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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046334
Ensembl Protein ID ENSP00000331487.5
UniProt Accession Q8TAT6; Q8N3J1; Q9H8V2; Q9H964; Q9NWR5; Q9P229; NPL4_HUMAN
Genbank Protein ID BAA96023.1; BAA91314.1; BAB14372.1; BAB14499.1; AAH25930.1; CAD38971.1
Protein Name Nuclear protein localization protein 4 homolog
Genbank Nucleotide ID AB040932; AK000664; AK023046; AK023272; BC025930; AL834300
Gene Name NPLOC4; KIAA1499; NPL4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000182446.13 ENST00000331134.10 ENSP00000331487.5
ENSG00000182446.13 ENST00000573519.5 ENSP00000459457.1
ENSG00000182446.13 ENST00000571714.5 ENSP00000460465.1
ENSG00000182446.13 ENST00000572824.1 ENSP00000458384.1
ENSG00000182446.13 ENST00000573212.5 ENSP00000459462.1
ENSG00000182446.13 ENST00000374747.9 ENSP00000363879.5
ENSG00000182446.13 ENST00000574897.5 ENSP00000461543.1
ENSG00000182446.13 ENST00000570324.1 ENSP00000461478.1
ENSG00000182446.13 ENST00000625705.1 ENSP00000486640.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/NZF NZF 18586029; 24019527
Classification
Family E-value Score Start End
UBD/ZnF/NZF 3.50e-12 47.3 581 608
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +a+WaC++CTf+N+P +++CemCs pR+
   Q: 581  AAMWACQHCTFMNQPGTGHCEMCSLPRT 608
           689***********************95 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1L, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
 The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1L, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
Protein Sequence
(Fasta)
MAESIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR NKTGEITASS 60
NKSLNLLKIK HGDLLFLFPS SLAGPSSEME TSVPPGFKVF GAPNVVEDEI DQYLSKQDGK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046334|UBD,NZF|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATGGGGGACG CGGAGCGAGC GAAGTGAGCG AGCTGGGTAG GTCCTGCGGC GAAGTCACCC 60
GAAGCCCGAG CGAAATCAGG CGGCGGCGGC GGCGCAGGCC GCGCTTTTTA GCCGGGCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046334|UBD,NZF|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR024682--Npl4_Ub-like_dom
IPR007716--NPL4_Zn-bd_put
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF05021--NPL4
PF11543--UN_NPL4
PF05020--zf-NPL4
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0042175--C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036501--C:UFD1-NPL4 complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0070987--P:error-free translesion synthesis
GO:0007030--P:Golgi organization
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:55666
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000460 Aegilops tauschii 28.41 3.00e-15 76.60
IUUC-Aml-002268 Ailuropoda melanoleuca 96.85 0.00e+00 1206.00
IUUC-Atr-002939 Amborella trichopoda 29.15 3.00e-19 89.40
IUUC-Apl-003496 Anas platyrhynchos 89.02 0.00e+00 1082.00
IUUC-Aca-005230 Anolis carolinensis 90.64 0.00e+00 1162.00
IUUC-Aly-006056 Arabidopsis lyrata 30.12 7.00e-23 101.00
IUUC-Ath-006993 Arabidopsis thaliana 27.86 4.00e-21 95.90
IUUC-Ago-007954 Ashbya gossypii 36.24 4.00e-79 288.00
IUUC-Acl-008208 Aspergillus clavatus 33.81 4.00e-91 329.00
IUUC-Afl-008574 Aspergillus flavus 35.86 4.00e-89 322.00
IUUC-Afu-008825 Aspergillus fumigatus 34.70 9.00e-97 347.00
IUUC-Ani-009495 Aspergillus nidulans 39.28 8.00e-93 334.00
IUUC-Ang-009762 Aspergillus niger 33.55 4.00e-88 319.00
IUUC-Aor-010199 Aspergillus oryzae 35.32 4.00e-87 315.00
IUUC-Ate-010592 Aspergillus terreus 37.57 5.00e-92 332.00
IUUC-Ame-011587 Astyanax mexicanus 72.58 5.00e-104 371.00
IUUC-Bgr-012124 Blumeria graminis 32.52 1.00e-87 317.00
IUUC-Bta-013312 Bos taurus 97.20 0.00e+00 1245.00
IUUC-Bci-013648 Botrytis cinerea 32.85 6.00e-95 342.00
IUUC-Bdi-014326 Brachypodium distachyon 29.09 5.00e-16 79.00
IUUC-Bol-016294 Brassica oleracea 29.03 4.00e-21 95.90
IUUC-Bra-017023 Brassica rapa 28.74 5.00e-21 95.50
IUUC-Cel-018713 Caenorhabditis elegans 43.44 2.00e-130 459.00
IUUC-Cja-018869 Callithrix jacchus 99.01 0.00e+00 1235.00
IUUC-Cfa-020757 Canis familiaris 97.85 0.00e+00 1226.00
IUUC-Cpo-022390 Cavia porcellus 97.35 0.00e+00 1204.00
IUUC-Csa-023366 Chlorocebus sabaeus 99.67 0.00e+00 1271.00
IUUC-Cho-024455 Choloepus hoffmanni 79.10 0.00e+00 840.00
IUUC-Cin-025638 Ciona intestinalis 48.56 1.00e-145 509.00
IUUC-Csv-026310 Ciona savignyi 45.57 3.00e-133 468.00
IUUC-Cgl-026685 Colletotrichum gloeosporioides 33.55 6.00e-90 325.00
IUUC-Cne-026794 Cryptococcus neoformans 29.12 2.00e-72 267.00
IUUC-Cme-027248 Cyanidioschyzon merolae 27.22 3.00e-16 80.10
IUUC-Dre-027689 Danio rerio 81.18 0.00e+00 1055.00
IUUC-Dno-030004 Dasypus novemcinctus 96.22 0.00e+00 1217.00
IUUC-Dor-030585 Dipodomys ordii 96.10 0.00e+00 978.00
IUUC-Dse-031202 Dothistroma septosporum 33.44 4.00e-89 322.00
IUUC-Dme-032092 Drosophila melanogaster 47.78 4.00e-175 608.00
IUUC-Ete-033009 Echinops telfairi 96.53 3.00e-99 355.00
IUUC-Eca-034001 Equus caballus 97.53 0.00e+00 1255.00
IUUC-Eeu-034485 Erinaceus europaeus 80.95 0.00e+00 832.00
IUUC-Fca-036128 Felis catus 97.04 0.00e+00 1189.00
IUUC-Fal-037523 Ficedula albicollis 90.97 0.00e+00 1171.00
IUUC-Fox-037802 Fusarium oxysporum 34.00 7.00e-95 341.00
IUUC-Fso-038152 Fusarium solani 33.72 2.00e-94 339.00
IUUC-Gmo-038486 Gadus morhua 75.00 0.00e+00 958.00
IUUC-Ggr-039916 Gaeumannomyces graminis 37.03 5.00e-85 308.00
IUUC-Gga-041208 Gallus gallus 92.28 0.00e+00 1191.00
IUUC-Gac-042304 Gasterosteus aculeatus 78.01 0.00e+00 985.00
IUUC-Gma-044178 Glycine max 27.27 5.00e-16 79.00
IUUC-Ggo-045236 Gorilla gorilla 96.19 0.00e+00 1205.00
IUUC-Hvu-047323 Hordeum vulgare 26.24 1.00e-08 53.10
IUUC-Itr-047878 Ictidomys tridecemlineatus 97.56 0.00e+00 726.00
IUUC-Lch-050302 Latimeria chalumnae 82.95 0.00e+00 1062.00
IUUC-Lpe-051362 Leersia perrieri 29.30 4.00e-18 85.90
IUUC-Loc-052548 Lepisosteus oculatus 82.85 0.00e+00 1037.00
IUUC-Lma-053092 Leptosphaeria maculans 33.77 1.00e-95 344.00
IUUC-Laf-053911 Loxodonta africana 96.72 0.00e+00 1235.00
IUUC-Mcc-055830 Macaca mulatta 99.17 0.00e+00 1244.00
IUUC-Meu-056460 Macropus eugenii 57.89 8.00e-149 520.00
IUUC-Mor-057189 Magnaporthe oryzae 36.95 1.00e-87 317.00
IUUC-Mpo-057366 Magnaporthe poae 37.76 2.00e-85 309.00
IUUC-Mtr-057834 Medicago truncatula 27.06 1.00e-17 84.00
IUUC-Mla-059190 Melampsora laricipopulina 32.33 6.00e-85 308.00
IUUC-Mga-060036 Meleagris gallopavo 92.05 0.00e+00 1179.00
IUUC-Mvi-060275 Microbotryum violaceum 29.85 7.00e-80 291.00
IUUC-Mmr-061300 Microcebus murinus 98.18 0.00e+00 1242.00
IUUC-Mdo-062911 Monodelphis domestica 96.36 0.00e+00 1058.00
IUUC-Mmu-063916 Mus musculus 97.37 0.00e+00 1221.00
IUUC-Mac-065601 Musa acuminata 27.16 7.00e-12 65.10
IUUC-Mpu-065912 Mustela putorius furo 96.20 0.00e+00 1207.00
IUUC-Mlu-067965 Myotis lucifugus 94.90 0.00e+00 1190.00
IUUC-Nfi-068465 Neosartorya fischeri 34.70 5.00e-97 348.00
IUUC-Ncr-068936 Neurospora crassa 32.79 5.00e-91 328.00
IUUC-Nle-069570 Nomascus leucogenys 99.18 0.00e+00 1263.00
IUUC-Opr-071097 Ochotona princeps 92.20 0.00e+00 922.00
IUUC-Ont-071430 Oreochromis niloticus 79.87 0.00e+00 1031.00
IUUC-Oan-073709 Ornithorhynchus anatinus 82.62 0.00e+00 798.00
IUUC-Ocu-074875 Oryctolagus cuniculus 91.56 0.00e+00 1144.00
IUUC-Oba-075214 Oryza barthii 28.06 4.00e-18 85.90
IUUC-Obr-076758 Oryza brachyantha 29.15 8.00e-18 84.30
IUUC-Ogl-077665 Oryza glaberrima 28.06 4.00e-18 85.90
IUUC-Ogu-078899 Oryza glumaepatula 28.06 4.00e-18 85.90
IUUC-Oin-079167 Oryza indica 28.06 4.00e-18 85.90
IUUC-Olo-080451 Oryza longistaminata 28.57 4.00e-18 85.50
IUUC-Ome-081836 Oryza meridionalis 28.06 5.00e-18 85.50
IUUC-Oni-083019 Oryza nivara 28.06 4.00e-18 85.90
IUUC-Opu-083122 Oryza punctata 28.62 2.00e-18 86.70
IUUC-Oru-084900 Oryza rufipogon 28.06 4.00e-18 85.90
IUUC-Osa-086054 Oryza sativa 28.06 4.00e-18 85.90
IUUC-Ola-087077 Oryzias latipes 69.27 0.00e+00 867.00
IUUC-Olu-087601 Ostreococcus lucimarinus 26.27 6.00e-06 45.40
IUUC-Oga-088049 Otolemur garnettii 83.83 0.00e+00 1042.00
IUUC-Oar-089678 Ovis aries 96.86 0.00e+00 1239.00
IUUC-Ptr-091380 Pan troglodytes 98.58 0.00e+00 1154.00
IUUC-Pan-092821 Papio anubis 98.51 0.00e+00 1247.00
IUUC-Psi-093074 Pelodiscus sinensis 92.11 0.00e+00 1177.00
IUUC-Pma-094102 Petromyzon marinus 69.03 0.00e+00 899.00
IUUC-Pno-094987 Phaeosphaeria nodorum 34.43 9.00e-94 338.00
IUUC-Ppa-095368 Physcomitrella patens 27.93 4.00e-18 85.50
IUUC-Pfo-097245 Poecilia formosa 80.85 0.00e+00 1008.00
IUUC-Pab-098763 Pongo abelii 99.50 0.00e+00 1260.00
IUUC-Pop-099355 Populus trichocarpa 30.77 6.00e-15 74.70
IUUC-Ppe-101990 Prunus persica 28.48 2.00e-18 86.70
IUUC-Pva-102308 Pteropus vampyrus 88.76 0.00e+00 966.00
IUUC-Pgr-103553 Puccinia graminis 32.53 4.00e-81 295.00
IUUC-Pte-104100 Pyrenophora teres 32.40 1.00e-89 324.00
IUUC-Pyt-104482 Pyrenophora triticirepentis 34.05 3.00e-91 329.00
IUUC-Rno-105582 Rattus norvegicus 96.88 0.00e+00 1215.00
IUUC-Sce-106145 Saccharomyces cerevisiae 34.24 2.00e-90 326.00
IUUC-Sha-106647 Sarcophilus harrisii 95.25 0.00e+00 1190.00
IUUC-Sja-107972 Schizosaccharomyces japonicus 35.90 1.00e-85 311.00
IUUC-Spo-108281 Schizosaccharomyces pombe 34.78 3.00e-92 332.00
IUUC-Ssl-108617 Sclerotinia sclerotiorum 33.96 3.00e-91 329.00
IUUC-Smo-108933 Selaginella moellendorffii 30.40 4.00e-19 89.40
IUUC-Sit-110083 Setaria italica 27.86 1.00e-16 80.90
IUUC-Sly-111645 Solanum lycopersicum 26.80 1.00e-16 81.30
IUUC-Stu-112422 Solanum tuberosum 26.80 6.00e-17 82.00
IUUC-Sbi-113987 Sorghum bicolor 29.30 2.00e-17 83.60
IUUC-Sre-115095 Sporisorium reilianum 37.80 2.00e-80 293.00
IUUC-Ssc-116141 Sus scrofa 95.36 0.00e+00 1095.00
IUUC-Tgu-117492 Taeniopygia guttata 91.09 0.00e+00 864.00
IUUC-Tru-118463 Takifugu rubripes 78.12 0.00e+00 983.00
IUUC-Tsy-118993 Tarsius syrichta 89.27 0.00e+00 1010.00
IUUC-Tni-119896 Tetraodon nigroviridis 80.13 0.00e+00 989.00
IUUC-Tca-121169 Theobroma cacao 28.43 5.00e-20 92.40
IUUC-Tre-122046 Trichoderma reesei 32.84 1.00e-90 327.00
IUUC-Tvi-122415 Trichoderma virens 33.39 8.00e-92 331.00
IUUC-Tae-125503 Triticum aestivum 28.41 2.00e-15 77.00
IUUC-Tme-127123 Tuber melanosporum 35.96 2.00e-102 367.00
IUUC-Tbe-127629 Tupaia belangeri 92.08 2.00e-158 552.00
IUUC-Ttr-128476 Tursiops truncatus 86.59 0.00e+00 972.00
IUUC-Uma-129492 Ustilago maydis 34.83 2.00e-83 303.00
IUUC-Vda-129702 Verticillium dahliae 33.22 5.00e-89 322.00
IUUC-Vvi-131090 Vitis vinifera 30.41 3.00e-14 72.80
IUUC-Xtr-131786 Xenopus tropicalis 85.57 0.00e+00 1080.00
IUUC-Xma-133997 Xiphophorus maculatus 78.16 0.00e+00 1002.00
IUUC-Yli-134537 Yarrowia lipolytica 35.11 8.00e-89 321.00
IUUC-Zma-134847 Zea mays 30.07 2.00e-18 87.00
Created Date 25-Jun-2017

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