iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pgr-103620

Ensembl Protein ID

EHS63947

UniProt Accession

H6QSZ3; H6QSZ3_PUCGT

Genbank Protein ID

EHS63947.1

Protein Name

E3 ubiquitin-protein ligase NEDD4

Genbank Nucleotide ID

DS178302

Gene Name

PGTG_21963

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PGTG_21963	EHS63947	EHS63947

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-123	410.8	386	717

Active Site

Position(s)	Description	Evidence
686	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gE+gld+gGv+ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr+l++a++++r+ld+ + +sfyk++l+
   Q: 386  PNDLKKRLMIKFDGEDGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAVDNYTLQINPHSGV-NPEHLNYFKFIGRVLALAIFHRRFLDAYFITSFYKMILK 485
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ l d+e+vd+e+++sl++++en   di++  ++ +fsv++e++ge+ + +L ++G+nipVt++Nk++Y++l++++r++++++ q++af +Gf+e+ip+
   Q: 486  KKIALADMESVDAEIFRSLTWMLEN---DITDV-IENSFSVEDEKFGEVVTIDLRENGRNIPVTEANKKDYIELITQWRIEKRVADQFKAFLSGFHELIPQ 582
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           el+++F+e+elelli G+++idv+d+ k+t y+g y++d+++i+wFw++++++ +e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 583  ELINVFDERELELLIGGMSDIDVDDWIKHTDYRG-YQPDDQVIKWFWQAVRAWPAEKKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEITQLPK 682
           ********************************76.*********************************************************9999***** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+L+LP+Y++ ++l++k+ +Aieet gF +
   Q: 683  SHTCFNRLDLPPYPNFDQLEQKISFAIEETLGFAV 717
           ********************************975 PP

Organism

Puccinia graminis

Protein Sequence
(Fasta)

MVVHGKLIVQ LSTNTSTPIR NRPQPVPPSN ESSSSLNGTS NPTAGQSSAL TSASPSPAAA 60
PGSTSSTNSE LTSPAQAPLT TAPSTSTSST AGTMTNPSSV TGNSSTNRNY STTEDQYGPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCGTCC ATGGCAAGCT CATCGTCCAG CTCTCCACCA ACACTTCCAC CCCTATCCGT 60
AATCGTCCTC AGCCCGTGCC ACCCTCGAAC GAGAGCTCGT CTAGCCTTAA TGGTACTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

pgr:PGTG_21963

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	52.49	3.00e-144	504.00
IUUC-Apl-003752	Anas platyrhynchos	52.07	2.00e-148	518.00
IUUC-Aca-005338	Anolis carolinensis	51.45	3.00e-147	514.00
IUUC-Ago-007742	Ashbya gossypii	66.61	0.00e+00	863.00
IUUC-Acl-008273	Aspergillus clavatus	68.51	0.00e+00	860.00
IUUC-Afl-008713	Aspergillus flavus	67.69	0.00e+00	849.00
IUUC-Afu-009103	Aspergillus fumigatus	68.77	0.00e+00	861.00
IUUC-Ani-009259	Aspergillus nidulans	61.75	0.00e+00	847.00
IUUC-Ang-009738	Aspergillus niger	78.17	0.00e+00	808.00
IUUC-Aor-010053	Aspergillus oryzae	73.91	1.00e-136	477.00
IUUC-Ate-010529	Aspergillus terreus	68.99	0.00e+00	857.00
IUUC-Ame-010810	Astyanax mexicanus	51.66	1.00e-142	499.00
IUUC-Bgr-012148	Blumeria graminis	77.08	0.00e+00	801.00
IUUC-Bta-012679	Bos taurus	52.49	1.00e-144	505.00
IUUC-Bci-013785	Botrytis cinerea	77.04	0.00e+00	796.00
IUUC-Cel-018299	Caenorhabditis elegans	49.59	7.00e-140	489.00
IUUC-Cja-018732	Callithrix jacchus	52.49	1.00e-144	505.00
IUUC-Cfa-021226	Canis familiaris	52.49	2.00e-144	505.00
IUUC-Cpo-021671	Cavia porcellus	52.49	2.00e-144	504.00
IUUC-Csa-023334	Chlorocebus sabaeus	52.60	1.00e-147	515.00
IUUC-Cho-024695	Choloepus hoffmanni	46.68	4.00e-157	546.00
IUUC-Cin-025126	Ciona intestinalis	47.90	1.00e-133	468.00
IUUC-Csv-026256	Ciona savignyi	48.98	3.00e-141	493.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	61.04	0.00e+00	860.00
IUUC-Cne-026849	Cryptococcus neoformans	70.70	0.00e+00	928.00
IUUC-Dre-027770	Danio rerio	51.87	4.00e-143	500.00
IUUC-Dno-029466	Dasypus novemcinctus	52.49	1.00e-144	505.00
IUUC-Dor-030138	Dipodomys ordii	51.66	7.00e-140	489.00
IUUC-Dse-031241	Dothistroma septosporum	63.79	0.00e+00	899.00
IUUC-Dme-032041	Drosophila melanogaster	50.72	6.00e-140	489.00
IUUC-Ete-032779	Echinops telfairi	43.76	6.00e-134	469.00
IUUC-Eca-033445	Equus caballus	52.49	2.00e-144	504.00
IUUC-Eeu-035247	Erinaceus europaeus	52.49	5.00e-144	503.00
IUUC-Fca-035605	Felis catus	51.24	3.00e-147	514.00
IUUC-Fal-037126	Ficedula albicollis	52.49	6.00e-150	523.00
IUUC-Fox-037774	Fusarium oxysporum	61.13	0.00e+00	858.00
IUUC-Fso-038393	Fusarium solani	61.05	0.00e+00	846.00
IUUC-Gmo-039674	Gadus morhua	51.45	5.00e-140	490.00
IUUC-Ggr-040107	Gaeumannomyces graminis	61.24	0.00e+00	863.00
IUUC-Gac-042020	Gasterosteus aculeatus	51.87	1.00e-141	495.00
IUUC-Ggo-045332	Gorilla gorilla	52.49	2.00e-144	504.00
IUUC-Hsa-045968	Homo sapiens	52.49	1.00e-144	505.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	51.04	1.00e-146	512.00
IUUC-Kpa-049273	Komagataella pastoris	69.26	0.00e+00	889.00
IUUC-Loc-052645	Lepisosteus oculatus	47.77	1.00e-150	525.00
IUUC-Lma-052980	Leptosphaeria maculans	58.96	7.00e-155	538.00
IUUC-Laf-053850	Loxodonta africana	52.49	3.00e-144	504.00
IUUC-Mcc-055821	Macaca mulatta	52.49	2.00e-144	505.00
IUUC-Meu-056436	Macropus eugenii	45.63	1.00e-119	422.00
IUUC-Mor-057097	Magnaporthe oryzae	62.23	0.00e+00	890.00
IUUC-Mpo-057442	Magnaporthe poae	75.35	0.00e+00	806.00
IUUC-Mla-058996	Melampsora laricipopulina	81.49	0.00e+00	1149.00
IUUC-Mga-059661	Meleagris gallopavo	52.07	2.00e-148	518.00
IUUC-Mvi-060395	Microbotryum violaceum	85.86	0.00e+00	902.00
IUUC-Mmr-061061	Microcebus murinus	45.71	5.00e-157	547.00
IUUC-Mdo-062505	Monodelphis domestica	51.04	1.00e-146	511.00
IUUC-Mmu-064136	Mus musculus	52.49	9.00e-145	506.00
IUUC-Mpu-066765	Mustela putorius furo	52.49	2.00e-144	504.00
IUUC-Mlu-067565	Myotis lucifugus	52.70	1.00e-144	505.00
IUUC-Nfi-068427	Neosartorya fischeri	68.77	0.00e+00	862.00
IUUC-Ncr-068918	Neurospora crassa	66.94	0.00e+00	849.00
IUUC-Nle-069225	Nomascus leucogenys	52.39	3.00e-149	521.00
IUUC-Opr-071044	Ochotona princeps	52.49	2.00e-144	504.00
IUUC-Ont-072044	Oreochromis niloticus	53.53	1.00e-149	522.00
IUUC-Oan-073019	Ornithorhynchus anatinus	52.39	4.00e-141	493.00
IUUC-Ocu-074160	Oryctolagus cuniculus	52.49	3.00e-144	504.00
IUUC-Ola-087467	Oryzias latipes	45.86	1.00e-145	509.00
IUUC-Oga-088460	Otolemur garnettii	52.49	3.00e-144	504.00
IUUC-Oar-090198	Ovis aries	52.49	1.00e-144	505.00
IUUC-Ptr-090939	Pan troglodytes	52.49	1.00e-144	505.00
IUUC-Pan-092284	Papio anubis	52.49	1.00e-144	505.00
IUUC-Pma-094364	Petromyzon marinus	51.87	3.00e-143	499.00
IUUC-Pno-095118	Phaeosphaeria nodorum	77.50	0.00e+00	814.00
IUUC-Pfo-096768	Poecilia formosa	52.38	4.00e-142	497.00
IUUC-Pab-098088	Pongo abelii	52.49	1.00e-144	505.00
IUUC-Pca-100596	Procavia capensis	48.86	5.00e-138	483.00
IUUC-Pva-102354	Pteropus vampyrus	52.49	4.00e-144	503.00
IUUC-Ptt-103806	Puccinia triticina	98.29	0.00e+00	858.00
IUUC-Pte-104016	Pyrenophora teres	69.06	0.00e+00	859.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	69.06	0.00e+00	859.00
IUUC-Rno-105318	Rattus norvegicus	52.49	1.00e-144	505.00
IUUC-Sce-106289	Saccharomyces cerevisiae	65.56	0.00e+00	865.00
IUUC-Sha-107482	Sarcophilus harrisii	52.16	7.00e-143	499.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	61.42	0.00e+00	886.00
IUUC-Spo-108171	Schizosaccharomyces pombe	61.84	0.00e+00	870.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	61.83	0.00e+00	853.00
IUUC-Stu-112894	Solanum tuberosum	33.15	5.00e-54	204.00
IUUC-Sar-113761	Sorex araneus	51.04	6.00e-146	509.00
IUUC-Sre-114929	Sporisorium reilianum	73.01	0.00e+00	934.00
IUUC-Ssc-116413	Sus scrofa	47.04	4.00e-133	466.00
IUUC-Tgu-116632	Taeniopygia guttata	47.12	1.00e-156	545.00
IUUC-Tru-118610	Takifugu rubripes	53.32	5.00e-149	520.00
IUUC-Tsy-119492	Tarsius syrichta	52.49	3.00e-143	501.00
IUUC-Tni-119993	Tetraodon nigroviridis	47.11	2.00e-146	511.00
IUUC-Tre-122203	Trichoderma reesei	61.69	0.00e+00	845.00
IUUC-Tvi-122595	Trichoderma virens	61.00	0.00e+00	852.00
IUUC-Tme-126897	Tuber melanosporum	79.12	0.00e+00	809.00
IUUC-Tbe-127793	Tupaia belangeri	47.41	1.00e-132	465.00
IUUC-Ttr-128235	Tursiops truncatus	52.28	2.00e-143	501.00
IUUC-Uma-129332	Ustilago maydis	72.80	0.00e+00	903.00
IUUC-Vda-129753	Verticillium dahliae	60.79	0.00e+00	868.00
IUUC-Vpa-130503	Vicugna pacos	52.39	9.00e-139	486.00
IUUC-Xtr-132859	Xenopus tropicalis	52.49	1.00e-144	505.00
IUUC-Xma-133797	Xiphophorus maculatus	52.28	6.00e-144	503.00
IUUC-Yli-134668	Yarrowia lipolytica	69.61	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence