iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021923

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02054092

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000005045.3	ENSCPOT00000005099.2	ENSCPOP00000004539.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.70e-85	284.9	4043	4293
UBD/Alpha-Helix/UBA	5.30e-08	32.7	1317	1354

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4043 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4128
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4129 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4212
           *************************************99...********************************************* PP
   S: 176  lvveyrlke....gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl 253
           lv+++r++      i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s + + +w ++
   Q: 4213 LVCQMRMTVlasgAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQEKELWVAV 4293
           *******8655568**************************************************66.*****9999999765 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1317 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1354
           89**********************.7***********98 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGTAG ACAGAACTAA ACTGAAAAAG ACACCTACTG AAGCTGTAAG TACCCAGAAG 60
TTTGCTTTGC CTTTGTTTTC CTCATTTTAA AATAAGCTCA CTAGTACTGA TCTTCCAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	37.88	2.00e-90	329.00
IUUC-Aml-001684	Ailuropoda melanoleuca	97.92	0.00e+00	4390.00
IUUC-Apl-003729	Anas platyrhynchos	80.94	1.00e-178	618.00
IUUC-Aca-005263	Anolis carolinensis	92.24	0.00e+00	3108.00
IUUC-Aly-006083	Arabidopsis lyrata	44.04	7.00e-93	337.00
IUUC-Ath-007472	Arabidopsis thaliana	44.04	4.00e-93	338.00
IUUC-Ago-008005	Ashbya gossypii	38.91	2.00e-95	345.00
IUUC-Acl-008254	Aspergillus clavatus	38.87	3.00e-95	345.00
IUUC-Afl-008712	Aspergillus flavus	38.61	5.00e-97	349.00
IUUC-Ang-009771	Aspergillus niger	39.52	6.00e-96	347.00
IUUC-Aor-010186	Aspergillus oryzae	40.38	1.00e-91	331.00
IUUC-Ame-011067	Astyanax mexicanus	80.96	0.00e+00	3661.00
IUUC-Bgr-012043	Blumeria graminis	39.26	1.00e-100	363.00
IUUC-Bta-012813	Bos taurus	98.13	0.00e+00	4417.00
IUUC-Bci-013995	Botrytis cinerea	38.34	7.00e-99	357.00
IUUC-Cel-018179	Caenorhabditis elegans	52.41	1.00e-143	506.00
IUUC-Cja-018741	Callithrix jacchus	98.71	0.00e+00	4418.00
IUUC-Cfa-020083	Canis familiaris	96.21	0.00e+00	4380.00
IUUC-Csa-023853	Chlorocebus sabaeus	98.75	0.00e+00	4410.00
IUUC-Cho-024718	Choloepus hoffmanni	97.48	0.00e+00	680.00
IUUC-Cin-025627	Ciona intestinalis	42.56	0.00e+00	1924.00
IUUC-Csv-025824	Ciona savignyi	47.96	0.00e+00	1447.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	42.86	3.00e-97	352.00
IUUC-Cne-027095	Cryptococcus neoformans	35.95	1.00e-81	300.00
IUUC-Dre-028525	Danio rerio	82.08	0.00e+00	3632.00
IUUC-Dno-029680	Dasypus novemcinctus	97.13	0.00e+00	4334.00
IUUC-Dor-030902	Dipodomys ordii	95.91	0.00e+00	1204.00
IUUC-Dse-031197	Dothistroma septosporum	39.38	3.00e-100	362.00
IUUC-Dme-032122	Drosophila melanogaster	59.00	0.00e+00	639.00
IUUC-Ete-032690	Echinops telfairi	87.76	0.00e+00	1907.00
IUUC-Eca-033915	Equus caballus	98.04	0.00e+00	4370.00
IUUC-Eeu-034963	Erinaceus europaeus	93.40	0.00e+00	2940.00
IUUC-Fca-035824	Felis catus	98.13	0.00e+00	4404.00
IUUC-Fox-037756	Fusarium oxysporum	43.90	6.00e-98	354.00
IUUC-Fso-038464	Fusarium solani	44.50	9.00e-98	353.00
IUUC-Gmo-039073	Gadus morhua	82.97	0.00e+00	3647.00
IUUC-Ggr-039946	Gaeumannomyces graminis	38.24	4.00e-96	348.00
IUUC-Gga-040309	Gallus gallus	79.05	2.00e-141	494.00
IUUC-Gac-042430	Gasterosteus aculeatus	83.33	0.00e+00	3738.00
IUUC-Ggo-044785	Gorilla gorilla	98.67	0.00e+00	4369.00
IUUC-Hsa-046879	Homo sapiens	98.71	0.00e+00	4369.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	89.67	0.00e+00	1330.00
IUUC-Kpa-049228	Komagataella pastoris	41.79	1.00e-104	376.00
IUUC-Lch-050252	Latimeria chalumnae	88.76	0.00e+00	3370.00
IUUC-Loc-052472	Lepisosteus oculatus	83.56	0.00e+00	3741.00
IUUC-Lma-053159	Leptosphaeria maculans	38.10	7.00e-99	357.00
IUUC-Laf-054154	Loxodonta africana	97.10	0.00e+00	4354.00
IUUC-Mcc-055085	Macaca mulatta	97.12	0.00e+00	4364.00
IUUC-Meu-056727	Macropus eugenii	94.24	0.00e+00	1900.00
IUUC-Mor-057201	Magnaporthe oryzae	38.71	4.00e-97	351.00
IUUC-Mvi-060320	Microbotryum violaceum	43.39	2.00e-94	342.00
IUUC-Mmr-060820	Microcebus murinus	96.34	0.00e+00	4328.00
IUUC-Mdo-062930	Monodelphis domestica	91.73	0.00e+00	4125.00
IUUC-Mmu-063601	Mus musculus	98.05	0.00e+00	4263.00
IUUC-Mpu-066653	Mustela putorius furo	96.06	0.00e+00	4270.00
IUUC-Mlu-067418	Myotis lucifugus	97.80	0.00e+00	4445.00
IUUC-Ncr-068813	Neurospora crassa	38.53	9.00e-99	357.00
IUUC-Nle-069418	Nomascus leucogenys	98.30	0.00e+00	4337.00
IUUC-Opr-070187	Ochotona princeps	70.07	0.00e+00	724.00
IUUC-Ont-071300	Oreochromis niloticus	83.60	0.00e+00	3703.00
IUUC-Oan-073046	Ornithorhynchus anatinus	88.11	0.00e+00	5262.00
IUUC-Ocu-074178	Oryctolagus cuniculus	94.15	0.00e+00	7285.00
IUUC-Ola-087437	Oryzias latipes	85.39	0.00e+00	2128.00
IUUC-Oga-088903	Otolemur garnettii	97.76	0.00e+00	4360.00
IUUC-Oar-090210	Ovis aries	96.53	0.00e+00	4367.00
IUUC-Ptr-090502	Pan troglodytes	98.64	0.00e+00	3367.00
IUUC-Pan-092368	Papio anubis	98.69	0.00e+00	3408.00
IUUC-Pma-094246	Petromyzon marinus	74.50	0.00e+00	1292.00
IUUC-Pno-094871	Phaeosphaeria nodorum	43.50	9.00e-98	353.00
IUUC-Pfo-096232	Poecilia formosa	81.18	0.00e+00	3675.00
IUUC-Pab-098583	Pongo abelii	98.75	0.00e+00	4375.00
IUUC-Pop-099613	Populus trichocarpa	44.49	8.00e-94	340.00
IUUC-Pca-100310	Procavia capensis	83.64	0.00e+00	1648.00
IUUC-Ppe-102109	Prunus persica	44.72	1.00e-93	340.00
IUUC-Pva-102116	Pteropus vampyrus	98.13	0.00e+00	4424.00
IUUC-Pte-104018	Pyrenophora teres	43.24	5.00e-96	347.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	42.95	9.00e-96	347.00
IUUC-Rno-105889	Rattus norvegicus	90.75	0.00e+00	3872.00
IUUC-Sce-106449	Saccharomyces cerevisiae	37.68	9.00e-94	340.00
IUUC-Sha-106961	Sarcophilus harrisii	89.93	0.00e+00	4057.00
IUUC-Spo-108024	Schizosaccharomyces pombe	38.72	4.00e-95	344.00
IUUC-Sar-113291	Sorex araneus	92.20	0.00e+00	2712.00
IUUC-Ssc-115754	Sus scrofa	98.17	0.00e+00	4410.00
IUUC-Tru-118570	Takifugu rubripes	83.21	0.00e+00	3762.00
IUUC-Tsy-119159	Tarsius syrichta	98.11	0.00e+00	2022.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.84	0.00e+00	2004.00
IUUC-Tme-127172	Tuber melanosporum	37.87	4.00e-101	365.00
IUUC-Tbe-127506	Tupaia belangeri	94.87	0.00e+00	1481.00
IUUC-Ttr-129253	Tursiops truncatus	90.23	0.00e+00	2168.00
IUUC-Vda-129886	Verticillium dahliae	39.27	5.00e-101	364.00
IUUC-Vpa-130708	Vicugna pacos	96.20	0.00e+00	3850.00
IUUC-Xtr-132123	Xenopus tropicalis	83.01	0.00e+00	6255.00
IUUC-Xma-133869	Xiphophorus maculatus	81.13	0.00e+00	3682.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence