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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063946
Ensembl Protein ID ENSMUSP00000088676.3
UniProt Accession Q9D2P4; A3KGW2; Q8BHY9; URM1_MOUSE
Genbank Protein ID BAB31673.1; BAC33621.1; BAC33956.1; CAM46216.1; EDL08423.1; AAH26994.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID AK019352; AK049227; AK049849; AL928926; CH466542; BC026994
Gene Name Urm1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000069020.9 ENSMUST00000091142.3 ENSMUSP00000088676.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 44.44 1.00e-17 82.40 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPLCVKVE FGGGAELLFD GVKKHQVALP GQEEPWDIRN LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLG ELDYQLQDQD SILFISTLHG G 101
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063946|ULD,UBQ_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GGAGGTCAAC CACTCCATTA TTGACTCTTA ATGGCCACCA AGCACAGAAC AGGTAGGACT 60
TTATCCTCCG CCTGCTGATG AGGAACCAGA GACGAGGAGG AGTAAAGCCT CTCCAAACAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063946|ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG mmu:68205
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 94.06 3.00e-52 196.00
IUUC-Atr-003089 Amborella trichopoda 59.79 3.00e-30 122.00
IUUC-Apl-003382 Anas platyrhynchos 86.81 8.00e-43 164.00
IUUC-Aca-004981 Anolis carolinensis 80.20 7.00e-47 177.00
IUUC-Aly-005517 Arabidopsis lyrata 55.43 2.00e-27 113.00
IUUC-Ath-006718 Arabidopsis thaliana 55.95 4.00e-24 102.00
IUUC-Ago-007917 Ashbya gossypii 43.30 6.00e-20 88.60
IUUC-Acl-008054 Aspergillus clavatus 68.00 3.00e-15 72.80
IUUC-Afl-008704 Aspergillus flavus 55.06 3.00e-20 89.40
IUUC-Aor-009890 Aspergillus oryzae 56.44 1.00e-24 104.00
IUUC-Bta-012448 Bos taurus 94.06 6.00e-52 194.00
IUUC-Bci-013865 Botrytis cinerea 46.08 3.00e-21 93.20
IUUC-Bdi-014980 Brachypodium distachyon 68.75 8.00e-24 101.00
IUUC-Bol-016055 Brassica oleracea 55.00 7.00e-24 101.00
IUUC-Bra-016845 Brassica rapa 55.00 7.00e-24 101.00
IUUC-Cel-018485 Caenorhabditis elegans 34.95 5.00e-12 62.40
IUUC-Cja-019587 Callithrix jacchus 96.04 1.00e-52 197.00
IUUC-Cfa-020653 Canis familiaris 95.05 4.00e-52 195.00
IUUC-Cpo-021622 Cavia porcellus 96.04 1.00e-52 197.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 54.17 1.00e-25 107.00
IUUC-Csa-023756 Chlorocebus sabaeus 94.94 1.00e-39 154.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 47.42 2.00e-20 90.90
IUUC-Cne-026953 Cryptococcus neoformans 57.28 4.00e-28 116.00
IUUC-Cme-027314 Cyanidioschyzon merolae 43.88 8.00e-18 81.30
IUUC-Dre-027884 Danio rerio 76.24 9.00e-44 167.00
IUUC-Dno-029262 Dasypus novemcinctus 91.36 4.00e-38 150.00
IUUC-Dor-030601 Dipodomys ordii 64.36 3.00e-27 112.00
IUUC-Dme-031893 Drosophila melanogaster 62.75 3.00e-32 129.00
IUUC-Ete-032773 Echinops telfairi 90.10 1.00e-47 181.00
IUUC-Eca-034187 Equus caballus 97.03 1.00e-52 197.00
IUUC-Eeu-034808 Erinaceus europaeus 92.08 4.00e-51 192.00
IUUC-Fca-036107 Felis catus 94.06 5.00e-52 194.00
IUUC-Fal-036607 Ficedula albicollis 85.71 3.00e-42 162.00
IUUC-Fox-037698 Fusarium oxysporum 47.12 5.00e-22 95.90
IUUC-Gmo-039492 Gadus morhua 74.26 5.00e-43 165.00
IUUC-Ggr-039965 Gaeumannomyces graminis 50.00 5.00e-21 93.20
IUUC-Gga-041268 Gallus gallus 85.15 7.00e-48 181.00
IUUC-Gac-042111 Gasterosteus aculeatus 79.21 4.00e-46 175.00
IUUC-Gma-043240 Glycine max 52.38 1.00e-22 97.40
IUUC-Ggo-045176 Gorilla gorilla 92.41 8.00e-31 125.00
IUUC-Hsa-046077 Homo sapiens 93.07 9.00e-44 167.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 95.51 7.00e-38 147.00
IUUC-Kpa-049157 Komagataella pastoris 49.49 2.00e-20 90.10
IUUC-Lch-049889 Latimeria chalumnae 76.24 3.00e-44 169.00
IUUC-Lpe-050783 Leersia perrieri 56.63 1.00e-22 97.40
IUUC-Loc-052400 Lepisosteus oculatus 76.24 4.00e-44 168.00
IUUC-Lma-053259 Leptosphaeria maculans 48.48 2.00e-21 93.60
IUUC-Laf-053596 Loxodonta africana 93.20 1.00e-50 190.00
IUUC-Mcc-054845 Macaca mulatta 89.80 1.00e-46 177.00
IUUC-Meu-055968 Macropus eugenii 91.09 2.00e-50 190.00
IUUC-Mor-057126 Magnaporthe oryzae 44.23 2.00e-18 84.30
IUUC-Mpo-057311 Magnaporthe poae 50.50 7.00e-22 95.90
IUUC-Mtr-058266 Medicago truncatula 50.00 3.00e-22 96.30
IUUC-Mla-058847 Melampsora laricipopulina 41.58 1.00e-12 65.10
IUUC-Mga-059468 Meleagris gallopavo 86.81 7.00e-43 164.00
IUUC-Mvi-060235 Microbotryum violaceum 35.76 9.00e-19 85.90
IUUC-Mdo-061948 Monodelphis domestica 90.10 2.00e-50 189.00
IUUC-Mac-064812 Musa acuminata 58.33 1.00e-24 103.00
IUUC-Mpu-066763 Mustela putorius furo 95.05 4.00e-51 192.00
IUUC-Mlu-066970 Myotis lucifugus 96.20 1.00e-39 153.00
IUUC-Ncr-068824 Neurospora crassa 46.46 1.00e-19 87.40
IUUC-Nle-069849 Nomascus leucogenys 93.67 4.00e-39 153.00
IUUC-Opr-070227 Ochotona princeps 96.04 1.00e-52 197.00
IUUC-Ont-072530 Oreochromis niloticus 79.21 1.00e-45 173.00
IUUC-Oan-073191 Ornithorhynchus anatinus 82.47 9.00e-43 164.00
IUUC-Ocu-074460 Oryctolagus cuniculus 94.90 3.00e-50 189.00
IUUC-Oba-075499 Oryza barthii 65.62 3.00e-22 97.80
IUUC-Obr-076896 Oryza brachyantha 56.25 2.00e-21 95.90
IUUC-Ogl-077834 Oryza glaberrima 65.62 8.00e-23 98.20
IUUC-Ogu-078622 Oryza glumaepatula 65.62 8.00e-23 98.20
IUUC-Oin-079358 Oryza indica 65.62 3.00e-22 98.20
IUUC-Olo-081035 Oryza longistaminata 51.49 3.00e-23 100.00
IUUC-Oni-082425 Oryza nivara 65.62 8.00e-23 98.20
IUUC-Opu-083461 Oryza punctata 65.08 5.00e-22 96.70
IUUC-Oru-084875 Oryza rufipogon 59.15 1.00e-20 90.90
IUUC-Oga-089128 Otolemur garnettii 96.04 2.00e-52 196.00
IUUC-Oar-089896 Ovis aries 94.06 6.00e-52 194.00
IUUC-Ptr-091618 Pan troglodytes 92.41 7.00e-31 125.00
IUUC-Pan-092238 Papio anubis 94.94 1.00e-39 154.00
IUUC-Psi-093879 Pelodiscus sinensis 83.17 8.00e-47 177.00
IUUC-Pma-094484 Petromyzon marinus 79.21 3.00e-35 139.00
IUUC-Ppa-095801 Physcomitrella patens 55.56 4.00e-22 95.50
IUUC-Pfo-097192 Poecilia formosa 80.20 9.00e-46 174.00
IUUC-Pab-098203 Pongo abelii 93.07 1.00e-43 167.00
IUUC-Pop-099614 Populus trichocarpa 55.95 1.00e-23 100.00
IUUC-Pca-100507 Procavia capensis 94.94 2.00e-39 153.00
IUUC-Ppe-101174 Prunus persica 55.67 4.00e-28 115.00
IUUC-Pva-102735 Pteropus vampyrus 94.06 1.00e-48 184.00
IUUC-Pgr-103510 Puccinia graminis 40.59 2.00e-12 63.90
IUUC-Ptt-103918 Puccinia triticina 36.63 1.00e-10 58.20
IUUC-Pte-104173 Pyrenophora teres 48.54 4.00e-23 99.40
IUUC-Pyt-104806 Pyrenophora triticirepentis 48.54 5.00e-23 99.00
IUUC-Rno-105820 Rattus norvegicus 97.03 3.00e-53 199.00
IUUC-Sce-106366 Saccharomyces cerevisiae 44.44 4.00e-18 82.40
IUUC-Sja-107727 Schizosaccharomyces japonicus 39.58 5.00e-16 76.30
IUUC-Spo-108074 Schizosaccharomyces pombe 39.80 8.00e-10 54.70
IUUC-Smo-108944 Selaginella moellendorffii 60.67 2.00e-26 109.00
IUUC-Sit-110277 Setaria italica 55.95 2.00e-23 100.00
IUUC-Sly-111505 Solanum lycopersicum 53.57 3.00e-24 103.00
IUUC-Stu-112076 Solanum tuberosum 54.76 9.00e-25 104.00
IUUC-Sbi-114274 Sorghum bicolor 56.10 3.00e-23 99.80
IUUC-Sre-114953 Sporisorium reilianum 59.00 5.00e-27 112.00
IUUC-Ssc-115418 Sus scrofa 95.05 4.00e-52 195.00
IUUC-Tgu-117311 Taeniopygia guttata 85.71 4.00e-42 162.00
IUUC-Tru-118598 Takifugu rubripes 80.90 4.00e-40 155.00
IUUC-Tni-120109 Tetraodon nigroviridis 76.47 2.00e-42 163.00
IUUC-Tca-120942 Theobroma cacao 54.22 6.00e-23 98.60
IUUC-Tre-122099 Trichoderma reesei 48.94 6.00e-16 75.10
IUUC-Tvi-122285 Trichoderma virens 50.96 1.00e-19 87.80
IUUC-Tae-125193 Triticum aestivum 56.63 6.00e-23 98.60
IUUC-Tur-126677 Triticum urartu 49.47 2.00e-20 90.50
IUUC-Tme-127120 Tuber melanosporum 48.08 1.00e-23 101.00
IUUC-Tbe-128050 Tupaia belangeri 68.32 2.00e-32 130.00
IUUC-Ttr-129019 Tursiops truncatus 94.06 2.00e-49 186.00
IUUC-Uma-129483 Ustilago maydis 57.00 2.00e-25 106.00
IUUC-Vda-129690 Verticillium dahliae 41.96 1.00e-16 77.80
IUUC-Vvi-131174 Vitis vinifera 57.83 3.00e-24 102.00
IUUC-Xma-133862 Xiphophorus maculatus 80.20 9.00e-46 174.00
IUUC-Yli-134398 Yarrowia lipolytica 47.47 2.00e-19 86.70
IUUC-Zma-134964 Zea mays 64.06 5.00e-22 95.50
Created Date 25-Jun-2017

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