iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001355

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01107514

Gene Name

UBE3C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000001353.1	ENSAMET00000001526.1	ENSAMEP00000001469.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-104	348.5	747	1084

Active Site

Position(s)	Description	Evidence
1052	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqd 84
            dlkkr++v++++     E+g+d gG++refl++l+k  +np+ g+f++++++    +p+ ++ +      +++ flGr+lgkal++
   Q: 747  PDLKKRIRVHLLNahgldEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPSPAAQMLVGG-SFARHYFFLGRMLGKALYE 832
           689**********99**9*********************************************9976.8888888************ PP
   S: 85   grlldlplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneN 169
           + l++lp++ +f+++llg+  ++++++l+++dpe+yk+l ++k++ e d+eelgl++t+   ++ lge++++eLk gG++ipVt +N
   Q: 833  NMLVELPFAGFFLSKLLGTsaDVDIHHLASLDPEVYKNLLFLKSY-EGDVEELGLNFTVV--NNDLGEAQVVELKFGGKDIPVTSAN 916
           ******************9666889******************99.78999987777765..888********************** PP
   S: 170  keeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevlee 255
           + +Y++lv++yrl+++i++++ afr+G+ +v++le+l++F+++e+++li+G    i++edlk++t+y ggy++d+p+i+ Fw+v+e+
   Q: 917  RIAYIHLVADYRLNRQIRQHCLAFRQGLANVLDLEWLRMFDQQEIQVLISGAqVPISLEDLKSFTNYSGGYSADHPVIRVFWRVVEG 1003
           ****************************************************899******************************** PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           f++ee++++L+FvT++sr Pl Gf+el p  f+i++ +sd +rlP+++TC+n+LkLPe+  ++ l++kLlyAie ++gFels
   Q: 1004 FTDEEKRKLLKFVTSCSRPPLLGFKELYPA-FCIHNGGSDlERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFELS 1084
           ****************************88.*****99999**************************************985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

VFLFYLKCLS FPFITLVPST YQEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR 60
DRKQQHAIQR SAFDRCAGAS QSGGTFSIAS GPNLTLLVRQ LLFFYKQNED SKRLIWMYQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATTTTTAT TTTATTTGAA ATGTTTAAGT TTCCCATTTA TTACTTTGGT TCCTTCTACA 60
TACCAAGTAA GTTTGTTCAA AATTTAGTTT TATGATGAAA AGAGAATTTT AAAAAATTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003731	Anas platyrhynchos	88.55	0.00e+00	1878.00
IUUC-Aca-005248	Anolis carolinensis	87.14	0.00e+00	1879.00
IUUC-Aly-005768	Arabidopsis lyrata	34.45	3.00e-107	383.00
IUUC-Ath-006576	Arabidopsis thaliana	34.15	4.00e-108	386.00
IUUC-Ago-007748	Ashbya gossypii	42.08	7.00e-77	282.00
IUUC-Acl-008158	Aspergillus clavatus	37.95	1.00e-75	278.00
IUUC-Afl-008398	Aspergillus flavus	34.02	2.00e-77	284.00
IUUC-Afu-008937	Aspergillus fumigatus	38.43	4.00e-78	286.00
IUUC-Ani-009252	Aspergillus nidulans	38.17	4.00e-80	293.00
IUUC-Ang-009773	Aspergillus niger	34.02	4.00e-78	286.00
IUUC-Aor-009940	Aspergillus oryzae	34.02	2.00e-77	284.00
IUUC-Ate-010395	Aspergillus terreus	38.81	3.00e-76	280.00
IUUC-Ame-010769	Astyanax mexicanus	63.08	0.00e+00	1037.00
IUUC-Bgr-012269	Blumeria graminis	37.34	5.00e-74	271.00
IUUC-Bta-012841	Bos taurus	90.78	0.00e+00	1897.00
IUUC-Bci-013743	Botrytis cinerea	29.42	7.00e-84	305.00
IUUC-Bol-015390	Brassica oleracea	34.16	3.00e-101	363.00
IUUC-Bra-016853	Brassica rapa	34.88	3.00e-108	386.00
IUUC-Cel-018638	Caenorhabditis elegans	39.61	3.00e-89	323.00
IUUC-Cja-019743	Callithrix jacchus	92.44	0.00e+00	1920.00
IUUC-Cfa-021031	Canis familiaris	96.66	0.00e+00	2006.00
IUUC-Cpo-022401	Cavia porcellus	90.21	0.00e+00	1904.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	43.48	3.00e-82	298.00
IUUC-Csa-024107	Chlorocebus sabaeus	93.48	0.00e+00	1951.00
IUUC-Cho-024750	Choloepus hoffmanni	82.29	0.00e+00	800.00
IUUC-Cin-025432	Ciona intestinalis	44.39	5.00e-96	344.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	33.97	9.00e-87	315.00
IUUC-Cne-026841	Cryptococcus neoformans	36.82	9.00e-95	342.00
IUUC-Cme-027265	Cyanidioschyzon merolae	46.62	1.00e-101	364.00
IUUC-Dre-028196	Danio rerio	76.42	0.00e+00	1569.00
IUUC-Dno-029024	Dasypus novemcinctus	92.82	0.00e+00	1959.00
IUUC-Dor-030483	Dipodomys ordii	90.08	0.00e+00	677.00
IUUC-Dse-031416	Dothistroma septosporum	33.73	5.00e-77	283.00
IUUC-Dme-031946	Drosophila melanogaster	36.66	0.00e+00	650.00
IUUC-Ete-032240	Echinops telfairi	82.69	2.00e-174	606.00
IUUC-Eca-033828	Equus caballus	94.44	0.00e+00	1977.00
IUUC-Eeu-034604	Erinaceus europaeus	84.62	8.00e-126	444.00
IUUC-Fca-035907	Felis catus	95.15	0.00e+00	2009.00
IUUC-Fal-037389	Ficedula albicollis	88.63	0.00e+00	1901.00
IUUC-Fox-037788	Fusarium oxysporum	36.23	1.00e-90	328.00
IUUC-Fso-038088	Fusarium solani	36.20	8.00e-89	322.00
IUUC-Gmo-039254	Gadus morhua	65.38	0.00e+00	1196.00
IUUC-Ggr-039941	Gaeumannomyces graminis	34.43	2.00e-83	304.00
IUUC-Gga-040310	Gallus gallus	88.72	0.00e+00	1900.00
IUUC-Gac-042054	Gasterosteus aculeatus	67.88	0.00e+00	1255.00
IUUC-Gma-042836	Glycine max	33.68	6.00e-101	362.00
IUUC-Ggo-045031	Gorilla gorilla	93.85	0.00e+00	1957.00
IUUC-Hsa-045880	Homo sapiens	93.76	0.00e+00	1956.00
IUUC-Itr-048555	Ictidomys tridecemlineatus	84.87	0.00e+00	693.00
IUUC-Lch-050403	Latimeria chalumnae	79.90	0.00e+00	1627.00
IUUC-Loc-052218	Lepisosteus oculatus	80.28	0.00e+00	1669.00
IUUC-Lma-053096	Leptosphaeria maculans	38.36	1.00e-79	291.00
IUUC-Laf-054162	Loxodonta africana	89.66	0.00e+00	1691.00
IUUC-Mcc-055127	Macaca mulatta	93.57	0.00e+00	1952.00
IUUC-Meu-056187	Macropus eugenii	81.74	3.00e-104	373.00
IUUC-Mor-057021	Magnaporthe oryzae	33.97	2.00e-76	281.00
IUUC-Mpo-057570	Magnaporthe poae	36.68	1.00e-75	278.00
IUUC-Mtr-058154	Medicago truncatula	35.23	3.00e-103	369.00
IUUC-Mla-059124	Melampsora laricipopulina	48.40	2.00e-101	362.00
IUUC-Mga-059581	Meleagris gallopavo	88.54	0.00e+00	1897.00
IUUC-Mvi-060445	Microbotryum violaceum	37.70	3.00e-104	373.00
IUUC-Mmr-061360	Microcebus murinus	89.51	0.00e+00	1844.00
IUUC-Mdo-062194	Monodelphis domestica	89.27	0.00e+00	1906.00
IUUC-Mmu-064189	Mus musculus	90.59	0.00e+00	1933.00
IUUC-Mac-065275	Musa acuminata	48.90	6.00e-107	381.00
IUUC-Mpu-066439	Mustela putorius furo	95.22	0.00e+00	1983.00
IUUC-Mlu-068228	Myotis lucifugus	89.22	0.00e+00	1904.00
IUUC-Nfi-068280	Neosartorya fischeri	38.43	3.00e-78	287.00
IUUC-Ncr-068869	Neurospora crassa	35.96	2.00e-81	297.00
IUUC-Nle-069687	Nomascus leucogenys	93.97	0.00e+00	1940.00
IUUC-Opr-070592	Ochotona princeps	76.30	3.00e-124	439.00
IUUC-Ont-071836	Oreochromis niloticus	76.63	0.00e+00	1602.00
IUUC-Oan-072800	Ornithorhynchus anatinus	89.00	0.00e+00	1896.00
IUUC-Ocu-074587	Oryctolagus cuniculus	93.66	0.00e+00	1962.00
IUUC-Ola-087209	Oryzias latipes	76.14	0.00e+00	1572.00
IUUC-Olu-087699	Ostreococcus lucimarinus	42.32	3.00e-85	308.00
IUUC-Oga-088776	Otolemur garnettii	87.14	0.00e+00	1757.00
IUUC-Oar-089441	Ovis aries	90.14	0.00e+00	1881.00
IUUC-Ptr-091273	Pan troglodytes	93.66	0.00e+00	1954.00
IUUC-Pan-091981	Papio anubis	93.48	0.00e+00	1952.00
IUUC-Psi-093203	Pelodiscus sinensis	87.21	0.00e+00	1626.00
IUUC-Pma-094738	Petromyzon marinus	64.33	0.00e+00	1303.00
IUUC-Pno-095132	Phaeosphaeria nodorum	28.96	3.00e-58	220.00
IUUC-Ppa-095682	Physcomitrella patens	35.33	5.00e-112	399.00
IUUC-Pfo-097511	Poecilia formosa	76.51	0.00e+00	1613.00
IUUC-Pab-098634	Pongo abelii	89.66	0.00e+00	1873.00
IUUC-Pop-098928	Populus trichocarpa	34.83	4.00e-97	349.00
IUUC-Pca-100987	Procavia capensis	97.91	0.00e+00	789.00
IUUC-Pva-103034	Pteropus vampyrus	88.32	0.00e+00	1821.00
IUUC-Pgr-103513	Puccinia graminis	39.00	4.00e-106	379.00
IUUC-Ptt-103967	Puccinia triticina	41.32	2.00e-94	340.00
IUUC-Pte-104105	Pyrenophora teres	34.26	4.00e-81	296.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.37	1.00e-77	285.00
IUUC-Rno-105380	Rattus norvegicus	88.87	0.00e+00	1660.00
IUUC-Sce-106446	Saccharomyces cerevisiae	40.38	5.00e-68	253.00
IUUC-Sha-107108	Sarcophilus harrisii	83.07	0.00e+00	1753.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	42.49	9.00e-94	338.00
IUUC-Spo-108097	Schizosaccharomyces pombe	44.36	8.00e-94	338.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	29.36	6.00e-81	296.00
IUUC-Sar-113687	Sorex araneus	81.44	0.00e+00	899.00
IUUC-Sre-115038	Sporisorium reilianum	44.47	5.00e-97	349.00
IUUC-Ssc-116168	Sus scrofa	85.84	0.00e+00	779.00
IUUC-Tgu-116729	Taeniopygia guttata	88.55	0.00e+00	1890.00
IUUC-Tru-118068	Takifugu rubripes	75.40	0.00e+00	1565.00
IUUC-Tsy-118942	Tarsius syrichta	91.06	0.00e+00	711.00
IUUC-Tni-120732	Tetraodon nigroviridis	74.54	0.00e+00	1517.00
IUUC-Tre-121892	Trichoderma reesei	37.48	1.00e-86	315.00
IUUC-Tvi-122354	Trichoderma virens	35.69	1.00e-87	318.00
IUUC-Tme-127102	Tuber melanosporum	35.81	2.00e-90	327.00
IUUC-Tbe-127351	Tupaia belangeri	80.48	0.00e+00	1512.00
IUUC-Ttr-129061	Tursiops truncatus	90.03	0.00e+00	1860.00
IUUC-Uma-129343	Ustilago maydis	43.98	4.00e-97	350.00
IUUC-Vda-129748	Verticillium dahliae	38.60	8.00e-80	292.00
IUUC-Vvi-131234	Vitis vinifera	35.59	7.00e-101	362.00
IUUC-Xtr-132094	Xenopus tropicalis	84.00	0.00e+00	1740.00
IUUC-Xma-133923	Xiphophorus maculatus	76.79	0.00e+00	1616.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence