iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106961

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01232966

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000001097.1	ENSSHAT00000001245.1	ENSSHAP00000001230.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-122	409.1	3980	4314
UBD/Alpha-Helix/UBA	6.10e-08	32.7	1362	1399

Active Site

Position(s)	Description	Evidence
4282	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 3980 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4065
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4066 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4149
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4150 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4235
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4236 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4314
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1362 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1399
           89**********************.7***********98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKSCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMAWMLM CDGPQKEHLK LLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNCCCCCC CCCTTTTGCC 60
TATGCAGTGA AGATGGCCTT GGGGTCTATT TGAAGGCCCA AACATTAATT TTAGGTTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	46.95	1.00e-106	382.00
IUUC-Aml-001684	Ailuropoda melanoleuca	90.36	0.00e+00	4395.00
IUUC-Atr-003044	Amborella trichopoda	52.69	5.00e-126	447.00
IUUC-Apl-003729	Anas platyrhynchos	93.54	0.00e+00	695.00
IUUC-Aca-005263	Anolis carolinensis	90.01	0.00e+00	4062.00
IUUC-Aly-006083	Arabidopsis lyrata	51.77	1.00e-126	449.00
IUUC-Ath-007472	Arabidopsis thaliana	51.77	1.00e-126	449.00
IUUC-Ago-008005	Ashbya gossypii	46.06	3.00e-132	468.00
IUUC-Acl-008254	Aspergillus clavatus	46.25	9.00e-135	476.00
IUUC-Afl-008712	Aspergillus flavus	45.39	5.00e-136	478.00
IUUC-Afu-009022	Aspergillus fumigatus	46.46	6.00e-134	473.00
IUUC-Ani-009412	Aspergillus nidulans	47.01	6.00e-136	480.00
IUUC-Ang-009771	Aspergillus niger	47.01	8.00e-135	476.00
IUUC-Aor-010186	Aspergillus oryzae	44.64	5.00e-126	446.00
IUUC-Ate-010253	Aspergillus terreus	46.14	2.00e-135	478.00
IUUC-Ame-011067	Astyanax mexicanus	80.98	0.00e+00	3628.00
IUUC-Bgr-012043	Blumeria graminis	46.80	1.00e-139	492.00
IUUC-Bta-012813	Bos taurus	90.22	0.00e+00	4413.00
IUUC-Bci-013995	Botrytis cinerea	46.15	5.00e-138	487.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	4.00e-127	451.00
IUUC-Bol-016533	Brassica oleracea	58.33	4.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	43.47	2.00e-124	441.00
IUUC-Cel-018179	Caenorhabditis elegans	61.52	0.00e+00	650.00
IUUC-Cja-018741	Callithrix jacchus	90.04	0.00e+00	4396.00
IUUC-Cfa-020083	Canis familiaris	91.10	0.00e+00	4433.00
IUUC-Cpo-021923	Cavia porcellus	89.68	0.00e+00	4036.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.19	7.00e-120	423.00
IUUC-Csa-023853	Chlorocebus sabaeus	90.18	0.00e+00	4400.00
IUUC-Cho-024718	Choloepus hoffmanni	99.73	0.00e+00	812.00
IUUC-Cin-025627	Ciona intestinalis	41.65	0.00e+00	1883.00
IUUC-Csv-025824	Ciona savignyi	46.85	0.00e+00	1408.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	45.31	1.00e-137	486.00
IUUC-Cne-027095	Cryptococcus neoformans	41.70	8.00e-106	380.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.24	6.00e-116	412.00
IUUC-Dre-028525	Danio rerio	81.84	0.00e+00	3588.00
IUUC-Dno-029680	Dasypus novemcinctus	89.68	0.00e+00	3993.00
IUUC-Dor-030902	Dipodomys ordii	91.85	0.00e+00	1157.00
IUUC-Dse-031197	Dothistroma septosporum	46.74	2.00e-138	488.00
IUUC-Dme-032122	Drosophila melanogaster	52.80	0.00e+00	834.00
IUUC-Ete-032690	Echinops telfairi	87.36	0.00e+00	1232.00
IUUC-Eca-033915	Equus caballus	89.70	0.00e+00	4355.00
IUUC-Eeu-034963	Erinaceus europaeus	87.79	0.00e+00	2787.00
IUUC-Fca-035824	Felis catus	90.50	0.00e+00	4402.00
IUUC-Fox-037756	Fusarium oxysporum	45.89	2.00e-138	489.00
IUUC-Fso-038464	Fusarium solani	54.72	3.00e-137	484.00
IUUC-Gmo-039073	Gadus morhua	80.87	0.00e+00	3549.00
IUUC-Ggr-039946	Gaeumannomyces graminis	45.57	5.00e-135	477.00
IUUC-Gga-040309	Gallus gallus	98.70	0.00e+00	655.00
IUUC-Gac-042430	Gasterosteus aculeatus	81.39	0.00e+00	3648.00
IUUC-Gma-043129	Glycine max	47.50	4.00e-126	447.00
IUUC-Ggo-044785	Gorilla gorilla	90.22	0.00e+00	4363.00
IUUC-Hsa-046879	Homo sapiens	90.22	0.00e+00	4364.00
IUUC-Hvu-047697	Hordeum vulgare	51.99	2.00e-127	452.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	95.84	0.00e+00	1452.00
IUUC-Kpa-049228	Komagataella pastoris	47.99	2.00e-141	498.00
IUUC-Lch-050252	Latimeria chalumnae	83.44	0.00e+00	3624.00
IUUC-Lpe-051550	Leersia perrieri	51.99	4.00e-127	451.00
IUUC-Loc-052472	Lepisosteus oculatus	83.27	0.00e+00	3685.00
IUUC-Lma-053159	Leptosphaeria maculans	45.88	9.00e-137	483.00
IUUC-Laf-054154	Loxodonta africana	89.77	0.00e+00	4359.00
IUUC-Mcc-055085	Macaca mulatta	90.85	0.00e+00	4402.00
IUUC-Meu-056727	Macropus eugenii	94.93	0.00e+00	1949.00
IUUC-Mor-057201	Magnaporthe oryzae	45.60	1.00e-135	479.00
IUUC-Mpo-057597	Magnaporthe poae	45.36	1.00e-133	473.00
IUUC-Mtr-058088	Medicago truncatula	52.69	1.00e-126	449.00
IUUC-Mla-058888	Melampsora laricipopulina	49.37	1.00e-116	412.00
IUUC-Mvi-060320	Microbotryum violaceum	50.24	1.00e-123	439.00
IUUC-Mmr-060820	Microcebus murinus	90.62	0.00e+00	4403.00
IUUC-Mdo-062930	Monodelphis domestica	96.11	0.00e+00	4677.00
IUUC-Mmu-063601	Mus musculus	90.14	0.00e+00	4305.00
IUUC-Mac-065557	Musa acuminata	52.09	4.00e-119	424.00
IUUC-Mpu-066653	Mustela putorius furo	88.57	0.00e+00	4260.00
IUUC-Mlu-067418	Myotis lucifugus	90.30	0.00e+00	4469.00
IUUC-Nfi-068278	Neosartorya fischeri	46.64	1.00e-134	475.00
IUUC-Ncr-068813	Neurospora crassa	46.87	7.00e-137	483.00
IUUC-Nle-069418	Nomascus leucogenys	90.00	0.00e+00	4338.00
IUUC-Opr-070187	Ochotona princeps	83.30	0.00e+00	879.00
IUUC-Ont-071300	Oreochromis niloticus	81.63	0.00e+00	3608.00
IUUC-Oan-073046	Ornithorhynchus anatinus	84.53	0.00e+00	4160.00
IUUC-Ocu-074178	Oryctolagus cuniculus	89.36	0.00e+00	4429.00
IUUC-Oba-075757	Oryza barthii	51.76	4.00e-127	451.00
IUUC-Obr-076553	Oryza brachyantha	51.76	5.00e-126	447.00
IUUC-Ogl-077520	Oryza glaberrima	51.76	5.00e-127	450.00
IUUC-Ogu-078278	Oryza glumaepatula	51.76	4.00e-127	451.00
IUUC-Oin-079767	Oryza indica	51.76	4.00e-127	451.00
IUUC-Olo-080380	Oryza longistaminata	51.28	3.00e-125	444.00
IUUC-Ome-081925	Oryza meridionalis	51.28	2.00e-125	445.00
IUUC-Oni-082619	Oryza nivara	51.76	5.00e-127	450.00
IUUC-Opu-083684	Oryza punctata	51.28	1.00e-125	446.00
IUUC-Oru-084501	Oryza rufipogon	51.76	5.00e-127	450.00
IUUC-Osa-086251	Oryza sativa	51.76	1.00e-125	444.00
IUUC-Ola-087437	Oryzias latipes	82.16	0.00e+00	2084.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.50	4.00e-114	404.00
IUUC-Oga-088903	Otolemur garnettii	90.00	0.00e+00	4371.00
IUUC-Oar-090210	Ovis aries	90.79	0.00e+00	4414.00
IUUC-Ptr-090502	Pan troglodytes	90.54	0.00e+00	3407.00
IUUC-Pan-092368	Papio anubis	89.67	0.00e+00	4420.00
IUUC-Pma-094246	Petromyzon marinus	73.62	0.00e+00	1259.00
IUUC-Pno-094871	Phaeosphaeria nodorum	53.00	5.00e-135	477.00
IUUC-Ppa-095657	Physcomitrella patens	51.36	2.00e-125	445.00
IUUC-Pfo-096232	Poecilia formosa	80.33	0.00e+00	3630.00
IUUC-Pab-098583	Pongo abelii	90.22	0.00e+00	4362.00
IUUC-Pop-099613	Populus trichocarpa	53.16	2.00e-128	454.00
IUUC-Pca-100310	Procavia capensis	77.58	0.00e+00	1570.00
IUUC-Ppe-102109	Prunus persica	52.46	5.00e-127	450.00
IUUC-Pva-102116	Pteropus vampyrus	89.82	0.00e+00	4420.00
IUUC-Pgr-103465	Puccinia graminis	43.48	5.00e-128	454.00
IUUC-Ptt-103813	Puccinia triticina	41.40	1.00e-115	412.00
IUUC-Pte-104018	Pyrenophora teres	52.62	9.00e-134	473.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.64	1.00e-133	472.00
IUUC-Rno-105889	Rattus norvegicus	82.75	0.00e+00	3858.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.65	6.00e-129	456.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.73	1.00e-128	456.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.87	2.00e-131	465.00
IUUC-Smo-109428	Selaginella moellendorffii	53.04	1.00e-130	462.00
IUUC-Sit-110598	Setaria italica	52.46	9.00e-128	452.00
IUUC-Sly-111285	Solanum lycopersicum	51.67	6.00e-128	453.00
IUUC-Stu-112582	Solanum tuberosum	32.35	7.00e-57	215.00
IUUC-Sar-113291	Sorex araneus	85.61	0.00e+00	2805.00
IUUC-Sbi-114042	Sorghum bicolor	52.46	5.00e-128	454.00
IUUC-Sre-114958	Sporisorium reilianum	49.00	3.00e-140	491.00
IUUC-Ssc-115754	Sus scrofa	90.25	0.00e+00	4390.00
IUUC-Tru-118570	Takifugu rubripes	80.87	0.00e+00	3652.00
IUUC-Tsy-119159	Tarsius syrichta	88.12	0.00e+00	2126.00
IUUC-Tni-120836	Tetraodon nigroviridis	76.26	0.00e+00	1923.00
IUUC-Tca-121479	Theobroma cacao	51.29	1.00e-124	442.00
IUUC-Tre-121909	Trichoderma reesei	53.65	2.00e-133	472.00
IUUC-Tvi-122370	Trichoderma virens	53.41	1.00e-133	472.00
IUUC-Tae-125214	Triticum aestivum	51.04	1.00e-125	444.00
IUUC-Tme-127172	Tuber melanosporum	45.92	7.00e-141	496.00
IUUC-Tbe-127506	Tupaia belangeri	84.64	0.00e+00	1290.00
IUUC-Ttr-129253	Tursiops truncatus	82.09	0.00e+00	1937.00
IUUC-Uma-129355	Ustilago maydis	48.36	6.00e-142	497.00
IUUC-Vda-129886	Verticillium dahliae	47.63	4.00e-139	491.00
IUUC-Vpa-130708	Vicugna pacos	88.64	0.00e+00	3546.00
IUUC-Vvi-131170	Vitis vinifera	51.00	5.00e-127	449.00
IUUC-Xtr-132123	Xenopus tropicalis	86.52	0.00e+00	4219.00
IUUC-Xma-133869	Xiphophorus maculatus	80.44	0.00e+00	3661.00
IUUC-Yli-134657	Yarrowia lipolytica	45.63	3.00e-131	464.00
IUUC-Zma-135570	Zea mays	44.58	1.00e-128	456.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence