iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106835

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01135239

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000018173.1	ENSSHAT00000021617.1	ENSSHAP00000021444.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-96	324.1	1689	2068

Active Site

Position(s)	Description	Evidence
2035	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + +++  +  +                       ++  
   Q: 1689 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLTNPKGSQEG-T--KyiqnlqglfalpfgrtakpahiaKVKM 1771
           56899***********.**********************6666533333322221.1..1234558888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1772 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletlnm 1858
           **********************************654444**************999999855555511555666666444444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F
   Q: 1859 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYF 1933
           4333333............35555588999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1934 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSGFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 2020
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2021 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2068
           988888***************************************985 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKAYSPPESR KSISKAPKVQ 60
SNTTSEQSRG HISKRSCSSS SAVIVPQPED PDRANTSEKQ KTGQVPKKDS SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCAACTGA GGAAGGCTGG ACAGAAAGCA GTCCCGGAAG GTGCCAAACT CACGGGTGTG 60
GCTACTACTA CCTGTCAGAG AGCAACTTAT CAGTTCTGTT TTGATAGACC AAGGTTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

shr:100932266

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.39	2.00e-125	444.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.70	0.00e+00	3620.00
IUUC-Atr-002821	Amborella trichopoda	37.30	5.00e-116	413.00
IUUC-Apl-003531	Anas platyrhynchos	92.15	0.00e+00	3409.00
IUUC-Aly-005962	Arabidopsis lyrata	38.80	2.00e-113	404.00
IUUC-Ath-006636	Arabidopsis thaliana	38.52	1.00e-112	401.00
IUUC-Ago-007875	Ashbya gossypii	36.01	9.00e-81	295.00
IUUC-Acl-008242	Aspergillus clavatus	35.70	1.00e-113	405.00
IUUC-Afl-008736	Aspergillus flavus	38.64	1.00e-109	392.00
IUUC-Afu-008812	Aspergillus fumigatus	35.10	4.00e-114	406.00
IUUC-Ani-009407	Aspergillus nidulans	36.67	5.00e-110	393.00
IUUC-Ang-009763	Aspergillus niger	39.82	2.00e-105	377.00
IUUC-Aor-009941	Aspergillus oryzae	30.74	3.00e-112	400.00
IUUC-Ate-010459	Aspergillus terreus	37.31	1.00e-84	308.00
IUUC-Ame-011761	Astyanax mexicanus	88.63	0.00e+00	3007.00
IUUC-Bgr-012265	Blumeria graminis	35.16	7.00e-104	372.00
IUUC-Bta-013070	Bos taurus	94.55	0.00e+00	3477.00
IUUC-Bci-013890	Botrytis cinerea	39.52	1.00e-101	365.00
IUUC-Bdi-014046	Brachypodium distachyon	38.04	3.00e-121	430.00
IUUC-Bol-015942	Brassica oleracea	44.42	2.00e-113	404.00
IUUC-Bra-016849	Brassica rapa	44.42	5.00e-113	403.00
IUUC-Cja-019046	Callithrix jacchus	94.64	0.00e+00	3580.00
IUUC-Cfa-020521	Canis familiaris	94.00	0.00e+00	3482.00
IUUC-Cpo-021639	Cavia porcellus	91.55	0.00e+00	3486.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	40.46	2.00e-89	323.00
IUUC-Csa-023231	Chlorocebus sabaeus	96.86	0.00e+00	3653.00
IUUC-Cho-024380	Choloepus hoffmanni	91.40	0.00e+00	2123.00
IUUC-Cin-025482	Ciona intestinalis	50.84	4.00e-158	551.00
IUUC-Csv-026121	Ciona savignyi	48.08	0.00e+00	1540.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.79	2.00e-109	390.00
IUUC-Cne-026857	Cryptococcus neoformans	39.58	3.00e-93	337.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	2.00e-74	274.00
IUUC-Dre-028174	Danio rerio	88.35	0.00e+00	3053.00
IUUC-Dor-030939	Dipodomys ordii	85.16	0.00e+00	2735.00
IUUC-Dse-031444	Dothistroma septosporum	39.11	4.00e-104	374.00
IUUC-Dme-032162	Drosophila melanogaster	67.73	2.00e-174	608.00
IUUC-Ete-032345	Echinops telfairi	89.00	0.00e+00	2267.00
IUUC-Eca-033229	Equus caballus	95.16	0.00e+00	3524.00
IUUC-Eeu-035205	Erinaceus europaeus	83.75	0.00e+00	3035.00
IUUC-Fca-036444	Felis catus	94.98	0.00e+00	3579.00
IUUC-Fal-037131	Ficedula albicollis	95.22	0.00e+00	3569.00
IUUC-Fox-038035	Fusarium oxysporum	36.16	1.00e-108	387.00
IUUC-Fso-038320	Fusarium solani	36.16	3.00e-109	390.00
IUUC-Gmo-039497	Gadus morhua	80.25	0.00e+00	3067.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.90	7.00e-108	386.00
IUUC-Gga-041021	Gallus gallus	95.55	0.00e+00	3570.00
IUUC-Gac-042474	Gasterosteus aculeatus	79.58	0.00e+00	3048.00
IUUC-Gma-043060	Glycine max	38.64	2.00e-120	427.00
IUUC-Ggo-044855	Gorilla gorilla	94.44	0.00e+00	3573.00
IUUC-Hsa-046147	Homo sapiens	92.41	0.00e+00	3485.00
IUUC-Hvu-047775	Hordeum vulgare	38.39	3.00e-123	437.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.54	0.00e+00	3487.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	7.00e-85	309.00
IUUC-Lch-049818	Latimeria chalumnae	85.44	0.00e+00	3127.00
IUUC-Lpe-051017	Leersia perrieri	38.44	8.00e-118	419.00
IUUC-Loc-051777	Lepisosteus oculatus	88.56	0.00e+00	3386.00
IUUC-Lma-052990	Leptosphaeria maculans	35.71	2.00e-111	397.00
IUUC-Laf-053727	Loxodonta africana	95.45	0.00e+00	3575.00
IUUC-Mcc-055799	Macaca mulatta	95.31	0.00e+00	3564.00
IUUC-Meu-056065	Macropus eugenii	96.24	0.00e+00	2144.00
IUUC-Mor-057054	Magnaporthe oryzae	34.39	5.00e-106	380.00
IUUC-Mpo-057417	Magnaporthe poae	39.17	1.00e-107	385.00
IUUC-Mtr-057849	Medicago truncatula	37.24	1.00e-112	402.00
IUUC-Mla-058870	Melampsora laricipopulina	42.57	2.00e-106	380.00
IUUC-Mga-059580	Meleagris gallopavo	93.88	0.00e+00	3033.00
IUUC-Mvi-060507	Microbotryum violaceum	40.18	2.00e-113	404.00
IUUC-Mmr-060816	Microcebus murinus	96.86	0.00e+00	3658.00
IUUC-Mdo-062866	Monodelphis domestica	96.71	0.00e+00	3506.00
IUUC-Mmu-063906	Mus musculus	94.15	0.00e+00	3561.00
IUUC-Mac-064675	Musa acuminata	39.10	9.00e-112	397.00
IUUC-Mpu-066199	Mustela putorius furo	95.16	0.00e+00	3549.00
IUUC-Mlu-067110	Myotis lucifugus	94.49	0.00e+00	3553.00
IUUC-Nfi-068482	Neosartorya fischeri	35.25	7.00e-114	405.00
IUUC-Ncr-068906	Neurospora crassa	38.94	9.00e-108	385.00
IUUC-Nle-069410	Nomascus leucogenys	95.16	0.00e+00	3564.00
IUUC-Opr-070401	Ochotona princeps	84.20	0.00e+00	1914.00
IUUC-Ont-072100	Oreochromis niloticus	83.50	0.00e+00	3159.00
IUUC-Oan-073121	Ornithorhynchus anatinus	96.09	0.00e+00	3704.00
IUUC-Ocu-074623	Oryctolagus cuniculus	94.73	0.00e+00	3576.00
IUUC-Oba-075380	Oryza barthii	37.00	2.00e-113	403.00
IUUC-Obr-076915	Oryza brachyantha	37.62	4.00e-118	420.00
IUUC-Ogl-077055	Oryza glaberrima	38.56	1.00e-117	418.00
IUUC-Ogu-078892	Oryza glumaepatula	40.54	3.00e-112	400.00
IUUC-Oin-079256	Oryza indica	38.38	2.00e-116	414.00
IUUC-Olo-080343	Oryza longistaminata	38.38	9.00e-117	415.00
IUUC-Ome-081422	Oryza meridionalis	38.10	4.00e-116	413.00
IUUC-Oni-083047	Oryza nivara	36.81	3.00e-114	406.00
IUUC-Opu-083641	Oryza punctata	36.36	2.00e-110	394.00
IUUC-Oru-084439	Oryza rufipogon	36.66	5.00e-113	402.00
IUUC-Osa-085972	Oryza sativa	38.16	1.00e-115	410.00
IUUC-Ola-087173	Oryzias latipes	80.73	0.00e+00	3092.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.70	7.00e-88	317.00
IUUC-Oga-087908	Otolemur garnettii	94.25	0.00e+00	3563.00
IUUC-Oar-090277	Ovis aries	95.77	0.00e+00	3548.00
IUUC-Ptr-091543	Pan troglodytes	92.46	0.00e+00	3489.00
IUUC-Pan-092243	Papio anubis	95.36	0.00e+00	3565.00
IUUC-Psi-093150	Pelodiscus sinensis	94.73	0.00e+00	3597.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.90	9.00e-112	399.00
IUUC-Ppa-095181	Physcomitrella patens	42.33	1.00e-107	384.00
IUUC-Pfo-096267	Poecilia formosa	88.46	0.00e+00	3063.00
IUUC-Pab-098072	Pongo abelii	95.45	0.00e+00	3575.00
IUUC-Pop-099190	Populus trichocarpa	37.14	2.00e-115	411.00
IUUC-Pca-100311	Procavia capensis	88.68	0.00e+00	3209.00
IUUC-Ppe-101284	Prunus persica	37.72	7.00e-116	412.00
IUUC-Pva-102215	Pteropus vampyrus	93.09	0.00e+00	1321.00
IUUC-Pgr-103694	Puccinia graminis	40.44	4.00e-103	370.00
IUUC-Ptt-103916	Puccinia triticina	39.24	1.00e-96	348.00
IUUC-Pte-104346	Pyrenophora teres	39.41	9.00e-109	389.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.48	4.00e-109	390.00
IUUC-Rno-105315	Rattus norvegicus	94.87	0.00e+00	3513.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.81	4.00e-70	260.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.85	1.00e-95	345.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.62	5.00e-95	343.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	39.72	4.00e-105	377.00
IUUC-Smo-109590	Selaginella moellendorffii	43.10	2.00e-111	397.00
IUUC-Sit-110717	Setaria italica	38.21	7.00e-120	426.00
IUUC-Sly-111469	Solanum lycopersicum	39.40	3.00e-121	430.00
IUUC-Stu-112896	Solanum tuberosum	37.80	1.00e-104	374.00
IUUC-Sar-113224	Sorex araneus	84.49	0.00e+00	1861.00
IUUC-Sbi-114313	Sorghum bicolor	38.16	2.00e-123	437.00
IUUC-Sre-114993	Sporisorium reilianum	33.95	9.00e-100	359.00
IUUC-Ssc-115535	Sus scrofa	90.65	0.00e+00	3421.00
IUUC-Tgu-117493	Taeniopygia guttata	93.77	0.00e+00	2770.00
IUUC-Tru-118669	Takifugu rubripes	81.97	0.00e+00	3055.00
IUUC-Tsy-119373	Tarsius syrichta	91.99	0.00e+00	1828.00
IUUC-Tni-120049	Tetraodon nigroviridis	78.17	0.00e+00	870.00
IUUC-Tca-121779	Theobroma cacao	38.61	1.00e-113	405.00
IUUC-Tre-122195	Trichoderma reesei	35.95	6.00e-105	376.00
IUUC-Tvi-122650	Trichoderma virens	35.53	1.00e-107	385.00
IUUC-Tae-123580	Triticum aestivum	38.29	2.00e-123	436.00
IUUC-Tur-126295	Triticum urartu	38.25	4.00e-124	439.00
IUUC-Tme-126964	Tuber melanosporum	40.08	3.00e-104	374.00
IUUC-Tbe-128149	Tupaia belangeri	83.63	0.00e+00	1245.00
IUUC-Ttr-128165	Tursiops truncatus	92.87	0.00e+00	3005.00
IUUC-Uma-129365	Ustilago maydis	35.54	3.00e-87	318.00
IUUC-Vda-129725	Verticillium dahliae	40.88	1.00e-107	385.00
IUUC-Vpa-130678	Vicugna pacos	95.02	0.00e+00	2638.00
IUUC-Vvi-131147	Vitis vinifera	38.94	7.00e-120	426.00
IUUC-Xtr-132636	Xenopus tropicalis	87.55	0.00e+00	3265.00
IUUC-Xma-133458	Xiphophorus maculatus	82.33	0.00e+00	3153.00
IUUC-Yli-134481	Yarrowia lipolytica	39.52	5.00e-97	349.00
IUUC-Zma-135782	Zea mays	36.96	1.00e-116	415.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence