iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007988

Ensembl Protein ID

AAS52758

UniProt Accession

Q757D9; BRE1_ASHGO

Genbank Protein ID

AAS52758.1

Protein Name

E3 ubiquitin-protein ligase BRE1; RING-type E3 ubiquitin transferase BRE1

Genbank Nucleotide ID

AE016818

Gene Name

BRE1; AER074W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AER074W	AAS52758	AAS52758

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	22.84	8.00e-15	79.30	IUUC-Dme-032034
E3 activity/RING/RING	31.69	1.00e-13	76.30	IUUC-Hsa-046462
E3 activity/RING/RING	47.57	4.00e-118	420.00	IUUC-Sce-106384
E3 activity/RING/RING	27.61	7.00e-30	126.00	IUUC-Spo-108304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ashbya gossypii

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MEEPAAKRPK LSDRSEPLTQ RDVVLFQKEA LFRQLNRYRA EARAGQVQVE ELRRAHGQVG 60
ERLAAVCGVV RSVARAVADA RGDGDARALC ERVAGGDDDE VVARAAEFAA VVAGGLGRGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAAC CGGCGGCGAA GAGACCGAAG CTGTCGGATC GGTCAGAGCC GTTGACACAG 60
CGAGACGTGG TGCTGTTCCA GAAGGAGGCG CTCTTCCGGC AGCTGAACCG GTACCGTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF08647--BRE1

SMART

SM00184--RING

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0000790--C:nuclear chromatin
GO:0003688--F:DNA replication origin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006348--P:chromatin silencing at telomere
GO:0000724--P:double-strand break repair via homologous recombination
GO:0010390--P:histone monoubiquitination
GO:0031573--P:intra-S DNA damage checkpoint
GO:0042138--P:meiotic DNA double-strand break formation
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0070534--P:protein K63-linked ubiquitination
GO:0030174--P:regulation of DNA-dependent DNA replication initiation
GO:0000722--P:telomere maintenance via recombination
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

ago:AGOS_AER074W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001976	Ailuropoda melanoleuca	39.39	2.00e-14	73.20
IUUC-Apl-003407	Anas platyrhynchos	23.37	2.00e-15	75.90
IUUC-Aca-004850	Anolis carolinensis	39.39	2.00e-14	72.40
IUUC-Aly-006469	Arabidopsis lyrata	37.88	5.00e-12	64.70
IUUC-Ath-006615	Arabidopsis thaliana	37.88	6.00e-12	64.30
IUUC-Acl-008319	Aspergillus clavatus	27.76	1.00e-33	135.00
IUUC-Afl-008679	Aspergillus flavus	31.54	5.00e-15	74.30
IUUC-Afu-008884	Aspergillus fumigatus	26.67	2.80e-01	28.50
IUUC-Ani-009487	Aspergillus nidulans	27.52	9.00e-12	63.20
IUUC-Ang-009601	Aspergillus niger	30.53	3.00e-35	141.00
IUUC-Aor-010142	Aspergillus oryzae	30.68	1.00e-37	149.00
IUUC-Ate-010547	Aspergillus terreus	30.26	3.00e-38	150.00
IUUC-Ame-011916	Astyanax mexicanus	24.71	2.00e-15	75.90
IUUC-Bgr-012245	Blumeria graminis	29.16	3.00e-37	147.00
IUUC-Bta-012357	Bos taurus	30.00	5.00e-15	74.70
IUUC-Bci-013926	Botrytis cinerea	31.27	2.00e-42	164.00
IUUC-Bdi-014799	Brachypodium distachyon	22.39	1.00e-11	63.20
IUUC-Bol-015858	Brassica oleracea	29.31	9.00e-14	70.50
IUUC-Bra-016804	Brassica rapa	29.31	1.00e-13	70.10
IUUC-Cel-018659	Caenorhabditis elegans	30.86	4.00e-10	58.20
IUUC-Cja-019042	Callithrix jacchus	22.99	1.00e-12	67.00
IUUC-Cfa-020320	Canis familiaris	39.39	2.00e-14	72.80
IUUC-Cpo-021539	Cavia porcellus	24.14	6.00e-16	77.80
IUUC-Cre-022940	Chlamydomonas reinhardtii	34.12	3.00e-07	48.10
IUUC-Csa-023509	Chlorocebus sabaeus	39.39	2.00e-14	72.80
IUUC-Cho-024616	Choloepus hoffmanni	39.39	4.00e-14	71.60
IUUC-Cin-025174	Ciona intestinalis	25.55	9.00e-22	97.10
IUUC-Csv-025830	Ciona savignyi	23.37	5.00e-15	74.30
IUUC-Cgl-026569	Colletotrichum gloeosporioides	48.44	4.00e-19	87.40
IUUC-Cne-026878	Cryptococcus neoformans	29.03	4.00e-25	107.00
IUUC-Cme-027134	Cyanidioschyzon merolae	33.33	6.00e-12	63.50
IUUC-Dre-028146	Danio rerio	23.95	2.00e-14	72.40
IUUC-Dno-029537	Dasypus novemcinctus	39.39	2.00e-14	72.40
IUUC-Dor-030250	Dipodomys ordii	39.39	2.00e-14	72.80
IUUC-Dse-031300	Dothistroma septosporum	28.06	4.00e-33	134.00
IUUC-Dme-032034	Drosophila melanogaster	24.05	7.00e-15	74.30
IUUC-Ete-033164	Echinops telfairi	39.39	4.00e-14	71.60
IUUC-Eca-033347	Equus caballus	39.39	2.00e-14	72.80
IUUC-Eeu-034801	Erinaceus europaeus	39.39	6.00e-14	70.50
IUUC-Fca-035720	Felis catus	24.52	4.00e-16	78.20
IUUC-Fal-037622	Ficedula albicollis	39.39	1.00e-14	73.20
IUUC-Fox-038017	Fusarium oxysporum	29.53	9.00e-35	139.00
IUUC-Fso-038414	Fusarium solani	30.89	6.00e-39	153.00
IUUC-Gmo-039446	Gadus morhua	25.86	5.00e-16	77.80
IUUC-Ggr-040117	Gaeumannomyces graminis	27.29	4.00e-34	137.00
IUUC-Gga-040412	Gallus gallus	23.37	5.00e-15	74.70
IUUC-Gac-042205	Gasterosteus aculeatus	40.54	2.00e-15	75.90
IUUC-Gma-042797	Glycine max	24.78	5.00e-15	74.70
IUUC-Ggo-044703	Gorilla gorilla	39.39	2.00e-14	72.80
IUUC-Hsa-046462	Homo sapiens	39.39	2.00e-14	72.80
IUUC-Itr-048298	Ictidomys tridecemlineatus	22.94	2.00e-11	62.40
IUUC-Kpa-049345	Komagataella pastoris	27.96	4.00e-48	184.00
IUUC-Lch-049505	Latimeria chalumnae	33.88	7.00e-16	77.40
IUUC-Lpe-051253	Leersia perrieri	23.13	1.00e-12	66.60
IUUC-Loc-052847	Lepisosteus oculatus	39.39	3.00e-13	67.00
IUUC-Lma-053312	Leptosphaeria maculans	29.92	4.00e-28	117.00
IUUC-Laf-054122	Loxodonta africana	39.39	2.00e-14	72.80
IUUC-Mcc-054647	Macaca mulatta	39.39	2.00e-14	72.80
IUUC-Meu-056559	Macropus eugenii	39.39	2.00e-14	72.40
IUUC-Mor-057068	Magnaporthe oryzae	30.34	3.00e-33	134.00
IUUC-Mpo-057568	Magnaporthe poae	27.77	1.00e-35	142.00
IUUC-Mtr-057632	Medicago truncatula	24.56	5.00e-15	74.30
IUUC-Mla-059072	Melampsora laricipopulina	26.67	2.00e-19	89.00
IUUC-Mga-059731	Meleagris gallopavo	23.37	1.00e-14	73.60
IUUC-Mvi-060341	Microbotryum violaceum	26.26	8.00e-21	93.60
IUUC-Mmr-061177	Microcebus murinus	24.14	7.00e-16	77.40
IUUC-Mdo-062599	Monodelphis domestica	39.39	2.00e-14	72.80
IUUC-Mmu-063278	Mus musculus	22.65	1.00e-09	57.00
IUUC-Mac-065103	Musa acuminata	21.11	5.00e-13	67.80
IUUC-Mpu-065910	Mustela putorius furo	39.39	1.00e-14	73.20
IUUC-Nfi-068269	Neosartorya fischeri	25.05	9.00e-16	76.60
IUUC-Ncr-068695	Neurospora crassa	28.10	2.00e-37	148.00
IUUC-Nle-069058	Nomascus leucogenys	39.39	2.00e-14	72.80
IUUC-Opr-071149	Ochotona princeps	39.39	2.00e-14	72.40
IUUC-Ont-072543	Oreochromis niloticus	41.33	5.00e-15	74.70
IUUC-Oan-072996	Ornithorhynchus anatinus	29.44	1.00e-14	72.80
IUUC-Ocu-074773	Oryctolagus cuniculus	39.39	2.00e-14	72.80
IUUC-Oba-075000	Oryza barthii	25.96	6.00e-13	67.40
IUUC-Obr-076532	Oryza brachyantha	23.59	3.00e-12	65.10
IUUC-Ogl-077200	Oryza glaberrima	25.96	7.00e-13	67.40
IUUC-Ogu-078279	Oryza glumaepatula	25.96	7.00e-13	67.40
IUUC-Oin-079097	Oryza indica	25.96	6.00e-13	67.40
IUUC-Olo-080612	Oryza longistaminata	34.43	1.00e-09	57.40
IUUC-Ome-081304	Oryza meridionalis	37.50	4.00e-13	68.20
IUUC-Oni-082162	Oryza nivara	25.96	7.00e-13	67.40
IUUC-Opu-083683	Oryza punctata	34.43	2.00e-10	58.90
IUUC-Oru-084382	Oryza rufipogon	25.96	7.00e-13	67.00
IUUC-Osa-085839	Oryza sativa	34.43	2.00e-10	58.90
IUUC-Ola-087287	Oryzias latipes	40.54	4.00e-15	74.70
IUUC-Olu-087683	Ostreococcus lucimarinus	29.87	2.00e-09	52.00
IUUC-Oga-088961	Otolemur garnettii	21.83	2.00e-09	55.80
IUUC-Oar-089755	Ovis aries	30.00	5.00e-15	74.30
IUUC-Ptr-091602	Pan troglodytes	39.39	2.00e-14	72.80
IUUC-Pan-092263	Papio anubis	39.39	2.00e-14	72.80
IUUC-Psi-093554	Pelodiscus sinensis	39.39	1.00e-14	73.20
IUUC-Pma-094351	Petromyzon marinus	31.25	3.00e+00	22.70
IUUC-Pno-095079	Phaeosphaeria nodorum	34.24	9.00e-28	116.00
IUUC-Ppa-095651	Physcomitrella patens	22.85	5.00e-15	74.70
IUUC-Pfo-097527	Poecilia formosa	39.19	1.00e-14	73.20
IUUC-Pab-098598	Pongo abelii	39.39	2.00e-14	72.80
IUUC-Pop-099583	Populus trichocarpa	40.91	2.00e-14	71.20
IUUC-Pca-100544	Procavia capensis	24.52	5.00e-16	78.20
IUUC-Ppe-102065	Prunus persica	36.36	7.00e-12	63.90
IUUC-Pva-102720	Pteropus vampyrus	39.39	2.00e-14	72.80
IUUC-Pgr-103536	Puccinia graminis	25.48	2.00e-18	85.90
IUUC-Pte-104415	Pyrenophora teres	28.68	3.00e-28	117.00
IUUC-Pyt-104762	Pyrenophora triticirepentis	29.44	5.00e-29	120.00
IUUC-Rno-104996	Rattus norvegicus	39.39	2.00e-14	72.80
IUUC-Sce-106384	Saccharomyces cerevisiae	44.19	8.00e-152	528.00
IUUC-Sha-107000	Sarcophilus harrisii	39.39	2.00e-14	72.80
IUUC-Sja-107993	Schizosaccharomyces japonicus	30.00	2.00e-26	112.00
IUUC-Spo-108304	Schizosaccharomyces pombe	33.46	5.00e-30	123.00
IUUC-Ssl-108546	Sclerotinia sclerotiorum	31.36	6.00e-42	163.00
IUUC-Smo-109550	Selaginella moellendorffii	40.91	1.00e-13	70.10
IUUC-Sit-110382	Setaria italica	22.22	4.00e-14	71.20
IUUC-Sly-111490	Solanum lycopersicum	33.33	1.00e-11	63.20
IUUC-Sar-113349	Sorex araneus	31.69	7.00e-15	74.30
IUUC-Sbi-114734	Sorghum bicolor	31.08	1.00e-11	60.80
IUUC-Sre-115087	Sporisorium reilianum	26.95	4.00e-23	101.00
IUUC-Ssc-115723	Sus scrofa	39.39	2.00e-14	72.80
IUUC-Tgu-116549	Taeniopygia guttata	39.39	2.00e-14	72.80
IUUC-Tru-118776	Takifugu rubripes	40.54	4.00e-15	74.70
IUUC-Tsy-118808	Tarsius syrichta	39.39	2.00e-14	72.40
IUUC-Tni-120790	Tetraodon nigroviridis	40.54	5.00e-15	74.30
IUUC-Tca-121060	Theobroma cacao	36.36	4.00e-12	64.70
IUUC-Tre-122150	Trichoderma reesei	25.79	1.00e-39	155.00
IUUC-Tvi-122431	Trichoderma virens	27.06	6.00e-40	156.00
IUUC-Tae-122767	Triticum aestivum	23.46	2.00e-14	72.80
IUUC-Tur-126160	Triticum urartu	36.07	7.00e-11	60.50
IUUC-Tme-127177	Tuber melanosporum	30.50	3.00e-37	148.00
IUUC-Tbe-127597	Tupaia belangeri	24.52	5.00e-16	77.80
IUUC-Ttr-128266	Tursiops truncatus	39.39	2.00e-14	72.40
IUUC-Uma-129488	Ustilago maydis	23.88	4.00e-18	84.70
IUUC-Vda-129815	Verticillium dahliae	28.64	4.00e-34	137.00
IUUC-Vpa-130237	Vicugna pacos	39.39	2.00e-14	72.80
IUUC-Vvi-131316	Vitis vinifera	37.88	1.00e-12	66.60
IUUC-Xtr-132906	Xenopus tropicalis	39.39	4.00e-14	71.60
IUUC-Xma-133365	Xiphophorus maculatus	39.19	1.00e-14	73.20
IUUC-Yli-134445	Yarrowia lipolytica	34.37	5.00e-45	173.00
IUUC-Zma-135805	Zea mays	32.43	5.00e-12	64.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence