iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054432

UUCD1 version

UUC-LoA-00386

Ensembl Protein ID

ENSLAFP00000009364.3

UniProt Accession

G3T717; G3T717_LOXAF

Protein Name

Uncharacterized protein

Gene Name

WDR5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011192.3	ENSLAFT00000011193.3	ENSLAFP00000009364.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-58	192.8	127	166
UBD/Beta-Prp	1.70e-87	293.7	40	348

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ v+c++f +  +l+vsGs D ++++WD++tg++lk+
   Q: 127  GHSNYVFCCNFnPQsNLIVSGSFDESVRIWDVKTGKCLKT 166
           8***********666**********************986 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           tl gh k+v + vkfsp++++la++s+d+ ik+w + +gk+ +++sgh+ ++++v +s+d+++lv++s+D+t+k+wd+s+gkc+ tlkg
   Q: 40   TLAGHTKAVSS-VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127
           67777776666.***************************************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...... 175
           h+++v +++f+p+++ +vsGs d+ +r+wd++tg+cl+ tl  h++ v+ v+++ dg+l+vs+s+D+ +r+Wd ++g++l+tl      
   Q: 128  HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLigewpg 215
           **************************************.************************************************** PP
   S: 176  ..........tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdl 251
                     + +++++v  ++f++ngk+++++ ld+t+klwd+++g+c++t++gh++  +++ +      ++++vsgs+D+ ++iW+l
   Q: 216  fapessprlhSDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNL 304
           *********9888*************************************************98887899******************* PP
   S: 252  rsgdllktlqlhnssvisvavlsfgdnvlvlgse..dskvniwkl 294
           ++++++++lq+h + vis a+ ++++n++++++   d+++++wk 
   Q: 305  QTKEIVQKLQGHTDVVISTAC-HPTENIIASAALenDKTIKLWKS 348
           *********************.*******9998888*******96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAACGG AGGAGAAGAA GCCGGAGACC GAAGCTGCCA GGGCACAGCC GACCCCTTCG 60
TCGTCGGCCA CTCAGAGCAA GGTGTGTGCA GAGCACTCCT TGGGGGGCTT CTGGGGGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0048188--C:Set1C/COMPASS complex
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0043996--F:histone acetyltransferase activity (H4-K8 specific)
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0043966--P:histone H3 acetylation
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000502	Aegilops tauschii	50.32	6.00e-87	313.00
IUUC-Aml-002420	Ailuropoda melanoleuca	95.22	0.00e+00	639.00
IUUC-Atr-002439	Amborella trichopoda	66.04	9.00e-127	446.00
IUUC-Apl-003436	Anas platyrhynchos	85.71	6.00e-165	573.00
IUUC-Aca-004259	Anolis carolinensis	91.71	0.00e+00	626.00
IUUC-Aly-005723	Arabidopsis lyrata	61.86	7.00e-114	403.00
IUUC-Ath-007308	Arabidopsis thaliana	62.15	1.00e-113	402.00
IUUC-Acl-008045	Aspergillus clavatus	44.00	1.00e-80	294.00
IUUC-Afl-008596	Aspergillus flavus	42.77	4.00e-78	285.00
IUUC-Afu-009074	Aspergillus fumigatus	44.75	7.00e-81	294.00
IUUC-Ani-009318	Aspergillus nidulans	47.65	3.00e-80	292.00
IUUC-Ang-009775	Aspergillus niger	43.69	3.00e-80	292.00
IUUC-Aor-010222	Aspergillus oryzae	42.77	3.00e-78	285.00
IUUC-Ate-010583	Aspergillus terreus	46.46	6.00e-78	284.00
IUUC-Ame-011349	Astyanax mexicanus	94.08	2.00e-175	608.00
IUUC-Bgr-011968	Blumeria graminis	48.11	9.00e-82	297.00
IUUC-Bta-013016	Bos taurus	94.75	4.00e-178	616.00
IUUC-Bci-013948	Botrytis cinerea	48.79	1.00e-82	300.00
IUUC-Bdi-014263	Brachypodium distachyon	59.31	4.00e-117	414.00
IUUC-Bol-015900	Brassica oleracea	59.38	3.00e-110	391.00
IUUC-Bra-017143	Brassica rapa	59.06	2.00e-111	394.00
IUUC-Cel-018355	Caenorhabditis elegans	68.57	5.00e-129	453.00
IUUC-Cja-019936	Callithrix jacchus	95.22	0.00e+00	639.00
IUUC-Cfa-020596	Canis familiaris	95.22	0.00e+00	639.00
IUUC-Cpo-021318	Cavia porcellus	95.22	0.00e+00	639.00
IUUC-Cre-022935	Chlamydomonas reinhardtii	46.15	3.00e-76	278.00
IUUC-Csa-023053	Chlorocebus sabaeus	95.22	0.00e+00	639.00
IUUC-Cin-025495	Ciona intestinalis	82.84	2.00e-166	578.00
IUUC-Csv-025988	Ciona savignyi	87.14	7.00e-161	559.00
IUUC-Cgl-026771	Colletotrichum gloeosporioides	33.96	2.00e-47	184.00
IUUC-Cne-027025	Cryptococcus neoformans	30.86	3.00e-50	192.00
IUUC-Cme-027119	Cyanidioschyzon merolae	48.77	6.00e-104	370.00
IUUC-Dre-027521	Danio rerio	91.43	8.00e-180	622.00
IUUC-Dno-029739	Dasypus novemcinctus	95.00	6.00e-176	609.00
IUUC-Dor-030966	Dipodomys ordii	95.05	5.00e-178	616.00
IUUC-Dse-031189	Dothistroma septosporum	46.88	5.00e-83	301.00
IUUC-Dme-031613	Drosophila melanogaster	89.97	9.00e-169	585.00
IUUC-Eca-033790	Equus caballus	95.22	0.00e+00	639.00
IUUC-Fca-035901	Felis catus	95.22	0.00e+00	639.00
IUUC-Fal-037413	Ficedula albicollis	92.57	0.00e+00	627.00
IUUC-Fox-037876	Fusarium oxysporum	43.61	2.00e-55	208.00
IUUC-Gmo-039131	Gadus morhua	89.43	5.00e-176	609.00
IUUC-Ggr-040071	Gaeumannomyces graminis	38.51	1.00e-61	231.00
IUUC-Gga-040789	Gallus gallus	92.57	0.00e+00	627.00
IUUC-Gac-042634	Gasterosteus aculeatus	87.14	2.00e-174	604.00
IUUC-Gma-043692	Glycine max	63.08	4.00e-124	437.00
IUUC-Ggo-044443	Gorilla gorilla	95.22	0.00e+00	639.00
IUUC-Hsa-046290	Homo sapiens	95.22	0.00e+00	639.00
IUUC-Hvu-047077	Hordeum vulgare	53.81	3.00e-76	278.00
IUUC-Itr-048954	Ictidomys tridecemlineatus	95.22	0.00e+00	639.00
IUUC-Kpa-049404	Komagataella pastoris	43.43	3.00e-64	238.00
IUUC-Lch-049539	Latimeria chalumnae	94.03	0.00e+00	631.00
IUUC-Lpe-051082	Leersia perrieri	58.54	6.00e-116	410.00
IUUC-Loc-051743	Lepisosteus oculatus	94.08	2.00e-175	608.00
IUUC-Lma-053188	Leptosphaeria maculans	44.81	6.00e-83	301.00
IUUC-Mcc-055603	Macaca mulatta	95.22	0.00e+00	639.00
IUUC-Meu-056440	Macropus eugenii	87.54	3.00e-153	534.00
IUUC-Mor-056965	Magnaporthe oryzae	35.43	4.00e-66	245.00
IUUC-Mpo-057333	Magnaporthe poae	39.12	2.00e-58	220.00
IUUC-Mtr-057951	Medicago truncatula	62.35	2.00e-119	421.00
IUUC-Mla-058896	Melampsora laricipopulina	41.52	2.00e-70	258.00
IUUC-Mga-060046	Meleagris gallopavo	92.29	0.00e+00	627.00
IUUC-Mvi-060453	Microbotryum violaceum	45.80	2.00e-85	309.00
IUUC-Mmr-061020	Microcebus murinus	88.29	4.00e-174	603.00
IUUC-Mdo-062204	Monodelphis domestica	91.34	2.00e-178	617.00
IUUC-Mmu-063917	Mus musculus	95.22	0.00e+00	639.00
IUUC-Mac-065310	Musa acuminata	62.82	2.00e-119	421.00
IUUC-Mpu-066072	Mustela putorius furo	95.22	0.00e+00	639.00
IUUC-Mlu-068209	Myotis lucifugus	95.22	0.00e+00	639.00
IUUC-Nfi-068538	Neosartorya fischeri	44.44	5.00e-80	291.00
IUUC-Ncr-068651	Neurospora crassa	39.71	6.00e-70	258.00
IUUC-Ont-071458	Oreochromis niloticus	88.00	3.00e-176	610.00
IUUC-Oan-073597	Ornithorhynchus anatinus	95.02	8.00e-177	612.00
IUUC-Oba-075292	Oryza barthii	51.50	2.00e-96	345.00
IUUC-Obr-076723	Oryza brachyantha	52.17	9.00e-94	336.00
IUUC-Ogl-077251	Oryza glaberrima	57.41	1.00e-113	402.00
IUUC-Ogu-078882	Oryza glumaepatula	47.75	1.00e-99	356.00
IUUC-Oin-079601	Oryza indica	52.10	7.00e-109	386.00
IUUC-Olo-080976	Oryza longistaminata	59.18	5.00e-99	353.00
IUUC-Ome-081430	Oryza meridionalis	57.76	8.00e-114	403.00
IUUC-Oni-082182	Oryza nivara	47.37	3.00e-99	355.00
IUUC-Opu-083880	Oryza punctata	57.14	6.00e-113	400.00
IUUC-Oru-084935	Oryza rufipogon	51.06	1.00e-95	342.00
IUUC-Osa-085706	Oryza sativa	57.41	1.00e-113	402.00
IUUC-Ola-087134	Oryzias latipes	90.00	3.00e-176	610.00
IUUC-Oga-088672	Otolemur garnettii	94.86	0.00e+00	633.00
IUUC-Ptr-091513	Pan troglodytes	95.22	0.00e+00	639.00
IUUC-Pan-092046	Papio anubis	95.22	0.00e+00	639.00
IUUC-Psi-093192	Pelodiscus sinensis	92.29	0.00e+00	627.00
IUUC-Pno-094881	Phaeosphaeria nodorum	45.96	8.00e-87	313.00
IUUC-Ppa-095367	Physcomitrella patens	68.89	7.00e-131	459.00
IUUC-Pfo-097434	Poecilia formosa	87.71	7.00e-176	609.00
IUUC-Pab-097773	Pongo abelii	88.89	1.00e-162	565.00
IUUC-Pop-099778	Populus trichocarpa	61.75	2.00e-118	418.00
IUUC-Ppe-101341	Prunus persica	61.45	8.00e-120	422.00
IUUC-Pva-103020	Pteropus vampyrus	94.33	0.00e+00	635.00
IUUC-Ptt-103745	Puccinia triticina	33.45	4.00e-36	145.00
IUUC-Pte-104153	Pyrenophora teres	49.70	7.00e-91	327.00
IUUC-Pyt-104712	Pyrenophora triticirepentis	49.82	5.00e-76	277.00
IUUC-Rno-105858	Rattus norvegicus	95.22	0.00e+00	639.00
IUUC-Sha-107101	Sarcophilus harrisii	93.73	0.00e+00	630.00
IUUC-Sja-107858	Schizosaccharomyces japonicus	47.60	2.00e-65	242.00
IUUC-Smo-109155	Selaginella moellendorffii	67.79	1.00e-129	455.00
IUUC-Sit-110688	Setaria italica	58.86	6.00e-116	410.00
IUUC-Sly-110891	Solanum lycopersicum	65.40	1.00e-123	435.00
IUUC-Stu-112365	Solanum tuberosum	62.54	1.00e-123	435.00
IUUC-Sbi-114284	Sorghum bicolor	58.86	5.00e-115	407.00
IUUC-Sre-115180	Sporisorium reilianum	40.44	1.00e-63	236.00
IUUC-Ssc-116204	Sus scrofa	95.00	5.00e-176	610.00
IUUC-Tgu-117172	Taeniopygia guttata	92.57	0.00e+00	627.00
IUUC-Tru-118320	Takifugu rubripes	88.00	3.00e-175	607.00
IUUC-Tni-120660	Tetraodon nigroviridis	81.93	1.00e-106	378.00
IUUC-Tca-121051	Theobroma cacao	64.20	5.00e-122	430.00
IUUC-Tre-122237	Trichoderma reesei	43.27	8.00e-83	300.00
IUUC-Tvi-122635	Trichoderma virens	44.24	6.00e-82	297.00
IUUC-Tae-125819	Triticum aestivum	57.32	2.00e-117	414.00
IUUC-Tme-127061	Tuber melanosporum	53.71	5.00e-109	387.00
IUUC-Ttr-129309	Tursiops truncatus	89.55	1.00e-170	591.00
IUUC-Vda-129907	Verticillium dahliae	42.72	1.00e-75	277.00
IUUC-Vvi-131269	Vitis vinifera	63.19	8.00e-117	412.00
IUUC-Xtr-131945	Xenopus tropicalis	92.57	0.00e+00	627.00
IUUC-Xma-132997	Xiphophorus maculatus	87.71	7.00e-176	609.00
IUUC-Yli-134418	Yarrowia lipolytica	42.36	6.00e-74	271.00
IUUC-Zma-135765	Zea mays	58.54	9.00e-114	402.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence