iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000104691.14	ENST00000620074.4	ENSP00000477532.1
ENSG00000104691.14	ENST00000522968.1	ENSP00000483433.1
ENSG00000104691.14	ENST00000265616.9	ENSP00000479216.1
ENSG00000104691.14	ENST00000380154.9	ENSP00000482772.1
ENSG00000104691.14	ENST00000341403.9	ENSP00000478502.1
ENSG00000104691.14	ENST00000615729.4	ENSP00000481635.1
ENSG00000104691.14	ENST00000518059.5	ENSP00000480065.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/UBX	UBX	11243799

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/UBX	6.40e-12	47.5	189	264

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/UBX

   S: 3    teqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllve 80
           +e +t+++R+p+G+ l r+F +s + + ++++++ + +++ + ++L ++fPrr+l+ e  + +l++ g++  ++l++e
   Q: 189  EEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMT-RIGYHISLYSLSTSFPRRPLAVEGGQ-SLEDIGITVDTVLILE 264
           6799******************************.*************************5.************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.

Protein Sequence
(Fasta)

MASRGVVGIF FLSAVPLVCL ELRRGIPDIG IKDFLLLCGR ILLLLALLTL TISVTTSWLN 60
SFKSPQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKASRYIE NVLKPHQEMK LRKLEERFYQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCTTTTGC TGGGACACCC CACGGCAGTC GGGTGCGCCA AGAGAACAGA TGCTCTACTC 60
CGGCACCTGG AGGACTGTGG GTATAAGGTG TCCAAGAAAA AAAGCTCAGA TCTGCCAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
IPR017247--UBXN8

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005730--C:nucleolus
GO:0007338--P:single fertilization
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:7993

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002184	Ailuropoda melanoleuca	72.46	1.00e-84	305.00
IUUC-Aor-010227	Aspergillus oryzae	23.61	1.90e-01	31.20
IUUC-Ame-011207	Astyanax mexicanus	49.72	7.00e-34	137.00
IUUC-Bta-013470	Bos taurus	80.36	7.00e-93	333.00
IUUC-Cja-018892	Callithrix jacchus	83.81	7.00e-97	346.00
IUUC-Cfa-020669	Canis familiaris	81.82	3.00e-96	344.00
IUUC-Cpo-022004	Cavia porcellus	70.53	6.00e-36	141.00
IUUC-Csa-023031	Chlorocebus sabaeus	94.44	2.00e-125	441.00
IUUC-Cho-024725	Choloepus hoffmanni	72.36	9.00e-79	286.00
IUUC-Dre-028375	Danio rerio	42.71	2.00e-38	152.00
IUUC-Dno-029893	Dasypus novemcinctus	71.77	1.00e-85	309.00
IUUC-Ete-032415	Echinops telfairi	66.18	5.00e-80	290.00
IUUC-Eca-033355	Equus caballus	80.00	2.00e-86	311.00
IUUC-Fca-035484	Felis catus	81.16	7.00e-105	373.00
IUUC-Ggo-045614	Gorilla gorilla	97.04	5.00e-56	209.00
IUUC-Hvu-047478	Hordeum vulgare	37.97	6.00e-07	49.30
IUUC-Itr-048043	Ictidomys tridecemlineatus	76.26	8.00e-93	333.00
IUUC-Loc-052315	Lepisosteus oculatus	49.48	2.00e-47	182.00
IUUC-Laf-053549	Loxodonta africana	75.36	2.00e-94	338.00
IUUC-Mcc-054936	Macaca mulatta	95.56	1.00e-128	452.00
IUUC-Mtr-058440	Medicago truncatula	37.50	1.00e-07	51.60
IUUC-Mmr-061208	Microcebus murinus	83.70	1.00e-112	399.00
IUUC-Mdo-062250	Monodelphis domestica	50.19	9.00e-49	187.00
IUUC-Mmu-063233	Mus musculus	73.29	4.00e-89	320.00
IUUC-Mac-065477	Musa acuminata	42.86	1.00e-05	45.10
IUUC-Mlu-067805	Myotis lucifugus	78.18	2.00e-104	371.00
IUUC-Nle-069024	Nomascus leucogenys	96.30	2.00e-89	320.00
IUUC-Opr-070542	Ochotona princeps	73.45	1.00e-92	332.00
IUUC-Ocu-073802	Oryctolagus cuniculus	74.18	8.00e-94	336.00
IUUC-Oba-075728	Oryza barthii	40.45	1.00e-09	58.50
IUUC-Obr-076105	Oryza brachyantha	41.25	1.00e-07	52.00
IUUC-Ogu-078920	Oryza glumaepatula	40.45	1.00e-09	58.50
IUUC-Oin-079876	Oryza indica	40.45	1.00e-09	58.50
IUUC-Oni-082433	Oryza nivara	40.45	1.00e-09	58.50
IUUC-Opu-083184	Oryza punctata	42.22	2.00e-10	60.80
IUUC-Oru-084236	Oryza rufipogon	40.45	1.00e-09	58.50
IUUC-Osa-085643	Oryza sativa	40.45	4.00e-10	58.90
IUUC-Olu-087658	Ostreococcus lucimarinus	31.03	6.00e-08	51.60
IUUC-Oar-089387	Ovis aries	81.45	2.00e-88	318.00
IUUC-Pan-091720	Papio anubis	89.26	3.00e-122	430.00
IUUC-Pab-097930	Pongo abelii	87.78	4.00e-116	410.00
IUUC-Pva-102593	Pteropus vampyrus	64.81	3.00e-66	244.00
IUUC-Rno-105965	Rattus norvegicus	73.45	5.00e-94	337.00
IUUC-Sha-107593	Sarcophilus harrisii	52.88	8.00e-48	183.00
IUUC-Sar-113353	Sorex araneus	72.36	2.00e-38	151.00
IUUC-Sbi-114655	Sorghum bicolor	42.22	6.00e-09	56.20
IUUC-Ssc-116351	Sus scrofa	75.36	2.00e-82	298.00
IUUC-Tsy-119093	Tarsius syrichta	79.63	3.00e-80	291.00
IUUC-Ttr-129027	Tursiops truncatus	66.55	1.00e-74	272.00
IUUC-Vpa-130457	Vicugna pacos	66.55	6.00e-59	220.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence