iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
265		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShlealledkkelqrlkavsakskddlvaqgfaeftiedfhntfmdlieqvergtsateLLASFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts +lq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++ ++f e + +
   Q: 170  YLVVYLRLLTSGHLQRESKFFEHFIEGGQTVKEFCQQEVEPMCKeSDHIHIMALAQALSISIQVEYMDRGE---GGTTNTHVFSEGS-E 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
            +++LlYr+gHYd+L++
   Q: 255  TKVYLLYRPGHYDILYK 271
           ***************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MAAEEPHQQN PEPLESDSEG INSLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLEDKKE LQRLKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG AGGAACCTCA TCAGCAGAAT CCGGAGCCAT TGGAAAGTGA CTCTGAAGGA 60
ATTAACAGTT TGGCCTACGA TGAAGCCATC ATGGCCCAGC AGGACCGAAT TCAGCAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Afl-008439	Aspergillus flavus	32.05	5.00e-09	54.30
IUUC-Cel-018295	Caenorhabditis elegans	33.70	9.00e-42	163.00
IUUC-Cin-025507	Ciona intestinalis	43.89	1.00e-45	175.00
IUUC-Gma-043712	Glycine max	42.38	3.00e-52	198.00
IUUC-Mtr-057712	Medicago truncatula	42.75	6.00e-48	184.00
IUUC-Mvi-060358	Microbotryum violaceum	35.54	2.00e-15	76.30
IUUC-Mac-065274	Musa acuminata	37.60	9.00e-41	160.00
IUUC-Pop-099401	Populus trichocarpa	40.34	3.00e-49	188.00
IUUC-Ppe-101977	Prunus persica	42.01	8.00e-53	200.00
IUUC-Sly-111640	Solanum lycopersicum	42.75	9.00e-51	193.00
IUUC-Tca-121467	Theobroma cacao	42.28	5.00e-52	197.00
IUUC-Vvi-131389	Vitis vinifera	43.75	2.00e-54	205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence