iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108081

UUCD1 version

UUC-ScP-00186

Ensembl Protein ID

SPAC12B10.01c.1:pep

UniProt Accession

Q10435; O14101; YDE1_SCHPO

Genbank Protein ID

CAA22594.1

Protein Name

Probable ubiquitin fusion degradation protein C12B10.01c; HECT-type E3 ubiquitin transferase C12B10.01c

Genbank Nucleotide ID

CU329670

Gene Name

SPAC12B10.01c; SPAC31F12.02c; SPAC637.15c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC12B10.01c	SPAC12B10.01c.1	SPAC12B10.01c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-75	253.2	1299	1647

Active Site

Position(s)	Description	Evidence
1614	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 5    lkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp...........ehlklFeflGrllgka 81
            ++ le+e+++E g +l G+t+ef++ +ske+  ++l ++++++ +++ ++ ++  +  +p           ++++lF  lG++++ +
   Q: 1299 SENILEIEYEDEVGSGL-GPTLEFYTSVSKEFTLNSLDIWRNDQPNSKFVYQASGLF-PSPipllgsspeneRKISLFFALGQFVARS 1384
           567899***********.**********************99998888766555444.34589999999999**************** PP
   S: 82   lqdgrlldlplsksfyklllgkklsledleevdpelykslkeikena........esdieelgldltfsvseeilgetkeeeLkpgGe 161
           ++d+r++ +++++ f+ +  + +l+++ +++vd+ l++sl +++++         e+di+ ++l+l f+     l+   + eL+p+G+
   Q: 1385 IYDSRIISIQFNPLFFAR--NIPLTISSVAKVDKGLANSLRYLEKLIpgknptnaETDIKLEDLHLDFT-----LPGFPSIELIPDGA 1465
           ****************97..7799********************9999988888888999999999999.....99************ PP
   S: 162  nipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqw 248
           ++pVt  N ++Y + v++y++ +g+++q+eaf++Gf++v+p ++l+++te+el +l     e+++  +l k +  ++gyt +sp+iq+
   Q: 1466 STPVTTFNVSDYLNYVIDYTVGKGVQQQLEAFQNGFSSVFPYTSLQVLTEHELVTLFGTVdEDWSYATLMKSIVADHGYTMESPTIQR 1553
           *****************************************************998877789************************** PP
   S: 249  FwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet. 330
           ++  +++++ +e+++fLqF+Tgs +lP+gGfa l+p l+v+r+     +  dd lPs++TC+nyLkLPeYss e+l ++L  Ai e+ 
   Q: 1554 LLTLMSQMNFQEQRDFLQFITGSRKLPIGGFAGLNPPLTVVRRlneppYVPDDYLPSVMTCVNYLKLPEYSSSEVLGSRLSKAILEGq 1641
           *********************************************9999999***********************************9 PP
   S: 331  kgFels 336
            +F+ls
   Q: 1642 GSFHLS 1647
           999985 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSVQAYTNTP NLPNLIHSES ITNSPVFIPN LRSKSDNKHR LNTSEELPFT KKRRATKHFL 60
KMEVSAKISE PPSSKSVEFG RHLNMRHDFS ELLEQPLTTS KTRVFKSFNE KLKGKPQLVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACGCTTTT GCCATCTCCC TATGTCAACA GCACATTCCG CCTTAAACAA GAGATCATAG 60
AAGGATCAAA TTAAAACTGG GATTTTGTCT CCTTGGTTCA GAAATTACTT GATTGTTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination

KEGG

spo:SPAC12B10.01c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.00	5.00e-89	321.00
IUUC-Aml-001502	Ailuropoda melanoleuca	38.54	3.00e-95	342.00
IUUC-Atr-002821	Amborella trichopoda	36.90	5.00e-86	311.00
IUUC-Apl-003531	Anas platyrhynchos	37.12	1.00e-88	320.00
IUUC-Aca-004521	Anolis carolinensis	36.77	2.00e-36	147.00
IUUC-Aly-005962	Arabidopsis lyrata	37.99	2.00e-89	322.00
IUUC-Ath-006636	Arabidopsis thaliana	37.84	2.00e-88	319.00
IUUC-Ago-007875	Ashbya gossypii	44.94	5.00e-107	380.00
IUUC-Acl-008242	Aspergillus clavatus	51.94	3.00e-139	488.00
IUUC-Afl-008736	Aspergillus flavus	50.82	2.00e-136	479.00
IUUC-Afu-008812	Aspergillus fumigatus	51.94	7.00e-139	487.00
IUUC-Ani-009407	Aspergillus nidulans	44.08	3.00e-133	468.00
IUUC-Ang-009763	Aspergillus niger	42.05	7.00e-126	444.00
IUUC-Aor-009941	Aspergillus oryzae	40.22	4.00e-150	524.00
IUUC-Ate-010459	Aspergillus terreus	41.92	2.00e-109	389.00
IUUC-Ame-011761	Astyanax mexicanus	39.96	5.00e-98	351.00
IUUC-Bgr-012265	Blumeria graminis	42.83	3.00e-131	461.00
IUUC-Bta-013070	Bos taurus	37.26	3.00e-95	342.00
IUUC-Bci-013890	Botrytis cinerea	49.39	9.00e-128	450.00
IUUC-Bdi-014046	Brachypodium distachyon	37.00	6.00e-89	321.00
IUUC-Bol-015942	Brassica oleracea	38.70	1.00e-90	327.00
IUUC-Bra-016849	Brassica rapa	38.11	8.00e-90	324.00
IUUC-Cel-018153	Caenorhabditis elegans	31.10	3.00e-63	236.00
IUUC-Cja-019046	Callithrix jacchus	38.54	3.00e-95	342.00
IUUC-Cfa-020521	Canis familiaris	38.34	7.00e-95	341.00
IUUC-Cpo-021639	Cavia porcellus	38.74	3.00e-95	342.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	35.63	1.00e-81	295.00
IUUC-Csa-023231	Chlorocebus sabaeus	38.54	4.00e-95	342.00
IUUC-Cho-024380	Choloepus hoffmanni	34.69	5.00e-78	285.00
IUUC-Cin-025482	Ciona intestinalis	36.16	7.00e-90	322.00
IUUC-Csv-026121	Ciona savignyi	36.03	3.00e-88	318.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	46.66	1.00e-142	499.00
IUUC-Cne-026857	Cryptococcus neoformans	41.39	3.00e-112	398.00
IUUC-Cme-027226	Cyanidioschyzon merolae	30.28	8.00e-63	234.00
IUUC-Dre-028174	Danio rerio	40.04	1.00e-97	350.00
IUUC-Dno-029954	Dasypus novemcinctus	36.77	3.00e-37	150.00
IUUC-Dor-030939	Dipodomys ordii	33.46	9.00e-77	281.00
IUUC-Dse-031444	Dothistroma septosporum	48.36	2.00e-132	465.00
IUUC-Dme-032162	Drosophila melanogaster	38.72	7.00e-52	198.00
IUUC-Ete-032345	Echinops telfairi	30.99	3.00e-65	242.00
IUUC-Eca-033229	Equus caballus	38.54	3.00e-95	342.00
IUUC-Eeu-035205	Erinaceus europaeus	38.34	1.00e-92	333.00
IUUC-Fca-036444	Felis catus	38.54	3.00e-95	342.00
IUUC-Fal-037131	Ficedula albicollis	38.74	1.00e-96	347.00
IUUC-Fox-038035	Fusarium oxysporum	45.56	5.00e-138	483.00
IUUC-Fso-038320	Fusarium solani	45.56	1.00e-137	483.00
IUUC-Gmo-039497	Gadus morhua	39.76	4.00e-98	351.00
IUUC-Ggr-040057	Gaeumannomyces graminis	44.75	1.00e-134	473.00
IUUC-Gga-041021	Gallus gallus	38.74	1.00e-96	347.00
IUUC-Gac-042474	Gasterosteus aculeatus	40.16	5.00e-99	355.00
IUUC-Gma-043715	Glycine max	36.99	2.00e-85	309.00
IUUC-Ggo-044855	Gorilla gorilla	38.54	4.00e-95	342.00
IUUC-Hsa-046147	Homo sapiens	38.54	4.00e-95	341.00
IUUC-Hvu-047811	Hordeum vulgare	27.94	2.00e-117	415.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	38.54	8.00e-96	344.00
IUUC-Kpa-049098	Komagataella pastoris	36.22	9.00e-117	413.00
IUUC-Lch-049818	Latimeria chalumnae	37.12	2.00e-94	340.00
IUUC-Lpe-051017	Leersia perrieri	35.11	4.00e-85	308.00
IUUC-Loc-051777	Lepisosteus oculatus	39.15	3.00e-98	352.00
IUUC-Lma-052990	Leptosphaeria maculans	47.88	4.00e-137	481.00
IUUC-Laf-053727	Loxodonta africana	38.74	2.00e-95	342.00
IUUC-Mcc-055799	Macaca mulatta	38.54	2.00e-95	342.00
IUUC-Meu-056065	Macropus eugenii	34.43	4.00e-70	258.00
IUUC-Mor-057054	Magnaporthe oryzae	45.34	1.00e-135	476.00
IUUC-Mpo-057417	Magnaporthe poae	45.08	3.00e-134	471.00
IUUC-Mtr-057849	Medicago truncatula	39.18	1.00e-90	327.00
IUUC-Mla-058870	Melampsora laricipopulina	44.40	2.00e-105	375.00
IUUC-Mga-059409	Meleagris gallopavo	37.67	3.00e-38	153.00
IUUC-Mvi-060507	Microbotryum violaceum	37.76	5.00e-114	404.00
IUUC-Mmr-060816	Microcebus murinus	38.62	6.00e-96	344.00
IUUC-Mdo-062866	Monodelphis domestica	34.81	3.00e-71	262.00
IUUC-Mmu-063906	Mus musculus	38.34	3.00e-94	338.00
IUUC-Mac-065046	Musa acuminata	27.29	1.00e-114	405.00
IUUC-Mpu-066199	Mustela putorius furo	38.54	2.00e-95	343.00
IUUC-Mlu-067110	Myotis lucifugus	38.62	4.00e-95	342.00
IUUC-Nfi-068482	Neosartorya fischeri	51.74	3.00e-138	485.00
IUUC-Ncr-068906	Neurospora crassa	45.47	5.00e-138	484.00
IUUC-Nle-069410	Nomascus leucogenys	38.54	4.00e-95	342.00
IUUC-Opr-070401	Ochotona princeps	44.17	2.00e-43	170.00
IUUC-Ont-072100	Oreochromis niloticus	40.04	7.00e-99	354.00
IUUC-Oan-073121	Ornithorhynchus anatinus	38.82	2.00e-95	343.00
IUUC-Ocu-074623	Oryctolagus cuniculus	38.54	1.00e-95	343.00
IUUC-Oba-075380	Oryza barthii	34.10	2.00e-88	318.00
IUUC-Obr-076904	Oryza brachyantha	27.52	2.00e-108	385.00
IUUC-Ogl-076926	Oryza glaberrima	34.10	4.00e-88	318.00
IUUC-Ogu-078892	Oryza glumaepatula	34.10	2.00e-88	319.00
IUUC-Oin-079148	Oryza indica	33.18	4.00e-84	304.00
IUUC-Olo-081086	Oryza longistaminata	33.38	1.00e-84	306.00
IUUC-Ome-081422	Oryza meridionalis	35.51	2.00e-84	306.00
IUUC-Oni-083047	Oryza nivara	34.10	3.00e-90	325.00
IUUC-Opu-083641	Oryza punctata	27.41	3.00e-119	421.00
IUUC-Oru-084439	Oryza rufipogon	34.10	2.00e-88	318.00
IUUC-Osa-085617	Oryza sativa	38.68	4.00e-87	313.00
IUUC-Ola-087173	Oryzias latipes	39.21	5.00e-98	351.00
IUUC-Olu-087871	Ostreococcus lucimarinus	34.08	2.00e-77	281.00
IUUC-Oga-087908	Otolemur garnettii	38.34	3.00e-94	339.00
IUUC-Oar-090277	Ovis aries	37.26	2.00e-95	343.00
IUUC-Ptr-091543	Pan troglodytes	38.54	3.00e-95	342.00
IUUC-Pan-092243	Papio anubis	38.54	2.00e-95	342.00
IUUC-Psi-093150	Pelodiscus sinensis	38.74	4.00e-96	345.00
IUUC-Pno-094891	Phaeosphaeria nodorum	47.98	8.00e-135	473.00
IUUC-Ppa-095181	Physcomitrella patens	38.41	9.00e-85	306.00
IUUC-Pfo-096267	Poecilia formosa	39.76	1.00e-97	350.00
IUUC-Pab-098072	Pongo abelii	38.54	3.00e-95	342.00
IUUC-Pop-099541	Populus trichocarpa	38.88	1.00e-88	320.00
IUUC-Pca-100311	Procavia capensis	37.64	1.00e-95	343.00
IUUC-Ppe-101284	Prunus persica	36.13	4.00e-89	322.00
IUUC-Pva-102215	Pteropus vampyrus	34.69	3.00e-78	285.00
IUUC-Pgr-103694	Puccinia graminis	39.24	1.00e-109	389.00
IUUC-Ptt-103916	Puccinia triticina	38.55	3.00e-102	365.00
IUUC-Pte-104346	Pyrenophora teres	49.62	6.00e-138	483.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	50.19	5.00e-138	484.00
IUUC-Rno-105315	Rattus norvegicus	38.54	4.00e-95	342.00
IUUC-Sce-106273	Saccharomyces cerevisiae	28.35	8.00e-118	416.00
IUUC-Sha-106835	Sarcophilus harrisii	38.62	2.00e-95	343.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	46.43	0.00e+00	1106.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	44.08	4.00e-132	464.00
IUUC-Smo-108776	Selaginella moellendorffii	38.25	2.00e-90	326.00
IUUC-Sit-110717	Setaria italica	36.31	1.00e-90	327.00
IUUC-Sly-111557	Solanum lycopersicum	37.52	3.00e-88	318.00
IUUC-Stu-112896	Solanum tuberosum	37.13	2.00e-78	285.00
IUUC-Sar-113224	Sorex araneus	40.00	6.00e-71	261.00
IUUC-Sbi-114106	Sorghum bicolor	27.47	2.00e-113	402.00
IUUC-Sre-114993	Sporisorium reilianum	43.09	9.00e-112	397.00
IUUC-Ssc-115535	Sus scrofa	35.55	4.00e-80	292.00
IUUC-Tgu-117167	Taeniopygia guttata	37.67	4.00e-38	152.00
IUUC-Tru-118669	Takifugu rubripes	40.37	3.00e-98	352.00
IUUC-Tsy-119373	Tarsius syrichta	30.99	1.00e-55	211.00
IUUC-Tni-120049	Tetraodon nigroviridis	53.24	1.00e-36	145.00
IUUC-Tca-121779	Theobroma cacao	35.40	4.00e-86	311.00
IUUC-Tre-122195	Trichoderma reesei	45.34	2.00e-138	485.00
IUUC-Tvi-122650	Trichoderma virens	43.23	3.00e-138	485.00
IUUC-Tae-123120	Triticum aestivum	37.55	7.00e-89	321.00
IUUC-Tur-126295	Triticum urartu	36.80	4.00e-87	315.00
IUUC-Tme-126964	Tuber melanosporum	44.01	2.00e-133	468.00
IUUC-Tbe-128149	Tupaia belangeri	29.57	7.00e-56	211.00
IUUC-Ttr-128165	Tursiops truncatus	38.54	2.00e-95	343.00
IUUC-Uma-129365	Ustilago maydis	43.57	2.00e-100	359.00
IUUC-Vda-129725	Verticillium dahliae	45.39	7.00e-138	483.00
IUUC-Vpa-130678	Vicugna pacos	38.54	3.00e-95	342.00
IUUC-Vvi-131539	Vitis vinifera	37.38	1.00e-86	313.00
IUUC-Xtr-132636	Xenopus tropicalis	38.99	2.00e-94	339.00
IUUC-Xma-133458	Xiphophorus maculatus	39.76	1.00e-97	350.00
IUUC-Yli-134481	Yarrowia lipolytica	41.43	9.00e-119	420.00
IUUC-Zma-135657	Zea mays	36.80	4.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence