iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19940128; 19898607; 8781238; 19520858; 19394298

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.60e-10	38.3	349	400

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++             k+ p+ lpCgH+ h++Cl++w        ++++CP+Cr
   Q: 349  CIICMDELihspnqqtwknknKK-PKRLPCGHILHLSCLKNW------MERSQTCPICR 400
           ********999999999888555.999***************......**********8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1. Ubiquitinated substrates are then removed to the cytosol via the action of the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex and targeted to the proteasome. ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M.

Protein Sequence
(Fasta)

MVPENRRKQL AIFVVVTYLL TFYCVYSATK TSVSFLQVTL KLNEGFNLMV LSIFILLNST 60
LLWQLLTKLL FGELRLIEHE HIFERLPFTI INTLFMSSLF HERYFFTVAF FGLLLLYLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGCCAG AAAATAGAAG GAAACAGTTG GCAATTTTTG TAGTTGTCAC ATATTTGCTC 60
ACATTTTATT GCGTGTATTC AGCCACCAAG ACAAGCGTTT CCTTTTTGCA AGTAACACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0000838--C:Hrd1p ubiquitin ligase ERAD-M complex
GO:0016021--C:integral component of membrane
GO:0042802--F:identical protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0051082--F:unfolded protein binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0031505--P:fungal-type cell wall organization
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YOL013C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000344	Aegilops tauschii	37.29	7.00e-10	56.60
IUUC-Aml-001539	Ailuropoda melanoleuca	25.96	6.00e-22	97.10
IUUC-Atr-002892	Amborella trichopoda	26.71	2.00e-14	71.60
IUUC-Apl-003404	Anas platyrhynchos	32.00	3.00e-09	55.10
IUUC-Aca-004799	Anolis carolinensis	26.25	1.00e-22	99.40
IUUC-Aly-006352	Arabidopsis lyrata	28.77	4.00e-14	70.50
IUUC-Ath-006702	Arabidopsis thaliana	25.69	2.00e-12	65.10
IUUC-Ago-007894	Ashbya gossypii	31.96	4.00e-48	183.00
IUUC-Acl-008041	Aspergillus clavatus	25.06	3.00e-25	108.00
IUUC-Afl-008427	Aspergillus flavus	24.65	3.00e-24	105.00
IUUC-Afu-009023	Aspergillus fumigatus	25.44	2.00e-27	115.00
IUUC-Ani-009133	Aspergillus nidulans	24.31	8.00e-27	113.00
IUUC-Ang-009612	Aspergillus niger	30.94	5.00e-20	90.90
IUUC-Aor-010045	Aspergillus oryzae	25.00	3.00e-26	111.00
IUUC-Ate-010533	Aspergillus terreus	27.25	5.00e-25	107.00
IUUC-Ame-011083	Astyanax mexicanus	25.96	3.00e-22	97.80
IUUC-Bgr-012122	Blumeria graminis	24.23	1.00e-22	100.00
IUUC-Bta-013375	Bos taurus	25.96	9.00e-22	96.30
IUUC-Bci-013675	Botrytis cinerea	25.07	2.00e-23	102.00
IUUC-Bdi-015070	Brachypodium distachyon	24.83	3.00e-12	64.30
IUUC-Bol-015674	Brassica oleracea	29.68	5.00e-14	70.10
IUUC-Bra-016681	Brassica rapa	29.68	6.00e-14	69.30
IUUC-Cel-018422	Caenorhabditis elegans	30.63	7.00e-13	67.00
IUUC-Cja-019779	Callithrix jacchus	24.41	3.00e-15	74.70
IUUC-Cfa-020189	Canis familiaris	25.88	2.00e-22	98.60
IUUC-Cpo-022209	Cavia porcellus	26.25	2.00e-22	98.60
IUUC-Cre-022743	Chlamydomonas reinhardtii	23.32	2.00e-18	84.30
IUUC-Csa-023571	Chlorocebus sabaeus	25.96	5.00e-22	97.40
IUUC-Cho-024889	Choloepus hoffmanni	28.67	4.00e-14	71.20
IUUC-Cin-025452	Ciona intestinalis	35.94	3.00e-08	48.50
IUUC-Csv-026160	Ciona savignyi	29.25	2.00e-13	68.60
IUUC-Cne-027002	Cryptococcus neoformans	24.57	3.00e-31	127.00
IUUC-Cme-027285	Cyanidioschyzon merolae	36.25	5.00e-12	63.90
IUUC-Dre-027999	Danio rerio	25.96	1.00e-22	99.00
IUUC-Dno-029250	Dasypus novemcinctus	25.96	7.00e-22	96.70
IUUC-Dor-030718	Dipodomys ordii	25.96	8.00e-22	96.70
IUUC-Dse-031498	Dothistroma septosporum	24.60	5.00e-19	87.80
IUUC-Dme-031969	Drosophila melanogaster	31.86	1.00e-14	73.20
IUUC-Ete-032962	Echinops telfairi	32.00	3.00e-09	54.70
IUUC-Eca-033258	Equus caballus	25.96	6.00e-22	97.10
IUUC-Eeu-034515	Erinaceus europaeus	37.93	4.00e-09	54.30
IUUC-Fca-035980	Felis catus	25.88	2.00e-22	99.00
IUUC-Fal-036758	Ficedula albicollis	31.17	2.00e-09	55.80
IUUC-Fox-037902	Fusarium oxysporum	26.14	2.00e-21	95.10
IUUC-Fso-038418	Fusarium solani	25.77	3.00e-19	88.60
IUUC-Gmo-039288	Gadus morhua	24.92	2.00e-18	85.10
IUUC-Ggr-040076	Gaeumannomyces graminis	24.69	1.00e-19	89.70
IUUC-Gga-041214	Gallus gallus	44.12	3.00e-13	66.20
IUUC-Gac-042347	Gasterosteus aculeatus	25.96	1.00e-22	99.40
IUUC-Gma-043917	Glycine max	27.10	9.00e-13	66.20
IUUC-Ggo-044858	Gorilla gorilla	25.88	1.00e-21	96.30
IUUC-Hsa-046412	Homo sapiens	25.96	7.00e-22	96.70
IUUC-Hvu-047279	Hordeum vulgare	24.16	3.00e-11	60.50
IUUC-Itr-048924	Ictidomys tridecemlineatus	25.96	8.00e-22	96.70
IUUC-Kpa-049117	Komagataella pastoris	25.05	4.00e-22	97.40
IUUC-Lch-049533	Latimeria chalumnae	38.55	1.00e-12	66.20
IUUC-Lpe-051402	Leersia perrieri	31.31	8.00e-09	51.60
IUUC-Loc-052843	Lepisosteus oculatus	29.37	4.00e-15	73.20
IUUC-Lma-052997	Leptosphaeria maculans	25.27	8.00e-25	107.00
IUUC-Laf-053482	Loxodonta africana	25.96	1.00e-21	96.30
IUUC-Mcc-055075	Macaca mulatta	25.96	6.00e-22	97.10
IUUC-Meu-056683	Macropus eugenii	29.17	4.00e-15	73.90
IUUC-Mor-057082	Magnaporthe oryzae	25.36	3.00e-24	105.00
IUUC-Mpo-057573	Magnaporthe poae	25.77	2.00e-19	88.20
IUUC-Mtr-058601	Medicago truncatula	27.22	4.00e-13	67.40
IUUC-Mla-059168	Melampsora laricipopulina	23.43	1.00e-26	113.00
IUUC-Mga-059765	Meleagris gallopavo	29.77	3.00e-14	69.70
IUUC-Mvi-060515	Microbotryum violaceum	27.39	7.00e-15	73.90
IUUC-Mmr-060922	Microcebus murinus	25.88	3.00e-22	97.80
IUUC-Mdo-062491	Monodelphis domestica	29.37	4.00e-15	74.30
IUUC-Mmu-063770	Mus musculus	25.96	6.00e-22	97.10
IUUC-Mac-064789	Musa acuminata	25.00	1.00e-12	66.20
IUUC-Mpu-066107	Mustela putorius furo	25.96	1.00e-21	95.90
IUUC-Mlu-067918	Myotis lucifugus	25.66	2.00e-20	91.70
IUUC-Nfi-068389	Neosartorya fischeri	26.11	4.00e-27	114.00
IUUC-Ncr-068742	Neurospora crassa	24.09	1.00e-23	103.00
IUUC-Nle-069139	Nomascus leucogenys	25.96	7.00e-22	96.70
IUUC-Opr-070898	Ochotona princeps	29.17	9.00e-15	73.20
IUUC-Ont-071991	Oreochromis niloticus	27.30	5.00e-22	97.40
IUUC-Oan-073717	Ornithorhynchus anatinus	32.00	4.00e-09	54.30
IUUC-Ocu-074065	Oryctolagus cuniculus	25.66	3.00e-21	94.40
IUUC-Oba-075221	Oryza barthii	23.33	6.00e-12	63.50
IUUC-Obr-076914	Oryza brachyantha	23.33	9.00e-12	62.80
IUUC-Ogl-076989	Oryza glaberrima	31.58	1.00e-08	52.40
IUUC-Ogu-078124	Oryza glumaepatula	23.33	6.00e-12	63.50
IUUC-Oin-080013	Oryza indica	23.33	8.00e-12	62.80
IUUC-Olo-080247	Oryza longistaminata	23.49	8.00e-12	62.80
IUUC-Ome-081769	Oryza meridionalis	23.49	5.00e-12	63.50
IUUC-Oni-082946	Oryza nivara	23.33	7.00e-12	63.20
IUUC-Opu-083769	Oryza punctata	40.74	1.00e-08	51.20
IUUC-Oru-085114	Oryza rufipogon	23.33	6.00e-12	63.50
IUUC-Osa-085829	Oryza sativa	23.49	6.00e-12	63.50
IUUC-Ola-087449	Oryzias latipes	25.96	1.00e-21	96.30
IUUC-Olu-087894	Ostreococcus lucimarinus	33.33	4.00e-16	76.60
IUUC-Oga-089036	Otolemur garnettii	25.96	5.00e-22	97.40
IUUC-Oar-089715	Ovis aries	25.96	6.00e-22	97.10
IUUC-Ptr-091000	Pan troglodytes	25.96	7.00e-22	96.70
IUUC-Pan-092187	Papio anubis	25.96	5.00e-22	97.40
IUUC-Psi-093377	Pelodiscus sinensis	29.37	3.00e-15	74.70
IUUC-Pma-094759	Petromyzon marinus	28.37	2.00e-13	68.20
IUUC-Pno-094883	Phaeosphaeria nodorum	24.24	2.00e-11	62.40
IUUC-Ppa-095684	Physcomitrella patens	29.91	1.00e-14	72.40
IUUC-Pfo-096861	Poecilia formosa	26.25	1.00e-20	92.40
IUUC-Pab-098030	Pongo abelii	25.96	7.00e-22	96.70
IUUC-Pop-099245	Populus trichocarpa	26.28	3.00e-13	68.20
IUUC-Pca-100191	Procavia capensis	29.37	6.00e-14	70.50
IUUC-Ppe-101829	Prunus persica	26.49	2.00e-12	65.50
IUUC-Pva-102689	Pteropus vampyrus	25.96	9.00e-22	96.70
IUUC-Pgr-103286	Puccinia graminis	24.10	2.00e-25	108.00
IUUC-Ptt-103919	Puccinia triticina	23.80	5.00e-24	103.00
IUUC-Pte-104372	Pyrenophora teres	24.94	2.00e-24	105.00
IUUC-Pyt-104456	Pyrenophora triticirepentis	23.41	3.00e-23	101.00
IUUC-Rno-105723	Rattus norvegicus	25.96	8.00e-22	96.70
IUUC-Sha-107300	Sarcophilus harrisii	29.17	2.00e-15	74.70
IUUC-Sja-107685	Schizosaccharomyces japonicus	25.06	4.00e-21	94.00
IUUC-Spo-108308	Schizosaccharomyces pombe	25.78	3.00e-24	105.00
IUUC-Ssl-108558	Sclerotinia sclerotiorum	29.19	2.00e-17	82.40
IUUC-Smo-109123	Selaginella moellendorffii	30.17	2.00e-14	71.60
IUUC-Sit-110276	Setaria italica	25.32	2.00e-12	65.10
IUUC-Sly-111531	Solanum lycopersicum	27.22	6.00e-15	73.60
IUUC-Stu-112048	Solanum tuberosum	25.32	2.00e-13	68.60
IUUC-Sar-113397	Sorex araneus	30.23	3.00e-09	54.70
IUUC-Sbi-114192	Sorghum bicolor	24.16	5.00e-12	63.50
IUUC-Sre-115212	Sporisorium reilianum	25.81	1.00e-10	60.10
IUUC-Ssc-116323	Sus scrofa	25.96	4.00e-22	97.40
IUUC-Tgu-116717	Taeniopygia guttata	32.00	2.00e-09	55.10
IUUC-Tru-118045	Takifugu rubripes	25.59	3.00e-21	94.70
IUUC-Tsy-119442	Tarsius syrichta	32.00	4.00e-09	54.30
IUUC-Tni-120106	Tetraodon nigroviridis	29.86	2.00e-15	75.10
IUUC-Tca-121462	Theobroma cacao	26.92	1.00e-12	65.90
IUUC-Tre-122204	Trichoderma reesei	29.08	3.00e-17	82.00
IUUC-Tvi-122550	Trichoderma virens	29.71	8.00e-17	80.50
IUUC-Tae-124064	Triticum aestivum	25.55	9.00e-13	66.20
IUUC-Tur-126538	Triticum urartu	37.93	2.00e-09	55.80
IUUC-Tme-127197	Tuber melanosporum	27.78	1.00e-17	83.60
IUUC-Tbe-127385	Tupaia belangeri	29.17	1.00e-14	72.80
IUUC-Ttr-128795	Tursiops truncatus	25.96	6.00e-22	97.10
IUUC-Uma-129401	Ustilago maydis	51.43	3.00e-09	55.50
IUUC-Vda-129968	Verticillium dahliae	25.20	2.00e-20	92.40
IUUC-Vpa-130483	Vicugna pacos	30.23	6.00e-09	53.90
IUUC-Vvi-130944	Vitis vinifera	36.90	2.00e-11	61.60
IUUC-Xtr-131884	Xenopus tropicalis	28.67	1.00e-14	73.20
IUUC-Xma-133488	Xiphophorus maculatus	26.25	1.00e-20	92.40
IUUC-Yli-134552	Yarrowia lipolytica	23.17	1.00e-17	82.00
IUUC-Zma-135530	Zea mays	23.65	8.00e-12	63.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence