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Tag Content
iUUCD ID IUUC-Bta-012789
Ensembl Protein ID ENSBTAP00000042616.3
UniProt Accession A6QLA0; NFX1_BOVIN
Genbank Protein ID AAI47891.1
Protein Name Transcriptional repressor NF-X1; Nuclear transcription factor, X box-binding protein 1
Genbank Nucleotide ID BC147890
Gene Name NFX1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000012385.5 ENSBTAT00000045206.3 ENSBTAP00000042616.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 90.18 0.00e+00 2003.00 IUUC-Hsa-046870
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination (By similarity).
 Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination (By similarity).
Protein Sequence
(Fasta)
MAEAPPVSGA FKFNTDAAEF IPQERKNSGL YCGSQRRLDS NRIGRRNYSS PPPCHLSRQI 60
SYDDISAVHQ HSFYPSGSKP KSQQTSFQSS VTNKSLKNHG LQNQPWQKLR SEKQHIRVKR 120
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Protein Fasta Sequence


>IUUC-Bta-012789|E3,RING|Bos taurus
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Nucleotide Sequence
(Fasta)
ACATGACCGG GTGACAGCGC TCGCTGGGCT GCAGGGCTCG CTTTAGGTGT TGCGGCACGG 60
GATGGCGGAG GCGCCTCCTG TCTCAGGTAC TGTACCGGCC CTCGCAGGAC TGGGCCCCTT 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012789|E3,RING|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034078--NFX1_fam
IPR001374--R3H_dom
IPR034076--R3H_NF-X1
IPR019786--Zinc_finger_PHD-type_CS
IPR000967--Znf_NFX1
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
PROSITE

PS51061--R3H
PS50089--ZF_RING_2
Pfam

PF01424--R3H
PF01422--zf-NF-X1
SMART

SM00393--R3H
SM00184--RING
SM00438--ZnF_NFX
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0045347--P:negative regulation of MHC class II biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG bta:515680
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000224 Aegilops tauschii 38.04 6.00e-83 301.00
IUUC-Aml-001716 Ailuropoda melanoleuca 91.34 0.00e+00 2009.00
IUUC-Atr-002895 Amborella trichopoda 37.18 1.00e-135 477.00
IUUC-Apl-003650 Anas platyrhynchos 59.01 0.00e+00 1211.00
IUUC-Aca-004313 Anolis carolinensis 59.66 0.00e+00 1283.00
IUUC-Aly-006515 Arabidopsis lyrata 37.93 1.00e-130 461.00
IUUC-Ath-007056 Arabidopsis thaliana 37.81 9.00e-130 458.00
IUUC-Ago-007777 Ashbya gossypii 32.00 4.00e-87 316.00
IUUC-Acl-008068 Aspergillus clavatus 34.96 5.00e-82 299.00
IUUC-Afl-008499 Aspergillus flavus 36.65 8.00e-48 184.00
IUUC-Afu-009016 Aspergillus fumigatus 32.56 2.00e-109 390.00
IUUC-Ani-009477 Aspergillus nidulans 36.36 1.00e-115 411.00
IUUC-Ang-009605 Aspergillus niger 36.11 2.00e-116 414.00
IUUC-Aor-010166 Aspergillus oryzae 35.35 2.00e-53 203.00
IUUC-Ame-010640 Astyanax mexicanus 62.61 0.00e+00 994.00
IUUC-Bgr-012024 Blumeria graminis 32.29 2.00e-101 363.00
IUUC-Bci-013768 Botrytis cinerea 35.35 1.00e-112 401.00
IUUC-Bdi-014723 Brachypodium distachyon 38.64 4.00e-118 419.00
IUUC-Bol-015394 Brassica oleracea 37.25 5.00e-133 469.00
IUUC-Bra-017266 Brassica rapa 37.61 2.00e-131 463.00
IUUC-Cel-018668 Caenorhabditis elegans 40.21 3.00e-151 529.00
IUUC-Cja-019769 Callithrix jacchus 87.82 0.00e+00 1928.00
IUUC-Cfa-020727 Canis familiaris 91.36 0.00e+00 2011.00
IUUC-Cpo-021741 Cavia porcellus 88.48 0.00e+00 1966.00
IUUC-Csa-024054 Chlorocebus sabaeus 90.09 0.00e+00 1994.00
IUUC-Cho-025031 Choloepus hoffmanni 85.47 0.00e+00 1346.00
IUUC-Cin-025164 Ciona intestinalis 43.98 0.00e+00 654.00
IUUC-Csv-026260 Ciona savignyi 46.62 0.00e+00 697.00
IUUC-Cgl-026451 Colletotrichum gloeosporioides 36.14 5.00e-82 299.00
IUUC-Cne-026923 Cryptococcus neoformans 36.32 4.00e-81 296.00
IUUC-Dre-028227 Danio rerio 64.93 0.00e+00 1049.00
IUUC-Dno-029830 Dasypus novemcinctus 86.20 0.00e+00 1904.00
IUUC-Dor-030436 Dipodomys ordii 84.46 0.00e+00 1118.00
IUUC-Dse-031485 Dothistroma septosporum 35.29 8.00e-107 382.00
IUUC-Dme-031875 Drosophila melanogaster 44.15 6.00e-165 575.00
IUUC-Eca-033415 Equus caballus 88.10 0.00e+00 1120.00
IUUC-Eeu-034528 Erinaceus europaeus 87.12 0.00e+00 1006.00
IUUC-Fca-036238 Felis catus 94.32 0.00e+00 1360.00
IUUC-Fal-037124 Ficedula albicollis 60.42 0.00e+00 1263.00
IUUC-Fox-038075 Fusarium oxysporum 29.58 1.00e-05 45.40
IUUC-Fso-038310 Fusarium solani 34.02 3.00e-96 346.00
IUUC-Gmo-039506 Gadus morhua 63.14 0.00e+00 957.00
IUUC-Ggr-039984 Gaeumannomyces graminis 36.20 1.00e-122 434.00
IUUC-Gga-040674 Gallus gallus 74.48 0.00e+00 1126.00
IUUC-Gac-041416 Gasterosteus aculeatus 63.84 0.00e+00 966.00
IUUC-Gma-043625 Glycine max 39.69 4.00e-124 439.00
IUUC-Ggo-045017 Gorilla gorilla 89.69 0.00e+00 1989.00
IUUC-Hsa-046870 Homo sapiens 90.18 0.00e+00 2001.00
IUUC-Hvu-047466 Hordeum vulgare 37.68 4.00e-78 285.00
IUUC-Itr-048703 Ictidomys tridecemlineatus 82.27 0.00e+00 674.00
IUUC-Kpa-049244 Komagataella pastoris 31.54 8.00e-74 271.00
IUUC-Lch-050376 Latimeria chalumnae 57.48 0.00e+00 1179.00
IUUC-Lpe-050955 Leersia perrieri 36.75 2.00e-96 347.00
IUUC-Loc-051948 Lepisosteus oculatus 54.00 0.00e+00 1152.00
IUUC-Lma-052950 Leptosphaeria maculans 35.85 6.00e-105 375.00
IUUC-Laf-054206 Loxodonta africana 87.89 0.00e+00 1265.00
IUUC-Mcc-055005 Macaca mulatta 90.00 0.00e+00 1989.00
IUUC-Meu-056120 Macropus eugenii 60.70 0.00e+00 681.00
IUUC-Mor-057238 Magnaporthe oryzae 34.26 2.00e-112 400.00
IUUC-Mpo-057574 Magnaporthe poae 35.11 1.00e-119 424.00
IUUC-Mtr-057823 Medicago truncatula 38.50 2.00e-116 413.00
IUUC-Mla-058822 Melampsora laricipopulina 34.57 1.00e-97 350.00
IUUC-Mga-059785 Meleagris gallopavo 49.65 2.00e-168 585.00
IUUC-Mvi-060543 Microbotryum violaceum 33.14 1.00e-87 318.00
IUUC-Mmr-060611 Microcebus murinus 88.12 0.00e+00 1921.00
IUUC-Mdo-062719 Monodelphis domestica 70.07 0.00e+00 1503.00
IUUC-Mmu-064376 Mus musculus 86.07 0.00e+00 1864.00
IUUC-Mac-064834 Musa acuminata 35.52 3.00e-104 372.00
IUUC-Mpu-066298 Mustela putorius furo 91.42 0.00e+00 2011.00
IUUC-Mlu-067546 Myotis lucifugus 89.86 0.00e+00 2013.00
IUUC-Nfi-068388 Neosartorya fischeri 32.80 6.00e-115 409.00
IUUC-Ncr-068875 Neurospora crassa 33.94 4.00e-106 379.00
IUUC-Nle-069813 Nomascus leucogenys 89.73 0.00e+00 1989.00
IUUC-Opr-070995 Ochotona princeps 75.59 0.00e+00 1350.00
IUUC-Ont-072084 Oreochromis niloticus 60.27 0.00e+00 1037.00
IUUC-Oan-073545 Ornithorhynchus anatinus 58.41 0.00e+00 1170.00
IUUC-Ocu-074092 Oryctolagus cuniculus 85.45 0.00e+00 1906.00
IUUC-Oba-075828 Oryza barthii 37.54 1.00e-100 361.00
IUUC-Obr-076373 Oryza brachyantha 36.92 3.00e-76 279.00
IUUC-Ogl-077043 Oryza glaberrima 39.01 1.00e-111 397.00
IUUC-Ogu-078647 Oryza glumaepatula 38.64 2.00e-109 390.00
IUUC-Oin-079793 Oryza indica 37.17 6.00e-81 295.00
IUUC-Olo-080815 Oryza longistaminata 37.50 2.00e-101 363.00
IUUC-Ome-081650 Oryza meridionalis 38.40 3.00e-112 400.00
IUUC-Oni-082708 Oryza nivara 38.53 5.00e-113 402.00
IUUC-Opu-084078 Oryza punctata 38.77 7.00e-110 391.00
IUUC-Oru-084549 Oryza rufipogon 38.35 1.00e-112 401.00
IUUC-Osa-086095 Oryza sativa 36.73 3.00e-94 339.00
IUUC-Olu-087617 Ostreococcus lucimarinus 31.25 7.00e-11 62.40
IUUC-Oga-088453 Otolemur garnettii 86.16 0.00e+00 1876.00
IUUC-Oar-089769 Ovis aries 98.03 0.00e+00 2173.00
IUUC-Ptr-090803 Pan troglodytes 90.18 0.00e+00 2001.00
IUUC-Pan-092169 Papio anubis 90.09 0.00e+00 2009.00
IUUC-Psi-094065 Pelodiscus sinensis 62.34 0.00e+00 1391.00
IUUC-Pma-094592 Petromyzon marinus 55.89 0.00e+00 877.00
IUUC-Pno-095016 Phaeosphaeria nodorum 34.06 5.00e-15 75.10
IUUC-Ppa-095597 Physcomitrella patens 36.01 9.00e-125 441.00
IUUC-Pfo-096959 Poecilia formosa 59.55 0.00e+00 1063.00
IUUC-Pab-097732 Pongo abelii 92.97 0.00e+00 1256.00
IUUC-Pop-099062 Populus trichocarpa 38.46 9.00e-131 461.00
IUUC-Pca-100219 Procavia capensis 72.55 0.00e+00 1484.00
IUUC-Ppe-101695 Prunus persica 38.39 7.00e-125 441.00
IUUC-Pva-102402 Pteropus vampyrus 83.74 0.00e+00 1800.00
IUUC-Pgr-103317 Puccinia graminis 30.46 4.00e-89 323.00
IUUC-Ptt-103771 Puccinia triticina 30.18 1.00e-81 298.00
IUUC-Pte-104189 Pyrenophora teres 30.47 3.00e-09 57.00
IUUC-Pyt-104801 Pyrenophora triticirepentis 35.52 2.00e-103 370.00
IUUC-Rno-105721 Rattus norvegicus 86.43 0.00e+00 1904.00
IUUC-Sce-106350 Saccharomyces cerevisiae 30.26 1.00e-84 308.00
IUUC-Sha-106801 Sarcophilus harrisii 69.56 0.00e+00 1494.00
IUUC-Sja-107692 Schizosaccharomyces japonicus 36.33 2.00e-120 427.00
IUUC-Spo-108253 Schizosaccharomyces pombe 37.23 3.00e-118 419.00
IUUC-Ssl-108587 Sclerotinia sclerotiorum 35.94 3.00e-65 243.00
IUUC-Smo-108865 Selaginella moellendorffii 38.96 2.00e-112 399.00
IUUC-Sit-110153 Setaria italica 38.54 2.00e-115 410.00
IUUC-Sly-111638 Solanum lycopersicum 38.44 5.00e-123 435.00
IUUC-Stu-112099 Solanum tuberosum 38.56 8.00e-125 441.00
IUUC-Sar-113030 Sorex araneus 85.17 0.00e+00 652.00
IUUC-Sbi-113944 Sorghum bicolor 38.26 7.00e-118 418.00
IUUC-Sre-115206 Sporisorium reilianum 33.76 1.00e-103 371.00
IUUC-Ssc-115729 Sus scrofa 87.53 0.00e+00 777.00
IUUC-Tgu-117520 Taeniopygia guttata 67.59 0.00e+00 1028.00
IUUC-Tru-118487 Takifugu rubripes 64.77 0.00e+00 1028.00
IUUC-Tsy-119363 Tarsius syrichta 81.52 0.00e+00 1738.00
IUUC-Tca-121813 Theobroma cacao 38.17 5.00e-123 436.00
IUUC-Tre-122248 Trichoderma reesei 35.48 3.00e-104 373.00
IUUC-Tvi-122462 Trichoderma virens 36.59 1.00e-112 400.00
IUUC-Tae-123637 Triticum aestivum 39.15 2.00e-111 397.00
IUUC-Tur-126173 Triticum urartu 38.20 4.00e-101 362.00
IUUC-Tme-127213 Tuber melanosporum 34.94 4.00e-115 409.00
IUUC-Tbe-127399 Tupaia belangeri 89.63 0.00e+00 830.00
IUUC-Ttr-128798 Tursiops truncatus 94.42 0.00e+00 921.00
IUUC-Uma-129421 Ustilago maydis 32.82 3.00e-102 367.00
IUUC-Vda-129863 Verticillium dahliae 31.96 5.00e-101 362.00
IUUC-Vvi-131615 Vitis vinifera 37.39 1.00e-137 484.00
IUUC-Xtr-132309 Xenopus tropicalis 59.17 0.00e+00 1180.00
IUUC-Xma-133235 Xiphophorus maculatus 58.96 0.00e+00 1021.00
IUUC-Yli-134536 Yarrowia lipolytica 31.43 9.00e-91 328.00
IUUC-Zma-135358 Zea mays 38.38 1.00e-111 397.00
Created Date 25-Jun-2017

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