iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008852

Ensembl Protein ID

CADAFUAP00003713

UniProt Accession

Q4WHR7; Q4WHR7_ASPFU

Genbank Protein ID

EAL87538.1

Protein Name

HECT domain protein

Genbank Nucleotide ID

AAHF01000008

Gene Name

AFUA_2G04450

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00003713	CADAFUAT00003713	CADAFUAP00003713

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-71	238.7	951	1336

Active Site

Position(s)	Description	Evidence
1305	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 14   vgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkk 104
           +gEegld+gGv++ef+  l++e  np++g+f+++++ + +++ +p s     e l  Fe+lG l+ +a+++g  l+++++ +fy++llg k
   Q: 951  EGEEGLDHGGVQQEFFRVLMAEALNPSYGMFTMDARTRISWF-QPCSL----EPLYKFELLGLLMSLAIYNGLTLPVNFPVAFYRKLLGLK 1036
           47*****************************99999888877.66665....679***********************************9 PP
   S: 105  lsl.edleevdpelykslkeikenaes................................................................ 130
           ++  e++ +  pel k l+ +++ ++                                                                 
   Q: 1037 VKHlEHIRDGWPELTKGLELLLSWQDGdvgdvfmrtyeftfevfgavetvdmekvgrdavwplrardrsksselatnwselsqhadpadls 1127
           9877******************99844566667777777778888888888888999999999999999999999**************** PP
   S: 131  ...dieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeele 215
              ++++ ++d+  + s++        +++   p  e   Vtn+N+ ++vk+++ +   ++i+ q+eaf +Gf++ ++   ls+Ft+e ++
   Q: 1128 ppcSMSADHVDFLECGSSHRsksERLDYCVPTPPVEEASLVTNDNRAQFVKDYIFWLTDKSIRPQFEAFARGFYTCLDRAALSIFTPEAFK 1218
           ***77777777766633332222333444445899999***************************************************** PP
   S: 216  llicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCf 305
           +++ G +eid+ +l+++++y+gg+ + +++iq Fw+++++fs+e+++++L+FvT s+r+P++G+a+++   fvi++    d+rlP+s TCf
   Q: 1219 TVVEGIQEIDLGELERHARYEGGFGPHHRVIQDFWSIVKSFSQEKKAQLLEFVTASDRVPVNGIASIM---FVIQRnGVGDARLPTSLTCF 1306
           ********************************************************************...9998857788********** PP
   S: 306  nyLkLPeYsskeilkekLlyAieetkgFel 335
            +L LPeYssk++l+ekL  A e+++gF++
   Q: 1307 GRLLLPEYSSKSVLEEKLNKALENARGFGV 1336
           ****************************86 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MTRLRGASVG SYDAGVDRSQ FHRSKLPSNA PDIIVQNTID VSDPAQVLLW YREERRRQFN 60
LLVRKYKNQL LHGCQDPDCR TPTCASYRRR VSEGPYRRYT ELSARTLACY LASLDNPESG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACTAGGC TCCGCGGAGC TTCAGTGGGC TCGTACGATG CTGGCGTCGA TCGGTCTCAG 60
TTTCATCGGT CTAAGCTTCC TTCAAACGCG CCAGATATCA TCGTTCAGAA CACCATCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

afm:AFUA_2G04450

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Acl-008265	Aspergillus clavatus	71.09	0.00e+00	1748.00
IUUC-Afl-008437	Aspergillus flavus	65.41	0.00e+00	1410.00
IUUC-Ani-009330	Aspergillus nidulans	62.81	0.00e+00	1308.00
IUUC-Ang-009616	Aspergillus niger	64.85	0.00e+00	1658.00
IUUC-Aor-010162	Aspergillus oryzae	64.16	0.00e+00	1613.00
IUUC-Ate-010475	Aspergillus terreus	62.72	0.00e+00	1541.00
IUUC-Bgr-012015	Blumeria graminis	32.62	8.00e-168	582.00
IUUC-Bci-013608	Botrytis cinerea	38.11	2.00e-149	522.00
IUUC-Cgl-026488	Colletotrichum gloeosporioides	36.35	3.00e-134	471.00
IUUC-Dse-031435	Dothistroma septosporum	30.31	3.00e-78	284.00
IUUC-Fox-037915	Fusarium oxysporum	38.33	2.00e-133	468.00
IUUC-Fso-038357	Fusarium solani	39.84	1.00e-125	442.00
IUUC-Ggr-039765	Gaeumannomyces graminis	34.46	2.00e-156	545.00
IUUC-Lma-053245	Leptosphaeria maculans	32.59	4.00e-104	371.00
IUUC-Mor-057108	Magnaporthe oryzae	45.07	1.00e-132	466.00
IUUC-Nfi-068554	Neosartorya fischeri	95.06	0.00e+00	2471.00
IUUC-Ncr-068759	Neurospora crassa	33.60	5.00e-134	470.00
IUUC-Pno-094886	Phaeosphaeria nodorum	34.42	1.00e-126	446.00
IUUC-Pte-104055	Pyrenophora teres	35.32	7.00e-81	293.00
IUUC-Pyt-104647	Pyrenophora triticirepentis	33.04	9.00e-124	436.00
IUUC-Ssl-108420	Sclerotinia sclerotiorum	38.17	2.00e-151	528.00
IUUC-Tre-121985	Trichoderma reesei	39.05	6.00e-137	480.00
IUUC-Tvi-122335	Trichoderma virens	35.82	1.00e-133	469.00
IUUC-Tme-127119	Tuber melanosporum	29.01	2.00e-116	412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence