iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Meu-056065

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin protein ligase E3A

Genbank Nucleotide ID

DQ985736

Gene Name

TRIP12; UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMEUG00000005539.1	ENSMEUT00000005584.1	ENSMEUP00000005088.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-68	231.1	1659	1973

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + +++  +  +                       ++  
   Q: 1659 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLTNPKGSQEG-T--KyiqnlqglfalpfgrtakpahiaKVKM 1741
           56899***********.**********************6666533333322221.1..1234558888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.........dieelgldl 139
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+         +   ++l++
   Q: 1742 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslQYALETLNM 1828
           **********************************654444**************999999855555511555556666444444555 PP
   S: 140  tfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe 221
           + +  e++     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F +eel++l+cG+
   Q: 1829 NGCSVEDVgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGS 1915
           55544444777778999********************************************************************** PP
   S: 222  ..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlg 277
             +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+g
   Q: 1916 kaDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSGFDNEQQRLFLQFVTGSPRLPVG 1973
           7778999999999999****************************************97 PP

Organism

Macropus eugenii

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKAYSPPESR KSISKAPKVQ 60
SNTASEQSRG HISKRSCSSS SAVIVPQPED PDRANTSEKQ KTGQVPKKDS SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAACC GGCCTAATAA CAATCCAGGG GGGTCACTGC GACGTTCACA GAGGAACACT 60
GCCGGGGCCC AACCACAAGA CGACTCAATA GGAAGGAAGG TATGTGTTTA TCAAATGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0436--Ligase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.07	2.00e-104	374.00
IUUC-Aml-001502	Ailuropoda melanoleuca	94.40	0.00e+00	2145.00
IUUC-Atr-002821	Amborella trichopoda	34.98	4.00e-95	343.00
IUUC-Apl-003531	Anas platyrhynchos	91.09	0.00e+00	1959.00
IUUC-Aly-005962	Arabidopsis lyrata	36.42	4.00e-93	337.00
IUUC-Ath-006636	Arabidopsis thaliana	36.26	1.00e-92	335.00
IUUC-Ago-007875	Ashbya gossypii	33.41	6.00e-60	226.00
IUUC-Acl-008242	Aspergillus clavatus	32.89	1.00e-87	318.00
IUUC-Afl-008736	Aspergillus flavus	35.55	7.00e-84	306.00
IUUC-Afu-008812	Aspergillus fumigatus	31.71	3.00e-86	313.00
IUUC-Ani-009407	Aspergillus nidulans	33.78	2.00e-83	304.00
IUUC-Ang-009763	Aspergillus niger	36.67	2.00e-78	288.00
IUUC-Aor-009941	Aspergillus oryzae	28.36	2.00e-86	314.00
IUUC-Ate-010459	Aspergillus terreus	36.89	3.00e-84	307.00
IUUC-Ame-011761	Astyanax mexicanus	84.08	0.00e+00	1929.00
IUUC-Bgr-012265	Blumeria graminis	31.76	3.00e-76	280.00
IUUC-Bta-013070	Bos taurus	93.88	0.00e+00	2130.00
IUUC-Bci-013890	Botrytis cinerea	36.47	8.00e-77	282.00
IUUC-Bdi-014046	Brachypodium distachyon	35.54	2.00e-98	354.00
IUUC-Bol-015942	Brassica oleracea	42.25	8.00e-92	332.00
IUUC-Bra-016849	Brassica rapa	42.25	9.00e-92	332.00
IUUC-Cja-019046	Callithrix jacchus	94.23	0.00e+00	2112.00
IUUC-Cfa-020521	Canis familiaris	94.58	0.00e+00	2120.00
IUUC-Cpo-021639	Cavia porcellus	93.70	0.00e+00	2130.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.19	4.00e-72	265.00
IUUC-Csa-023231	Chlorocebus sabaeus	94.05	0.00e+00	2108.00
IUUC-Cho-024380	Choloepus hoffmanni	88.19	0.00e+00	1945.00
IUUC-Cin-025482	Ciona intestinalis	48.31	5.00e-132	464.00
IUUC-Csv-026121	Ciona savignyi	45.71	0.00e+00	762.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	31.72	4.00e-84	306.00
IUUC-Cne-026857	Cryptococcus neoformans	37.25	4.00e-71	263.00
IUUC-Cme-027226	Cyanidioschyzon merolae	31.64	3.00e-50	194.00
IUUC-Dre-028174	Danio rerio	82.57	0.00e+00	1884.00
IUUC-Dor-030939	Dipodomys ordii	86.35	0.00e+00	1873.00
IUUC-Dse-031444	Dothistroma septosporum	35.96	8.00e-79	289.00
IUUC-Dme-032162	Drosophila melanogaster	68.11	2.00e-116	414.00
IUUC-Ete-032345	Echinops telfairi	90.03	0.00e+00	1994.00
IUUC-Eca-033229	Equus caballus	94.14	0.00e+00	2105.00
IUUC-Eeu-035205	Erinaceus europaeus	85.87	0.00e+00	1829.00
IUUC-Fca-036444	Felis catus	93.36	0.00e+00	2118.00
IUUC-Fal-037131	Ficedula albicollis	92.91	0.00e+00	2013.00
IUUC-Fox-038035	Fusarium oxysporum	32.89	1.00e-82	300.00
IUUC-Fso-038320	Fusarium solani	33.22	3.00e-83	303.00
IUUC-Gmo-039497	Gadus morhua	82.77	0.00e+00	1897.00
IUUC-Ggr-040057	Gaeumannomyces graminis	32.15	2.00e-82	301.00
IUUC-Gga-041021	Gallus gallus	93.00	0.00e+00	2031.00
IUUC-Gac-042474	Gasterosteus aculeatus	83.74	0.00e+00	1878.00
IUUC-Gma-043060	Glycine max	36.31	1.00e-99	358.00
IUUC-Ggo-044855	Gorilla gorilla	93.96	0.00e+00	2107.00
IUUC-Hsa-046147	Homo sapiens	93.88	0.00e+00	2105.00
IUUC-Hvu-047775	Hordeum vulgare	36.07	6.00e-104	372.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	94.40	0.00e+00	2103.00
IUUC-Kpa-049098	Komagataella pastoris	34.85	4.00e-61	230.00
IUUC-Lch-049818	Latimeria chalumnae	84.47	0.00e+00	1892.00
IUUC-Lpe-051017	Leersia perrieri	36.48	3.00e-98	353.00
IUUC-Loc-051777	Lepisosteus oculatus	86.01	0.00e+00	1977.00
IUUC-Lma-052990	Leptosphaeria maculans	32.72	5.00e-85	310.00
IUUC-Laf-053727	Loxodonta africana	93.79	0.00e+00	2098.00
IUUC-Mcc-055799	Macaca mulatta	94.05	0.00e+00	2108.00
IUUC-Mor-057054	Magnaporthe oryzae	32.05	2.00e-81	298.00
IUUC-Mpo-057417	Magnaporthe poae	35.84	3.00e-81	297.00
IUUC-Mtr-057849	Medicago truncatula	34.91	2.00e-91	331.00
IUUC-Mla-058870	Melampsora laricipopulina	38.43	5.00e-78	286.00
IUUC-Mga-059580	Meleagris gallopavo	92.59	0.00e+00	1696.00
IUUC-Mvi-060507	Microbotryum violaceum	37.71	5.00e-91	330.00
IUUC-Mmr-060816	Microcebus murinus	94.40	0.00e+00	2111.00
IUUC-Mdo-062866	Monodelphis domestica	96.68	0.00e+00	2150.00
IUUC-Mmu-063906	Mus musculus	93.53	0.00e+00	2102.00
IUUC-Mac-064675	Musa acuminata	37.10	2.00e-92	333.00
IUUC-Mpu-066199	Mustela putorius furo	94.40	0.00e+00	2110.00
IUUC-Mlu-067110	Myotis lucifugus	93.70	0.00e+00	2103.00
IUUC-Nfi-068482	Neosartorya fischeri	31.88	2.00e-86	314.00
IUUC-Ncr-068906	Neurospora crassa	35.78	3.00e-82	301.00
IUUC-Nle-069410	Nomascus leucogenys	93.96	0.00e+00	2107.00
IUUC-Opr-070401	Ochotona princeps	81.10	0.00e+00	1746.00
IUUC-Ont-072100	Oreochromis niloticus	83.48	0.00e+00	1890.00
IUUC-Oan-073121	Ornithorhynchus anatinus	94.05	0.00e+00	2129.00
IUUC-Ocu-074623	Oryctolagus cuniculus	93.96	0.00e+00	2112.00
IUUC-Oba-075380	Oryza barthii	29.02	5.00e-93	335.00
IUUC-Obr-076915	Oryza brachyantha	35.27	1.00e-96	348.00
IUUC-Ogl-077055	Oryza glaberrima	36.02	9.00e-96	345.00
IUUC-Ogu-078892	Oryza glumaepatula	33.50	2.00e-89	323.00
IUUC-Oin-079256	Oryza indica	36.02	9.00e-96	345.00
IUUC-Olo-080343	Oryza longistaminata	36.18	4.00e-96	346.00
IUUC-Ome-081422	Oryza meridionalis	35.86	3.00e-95	343.00
IUUC-Oni-083047	Oryza nivara	33.66	4.00e-91	330.00
IUUC-Opu-083792	Oryza punctata	33.81	7.00e-81	296.00
IUUC-Oru-084439	Oryza rufipogon	33.50	7.00e-90	325.00
IUUC-Osa-085972	Oryza sativa	35.71	6.00e-94	338.00
IUUC-Ola-087173	Oryzias latipes	82.43	0.00e+00	1883.00
IUUC-Olu-087871	Ostreococcus lucimarinus	34.71	8.00e-72	264.00
IUUC-Oga-087908	Otolemur garnettii	94.13	0.00e+00	2100.00
IUUC-Oar-090277	Ovis aries	93.79	0.00e+00	2129.00
IUUC-Ptr-091543	Pan troglodytes	94.05	0.00e+00	2110.00
IUUC-Pan-092243	Papio anubis	94.14	0.00e+00	2110.00
IUUC-Psi-093150	Pelodiscus sinensis	93.44	0.00e+00	2072.00
IUUC-Pno-094891	Phaeosphaeria nodorum	37.63	2.00e-85	311.00
IUUC-Ppa-095181	Physcomitrella patens	40.74	4.00e-88	318.00
IUUC-Pfo-096267	Poecilia formosa	83.22	0.00e+00	1911.00
IUUC-Pab-098072	Pongo abelii	93.96	0.00e+00	2107.00
IUUC-Pop-099190	Populus trichocarpa	34.78	1.00e-94	341.00
IUUC-Pca-100311	Procavia capensis	87.49	0.00e+00	1992.00
IUUC-Ppe-101284	Prunus persica	35.55	5.00e-95	343.00
IUUC-Pva-102215	Pteropus vampyrus	87.92	0.00e+00	981.00
IUUC-Pgr-103694	Puccinia graminis	36.57	6.00e-76	280.00
IUUC-Ptt-103916	Puccinia triticina	35.19	1.00e-69	258.00
IUUC-Pte-104346	Pyrenophora teres	35.94	3.00e-82	300.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	36.02	2.00e-82	301.00
IUUC-Rno-105315	Rattus norvegicus	93.96	0.00e+00	2080.00
IUUC-Sce-106273	Saccharomyces cerevisiae	32.00	4.00e-49	190.00
IUUC-Sha-106835	Sarcophilus harrisii	96.24	0.00e+00	2143.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	33.10	5.00e-68	253.00
IUUC-Spo-108081	Schizosaccharomyces pombe	34.43	2.00e-69	258.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	36.70	2.00e-80	294.00
IUUC-Smo-108776	Selaginella moellendorffii	41.91	6.00e-92	333.00
IUUC-Sit-110717	Setaria italica	35.98	4.00e-99	356.00
IUUC-Sly-111469	Solanum lycopersicum	37.30	3.00e-100	360.00
IUUC-Stu-112896	Solanum tuberosum	35.17	2.00e-89	323.00
IUUC-Sar-113224	Sorex araneus	79.00	0.00e+00	667.00
IUUC-Sbi-114313	Sorghum bicolor	35.85	3.00e-102	367.00
IUUC-Sre-114993	Sporisorium reilianum	30.97	5.00e-74	273.00
IUUC-Ssc-115535	Sus scrofa	90.66	0.00e+00	1990.00
IUUC-Tgu-117493	Taeniopygia guttata	92.15	0.00e+00	1395.00
IUUC-Tru-118669	Takifugu rubripes	82.60	0.00e+00	1883.00
IUUC-Tsy-119373	Tarsius syrichta	89.41	0.00e+00	1790.00
IUUC-Tni-120049	Tetraodon nigroviridis	75.21	0.00e+00	738.00
IUUC-Tca-121779	Theobroma cacao	36.45	2.00e-93	338.00
IUUC-Tre-122195	Trichoderma reesei	33.67	1.00e-83	305.00
IUUC-Tvi-122650	Trichoderma virens	33.50	6.00e-86	313.00
IUUC-Tae-123580	Triticum aestivum	35.98	1.00e-102	367.00
IUUC-Tur-126295	Triticum urartu	35.90	1.00e-103	371.00
IUUC-Tme-126964	Tuber melanosporum	36.67	7.00e-79	289.00
IUUC-Tbe-128149	Tupaia belangeri	78.80	0.00e+00	1388.00
IUUC-Ttr-128165	Tursiops truncatus	90.03	0.00e+00	1991.00
IUUC-Uma-129365	Ustilago maydis	31.92	2.00e-61	231.00
IUUC-Vda-129725	Verticillium dahliae	37.33	2.00e-81	297.00
IUUC-Vpa-130678	Vicugna pacos	94.14	0.00e+00	2109.00
IUUC-Vvi-131147	Vitis vinifera	36.54	2.00e-98	354.00
IUUC-Xtr-132636	Xenopus tropicalis	89.02	0.00e+00	1977.00
IUUC-Xma-133458	Xiphophorus maculatus	83.30	0.00e+00	1942.00
IUUC-Yli-134481	Yarrowia lipolytica	36.24	3.00e-72	266.00
IUUC-Zma-135782	Zea mays	34.51	2.00e-95	344.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence