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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046290
UUCD1 version UUC-HoS-00083
Ensembl Protein ID ENSP00000351446.3
UniProt Accession P61964; Q91VA5; Q9NWX7; Q9UGP9; WDR5_HUMAN
Genbank Protein ID CAB66159.1; BAA91248.1; AAH01635.1
Protein Name WD repeat-containing protein 5; BMP2-induced 3-kb gene protein
Genbank Nucleotide ID AJ011376; AK000552; BC001635
Gene Name WDR5; BIG3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196363.9 ENST00000358625.3 ENSP00000351446.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17041588; 17588513
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-58 193.4 127 166
UBD/Beta-Prp 3.10e-88 297.5 40 332
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ v+c++f +  +l+vsGs D ++++WD++tg++lk+
   Q: 127  GHSNYVFCCNFnPQsNLIVSGSFDESVRIWDVKTGKCLKT 166
           8***********666**********************986 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           tl gh k+v + vkfsp++++la++s+d+ ik+w + +gk+ +++sgh+ ++++v +s+d+++lv++s+D+t+k+wd+s+gkc+ tlkgh++
   Q: 40   TLAGHTKAVSS-VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
           67777776666.******************************************************************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls 187
           +v +++f+p+++ +vsGs d+ +r+wd++tg+cl+ tl  h++ v+ v+++ dg+l+vs+s+D+ +r+Wd ++g++l+tl  +++++v  ++
   Q: 131  YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
           ***********************************.********************************************999********* PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfg 276
           f++ngk+++++ ld+t+klwd+++g+c++t++gh++  +++ +      ++++vsgs+D+ ++iW+l++++++++lq+h + vis a+ +++
   Q: 222  FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC-HPT 312
           ****************************************98887899****************************************.*** PP
   S: 277  dnvlvlgse..dskvniwkl 294
           +n++++++   d+++++wk 
   Q: 313  ENIIASAALenDKTIKLWKS 332
           ****9998888*******96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
 Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
Protein Sequence
(Fasta)
MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046290|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAGTTTGC GCACTGCGGA GCGGGCGCGG GTGACTCCAG AGCGGCCCTG CCAGTCCGCG 60
GGGCTGGCGG GGAGCAGGTT CGTGCACCGC GGGCTCTGTG CATGCAGAGG CGGGAAGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046290|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0036064--C:ciliary basal body
GO:0000123--C:histone acetyltransferase complex
GO:0035097--C:histone methyltransferase complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0035064--F:methylated histone binding
GO:0060271--P:cilium assembly
GO:0043966--P:histone H3 acetylation
GO:0051568--P:histone H3-K4 methylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0031175--P:neuron projection development
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated
KEGG hsa:11091
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000502 Aegilops tauschii 53.02 8.00e-90 323.00
IUUC-Aml-002420 Ailuropoda melanoleuca 100.00 0.00e+00 650.00
IUUC-Atr-002439 Amborella trichopoda 69.51 3.00e-130 457.00
IUUC-Apl-003436 Anas platyrhynchos 89.82 2.00e-168 584.00
IUUC-Aca-004259 Anolis carolinensis 96.11 0.00e+00 637.00
IUUC-Aly-005723 Arabidopsis lyrata 64.45 7.00e-117 413.00
IUUC-Ath-007308 Arabidopsis thaliana 65.45 4.00e-117 414.00
IUUC-Acl-008045 Aspergillus clavatus 45.95 2.00e-83 303.00
IUUC-Afl-008596 Aspergillus flavus 44.66 7.00e-81 294.00
IUUC-Afu-009074 Aspergillus fumigatus 46.75 1.00e-83 303.00
IUUC-Ani-009318 Aspergillus nidulans 50.00 5.00e-83 301.00
IUUC-Ang-009775 Aspergillus niger 45.63 5.00e-83 301.00
IUUC-Aor-010222 Aspergillus oryzae 44.66 7.00e-81 295.00
IUUC-Ate-010583 Aspergillus terreus 48.75 8.00e-81 294.00
IUUC-Ame-011349 Astyanax mexicanus 99.02 6.00e-179 619.00
IUUC-Bgr-011968 Blumeria graminis 50.33 1.00e-84 307.00
IUUC-Bta-013016 Bos taurus 99.68 0.00e+00 628.00
IUUC-Bci-013948 Botrytis cinerea 50.96 2.00e-85 310.00
IUUC-Bdi-014263 Brachypodium distachyon 62.46 1.00e-120 425.00
IUUC-Bol-015900 Brassica oleracea 62.50 1.00e-113 402.00
IUUC-Bra-017143 Brassica rapa 62.17 1.00e-114 405.00
IUUC-Cel-018355 Caenorhabditis elegans 72.24 3.00e-132 464.00
IUUC-Cja-019936 Callithrix jacchus 100.00 0.00e+00 650.00
IUUC-Cfa-020596 Canis familiaris 100.00 0.00e+00 650.00
IUUC-Cpo-021318 Cavia porcellus 100.00 0.00e+00 650.00
IUUC-Cre-022935 Chlamydomonas reinhardtii 48.76 2.00e-79 289.00
IUUC-Csa-023053 Chlorocebus sabaeus 100.00 0.00e+00 650.00
IUUC-Cin-025495 Ciona intestinalis 86.96 1.00e-169 588.00
IUUC-Csv-025988 Ciona savignyi 91.86 5.00e-164 570.00
IUUC-Cne-027025 Cryptococcus neoformans 32.13 4.00e-53 201.00
IUUC-Cme-027119 Cyanidioschyzon merolae 50.43 5.00e-106 377.00
IUUC-Dre-027521 Danio rerio 95.81 0.00e+00 633.00
IUUC-Dno-029739 Dasypus novemcinctus 100.00 5.00e-179 620.00
IUUC-Dor-030966 Dipodomys ordii 100.00 0.00e+00 627.00
IUUC-Dse-031189 Dothistroma septosporum 48.91 7.00e-86 310.00
IUUC-Dme-031613 Drosophila melanogaster 94.72 4.00e-172 597.00
IUUC-Eca-033790 Equus caballus 100.00 0.00e+00 650.00
IUUC-Fca-035901 Felis catus 100.00 0.00e+00 650.00
IUUC-Fal-037413 Ficedula albicollis 97.01 0.00e+00 639.00
IUUC-Fox-037876 Fusarium oxysporum 46.45 3.00e-58 218.00
IUUC-Gmo-039131 Gadus morhua 93.71 3.00e-179 620.00
IUUC-Ggr-040071 Gaeumannomyces graminis 40.27 1.00e-64 241.00
IUUC-Gga-040789 Gallus gallus 97.01 0.00e+00 639.00
IUUC-Gac-042634 Gasterosteus aculeatus 91.32 3.00e-177 613.00
IUUC-Gma-043692 Glycine max 66.34 2.00e-127 448.00
IUUC-Ggo-044443 Gorilla gorilla 100.00 0.00e+00 650.00
IUUC-Hvu-047077 Hordeum vulgare 57.73 9.00e-80 289.00
IUUC-Itr-048954 Ictidomys tridecemlineatus 100.00 0.00e+00 650.00
IUUC-Kpa-049404 Komagataella pastoris 45.42 1.00e-65 243.00
IUUC-Lch-049539 Latimeria chalumnae 98.75 0.00e+00 643.00
IUUC-Lpe-051082 Leersia perrieri 61.67 2.00e-119 421.00
IUUC-Loc-051743 Lepisosteus oculatus 99.02 6.00e-179 619.00
IUUC-Lma-053188 Leptosphaeria maculans 46.73 9.00e-86 310.00
IUUC-Laf-054432 Loxodonta africana 95.22 0.00e+00 639.00
IUUC-Mcc-055603 Macaca mulatta 100.00 0.00e+00 650.00
IUUC-Meu-056440 Macropus eugenii 92.13 3.00e-156 544.00
IUUC-Mor-056965 Magnaporthe oryzae 36.71 6.00e-69 255.00
IUUC-Mpo-057333 Magnaporthe poae 41.16 3.00e-61 229.00
IUUC-Mtr-057951 Medicago truncatula 65.58 1.00e-122 432.00
IUUC-Mla-058896 Melampsora laricipopulina 43.60 3.00e-72 265.00
IUUC-Mga-060046 Meleagris gallopavo 96.71 0.00e+00 638.00
IUUC-Mvi-060453 Microbotryum violaceum 48.02 1.00e-88 320.00
IUUC-Mmr-061020 Microcebus murinus 92.51 1.00e-177 615.00
IUUC-Mdo-062204 Monodelphis domestica 95.92 0.00e+00 629.00
IUUC-Mmu-063917 Mus musculus 100.00 0.00e+00 650.00
IUUC-Mac-065310 Musa acuminata 66.22 1.00e-122 432.00
IUUC-Mpu-066072 Mustela putorius furo 100.00 0.00e+00 650.00
IUUC-Mlu-068209 Myotis lucifugus 100.00 0.00e+00 650.00
IUUC-Nfi-068538 Neosartorya fischeri 46.43 7.00e-83 301.00
IUUC-Ncr-068651 Neurospora crassa 41.36 1.00e-72 267.00
IUUC-Ont-071458 Oreochromis niloticus 92.22 2.00e-179 621.00
IUUC-Oan-073597 Ornithorhynchus anatinus 100.00 2.00e-180 624.00
IUUC-Oba-075292 Oryza barthii 54.09 1.00e-99 356.00
IUUC-Obr-076723 Oryza brachyantha 54.90 9.00e-97 346.00
IUUC-Ogl-077251 Oryza glaberrima 60.39 5.00e-117 414.00
IUUC-Ogu-078882 Oryza glumaepatula 49.86 5.00e-103 368.00
IUUC-Oin-079601 Oryza indica 54.55 2.00e-112 398.00
IUUC-Olo-080976 Oryza longistaminata 62.95 2.00e-102 365.00
IUUC-Ome-081430 Oryza meridionalis 60.78 3.00e-117 414.00
IUUC-Oni-082182 Oryza nivara 49.45 1.00e-102 366.00
IUUC-Opu-083880 Oryza punctata 60.13 2.00e-116 411.00
IUUC-Oru-084935 Oryza rufipogon 53.65 8.00e-99 353.00
IUUC-Osa-085706 Oryza sativa 60.39 5.00e-117 414.00
IUUC-Ola-087134 Oryzias latipes 94.31 3.00e-179 620.00
IUUC-Olu-087660 Ostreococcus lucimarinus 42.50 4.00e-40 157.00
IUUC-Oga-088672 Otolemur garnettii 99.40 0.00e+00 644.00
IUUC-Ptr-091513 Pan troglodytes 100.00 0.00e+00 650.00
IUUC-Pan-092046 Papio anubis 100.00 0.00e+00 650.00
IUUC-Psi-093192 Pelodiscus sinensis 96.71 0.00e+00 639.00
IUUC-Pno-094881 Phaeosphaeria nodorum 48.04 1.00e-89 323.00
IUUC-Ppa-095367 Physcomitrella patens 72.58 5.00e-134 470.00
IUUC-Pfo-097434 Poecilia formosa 91.92 5.00e-179 619.00
IUUC-Pab-097773 Pongo abelii 93.51 5.00e-166 576.00
IUUC-Pop-099778 Populus trichocarpa 64.87 8.00e-122 429.00
IUUC-Pca-100281 Procavia capensis 79.02 7.00e-125 439.00
IUUC-Ppe-101341 Prunus persica 64.56 6.00e-123 433.00
IUUC-Pva-103020 Pteropus vampyrus 99.06 0.00e+00 647.00
IUUC-Pgr-103589 Puccinia graminis 39.27 8.00e-70 257.00
IUUC-Pte-104153 Pyrenophora teres 51.91 8.00e-94 337.00
IUUC-Pyt-104712 Pyrenophora triticirepentis 52.43 6.00e-79 287.00
IUUC-Rno-105858 Rattus norvegicus 100.00 0.00e+00 650.00
IUUC-Sce-106243 Saccharomyces cerevisiae 34.47 4.00e-40 158.00
IUUC-Sha-107101 Sarcophilus harrisii 98.43 0.00e+00 640.00
IUUC-Sja-107858 Schizosaccharomyces japonicus 51.17 1.00e-68 253.00
IUUC-Spo-108117 Schizosaccharomyces pombe 47.98 5.00e-64 238.00
IUUC-Smo-109155 Selaginella moellendorffii 71.29 1.00e-132 465.00
IUUC-Sit-110688 Setaria italica 62.00 3.00e-119 421.00
IUUC-Sly-110891 Solanum lycopersicum 68.90 9.00e-127 446.00
IUUC-Stu-112365 Solanum tuberosum 66.13 6.00e-127 446.00
IUUC-Sbi-114284 Sorghum bicolor 62.00 2.00e-118 418.00
IUUC-Sre-115180 Sporisorium reilianum 42.57 1.00e-66 246.00
IUUC-Ssc-116204 Sus scrofa 100.00 2.00e-179 621.00
IUUC-Tgu-117172 Taeniopygia guttata 97.01 0.00e+00 639.00
IUUC-Tru-118320 Takifugu rubripes 91.62 2.00e-178 618.00
IUUC-Tni-120660 Tetraodon nigroviridis 87.84 1.00e-109 388.00
IUUC-Tca-121051 Theobroma cacao 67.53 3.00e-125 441.00
IUUC-Tre-122237 Trichoderma reesei 45.09 1.00e-85 310.00
IUUC-Tvi-122635 Trichoderma virens 46.18 5.00e-85 308.00
IUUC-Tae-125819 Triticum aestivum 60.26 8.00e-121 426.00
IUUC-Tur-126217 Triticum urartu 55.84 1.00e-76 279.00
IUUC-Tme-127061 Tuber melanosporum 55.99 2.00e-112 398.00
IUUC-Ttr-129309 Tursiops truncatus 94.04 4.00e-174 603.00
IUUC-Uma-129585 Ustilago maydis 41.64 2.00e-73 269.00
IUUC-Vda-129907 Verticillium dahliae 44.71 9.00e-79 288.00
IUUC-Vvi-131269 Vitis vinifera 66.45 7.00e-120 423.00
IUUC-Xtr-131945 Xenopus tropicalis 97.01 0.00e+00 638.00
IUUC-Xma-132997 Xiphophorus maculatus 91.92 5.00e-179 619.00
IUUC-Yli-134418 Yarrowia lipolytica 42.95 1.00e-75 276.00
IUUC-Zma-135765 Zea mays 61.67 3.00e-117 414.00
Created Date 25-Jun-2017

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