iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027603

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Speckle-type POZ protein; HIB homolog 1; SPOP1

Genbank Nucleotide ID

BC053276

Gene Name

spop; zgc:64140

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000100519.1	ENSDART00000163473.1	ENSDARP00000130146.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.20e-29	103.4	200	266
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.00e-09	35.4	299	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D+ l+v+g+ef+ahk++Laa+S+vF+a+f++e+eesk k++vei+dv++evf++++ F+Ytgk+++ 
   Q: 200  TDCSLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESK-KNRVEINDVEAEVFKEMMFFIYTGKAPNL 266
           7*************************************.*************************9986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eN+++il +Adl+++++Lk +a+dfi++h 
   Q: 299  VENAAEILILADLHSADQLKTQAVDFINYHA 329
           79***************************95 PP

Organism

Danio rerio

Functional Description
(View)

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Protein Sequence
(Fasta)

MSRVPSPPPP AEMTSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG 60
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTCATTTA ACCCGGACGT GAAGCAGCTC CATAGAAAAA TATCCCATAC GGTAAAACAG 60
CTTATCTTCC AAAAAGGTAA GTGTATAAAC TCTTATACTC CAAAACATAC CAGGGGAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB
PF00917--MATH

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

dre:100005514

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002307	Ailuropoda melanoleuca	92.62	0.00e+00	682.00
IUUC-Atr-002922	Amborella trichopoda	29.86	3.00e-40	159.00
IUUC-Apl-003488	Anas platyrhynchos	97.59	0.00e+00	699.00
IUUC-Aca-005010	Anolis carolinensis	97.33	0.00e+00	697.00
IUUC-Bta-012931	Bos taurus	97.33	0.00e+00	697.00
IUUC-Bdi-014743	Brachypodium distachyon	32.26	2.00e-42	166.00
IUUC-Cel-018671	Caenorhabditis elegans	65.62	8.00e-135	473.00
IUUC-Cja-019981	Callithrix jacchus	97.07	0.00e+00	693.00
IUUC-Cfa-020115	Canis familiaris	97.33	0.00e+00	697.00
IUUC-Cpo-021366	Cavia porcellus	97.33	0.00e+00	694.00
IUUC-Cin-025636	Ciona intestinalis	76.01	5.00e-159	553.00
IUUC-Csv-026167	Ciona savignyi	71.17	1.00e-155	542.00
IUUC-Dno-029006	Dasypus novemcinctus	91.29	0.00e+00	628.00
IUUC-Dor-030503	Dipodomys ordii	97.30	0.00e+00	689.00
IUUC-Dme-032218	Drosophila melanogaster	79.14	3.00e-160	559.00
IUUC-Ete-032328	Echinops telfairi	97.13	0.00e+00	643.00
IUUC-Eca-033238	Equus caballus	97.33	0.00e+00	697.00
IUUC-Eeu-034739	Erinaceus europaeus	81.82	7.00e-173	599.00
IUUC-Fca-035435	Felis catus	97.33	0.00e+00	697.00
IUUC-Gmo-038600	Gadus morhua	95.99	0.00e+00	692.00
IUUC-Gga-040441	Gallus gallus	97.59	0.00e+00	699.00
IUUC-Gac-041911	Gasterosteus aculeatus	97.33	0.00e+00	697.00
IUUC-Gma-043988	Glycine max	30.66	7.00e-41	161.00
IUUC-Hsa-045835	Homo sapiens	97.33	0.00e+00	697.00
IUUC-Itr-048058	Ictidomys tridecemlineatus	95.12	0.00e+00	663.00
IUUC-Lch-050241	Latimeria chalumnae	97.33	0.00e+00	696.00
IUUC-Loc-052374	Lepisosteus oculatus	97.33	0.00e+00	699.00
IUUC-Laf-054192	Loxodonta africana	97.07	0.00e+00	693.00
IUUC-Mcc-055322	Macaca mulatta	97.33	0.00e+00	697.00
IUUC-Meu-056330	Macropus eugenii	91.44	0.00e+00	649.00
IUUC-Mtr-058012	Medicago truncatula	30.59	8.00e-41	161.00
IUUC-Mga-059579	Meleagris gallopavo	93.11	0.00e+00	685.00
IUUC-Mmr-061309	Microcebus murinus	97.33	0.00e+00	697.00
IUUC-Mmu-064227	Mus musculus	97.33	0.00e+00	697.00
IUUC-Mac-064772	Musa acuminata	31.92	3.00e-41	162.00
IUUC-Mpu-065693	Mustela putorius furo	97.33	0.00e+00	697.00
IUUC-Mlu-067827	Myotis lucifugus	96.80	0.00e+00	691.00
IUUC-Nle-069393	Nomascus leucogenys	97.33	0.00e+00	697.00
IUUC-Opr-070490	Ochotona princeps	95.45	0.00e+00	682.00
IUUC-Ont-071726	Oreochromis niloticus	97.59	0.00e+00	699.00
IUUC-Ocu-074932	Oryctolagus cuniculus	97.33	0.00e+00	697.00
IUUC-Obr-076031	Oryza brachyantha	28.38	3.00e-31	129.00
IUUC-Olo-080833	Oryza longistaminata	33.14	3.00e-38	152.00
IUUC-Ome-081184	Oryza meridionalis	32.63	1.00e-38	154.00
IUUC-Opu-083303	Oryza punctata	32.51	4.00e-28	120.00
IUUC-Oru-084614	Oryza rufipogon	32.54	3.00e-35	142.00
IUUC-Ola-086989	Oryzias latipes	97.33	0.00e+00	695.00
IUUC-Olu-087691	Ostreococcus lucimarinus	32.01	1.00e-34	140.00
IUUC-Oga-089107	Otolemur garnettii	97.33	0.00e+00	697.00
IUUC-Oar-089943	Ovis aries	97.07	0.00e+00	693.00
IUUC-Ptr-091201	Pan troglodytes	97.33	0.00e+00	697.00
IUUC-Pan-092504	Papio anubis	97.33	0.00e+00	697.00
IUUC-Psi-093063	Pelodiscus sinensis	97.59	0.00e+00	699.00
IUUC-Ppa-095322	Physcomitrella patens	31.03	9.00e-40	157.00
IUUC-Pfo-096411	Poecilia formosa	97.59	0.00e+00	699.00
IUUC-Pab-098640	Pongo abelii	97.33	0.00e+00	697.00
IUUC-Pca-100243	Procavia capensis	81.76	2.00e-126	445.00
IUUC-Pva-102296	Pteropus vampyrus	90.37	0.00e+00	630.00
IUUC-Rno-105399	Rattus norvegicus	97.33	0.00e+00	697.00
IUUC-Sha-106700	Sarcophilus harrisii	97.86	0.00e+00	700.00
IUUC-Spo-108262	Schizosaccharomyces pombe	36.84	1.10e-01	32.30
IUUC-Ssl-108548	Sclerotinia sclerotiorum	28.77	1.00e-06	47.40
IUUC-Smo-108684	Selaginella moellendorffii	30.74	3.00e-29	122.00
IUUC-Sit-109872	Setaria italica	33.13	8.00e-41	160.00
IUUC-Sly-110931	Solanum lycopersicum	30.42	5.00e-42	165.00
IUUC-Stu-112216	Solanum tuberosum	30.99	9.00e-42	164.00
IUUC-Sar-113489	Sorex araneus	97.33	0.00e+00	697.00
IUUC-Sbi-114217	Sorghum bicolor	33.60	7.00e-46	177.00
IUUC-Tru-117832	Takifugu rubripes	96.79	0.00e+00	693.00
IUUC-Tsy-118969	Tarsius syrichta	92.25	0.00e+00	653.00
IUUC-Tni-120221	Tetraodon nigroviridis	96.79	0.00e+00	693.00
IUUC-Tca-121715	Theobroma cacao	30.15	1.00e-42	167.00
IUUC-Tvi-122498	Trichoderma virens	33.00	2.00e-10	59.30
IUUC-Tbe-127298	Tupaia belangeri	97.06	0.00e+00	685.00
IUUC-Ttr-128952	Tursiops truncatus	97.06	0.00e+00	696.00
IUUC-Vpa-130735	Vicugna pacos	91.44	1.00e-180	625.00
IUUC-Vvi-131357	Vitis vinifera	30.42	4.00e-40	159.00
IUUC-Xtr-132806	Xenopus tropicalis	96.01	0.00e+00	686.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence