iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046764

Ensembl Protein ID

ENSP00000037243.2

UniProt Accession

P60520; O08765; Q6FG91; Q9DCP8; Q9UQF7; GBRL2_HUMAN

Genbank Protein ID

BAB21548.1; AAK20400.1; CAA09249.1; AAD27779.1; CAG47013.1; BAF82477.1; EAW95630.1; AAH05985.1; AAH14594.1; AAH29601.1

Protein Name

Gamma-aminobutyric acid receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; MAP1 light chain 3-related protein

Genbank Nucleotide ID

AB030710; AF087848; AJ010569; AF077046; CR542217; AK289788; CH471114; BC005985; BC014594; BC029601

Gene Name

GABARAPL2; FLC3A; GEF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000034713.7	ENST00000037243.6	ENSP00000037243.2
ENSG00000034713.7	ENST00000565057.5	ENSP00000456773.1
ENSG00000034713.7	ENST00000563744.1	ENSP00000457448.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG8	56.03	1.00e-35	142.00	IUUC-Sce-106150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Protein Sequence
(Fasta)

MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF 60
MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF 117

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACAGCCGG AAGTCCCGCC TGCCGTGTAG TCGCCGCCGT CGCTGCCGCT GCCGCTGCCG 60
CCGTCGTTGT TGTTGTGCTC GGTGCGCTGA GCTCCGCGGC TCCGCGAGCC GGTTCCGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0051117--F:ATPase binding
GO:0048487--F:beta-tubulin binding
GO:0050811--F:GABA receptor binding
GO:0008017--F:microtubule binding
GO:0000149--F:SNARE binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0006914--P:autophagy
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0032781--P:positive regulation of ATPase activity
GO:0015031--P:protein transport

KEGG

hsa:11345

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000059	Aegilops tauschii	60.00	6.00e-39	152.00
IUUC-Aml-001629	Ailuropoda melanoleuca	100.00	1.00e-65	241.00
IUUC-Atr-002842	Amborella trichopoda	62.50	6.00e-35	139.00
IUUC-Aca-005288	Anolis carolinensis	99.14	3.00e-65	239.00
IUUC-Aly-005554	Arabidopsis lyrata	62.07	3.00e-35	139.00
IUUC-Ath-006958	Arabidopsis thaliana	62.07	3.00e-35	139.00
IUUC-Ani-009196	Aspergillus nidulans	59.48	5.00e-39	152.00
IUUC-Ame-010751	Astyanax mexicanus	98.29	5.00e-65	238.00
IUUC-Bta-012520	Bos taurus	99.15	1.00e-65	240.00
IUUC-Bdi-014390	Brachypodium distachyon	61.06	1.00e-39	154.00
IUUC-Bol-016488	Brassica oleracea	62.93	6.00e-41	159.00
IUUC-Bra-017452	Brassica rapa	61.21	1.00e-40	157.00
IUUC-Cja-019273	Callithrix jacchus	99.15	8.00e-66	241.00
IUUC-Cfa-020373	Canis familiaris	100.00	4.00e-66	242.00
IUUC-Cpo-021831	Cavia porcellus	100.00	4.00e-66	242.00
IUUC-Cre-022866	Chlamydomonas reinhardtii	62.50	3.00e-35	140.00
IUUC-Csa-024201	Chlorocebus sabaeus	100.00	4.00e-66	242.00
IUUC-Dre-028371	Danio rerio	96.58	6.00e-64	235.00
IUUC-Dno-029331	Dasypus novemcinctus	100.00	1.00e-65	240.00
IUUC-Dor-030453	Dipodomys ordii	100.00	4.00e-66	242.00
IUUC-Eca-034113	Equus caballus	100.00	6.00e-66	242.00
IUUC-Fca-036385	Felis catus	100.00	4.00e-66	242.00
IUUC-Fal-036896	Ficedula albicollis	99.15	8.00e-66	241.00
IUUC-Gmo-039289	Gadus morhua	98.29	4.00e-65	239.00
IUUC-Ggr-039770	Gaeumannomyces graminis	58.62	1.00e-37	148.00
IUUC-Gac-041604	Gasterosteus aculeatus	98.29	7.00e-65	238.00
IUUC-Gma-043572	Glycine max	62.50	2.00e-34	137.00
IUUC-Ggo-044429	Gorilla gorilla	100.00	4.00e-66	242.00
IUUC-Hvu-047062	Hordeum vulgare	60.00	6.00e-39	152.00
IUUC-Kpa-049124	Komagataella pastoris	58.62	1.00e-38	151.00
IUUC-Lch-049542	Latimeria chalumnae	97.44	3.00e-64	236.00
IUUC-Lpe-051450	Leersia perrieri	60.34	3.00e-39	153.00
IUUC-Meu-056515	Macropus eugenii	100.00	4.00e-66	242.00
IUUC-Mor-057276	Magnaporthe oryzae	58.62	1.00e-37	148.00
IUUC-Mpo-057469	Magnaporthe poae	58.62	1.00e-37	148.00
IUUC-Mtr-058417	Medicago truncatula	61.74	1.00e-34	137.00
IUUC-Mdo-061915	Monodelphis domestica	100.00	2.00e-66	244.00
IUUC-Mmu-064152	Mus musculus	100.00	4.00e-66	242.00
IUUC-Mac-065529	Musa acuminata	61.74	2.00e-35	140.00
IUUC-Mpu-066760	Mustela putorius furo	100.00	2.00e-66	243.00
IUUC-Mlu-068211	Myotis lucifugus	100.00	4.00e-66	242.00
IUUC-Nle-069755	Nomascus leucogenys	100.00	4.00e-66	242.00
IUUC-Ont-072343	Oreochromis niloticus	97.44	5.00e-65	239.00
IUUC-Oan-073485	Ornithorhynchus anatinus	99.06	5.00e-58	215.00
IUUC-Ocu-073861	Oryctolagus cuniculus	100.00	4.00e-66	242.00
IUUC-Oba-075722	Oryza barthii	60.34	9.00e-40	155.00
IUUC-Obr-076374	Oryza brachyantha	61.06	2.00e-39	154.00
IUUC-Ogl-077551	Oryza glaberrima	60.34	9.00e-40	155.00
IUUC-Ogu-078499	Oryza glumaepatula	60.34	9.00e-40	155.00
IUUC-Oin-079771	Oryza indica	61.06	2.00e-39	154.00
IUUC-Olo-080412	Oryza longistaminata	61.06	2.00e-39	154.00
IUUC-Ome-081791	Oryza meridionalis	61.06	2.00e-39	154.00
IUUC-Oni-082774	Oryza nivara	61.06	2.00e-39	154.00
IUUC-Opu-083486	Oryza punctata	61.06	8.00e-39	154.00
IUUC-Oru-084425	Oryza rufipogon	60.34	4.00e-39	152.00
IUUC-Osa-085439	Oryza sativa	61.06	2.00e-39	154.00
IUUC-Ola-086310	Oryzias latipes	94.02	4.00e-63	232.00
IUUC-Oga-088483	Otolemur garnettii	100.00	4.00e-66	242.00
IUUC-Ptr-091560	Pan troglodytes	100.00	4.00e-66	242.00
IUUC-Pan-092269	Papio anubis	100.00	4.00e-66	242.00
IUUC-Pma-094337	Petromyzon marinus	85.34	9.00e-57	211.00
IUUC-Pfo-096380	Poecilia formosa	98.28	2.00e-64	236.00
IUUC-Pab-098563	Pongo abelii	100.00	4.00e-66	242.00
IUUC-Pop-099701	Populus trichocarpa	62.61	3.00e-35	140.00
IUUC-Ppe-101863	Prunus persica	62.07	1.00e-35	140.00
IUUC-Rno-105111	Rattus norvegicus	100.00	4.00e-66	242.00
IUUC-Sce-106150	Saccharomyces cerevisiae	56.03	5.00e-36	142.00
IUUC-Sja-107857	Schizosaccharomyces japonicus	57.76	3.00e-38	150.00
IUUC-Spo-108156	Schizosaccharomyces pombe	60.34	2.00e-33	134.00
IUUC-Smo-109082	Selaginella moellendorffii	59.48	3.00e-39	153.00
IUUC-Sly-110959	Solanum lycopersicum	60.34	6.00e-35	139.00
IUUC-Stu-112323	Solanum tuberosum	60.34	6.00e-35	139.00
IUUC-Sbi-114346	Sorghum bicolor	61.06	2.00e-39	153.00
IUUC-Sre-114964	Sporisorium reilianum	59.83	1.00e-39	154.00
IUUC-Ssc-115828	Sus scrofa	100.00	4.00e-66	242.00
IUUC-Tgu-117195	Taeniopygia guttata	99.15	7.00e-66	241.00
IUUC-Tni-120706	Tetraodon nigroviridis	96.58	6.00e-64	235.00
IUUC-Tca-121217	Theobroma cacao	61.74	5.00e-35	139.00
IUUC-Tae-122697	Triticum aestivum	60.00	2.00e-38	152.00
IUUC-Tur-126158	Triticum urartu	59.13	4.00e-38	149.00
IUUC-Tme-126955	Tuber melanosporum	58.97	6.00e-39	153.00
IUUC-Tbe-127765	Tupaia belangeri	100.00	9.00e-47	177.00
IUUC-Ttr-128205	Tursiops truncatus	100.00	4.00e-66	242.00
IUUC-Uma-129435	Ustilago maydis	60.34	1.00e-39	154.00
IUUC-Vpa-130804	Vicugna pacos	97.44	3.00e-64	236.00
IUUC-Vvi-131085	Vitis vinifera	61.95	7.00e-40	155.00
IUUC-Xtr-132685	Xenopus tropicalis	100.00	1.00e-65	241.00
IUUC-Xma-133675	Xiphophorus maculatus	98.28	2.00e-64	236.00
IUUC-Yli-134327	Yarrowia lipolytica	60.34	3.00e-33	133.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence