iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033454

UUCD1 version

UUC-EqC-00267

Ensembl Protein ID

ENSECAP00000018689.1

UniProt Accession

F6U418; F6U418_HORSE

Protein Name

Uncharacterized protein

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020598.1	ENSECAT00000022598.1	ENSECAP00000018683.1
ENSECAG00000020598.1	ENSECAT00000022605.1	ENSECAP00000018689.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-09	38.1	1109	1214
E3 activity/N-recognin/N-domain	6.10e-37	125.8	227	303
E3 activity/N-recognin/UBR-box	1.70e-31	108.7	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC......................................ledf........kdgplvlpCgHvfhadClqkw............ 29
           C++C                                      +           ++g+++++CgH++ha+C+q++            
   Q: 1109 CILCqeeqevkveskamvlaafvqrstvlskdrskfiqdpekY--DplfmhpdlSCGTHTGSCGHIMHAHCWQRYfdsvqakeqrrq 1193
           8888333333333333333333333333333333333333321..02344444455899**************************** PP
   S: 30   .....pglknssskefrCPlC 45
                + +++++++ef+CPlC
   Q: 1194 qrlrlHTSYDVENGEFLCPLC 1214
           ********************* PP

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknse.klaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v+ Gd+++ce+ak+ i++n++ ++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRCGDFQYCEQAKSIIVRNTSsRQTK-PLKVQV 303
           9**************************************************************98626666.****98 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC++Cf  ++H+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMDCFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MASELELEMQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRSPNPCPQK 60
EDMVAQHVLL APMEWYLCGE DSEFGFPKLQ QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTCGG AGCTGGAGCT CGAGATGCAG GCCATCGACC GGAGTTTGCT GGAATGTTCG 60
GCCGAGGAGA TCGCGGGGGT CAGTGTCGGG ACCCGGGCGG GGACGTCCTG CCTTCCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.65	1.00e-22	103.00
IUUC-Aml-001876	Ailuropoda melanoleuca	84.50	0.00e+00	2716.00
IUUC-Atr-002501	Amborella trichopoda	28.67	6.00e-28	120.00
IUUC-Apl-003828	Anas platyrhynchos	86.86	0.00e+00	3041.00
IUUC-Aca-005189	Anolis carolinensis	84.92	0.00e+00	3016.00
IUUC-Aly-005901	Arabidopsis lyrata	32.39	4.00e-26	114.00
IUUC-Ath-007148	Arabidopsis thaliana	30.99	9.00e-25	110.00
IUUC-Ago-007946	Ashbya gossypii	22.81	1.00e-26	116.00
IUUC-Afl-008479	Aspergillus flavus	23.30	5.00e-48	187.00
IUUC-Afu-008929	Aspergillus fumigatus	24.29	3.00e-54	208.00
IUUC-Ani-009334	Aspergillus nidulans	24.14	4.00e-50	194.00
IUUC-Ang-009550	Aspergillus niger	23.62	1.00e-47	186.00
IUUC-Aor-010124	Aspergillus oryzae	23.30	5.00e-48	187.00
IUUC-Ame-011917	Astyanax mexicanus	73.31	0.00e+00	2475.00
IUUC-Bta-012768	Bos taurus	92.32	0.00e+00	3230.00
IUUC-Bdi-014635	Brachypodium distachyon	26.09	1.00e-31	132.00
IUUC-Bol-015669	Brassica oleracea	31.45	1.00e-30	129.00
IUUC-Bra-017776	Brassica rapa	31.45	3.00e-31	131.00
IUUC-Cel-018476	Caenorhabditis elegans	31.34	9.00e-84	306.00
IUUC-Cja-019797	Callithrix jacchus	94.76	0.00e+00	2593.00
IUUC-Cfa-020950	Canis familiaris	95.50	0.00e+00	3333.00
IUUC-Cpo-022385	Cavia porcellus	90.89	0.00e+00	3209.00
IUUC-Csa-024082	Chlorocebus sabaeus	94.76	0.00e+00	3298.00
IUUC-Cho-025029	Choloepus hoffmanni	85.94	0.00e+00	2154.00
IUUC-Cin-025148	Ciona intestinalis	36.65	2.00e-139	489.00
IUUC-Csv-026296	Ciona savignyi	30.30	3.00e-21	95.90
IUUC-Cgl-026605	Colletotrichum gloeosporioides	23.87	3.00e-54	207.00
IUUC-Cne-026823	Cryptococcus neoformans	22.00	2.00e-39	158.00
IUUC-Dre-028343	Danio rerio	71.97	0.00e+00	2470.00
IUUC-Dno-030002	Dasypus novemcinctus	91.56	0.00e+00	1949.00
IUUC-Dor-030207	Dipodomys ordii	78.34	0.00e+00	1562.00
IUUC-Dse-031531	Dothistroma septosporum	24.56	8.00e-54	206.00
IUUC-Dme-031910	Drosophila melanogaster	34.76	0.00e+00	686.00
IUUC-Ete-033162	Echinops telfairi	83.46	0.00e+00	1364.00
IUUC-Eeu-034783	Erinaceus europaeus	77.85	0.00e+00	1528.00
IUUC-Fca-036588	Felis catus	95.16	0.00e+00	3310.00
IUUC-Fal-036919	Ficedula albicollis	86.92	0.00e+00	2986.00
IUUC-Fox-037984	Fusarium oxysporum	25.27	4.00e-40	161.00
IUUC-Fso-038463	Fusarium solani	24.45	5.00e-44	174.00
IUUC-Gmo-039698	Gadus morhua	69.27	0.00e+00	1602.00
IUUC-Ggr-040070	Gaeumannomyces graminis	23.51	2.00e-45	179.00
IUUC-Gga-041123	Gallus gallus	87.59	0.00e+00	3089.00
IUUC-Gac-042622	Gasterosteus aculeatus	65.32	0.00e+00	2178.00
IUUC-Gma-043622	Glycine max	29.04	1.00e-26	116.00
IUUC-Ggo-045583	Gorilla gorilla	93.20	0.00e+00	3265.00
IUUC-Hsa-046343	Homo sapiens	93.74	0.00e+00	3263.00
IUUC-Hvu-047707	Hordeum vulgare	29.79	5.00e-23	103.00
IUUC-Kpa-049088	Komagataella pastoris	23.42	3.00e-46	181.00
IUUC-Lch-049649	Latimeria chalumnae	74.72	0.00e+00	2586.00
IUUC-Lpe-051516	Leersia perrieri	26.02	1.00e-32	136.00
IUUC-Loc-052818	Lepisosteus oculatus	75.10	0.00e+00	2625.00
IUUC-Lma-053059	Leptosphaeria maculans	23.81	1.00e-49	192.00
IUUC-Laf-054142	Loxodonta africana	92.15	0.00e+00	3236.00
IUUC-Mcc-055677	Macaca mulatta	94.65	0.00e+00	3280.00
IUUC-Meu-056204	Macropus eugenii	68.99	0.00e+00	737.00
IUUC-Mor-057051	Magnaporthe oryzae	23.87	2.00e-51	199.00
IUUC-Mpo-057372	Magnaporthe poae	25.22	2.00e-47	185.00
IUUC-Mtr-058538	Medicago truncatula	29.64	5.00e-29	124.00
IUUC-Mla-058963	Melampsora laricipopulina	25.68	2.00e-55	211.00
IUUC-Mga-059698	Meleagris gallopavo	87.93	0.00e+00	3067.00
IUUC-Mvi-060535	Microbotryum violaceum	24.94	6.00e-53	203.00
IUUC-Mmr-060901	Microcebus murinus	91.46	0.00e+00	3175.00
IUUC-Mdo-062014	Monodelphis domestica	90.09	0.00e+00	3181.00
IUUC-Mmu-063699	Mus musculus	88.38	0.00e+00	3095.00
IUUC-Mac-064773	Musa acuminata	31.10	1.00e-27	119.00
IUUC-Mpu-066153	Mustela putorius furo	95.67	0.00e+00	3335.00
IUUC-Mlu-068151	Myotis lucifugus	92.03	0.00e+00	3206.00
IUUC-Nfi-068403	Neosartorya fischeri	23.95	1.00e-53	206.00
IUUC-Nle-069529	Nomascus leucogenys	94.82	0.00e+00	3303.00
IUUC-Opr-071107	Ochotona princeps	86.86	0.00e+00	1330.00
IUUC-Ont-072189	Oreochromis niloticus	66.20	0.00e+00	2153.00
IUUC-Oan-072893	Ornithorhynchus anatinus	87.87	0.00e+00	3090.00
IUUC-Ocu-074082	Oryctolagus cuniculus	90.84	0.00e+00	3173.00
IUUC-Obr-076117	Oryza brachyantha	26.12	3.00e-28	122.00
IUUC-Ogl-077571	Oryza glaberrima	28.46	3.00e-23	105.00
IUUC-Ogu-078497	Oryza glumaepatula	22.91	2.00e-14	76.30
IUUC-Olo-081056	Oryza longistaminata	25.61	3.00e-17	85.10
IUUC-Ome-081738	Oryza meridionalis	22.93	1.00e-15	80.10
IUUC-Opu-083202	Oryza punctata	27.09	1.00e-28	123.00
IUUC-Osa-085336	Oryza sativa	28.46	2.00e-23	104.00
IUUC-Ola-087460	Oryzias latipes	64.47	0.00e+00	2137.00
IUUC-Oga-088432	Otolemur garnettii	91.63	0.00e+00	3231.00
IUUC-Oar-090206	Ovis aries	92.12	0.00e+00	3240.00
IUUC-Ptr-091180	Pan troglodytes	93.45	0.00e+00	3264.00
IUUC-Pan-092375	Papio anubis	94.65	0.00e+00	3296.00
IUUC-Psi-093049	Pelodiscus sinensis	87.09	0.00e+00	3038.00
IUUC-Pma-094152	Petromyzon marinus	48.24	0.00e+00	666.00
IUUC-Ppa-095715	Physcomitrella patens	28.99	1.00e-23	106.00
IUUC-Pfo-096524	Poecilia formosa	63.39	0.00e+00	2039.00
IUUC-Pab-097989	Pongo abelii	92.94	0.00e+00	3214.00
IUUC-Pop-099496	Populus trichocarpa	27.00	3.00e-17	84.70
IUUC-Pca-100207	Procavia capensis	79.45	0.00e+00	1250.00
IUUC-Ppe-101802	Prunus persica	29.28	2.00e-27	119.00
IUUC-Pva-102538	Pteropus vampyrus	91.43	0.00e+00	1202.00
IUUC-Pgr-103372	Puccinia graminis	24.66	4.00e-52	201.00
IUUC-Ptt-103878	Puccinia triticina	24.29	2.00e-49	192.00
IUUC-Rno-105567	Rattus norvegicus	88.67	0.00e+00	3051.00
IUUC-Sce-106272	Saccharomyces cerevisiae	21.02	9.00e-26	113.00
IUUC-Sha-106980	Sarcophilus harrisii	90.02	0.00e+00	3048.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.80	7.00e-49	190.00
IUUC-Spo-108183	Schizosaccharomyces pombe	25.49	6.00e-53	203.00
IUUC-Smo-108719	Selaginella moellendorffii	31.54	1.00e-30	130.00
IUUC-Sit-110716	Setaria italica	26.59	3.00e-32	135.00
IUUC-Sly-111286	Solanum lycopersicum	29.52	2.00e-27	119.00
IUUC-Sar-113332	Sorex araneus	86.51	0.00e+00	2178.00
IUUC-Sbi-114577	Sorghum bicolor	29.01	1.00e-31	133.00
IUUC-Sre-115045	Sporisorium reilianum	25.48	3.00e-45	178.00
IUUC-Ssc-115525	Sus scrofa	93.79	0.00e+00	2537.00
IUUC-Tgu-116943	Taeniopygia guttata	87.77	0.00e+00	3082.00
IUUC-Tru-117673	Takifugu rubripes	65.34	0.00e+00	2170.00
IUUC-Tsy-119032	Tarsius syrichta	92.13	0.00e+00	1818.00
IUUC-Tni-119987	Tetraodon nigroviridis	64.66	0.00e+00	2119.00
IUUC-Tca-121077	Theobroma cacao	32.70	2.00e-26	115.00
IUUC-Tre-122137	Trichoderma reesei	24.98	1.00e-59	226.00
IUUC-Tvi-122272	Trichoderma virens	23.24	2.00e-55	212.00
IUUC-Tae-125358	Triticum aestivum	29.79	2.00e-22	102.00
IUUC-Tur-126562	Triticum urartu	28.94	2.00e-29	124.00
IUUC-Tme-127156	Tuber melanosporum	23.57	8.00e-52	200.00
IUUC-Tbe-128103	Tupaia belangeri	87.92	0.00e+00	1251.00
IUUC-Ttr-128253	Tursiops truncatus	87.70	0.00e+00	3021.00
IUUC-Uma-129344	Ustilago maydis	26.88	2.00e-51	199.00
IUUC-Vda-129778	Verticillium dahliae	24.37	8.00e-48	186.00
IUUC-Vpa-130540	Vicugna pacos	89.60	0.00e+00	2924.00
IUUC-Vvi-131290	Vitis vinifera	30.40	5.00e-29	124.00
IUUC-Xtr-132690	Xenopus tropicalis	79.69	0.00e+00	2823.00
IUUC-Xma-133748	Xiphophorus maculatus	64.51	0.00e+00	2014.00
IUUC-Yli-134662	Yarrowia lipolytica	23.84	7.00e-31	130.00
IUUC-Zma-135553	Zea mays	23.50	4.00e-17	84.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence