iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049273

Ensembl Protein ID

CAY68974

UniProt Accession

C4R0F0; C4R0F0_KOMPG

Genbank Protein ID

CAY68974.1

Protein Name

Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation

Genbank Nucleotide ID

FN392320

Gene Name

PAS_chr2-1_0354

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr2-1_0354	CAY68974	CAY68974

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-127	422.4	435	766

Active Site

Position(s)	Description	Evidence
735	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gEegld+gGv+ref++lls++++np ++lf+ys  d++tlq+np+sg+ npehl++F+f+Gr++g+ ++++r+ld+++  ++yk++l+
   Q: 435  PEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHDMFNPFYCLFEYSTHDNYTLQINPNSGI-NPEHLNYFKFIGRVVGLGIFHRRFLDAFFVGALYKMILH 534
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ l+d+e vd+e+y+slk+i+en   di++  ldltfs+++e +ge+ +++Lk+gG++i+Vt+eNk eYv+l++e+++++++++q++af +Gfne+ip+
   Q: 535  KKVILQDMEGVDAEFYRSLKWILEN---DITDV-LDLTFSAEDERFGEIVTVDLKEGGRDIEVTEENKMEYVELITEWKIHRRVEQQFKAFMDGFNELIPQ 631
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           el+++F+e+elelli G +++dved+kk+t y+g y+e++++iqwFw+++ e+++e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 632  ELINVFDERELELLIGGIADVDVEDWKKHTDYRG-YQESDEVIQWFWKCVTEWDKEQKARLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGESNQLPK 731
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+ +LP+Y+ +  lk+kL++A+eet gF++
   Q: 732  SHTCFNRVDLPPYKDYGSLKQKLTLAVEETVGFGQ 766
           *********************************96 PP

Organism

Komagataella pastoris

Protein Sequence
(Fasta)

MSALQPMKIT VQVVGADGLY KRDVFRSPDP FAVITVDGAQ TKSTSTAKRT LHPFWNESFE 60
FNCTQNSILA IQIFDQKKFK KKDQGFLGVI NLRIGDVIDL ENDISQSETL TRPLKKSNDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCGCCT TACAACCCAT GAAGATCACT GTTCAAGTGG TGGGTGCCGA TGGGTTATAC 60
AAGAGAGACG TATTTCGGTC ACCAGACCCA TTCGCTGTAA TCACCGTTGA CGGTGCTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ppa:PAS_chr2-1_0354

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	49.23	6.00e-165	572.00
IUUC-Apl-003752	Anas platyrhynchos	47.68	4.00e-167	579.00
IUUC-Aca-005338	Anolis carolinensis	48.97	9.00e-163	565.00
IUUC-Ago-007742	Ashbya gossypii	82.49	0.00e+00	1022.00
IUUC-Acl-008273	Aspergillus clavatus	66.30	0.00e+00	1038.00
IUUC-Afl-008713	Aspergillus flavus	67.12	0.00e+00	1039.00
IUUC-Afu-009103	Aspergillus fumigatus	65.61	0.00e+00	1025.00
IUUC-Ani-009259	Aspergillus nidulans	66.71	0.00e+00	1031.00
IUUC-Ang-009738	Aspergillus niger	65.64	0.00e+00	1035.00
IUUC-Aor-010053	Aspergillus oryzae	77.93	2.00e-143	499.00
IUUC-Ate-010529	Aspergillus terreus	68.00	0.00e+00	1049.00
IUUC-Ame-010601	Astyanax mexicanus	49.83	6.00e-163	565.00
IUUC-Bgr-012148	Blumeria graminis	66.75	0.00e+00	1003.00
IUUC-Bta-012782	Bos taurus	49.83	5.00e-165	572.00
IUUC-Bci-013785	Botrytis cinerea	65.68	0.00e+00	1033.00
IUUC-Cel-018299	Caenorhabditis elegans	47.09	4.00e-153	533.00
IUUC-Cja-018899	Callithrix jacchus	49.83	3.00e-164	570.00
IUUC-Cfa-021226	Canis familiaris	48.40	2.00e-158	551.00
IUUC-Cpo-022073	Cavia porcellus	50.17	4.00e-165	573.00
IUUC-Csa-023252	Chlorocebus sabaeus	49.05	2.00e-164	570.00
IUUC-Cho-024695	Choloepus hoffmanni	49.74	3.00e-165	573.00
IUUC-Cin-025212	Ciona intestinalis	46.48	4.00e-155	540.00
IUUC-Csv-026256	Ciona savignyi	48.21	4.00e-156	542.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	66.54	0.00e+00	1026.00
IUUC-Cne-026849	Cryptococcus neoformans	69.89	0.00e+00	892.00
IUUC-Dre-028809	Danio rerio	48.63	2.00e-160	557.00
IUUC-Dno-029884	Dasypus novemcinctus	49.31	2.00e-163	566.00
IUUC-Dor-030138	Dipodomys ordii	47.39	3.00e-154	537.00
IUUC-Dse-031241	Dothistroma septosporum	67.93	0.00e+00	1065.00
IUUC-Dme-032041	Drosophila melanogaster	47.30	7.00e-152	529.00
IUUC-Ete-032779	Echinops telfairi	45.30	7.00e-146	509.00
IUUC-Eca-033793	Equus caballus	49.66	1.00e-164	571.00
IUUC-Eeu-035247	Erinaceus europaeus	48.24	5.00e-157	546.00
IUUC-Fca-035605	Felis catus	49.23	9.00e-165	572.00
IUUC-Fal-037126	Ficedula albicollis	49.83	6.00e-165	572.00
IUUC-Fox-037774	Fusarium oxysporum	65.88	0.00e+00	1022.00
IUUC-Fso-038393	Fusarium solani	65.66	0.00e+00	1016.00
IUUC-Gmo-039679	Gadus morhua	46.77	2.00e-152	530.00
IUUC-Ggr-040107	Gaeumannomyces graminis	66.00	0.00e+00	1036.00
IUUC-Gga-040832	Gallus gallus	47.34	6.00e-166	575.00
IUUC-Gac-042020	Gasterosteus aculeatus	47.72	5.00e-157	546.00
IUUC-Ggo-045332	Gorilla gorilla	48.40	4.00e-158	550.00
IUUC-Hsa-046564	Homo sapiens	49.40	6.00e-165	572.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	49.66	1.00e-164	571.00
IUUC-Lch-050454	Latimeria chalumnae	49.05	6.00e-164	568.00
IUUC-Loc-052645	Lepisosteus oculatus	48.97	8.00e-158	548.00
IUUC-Lma-052980	Leptosphaeria maculans	62.48	8.00e-174	600.00
IUUC-Laf-054383	Loxodonta africana	49.66	5.00e-165	572.00
IUUC-Mcc-055532	Macaca mulatta	49.05	2.00e-164	570.00
IUUC-Meu-055953	Macropus eugenii	41.58	8.00e-123	432.00
IUUC-Mor-057097	Magnaporthe oryzae	66.58	0.00e+00	1049.00
IUUC-Mpo-057442	Magnaporthe poae	64.57	0.00e+00	945.00
IUUC-Mla-058996	Melampsora laricipopulina	67.51	0.00e+00	898.00
IUUC-Mga-059661	Meleagris gallopavo	50.00	1.00e-165	574.00
IUUC-Mvi-060395	Microbotryum violaceum	80.25	0.00e+00	840.00
IUUC-Mmr-061135	Microcebus murinus	49.83	3.00e-165	573.00
IUUC-Mdo-062505	Monodelphis domestica	49.48	2.00e-164	570.00
IUUC-Mmu-063375	Mus musculus	49.66	1.00e-164	571.00
IUUC-Mpu-066203	Mustela putorius furo	49.40	3.00e-165	573.00
IUUC-Mlu-067837	Myotis lucifugus	49.83	4.00e-165	572.00
IUUC-Nfi-068427	Neosartorya fischeri	67.00	0.00e+00	1041.00
IUUC-Ncr-068918	Neurospora crassa	65.72	0.00e+00	996.00
IUUC-Nle-069244	Nomascus leucogenys	49.40	2.00e-164	570.00
IUUC-Opr-071044	Ochotona princeps	48.24	9.00e-157	545.00
IUUC-Ont-071822	Oreochromis niloticus	46.19	4.00e-164	569.00
IUUC-Oan-073497	Ornithorhynchus anatinus	47.03	2.00e-159	554.00
IUUC-Ocu-074298	Oryctolagus cuniculus	49.83	4.00e-165	572.00
IUUC-Ola-086526	Oryzias latipes	46.30	8.00e-164	568.00
IUUC-Oga-088460	Otolemur garnettii	48.57	2.00e-158	550.00
IUUC-Oar-090198	Ovis aries	48.40	2.00e-158	551.00
IUUC-Ptr-090939	Pan troglodytes	48.23	2.00e-158	550.00
IUUC-Pan-092454	Papio anubis	49.05	3.00e-164	570.00
IUUC-Psi-093645	Pelodiscus sinensis	48.40	8.00e-160	555.00
IUUC-Pma-094364	Petromyzon marinus	52.16	8.00e-143	498.00
IUUC-Pno-095118	Phaeosphaeria nodorum	64.99	0.00e+00	1036.00
IUUC-Pfo-097346	Poecilia formosa	46.27	1.00e-162	565.00
IUUC-Pab-098088	Pongo abelii	48.23	4.00e-158	550.00
IUUC-Pca-100596	Procavia capensis	46.32	2.00e-150	524.00
IUUC-Pva-102354	Pteropus vampyrus	48.57	5.00e-158	549.00
IUUC-Pgr-103620	Puccinia graminis	69.04	0.00e+00	875.00
IUUC-Ptt-103806	Puccinia triticina	78.78	0.00e+00	703.00
IUUC-Pte-104016	Pyrenophora teres	66.59	0.00e+00	1049.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	66.59	0.00e+00	1049.00
IUUC-Rno-104924	Rattus norvegicus	49.66	1.00e-164	571.00
IUUC-Sce-106289	Saccharomyces cerevisiae	83.05	0.00e+00	1022.00
IUUC-Sha-107175	Sarcophilus harrisii	49.05	5.00e-164	569.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	66.24	0.00e+00	1023.00
IUUC-Spo-108171	Schizosaccharomyces pombe	66.92	0.00e+00	1036.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	66.05	0.00e+00	1031.00
IUUC-Stu-112582	Solanum tuberosum	36.03	5.00e-55	207.00
IUUC-Sar-113761	Sorex araneus	49.66	9.00e-164	568.00
IUUC-Sre-114929	Sporisorium reilianum	69.32	0.00e+00	865.00
IUUC-Ssc-115368	Sus scrofa	45.92	3.00e-157	546.00
IUUC-Tgu-116632	Taeniopygia guttata	48.90	1.00e-162	565.00
IUUC-Tru-118442	Takifugu rubripes	48.54	6.00e-163	565.00
IUUC-Tsy-119492	Tarsius syrichta	48.57	8.00e-157	545.00
IUUC-Tni-119993	Tetraodon nigroviridis	47.08	4.00e-153	533.00
IUUC-Tre-122203	Trichoderma reesei	65.63	0.00e+00	1013.00
IUUC-Tvi-122595	Trichoderma virens	65.19	0.00e+00	1020.00
IUUC-Tme-126897	Tuber melanosporum	68.35	0.00e+00	1008.00
IUUC-Tbe-127793	Tupaia belangeri	50.31	3.00e-140	490.00
IUUC-Ttr-128275	Tursiops truncatus	48.71	9.00e-160	555.00
IUUC-Uma-129332	Ustilago maydis	69.15	0.00e+00	830.00
IUUC-Vda-129753	Verticillium dahliae	66.58	0.00e+00	1007.00
IUUC-Vpa-130503	Vicugna pacos	51.79	6.00e-141	493.00
IUUC-Xtr-132859	Xenopus tropicalis	48.74	4.00e-158	549.00
IUUC-Xma-133797	Xiphophorus maculatus	48.07	9.00e-159	552.00
IUUC-Yli-134668	Yarrowia lipolytica	74.44	0.00e+00	966.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence