iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007126

UUCD1 version

UUC-ArT-01564

Ensembl Protein ID

AT4G12570.1

UniProt Accession

Q9SU29; UPL5_ARATH

Genbank Protein ID

CAB41727.2; CAB78300.1; AEE83149.1; BAF01094.1

Protein Name

E3 ubiquitin-protein ligase UPL5; HECT-type E3 ubiquitin transferase UPL5

Genbank Nucleotide ID

AL049730; AL161534; CP002687; AK229227

Gene Name

UPL5; At4g12570; T1P17.160

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G12570	AT4G12570.1	AT4G12570.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20409006; 12969426

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	2.90e-91	307.3	534	871
ULD/UDP/UBQ/UBQ_Other	1.30e-10	41.9	96	168

Active Site

Position(s)	Description	Evidence
839	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           ++l+  l++ef++Ee+++  Gv re+++l+++e++np+++lfl+s++d + ++pnp+s++ +p h ++Fef Gr++++al+++  + + + ++f+ +l
   Q: 534  EALHGGLFMEFKNEEATGP-GVLREWFYLVCQEIFNPKNTLFLRSADDFRRFSPNPASKV-DPLHPDFFEFTGRVIALALMHKVQVGVLFDRVFFLQL 629
           6788899***********9.***************************************9.68*********************************** PP
   S: 101  lgkklsledleevdpelykslkeikena.esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGf 197
            g k+sled++++d+ +y+s k+i+e++ e   +++gl ltf  ++e+lg++++ eL+p+G+   V+ +N+++Yv+l++e r+ + i eqv++f++Gf
   Q: 630  AGLKISLEDIKDTDRIMYNSCKQILEMDpEFFDSNAGLGLTFVLETEELGKRDTIELCPDGKLKAVNSKNRKQYVDLLIERRFATPILEQVKQFSRGF 727
           ********************99999987566888999************************************************************* PP
   S: 198  nev.....iplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvi 289
           +++      p ++++ +  e+l+ ++ G  + i+++d+k++t+y+ g++e++++i+wFw++l+++++ee++ +L F+T+++ +P++Gf+ l+ +l+++
   Q: 728  TDMlshsvPPRSFFKRLYLEDLDGMLRGGeNPISIDDWKAHTEYN-GFKETDRQIDWFWKILKKMTEEEQRSILFFWTSNKFVPVEGFRGLSSKLYIY 824
           98845442456699*************9989*************5.5*************************************************** PP
   S: 290  rkdasddrlPssnTCfnyLkLPeYsskeilkekL.lyAieet.kgFe 334
           r ++++drlP s+TCf++L++P+Y++ + ++++L l+A ++  ++F+
   Q: 825  RLYEANDRLPLSHTCFYRLCIPRYPTITLMEQRLrLIAQDHVsSSFG 871
           **********************************6677777666776 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekk 73
           q++v+ + g  +  ++ +++dtV +L ++ie k++ip+ +qr iykGk L+  ++L +y + ++  + l+ ++
   Q: 96   QIFVRMMSGGkTIVIHAEKYDTVEKLHQRIEWKTKIPALEQRVIYKGKQLQRENSLTYYSIEQDASLQLVARM 168
           8999999999999*************************************9999**************99876 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin protein ligase that regulates leaf senescence through ubiquitination and subsequent degradation of WRKY53.

Protein Sequence
(Fasta)

MTLSRSSADD STNNANRSYS AVAGTDNKRK RDEDSSDYVG VAESLEMLKK QEIDADHMAA 60
SAQQTLISWR SGENSRSLSS SGECSSSNRP ESTRLQIFVR MMSGGKTIVI HAEKYDTVEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGAGATAT TTTTACACTA ATTTTATAGA AATTCATTAA TCTAATCACA AATTAATAAA 60
ATAAAGAGGT GTGAAACGTT TAACAATGGC ATAGAGAGCG AGAGAGAGAG AGAGGAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0430--Lectin
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS00615--C_TYPE_LECTIN_1
PS50237--HECT
PS50053--UBIQUITIN_2

Pfam

PF00632--HECT
PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00119--HECTc
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030246--F:carbohydrate binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0010150--P:leaf senescence
GO:0016567--P:protein ubiquitination
GO:0042542--P:response to hydrogen peroxide
GO:0009753--P:response to jasmonic acid

KEGG

ath:AT4G12570

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000327	Aegilops tauschii	41.24	1.00e-147	516.00
IUUC-Atr-002891	Amborella trichopoda	41.02	1.00e-172	599.00
IUUC-Aly-005570	Arabidopsis lyrata	91.59	0.00e+00	1622.00
IUUC-Bdi-014613	Brachypodium distachyon	40.15	5.00e-159	554.00
IUUC-Bol-016237	Brassica oleracea	68.95	0.00e+00	1217.00
IUUC-Bra-017376	Brassica rapa	68.57	0.00e+00	1208.00
IUUC-Gma-043346	Glycine max	52.58	0.00e+00	841.00
IUUC-Hvu-047734	Hordeum vulgare	41.82	5.00e-161	560.00
IUUC-Lpe-051617	Leersia perrieri	39.98	8.00e-142	497.00
IUUC-Mtr-058709	Medicago truncatula	49.07	0.00e+00	741.00
IUUC-Mac-065415	Musa acuminata	42.47	4.00e-172	597.00
IUUC-Oba-075190	Oryza barthii	42.39	3.00e-137	481.00
IUUC-Obr-076197	Oryza brachyantha	40.34	6.00e-151	527.00
IUUC-Ogl-077892	Oryza glaberrima	38.16	3.00e-131	462.00
IUUC-Ogu-078711	Oryza glumaepatula	39.43	2.00e-140	492.00
IUUC-Oin-079504	Oryza indica	38.65	1.00e-136	479.00
IUUC-Olo-080730	Oryza longistaminata	42.39	4.00e-137	481.00
IUUC-Ome-081851	Oryza meridionalis	39.63	2.00e-143	503.00
IUUC-Oni-082230	Oryza nivara	39.43	3.00e-140	491.00
IUUC-Opu-084015	Oryza punctata	39.60	7.00e-142	497.00
IUUC-Oru-084327	Oryza rufipogon	39.43	2.00e-140	492.00
IUUC-Osa-086148	Oryza sativa	38.16	6.00e-132	464.00
IUUC-Ppa-095337	Physcomitrella patens	40.02	1.00e-169	589.00
IUUC-Pop-100027	Populus trichocarpa	52.09	0.00e+00	734.00
IUUC-Ppe-101443	Prunus persica	54.65	0.00e+00	865.00
IUUC-Smo-109099	Selaginella moellendorffii	40.25	1.00e-163	569.00
IUUC-Sit-110651	Setaria italica	40.42	2.00e-149	522.00
IUUC-Sly-111513	Solanum lycopersicum	51.23	0.00e+00	809.00
IUUC-Stu-112582	Solanum tuberosum	51.48	0.00e+00	817.00
IUUC-Sbi-114659	Sorghum bicolor	38.08	4.00e-112	398.00
IUUC-Tca-121392	Theobroma cacao	54.27	0.00e+00	867.00
IUUC-Tae-125860	Triticum aestivum	37.66	2.00e-133	469.00
IUUC-Tur-126774	Triticum urartu	44.33	7.00e-149	520.00
IUUC-Vvi-131149	Vitis vinifera	53.06	0.00e+00	843.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence