iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062505

UUCD1 version

UUC-MoD-00479

Ensembl Protein ID

ENSMODP00000003323.3

UniProt Accession

F6Z7A1; F6Z7A1_MONDO

Protein Name

Uncharacterized protein

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002732.3	ENSMODT00000003392.3	ENSMODP00000003323.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.50e-137	456.8	568	900

Active Site

Position(s)	Description	Evidence
869	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 568  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 655
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k++eLkp+G+ni Vt+eNkeeY++ v+e
   Q: 656  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHELKPNGSNILVTEENKEEYIRMVAE 741
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 742  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 829
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 830  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 900
           *********************************************************************96 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MRGASSFHPD PVLSQILWGI PSQVHSPVGG MSGSSSRSGS VGGLTMKSQL QIIVISAKLK 60
ENKKNWFGPS PYVEVSVDGQ SKKTEKCSNT NSPKWKQPLT VIVTPISKLN FRVWSHQTLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATGAAATA TTAAAAGACC TAGAGGAAAG TTTCAGTATG TTAGGAGACA ACCTTGTAGA 60
GTATTTATCA AAGAATCTAG ACAAGAATGA CTAAAGATGA GAAGGTATGT TGTCATCTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

KEGG

mdo:100032356

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	88.56	0.00e+00	1495.00
IUUC-Apl-003752	Anas platyrhynchos	86.52	0.00e+00	1489.00
IUUC-Aca-005338	Anolis carolinensis	83.30	0.00e+00	1437.00
IUUC-Ago-007742	Ashbya gossypii	48.54	7.00e-162	564.00
IUUC-Ame-010601	Astyanax mexicanus	87.65	0.00e+00	1123.00
IUUC-Bgr-012148	Blumeria graminis	46.02	2.00e-150	526.00
IUUC-Bta-012782	Bos taurus	87.11	0.00e+00	1471.00
IUUC-Cja-018899	Callithrix jacchus	84.11	0.00e+00	1456.00
IUUC-Cfa-020648	Canis familiaris	87.68	0.00e+00	1460.00
IUUC-Cpo-022073	Cavia porcellus	88.73	0.00e+00	1512.00
IUUC-Csa-023252	Chlorocebus sabaeus	87.69	0.00e+00	1495.00
IUUC-Cho-024695	Choloepus hoffmanni	81.93	0.00e+00	1444.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.37	5.00e-155	541.00
IUUC-Cne-026849	Cryptococcus neoformans	47.46	2.00e-158	553.00
IUUC-Dre-028451	Danio rerio	75.17	0.00e+00	1301.00
IUUC-Dno-029884	Dasypus novemcinctus	88.39	0.00e+00	1503.00
IUUC-Eca-033793	Equus caballus	87.87	0.00e+00	1489.00
IUUC-Eeu-034716	Erinaceus europaeus	92.58	0.00e+00	885.00
IUUC-Fca-035605	Felis catus	89.42	0.00e+00	1515.00
IUUC-Fal-037126	Ficedula albicollis	87.43	0.00e+00	1481.00
IUUC-Fso-038393	Fusarium solani	46.87	7.00e-153	534.00
IUUC-Gmo-038596	Gadus morhua	80.79	0.00e+00	1007.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.68	5.00e-154	538.00
IUUC-Gga-040832	Gallus gallus	87.66	0.00e+00	1511.00
IUUC-Gac-041658	Gasterosteus aculeatus	84.58	0.00e+00	1125.00
IUUC-Ggo-044535	Gorilla gorilla	84.24	0.00e+00	1472.00
IUUC-Hsa-046564	Homo sapiens	84.15	0.00e+00	1489.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	87.22	0.00e+00	1474.00
IUUC-Kpa-049273	Komagataella pastoris	48.88	4.00e-163	568.00
IUUC-Lch-050454	Latimeria chalumnae	80.28	0.00e+00	1409.00
IUUC-Loc-052647	Lepisosteus oculatus	74.40	0.00e+00	1343.00
IUUC-Laf-054383	Loxodonta africana	89.08	0.00e+00	1512.00
IUUC-Mcc-055532	Macaca mulatta	87.69	0.00e+00	1497.00
IUUC-Mor-057097	Magnaporthe oryzae	47.36	7.00e-155	541.00
IUUC-Mga-059661	Meleagris gallopavo	87.54	0.00e+00	1495.00
IUUC-Mvi-060395	Microbotryum violaceum	50.83	1.00e-147	516.00
IUUC-Mmr-061135	Microcebus murinus	88.01	0.00e+00	1524.00
IUUC-Mmu-063375	Mus musculus	87.72	0.00e+00	1493.00
IUUC-Mpu-066203	Mustela putorius furo	89.65	0.00e+00	1497.00
IUUC-Mlu-067837	Myotis lucifugus	87.76	0.00e+00	1484.00
IUUC-Nle-069244	Nomascus leucogenys	86.96	0.00e+00	1483.00
IUUC-Opr-070585	Ochotona princeps	83.59	0.00e+00	1456.00
IUUC-Ont-071798	Oreochromis niloticus	88.76	0.00e+00	1144.00
IUUC-Oan-073679	Ornithorhynchus anatinus	67.11	0.00e+00	978.00
IUUC-Ocu-074298	Oryctolagus cuniculus	88.88	0.00e+00	1518.00
IUUC-Ola-086526	Oryzias latipes	84.23	0.00e+00	1122.00
IUUC-Oga-088167	Otolemur garnettii	81.50	0.00e+00	1380.00
IUUC-Oar-090316	Ovis aries	71.15	0.00e+00	1111.00
IUUC-Ptr-090819	Pan troglodytes	83.35	0.00e+00	1451.00
IUUC-Pan-092454	Papio anubis	87.69	0.00e+00	1496.00
IUUC-Psi-093319	Pelodiscus sinensis	85.20	0.00e+00	1452.00
IUUC-Pfo-097346	Poecilia formosa	87.29	0.00e+00	1106.00
IUUC-Pab-097580	Pongo abelii	77.61	0.00e+00	1332.00
IUUC-Pca-100923	Procavia capensis	76.84	0.00e+00	1219.00
IUUC-Pva-103209	Pteropus vampyrus	87.67	0.00e+00	1442.00
IUUC-Pgr-103620	Puccinia graminis	51.04	5.00e-145	508.00
IUUC-Rno-104924	Rattus norvegicus	87.02	0.00e+00	1484.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.81	1.00e-161	563.00
IUUC-Sha-107175	Sarcophilus harrisii	95.11	0.00e+00	1622.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	45.78	9.00e-159	553.00
IUUC-Sar-113761	Sorex araneus	91.50	0.00e+00	1204.00
IUUC-Sre-114929	Sporisorium reilianum	45.91	1.00e-149	523.00
IUUC-Tgu-116632	Taeniopygia guttata	80.63	0.00e+00	1345.00
IUUC-Tru-118442	Takifugu rubripes	89.27	0.00e+00	1124.00
IUUC-Tsy-119198	Tarsius syrichta	81.72	0.00e+00	1357.00
IUUC-Tni-120168	Tetraodon nigroviridis	87.30	0.00e+00	1061.00
IUUC-Tre-122203	Trichoderma reesei	46.01	6.00e-149	521.00
IUUC-Tbe-127756	Tupaia belangeri	69.78	0.00e+00	1155.00
IUUC-Ttr-128504	Tursiops truncatus	80.75	0.00e+00	1039.00
IUUC-Vda-129753	Verticillium dahliae	46.43	1.00e-153	536.00
IUUC-Vpa-130103	Vicugna pacos	73.53	0.00e+00	1244.00
IUUC-Xtr-132885	Xenopus tropicalis	77.61	0.00e+00	1388.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence