iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sre-114929

Ensembl Protein ID

CBQ68081

UniProt Accession

E6ZL78; E6ZL78_SPORE

Genbank Protein ID

CBQ68081.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

FQ311430

Gene Name

sr11946

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
sr11946	CBQ68081	CBQ68081

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.30e-125	414.9	519	850

Active Site

Position(s)	Description	Evidence
819	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr+lg+a++++r+ld+ +  sfyk++l+
   Q: 519  PNDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLNYFKFIGRVLGLAIFHRRFLDAYFIVSFYKMILK 618
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk++l+dle+vd+++++sl+++++n   +ie + ++ tf++ e+++ge+ ++eLkpgGe+++Vt eNk++Yv+l++e+r+ ++++eq++af +Gf+e+ip+
   Q: 619  KKITLSDLESVDADYHRSLQWMLDN---SIEGI-VEETFTAVEDKFGEMVTVELKPGGEEVEVTDENKKDYVDLMTEWRISKRVEEQFKAFISGFTELIPQ 715
           ***********************99...89998.999**************************************************************** PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G++eidv+d+kk+t y+g +te+++++qwFw++++++  e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 716  DLINVFDERELELLIGGMSEIDVDDWKKFTDYRG-FTEQDQVVQWFWQCVRAWPTEKKSRLLQFATGTSRIPVNGFKDLQgsdgPRRFTIEKSGDVNQLPK 815
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+++LP+Y+s e+l++kL +Aiee+ gF+ 
   Q: 816  SHTCFNRIDLPPYPSFETLESKLALAIEEGMGFGN 850
           *********************************85 PP

Organism

Sporisorium reilianum

Protein Sequence
(Fasta)

MVNPRSPGSL SRKIRITVVA ADGLAKRDVF RLPDPFAIVT VDGEQTHSTS VIKKTLNPYW 60
NDSFDVNVTD SSVIAVQIFD QKKFKKRDQG FLGVINIRVA DVLDLELGGK RLLNKELKKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCAACC CCCGCAGCCC CGGCAGTCTC TCGAGAAAGA TCCGCATCAC CGTCGTCGCT 60
GCTGACGGCC TGGCCAAGCG CGACGTCTTT CGTCTTCCCG ATCCCTTCGC CATCGTCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	47.29	1.00e-157	549.00
IUUC-Apl-003886	Anas platyrhynchos	48.15	9.00e-155	539.00
IUUC-Aca-005388	Anolis carolinensis	46.51	3.00e-149	521.00
IUUC-Ago-007742	Ashbya gossypii	68.01	0.00e+00	861.00
IUUC-Acl-008273	Aspergillus clavatus	71.19	0.00e+00	892.00
IUUC-Afl-008713	Aspergillus flavus	63.56	0.00e+00	1016.00
IUUC-Afu-009103	Aspergillus fumigatus	62.83	0.00e+00	999.00
IUUC-Ani-009259	Aspergillus nidulans	63.12	0.00e+00	1019.00
IUUC-Ang-009738	Aspergillus niger	64.34	0.00e+00	1042.00
IUUC-Aor-010053	Aspergillus oryzae	73.58	2.00e-138	483.00
IUUC-Ate-010529	Aspergillus terreus	72.13	0.00e+00	893.00
IUUC-Ame-011081	Astyanax mexicanus	46.44	1.00e-153	535.00
IUUC-Bgr-012148	Blumeria graminis	62.82	0.00e+00	988.00
IUUC-Bta-012453	Bos taurus	51.86	3.00e-141	494.00
IUUC-Bci-013785	Botrytis cinerea	71.69	0.00e+00	895.00
IUUC-Cel-018299	Caenorhabditis elegans	45.32	4.00e-150	523.00
IUUC-Cja-019448	Callithrix jacchus	46.94	1.00e-148	518.00
IUUC-Cfa-020258	Canis familiaris	47.24	9.00e-158	549.00
IUUC-Cpo-021648	Cavia porcellus	46.67	3.00e-154	537.00
IUUC-Csa-023334	Chlorocebus sabaeus	47.18	6.00e-156	543.00
IUUC-Cho-024695	Choloepus hoffmanni	47.19	5.00e-157	546.00
IUUC-Cin-025212	Ciona intestinalis	45.50	1.00e-151	528.00
IUUC-Csv-026256	Ciona savignyi	45.69	6.00e-151	525.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	71.07	0.00e+00	876.00
IUUC-Cne-026849	Cryptococcus neoformans	76.22	0.00e+00	949.00
IUUC-Dre-028809	Danio rerio	46.69	9.00e-157	545.00
IUUC-Dno-029618	Dasypus novemcinctus	46.43	4.00e-149	520.00
IUUC-Dor-030176	Dipodomys ordii	46.43	2.00e-152	531.00
IUUC-Dse-031241	Dothistroma septosporum	63.73	0.00e+00	1042.00
IUUC-Dme-032041	Drosophila melanogaster	44.83	2.00e-145	508.00
IUUC-Ete-032779	Echinops telfairi	44.56	2.00e-137	481.00
IUUC-Eca-033441	Equus caballus	46.32	7.00e-152	529.00
IUUC-Eeu-035247	Erinaceus europaeus	46.58	3.00e-151	527.00
IUUC-Fal-037335	Ficedula albicollis	46.85	7.00e-150	523.00
IUUC-Fox-037774	Fusarium oxysporum	61.46	0.00e+00	991.00
IUUC-Fso-038393	Fusarium solani	61.89	0.00e+00	982.00
IUUC-Gmo-039679	Gadus morhua	47.45	3.00e-151	527.00
IUUC-Ggr-040107	Gaeumannomyces graminis	70.95	0.00e+00	881.00
IUUC-Gga-040524	Gallus gallus	47.52	9.00e-153	532.00
IUUC-Gac-041520	Gasterosteus aculeatus	47.72	3.00e-155	540.00
IUUC-Ggo-045001	Gorilla gorilla	46.77	3.00e-148	517.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	46.09	2.00e-148	518.00
IUUC-Kpa-049273	Komagataella pastoris	68.95	0.00e+00	874.00
IUUC-Lch-050398	Latimeria chalumnae	46.68	1.00e-148	519.00
IUUC-Loc-052116	Lepisosteus oculatus	45.76	6.00e-153	533.00
IUUC-Lma-052980	Leptosphaeria maculans	60.99	4.00e-169	585.00
IUUC-Laf-053551	Loxodonta africana	45.92	1.00e-147	515.00
IUUC-Mcc-055585	Macaca mulatta	47.29	1.00e-157	549.00
IUUC-Meu-056436	Macropus eugenii	45.32	1.00e-118	418.00
IUUC-Mor-057097	Magnaporthe oryzae	62.16	0.00e+00	1030.00
IUUC-Mpo-057442	Magnaporthe poae	72.86	0.00e+00	828.00
IUUC-Mla-058996	Melampsora laricipopulina	73.67	0.00e+00	960.00
IUUC-Mga-059362	Meleagris gallopavo	46.95	8.00e-155	539.00
IUUC-Mvi-060395	Microbotryum violaceum	74.92	0.00e+00	916.00
IUUC-Mmr-061061	Microcebus murinus	47.64	5.00e-160	556.00
IUUC-Mdo-062505	Monodelphis domestica	46.80	3.00e-157	547.00
IUUC-Mmu-063202	Mus musculus	46.60	1.00e-148	518.00
IUUC-Mpu-066567	Mustela putorius furo	47.35	2.00e-156	544.00
IUUC-Mlu-067565	Myotis lucifugus	46.74	6.00e-152	529.00
IUUC-Nfi-068427	Neosartorya fischeri	71.69	0.00e+00	897.00
IUUC-Ncr-068918	Neurospora crassa	70.97	0.00e+00	866.00
IUUC-Opr-071054	Ochotona princeps	46.36	1.00e-151	528.00
IUUC-Ont-071822	Oreochromis niloticus	47.36	7.00e-159	552.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.84	1.00e-149	522.00
IUUC-Ocu-074409	Oryctolagus cuniculus	47.95	2.00e-158	552.00
IUUC-Ola-086526	Oryzias latipes	46.63	3.00e-159	554.00
IUUC-Oga-088164	Otolemur garnettii	46.70	6.00e-155	539.00
IUUC-Oar-090198	Ovis aries	46.74	3.00e-152	530.00
IUUC-Pan-092117	Papio anubis	46.94	1.00e-148	519.00
IUUC-Psi-093645	Pelodiscus sinensis	46.32	2.00e-152	531.00
IUUC-Pma-094364	Petromyzon marinus	51.65	2.00e-140	491.00
IUUC-Pno-095118	Phaeosphaeria nodorum	62.41	0.00e+00	1038.00
IUUC-Pfo-096937	Poecilia formosa	47.47	3.00e-157	547.00
IUUC-Pab-098494	Pongo abelii	46.43	4.00e-154	536.00
IUUC-Pca-100596	Procavia capensis	44.46	6.00e-147	513.00
IUUC-Pva-102811	Pteropus vampyrus	45.92	4.00e-146	510.00
IUUC-Pgr-103620	Puccinia graminis	73.50	0.00e+00	940.00
IUUC-Ptt-103806	Puccinia triticina	72.08	0.00e+00	796.00
IUUC-Pte-104016	Pyrenophora teres	73.60	0.00e+00	902.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	73.60	0.00e+00	902.00
IUUC-Rno-106125	Rattus norvegicus	46.60	3.00e-148	517.00
IUUC-Sce-106289	Saccharomyces cerevisiae	68.81	0.00e+00	870.00
IUUC-Sha-107175	Sarcophilus harrisii	46.80	2.00e-157	548.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	61.23	0.00e+00	1023.00
IUUC-Spo-108171	Schizosaccharomyces pombe	71.48	0.00e+00	880.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	70.90	0.00e+00	897.00
IUUC-Sar-113761	Sorex araneus	46.52	2.00e-155	541.00
IUUC-Ssc-115368	Sus scrofa	46.10	6.00e-147	513.00
IUUC-Tgu-117130	Taeniopygia guttata	46.41	1.00e-150	525.00
IUUC-Tru-118442	Takifugu rubripes	47.70	2.00e-160	557.00
IUUC-Tsy-119492	Tarsius syrichta	46.58	7.00e-150	523.00
IUUC-Tni-120151	Tetraodon nigroviridis	45.92	2.00e-151	528.00
IUUC-Tre-122203	Trichoderma reesei	63.03	0.00e+00	1000.00
IUUC-Tvi-122595	Trichoderma virens	62.49	0.00e+00	1002.00
IUUC-Tme-126897	Tuber melanosporum	71.53	0.00e+00	843.00
IUUC-Tbe-127793	Tupaia belangeri	48.25	1.00e-135	475.00
IUUC-Ttr-128275	Tursiops truncatus	46.43	5.00e-154	536.00
IUUC-Uma-129332	Ustilago maydis	97.56	0.00e+00	1102.00
IUUC-Vda-129753	Verticillium dahliae	61.20	0.00e+00	977.00
IUUC-Vpa-130503	Vicugna pacos	51.76	3.00e-139	488.00
IUUC-Xtr-132885	Xenopus tropicalis	47.40	8.00e-157	545.00
IUUC-Xma-133987	Xiphophorus maculatus	47.47	7.00e-157	546.00
IUUC-Yli-134668	Yarrowia lipolytica	69.11	0.00e+00	889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence