iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040854

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase CHIP; RING-type E3 ubiquitin transferase CHIP

Genbank Nucleotide ID

AJ720999

Gene Name

STUB1; RCJMB04_32b21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000041432.1	ENSGALT00000081376.1	ENSGALP00000057641.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.40e-26	92.7	237	310

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p+++++ Is+elMr+P+++psGitydr+ Ie++l++ g+ +Pvtr+plt+++l+Pnl+++++i+a+++en++
   Q: 237  DIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQDQLIPNLAMKEVIDAFISENGW 310
           69********************************************************************9986 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation.

Protein Sequence
(Fasta)

MKGKEERERE GGGGAVGPGA AGPGAGGGSP EKSHSAQEHK EQGNRLFGGR KYPEAAAAYG 60
RAINRNPLVA VYYTNRALCY LKMQQHDKAL ADCKRALELD GQSVKAHFFL GQCQMEMENY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGAGGGGC GGTGCGGCGC TGTCGCAGTG CGCGGCCGGA GGCAGCTGAG CCGCCGGCCC 60
CGAGCGGCCG GGTCGGGCCG GGCCATGAAG GGGAAGGAGG AACGGGAGCG GGAGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:0042803--F:protein homodimerization activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071218--P:cellular response to misfolded protein
GO:0006281--P:DNA repair
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0032091--P:negative regulation of protein binding
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

gga:426918

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	36.54	6.00e-40	157.00
IUUC-Aml-001350	Ailuropoda melanoleuca	89.24	9.00e-133	465.00
IUUC-Atr-003168	Amborella trichopoda	35.68	6.00e-31	127.00
IUUC-Apl-003736	Anas platyrhynchos	98.01	2.00e-148	517.00
IUUC-Aca-004751	Anolis carolinensis	94.18	3.00e-154	537.00
IUUC-Aly-006292	Arabidopsis lyrata	33.10	1.00e-42	166.00
IUUC-Ath-007012	Arabidopsis thaliana	32.86	1.00e-42	166.00
IUUC-Acl-008025	Aspergillus clavatus	30.14	6.00e-35	140.00
IUUC-Afl-008721	Aspergillus flavus	30.31	4.00e-32	131.00
IUUC-Afu-008853	Aspergillus fumigatus	30.14	3.00e-34	138.00
IUUC-Ani-009349	Aspergillus nidulans	30.10	2.00e-31	129.00
IUUC-Ang-009674	Aspergillus niger	31.94	7.00e-32	130.00
IUUC-Aor-010014	Aspergillus oryzae	29.01	2.00e-27	115.00
IUUC-Ate-010467	Aspergillus terreus	28.77	9.00e-27	113.00
IUUC-Ame-011215	Astyanax mexicanus	61.99	4.00e-95	340.00
IUUC-Bgr-011971	Blumeria graminis	27.92	2.00e-25	109.00
IUUC-Bta-013025	Bos taurus	89.08	4.00e-149	520.00
IUUC-Bci-013945	Botrytis cinerea	39.51	4.00e-15	75.10
IUUC-Bdi-014483	Brachypodium distachyon	38.69	1.00e-45	176.00
IUUC-Bol-015676	Brassica oleracea	32.39	1.00e-44	173.00
IUUC-Bra-017897	Brassica rapa	29.19	4.00e-28	117.00
IUUC-Cel-018323	Caenorhabditis elegans	41.73	2.00e-56	211.00
IUUC-Cja-019657	Callithrix jacchus	87.76	5.00e-149	520.00
IUUC-Cfa-020470	Canis familiaris	88.79	3.00e-121	427.00
IUUC-Cpo-022033	Cavia porcellus	88.11	1.00e-148	518.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	25.78	2.00e-25	108.00
IUUC-Csa-023038	Chlorocebus sabaeus	88.11	9.00e-143	498.00
IUUC-Cin-025381	Ciona intestinalis	53.90	5.00e-89	320.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.37	7.00e-39	153.00
IUUC-Dre-027610	Danio rerio	82.17	9.00e-140	488.00
IUUC-Dno-030087	Dasypus novemcinctus	88.81	1.00e-150	525.00
IUUC-Dor-031029	Dipodomys ordii	82.87	7.00e-135	473.00
IUUC-Dse-031275	Dothistroma septosporum	32.44	1.00e-26	113.00
IUUC-Dme-031856	Drosophila melanogaster	57.82	5.00e-92	330.00
IUUC-Ete-033087	Echinops telfairi	84.27	3.00e-123	434.00
IUUC-Eca-033512	Equus caballus	88.84	2.00e-132	464.00
IUUC-Eeu-034763	Erinaceus europaeus	84.32	3.00e-89	320.00
IUUC-Fca-036460	Felis catus	89.13	5.00e-146	509.00
IUUC-Fal-037441	Ficedula albicollis	97.55	2.00e-168	584.00
IUUC-Fox-038028	Fusarium oxysporum	31.51	8.00e-38	150.00
IUUC-Fso-038323	Fusarium solani	32.26	1.00e-29	122.00
IUUC-Gmo-038511	Gadus morhua	79.37	6.00e-134	469.00
IUUC-Ggr-039964	Gaeumannomyces graminis	32.64	7.00e-28	117.00
IUUC-Gac-042175	Gasterosteus aculeatus	79.72	2.00e-131	461.00
IUUC-Gma-044046	Glycine max	34.66	2.00e-42	165.00
IUUC-Ggo-044512	Gorilla gorilla	88.11	9.00e-143	498.00
IUUC-Hsa-046872	Homo sapiens	88.11	9.00e-143	498.00
IUUC-Hvu-047372	Hordeum vulgare	35.90	3.00e-42	164.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	87.06	2.00e-147	514.00
IUUC-Lch-049988	Latimeria chalumnae	86.71	2.00e-138	484.00
IUUC-Lpe-050693	Leersia perrieri	35.53	5.00e-43	167.00
IUUC-Loc-052195	Lepisosteus oculatus	83.53	3.00e-123	434.00
IUUC-Lma-053207	Leptosphaeria maculans	28.34	8.00e-28	119.00
IUUC-Laf-054584	Loxodonta africana	87.76	1.00e-149	521.00
IUUC-Mcc-054689	Macaca mulatta	88.11	9.00e-143	498.00
IUUC-Meu-055998	Macropus eugenii	89.68	6.00e-80	290.00
IUUC-Mor-057116	Magnaporthe oryzae	34.75	4.00e-39	154.00
IUUC-Mtr-057684	Medicago truncatula	31.37	2.00e-38	152.00
IUUC-Mga-059332	Meleagris gallopavo	100.00	1.00e-150	524.00
IUUC-Mmr-061377	Microcebus murinus	88.46	1.00e-142	498.00
IUUC-Mdo-061963	Monodelphis domestica	90.56	1.00e-147	514.00
IUUC-Mmu-063146	Mus musculus	87.41	6.00e-141	493.00
IUUC-Mac-064932	Musa acuminata	33.82	2.00e-28	118.00
IUUC-Mpu-066418	Mustela putorius furo	89.16	8.00e-151	525.00
IUUC-Mlu-067066	Myotis lucifugus	88.81	2.00e-150	524.00
IUUC-Nfi-068601	Neosartorya fischeri	30.14	5.00e-34	137.00
IUUC-Ncr-068761	Neurospora crassa	41.67	4.00e-17	81.30
IUUC-Nle-069374	Nomascus leucogenys	88.11	9.00e-143	498.00
IUUC-Opr-070765	Ochotona princeps	83.70	5.00e-90	322.00
IUUC-Ont-071996	Oreochromis niloticus	83.57	5.00e-134	469.00
IUUC-Oba-075967	Oryza barthii	35.40	2.00e-43	168.00
IUUC-Obr-076440	Oryza brachyantha	35.75	5.00e-32	133.00
IUUC-Ogl-076959	Oryza glaberrima	36.10	7.00e-44	170.00
IUUC-Ogu-078247	Oryza glumaepatula	37.77	1.00e-41	163.00
IUUC-Oin-079616	Oryza indica	36.10	7.00e-44	170.00
IUUC-Olo-080492	Oryza longistaminata	35.41	1.00e-29	125.00
IUUC-Ome-081935	Oryza meridionalis	31.47	2.00e-21	98.60
IUUC-Oni-082535	Oryza nivara	37.77	1.00e-41	163.00
IUUC-Opu-083794	Oryza punctata	36.13	5.00e-43	167.00
IUUC-Oru-085153	Oryza rufipogon	35.40	3.00e-43	168.00
IUUC-Osa-085303	Oryza sativa	26.74	1.00e-17	84.00
IUUC-Ola-087081	Oryzias latipes	81.12	1.00e-137	482.00
IUUC-Olu-087790	Ostreococcus lucimarinus	30.07	9.00e-29	120.00
IUUC-Oga-088331	Otolemur garnettii	87.76	3.00e-142	497.00
IUUC-Oar-089987	Ovis aries	86.77	7.00e-129	452.00
IUUC-Ptr-090855	Pan troglodytes	88.11	9.00e-143	498.00
IUUC-Pan-092801	Papio anubis	84.62	9.00e-143	499.00
IUUC-Psi-093393	Pelodiscus sinensis	94.82	4.00e-144	503.00
IUUC-Pma-094680	Petromyzon marinus	69.75	5.00e-113	400.00
IUUC-Pno-094913	Phaeosphaeria nodorum	31.49	2.00e-34	139.00
IUUC-Ppa-095508	Physcomitrella patens	34.69	3.00e-46	178.00
IUUC-Pfo-096850	Poecilia formosa	81.47	1.00e-130	459.00
IUUC-Pab-097963	Pongo abelii	88.11	9.00e-143	498.00
IUUC-Pop-098805	Populus trichocarpa	43.88	3.00e-25	107.00
IUUC-Pca-100788	Procavia capensis	88.11	2.00e-150	524.00
IUUC-Ppe-101221	Prunus persica	34.64	4.00e-44	171.00
IUUC-Pva-103076	Pteropus vampyrus	88.46	3.00e-149	520.00
IUUC-Pte-104237	Pyrenophora teres	30.42	1.00e-33	136.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	30.42	1.00e-33	136.00
IUUC-Rno-105204	Rattus norvegicus	87.06	2.00e-140	491.00
IUUC-Sha-106579	Sarcophilus harrisii	89.84	4.00e-130	456.00
IUUC-Smo-109525	Selaginella moellendorffii	34.67	2.00e-42	165.00
IUUC-Sit-110665	Setaria italica	35.00	2.00e-43	169.00
IUUC-Sly-111473	Solanum lycopersicum	35.82	2.00e-44	172.00
IUUC-Stu-112353	Solanum tuberosum	35.36	1.00e-43	169.00
IUUC-Sbi-114250	Sorghum bicolor	37.36	2.00e-45	175.00
IUUC-Ssc-115416	Sus scrofa	88.81	4.00e-150	523.00
IUUC-Tgu-117272	Taeniopygia guttata	96.30	7.00e-59	217.00
IUUC-Tru-117777	Takifugu rubripes	82.17	2.00e-132	464.00
IUUC-Tni-120572	Tetraodon nigroviridis	82.52	2.00e-132	464.00
IUUC-Tca-121149	Theobroma cacao	36.82	3.00e-48	184.00
IUUC-Tre-122230	Trichoderma reesei	32.61	4.00e-32	131.00
IUUC-Tvi-122678	Trichoderma virens	33.94	3.00e-39	154.00
IUUC-Tae-124860	Triticum aestivum	35.77	7.00e-43	167.00
IUUC-Tur-126009	Triticum urartu	35.06	4.00e-39	154.00
IUUC-Tme-126948	Tuber melanosporum	35.36	1.00e-40	159.00
IUUC-Ttr-129031	Tursiops truncatus	88.77	1.00e-149	521.00
IUUC-Vda-130023	Verticillium dahliae	32.50	7.00e-38	150.00
IUUC-Vvi-131091	Vitis vinifera	42.62	5.00e-26	109.00
IUUC-Xtr-132871	Xenopus tropicalis	85.71	2.00e-132	464.00
IUUC-Xma-134220	Xiphophorus maculatus	81.82	5.00e-131	459.00
IUUC-Yli-134462	Yarrowia lipolytica	28.47	5.00e-27	114.00
IUUC-Zma-135007	Zea mays	37.00	1.00e-44	172.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence