-093796 Pelodiscus sinensis 68.51 0.00e+00 674.00
IUUC-Pfo-096166 Poecilia formosa 41.21 4.00e-77 281.00
IUUC-Pab-098347 Pongo abelii 89.49 7.00e-148 516.00
IUUC-Pop-098804 Populus trichocarpa 26.74 3.00e-04 38.90
IUUC-Pca-100709 Procavia capensis 90.87 6.00e-121 427.00
IUUC-Pva-102428 Pteropus vampyrus 89.92 0.00e+00 890.00
IUUC-Sha-107555 Sarcophilus harrisii 85.04 0.00e+00 829.00
IUUC-Stu-112785 Solanum tuberosum 24.00 2.00e-04 39.30
IUUC-Sar-113282 Sorex araneus 76.75 0.00e+00 630.00
IUUC-Ssc-116069 Sus scrofa 84.58 0.00e+00 728.00
IUUC-Tgu-116700 Taeniopygia guttata 71.23 0.00e+00 665.00
IUUC-Tru-117901 Takifugu rubripes 41.76 1.00e-75 277.00
IUUC-Tsy-119084 Tarsius syrichta 88.09 0.00e+00 652.00
IUUC-Tni-120603 Tetraodon nigroviridis 70.43 7.00e-47 181.00
IUUC-Tbe-127397 Tupaia belangeri 71.49 2.00e-179 621.00
IUUC-Ttr-128728 Tursiops truncatus 90.64 0.00e+00 836.00
IUUC-Vpa-130555 Vicugna pacos 90.22 0.00e+00 764.00
IUUC-Vvi-131340 Vitis vinifera 31.37 2.00e-04 39.30
IUUC-Xtr-132412 Xenopus tropicalis 58.67 5.00e-144 504.00
Created Date 25-Jun-2017

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