iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020948

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03011373

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000006813.3	ENSCAFT00000010962.3	ENSCAFP00000010159.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.70e-07	29.8	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC PAMASSCSAA VKDDSVSGTT STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAATTGAT AAGCACGTTA CTATGAGTCT GCTAAACTGT GAAAACAGCT GTGGATCCAG 60
CCAGTCTGAA AGCGACTGCT GTCCTGCCAT GGCCAGCTCC TGTAGCGCCG CAGTGAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	97.14	0.00e+00	904.00
IUUC-Apl-004062	Anas platyrhynchos	73.95	0.00e+00	754.00
IUUC-Aca-004636	Anolis carolinensis	69.70	0.00e+00	690.00
IUUC-Acl-008349	Aspergillus clavatus	28.51	5.00e-12	65.90
IUUC-Ang-009779	Aspergillus niger	28.16	3.00e-11	63.20
IUUC-Ame-011682	Astyanax mexicanus	52.08	3.00e-145	508.00
IUUC-Bta-012692	Bos taurus	90.00	0.00e+00	877.00
IUUC-Cja-019426	Callithrix jacchus	89.57	0.00e+00	860.00
IUUC-Cpo-021378	Cavia porcellus	91.45	0.00e+00	871.00
IUUC-Csa-024045	Chlorocebus sabaeus	88.96	0.00e+00	863.00
IUUC-Cho-024973	Choloepus hoffmanni	76.61	4.00e-107	381.00
IUUC-Csv-026300	Ciona savignyi	39.92	8.00e-47	180.00
IUUC-Dre-027557	Danio rerio	55.19	3.00e-153	535.00
IUUC-Dno-030032	Dasypus novemcinctus	89.57	3.00e-149	521.00
IUUC-Dor-030790	Dipodomys ordii	88.34	0.00e+00	853.00
IUUC-Dme-031921	Drosophila melanogaster	26.74	1.00e-32	134.00
IUUC-Ete-032952	Echinops telfairi	82.58	4.00e-138	484.00
IUUC-Eca-033924	Equus caballus	87.58	0.00e+00	783.00
IUUC-Eeu-034734	Erinaceus europaeus	81.22	0.00e+00	758.00
IUUC-Fca-036222	Felis catus	86.12	0.00e+00	774.00
IUUC-Fal-036834	Ficedula albicollis	75.42	0.00e+00	656.00
IUUC-Fox-037935	Fusarium oxysporum	28.97	1.00e-20	94.70
IUUC-Gmo-039061	Gadus morhua	61.79	5.00e-86	311.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.93	1.00e-11	64.70
IUUC-Gga-040599	Gallus gallus	74.85	0.00e+00	763.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.43	2.00e-149	522.00
IUUC-Ggo-044508	Gorilla gorilla	83.10	0.00e+00	788.00
IUUC-Hsa-046349	Homo sapiens	89.37	0.00e+00	895.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	89.16	0.00e+00	874.00
IUUC-Lch-049821	Latimeria chalumnae	66.07	0.00e+00	669.00
IUUC-Loc-051995	Lepisosteus oculatus	60.21	1.00e-160	559.00
IUUC-Laf-054115	Loxodonta africana	88.14	0.00e+00	861.00
IUUC-Mcc-055298	Macaca mulatta	88.96	0.00e+00	862.00
IUUC-Mor-057263	Magnaporthe oryzae	29.44	7.00e-17	82.00
IUUC-Mpo-057517	Magnaporthe poae	28.51	2.00e-13	70.50
IUUC-Mga-059340	Meleagris gallopavo	74.44	0.00e+00	740.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	1.00e-13	71.20
IUUC-Mmr-061063	Microcebus murinus	91.41	0.00e+00	862.00
IUUC-Mdo-062075	Monodelphis domestica	80.24	0.00e+00	810.00
IUUC-Mmu-063780	Mus musculus	85.28	0.00e+00	798.00
IUUC-Mpu-065748	Mustela putorius furo	95.71	0.00e+00	908.00
IUUC-Mlu-067888	Myotis lucifugus	89.16	0.00e+00	854.00
IUUC-Ncr-068632	Neurospora crassa	27.50	2.00e-14	74.30
IUUC-Nle-069234	Nomascus leucogenys	89.37	0.00e+00	868.00
IUUC-Opr-070393	Ochotona princeps	95.03	1.00e-90	326.00
IUUC-Ont-072459	Oreochromis niloticus	52.92	7.00e-158	550.00
IUUC-Oan-073578	Ornithorhynchus anatinus	80.82	0.00e+00	825.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.39	0.00e+00	874.00
IUUC-Ola-087319	Oryzias latipes	58.17	5.00e-88	318.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.89	3.00e-09	55.80
IUUC-Oga-087936	Otolemur garnettii	89.00	0.00e+00	860.00
IUUC-Oar-089379	Ovis aries	90.00	0.00e+00	888.00
IUUC-Ptr-090758	Pan troglodytes	89.78	0.00e+00	867.00
IUUC-Pan-092590	Papio anubis	89.16	0.00e+00	863.00
IUUC-Psi-093948	Pelodiscus sinensis	71.94	0.00e+00	730.00
IUUC-Pma-094434	Petromyzon marinus	43.15	3.00e-114	405.00
IUUC-Pfo-096912	Poecilia formosa	52.83	8.00e-149	520.00
IUUC-Pab-097651	Pongo abelii	89.98	0.00e+00	870.00
IUUC-Pca-100958	Procavia capensis	84.71	1.00e-173	602.00
IUUC-Pva-103247	Pteropus vampyrus	92.46	1.00e-128	453.00
IUUC-Pte-104279	Pyrenophora teres	26.94	9.00e-13	68.90
IUUC-Rno-104994	Rattus norvegicus	84.05	0.00e+00	816.00
IUUC-Sha-106494	Sarcophilus harrisii	81.60	0.00e+00	830.00
IUUC-Sar-113375	Sorex araneus	86.94	0.00e+00	834.00
IUUC-Sre-115218	Sporisorium reilianum	25.21	2.00e-14	74.30
IUUC-Ssc-115417	Sus scrofa	91.22	0.00e+00	887.00
IUUC-Tgu-117232	Taeniopygia guttata	74.24	0.00e+00	719.00
IUUC-Tru-118321	Takifugu rubripes	53.99	2.00e-150	525.00
IUUC-Tni-120475	Tetraodon nigroviridis	57.24	1.00e-147	516.00
IUUC-Tbe-127719	Tupaia belangeri	78.62	0.00e+00	743.00
IUUC-Ttr-129264	Tursiops truncatus	90.12	4.00e-125	441.00
IUUC-Uma-129620	Ustilago maydis	26.85	3.00e-17	83.60
IUUC-Vpa-130244	Vicugna pacos	90.12	1.00e-128	453.00
IUUC-Xtr-131948	Xenopus tropicalis	65.02	0.00e+00	667.00
IUUC-Xma-133132	Xiphophorus maculatus	56.53	1.00e-150	526.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence