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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108183
UUCD1 version UUC-ScP-00025
Ensembl Protein ID SPBC19C7.02.1:pep
UniProt Accession O60152; UBR1_SCHPO
Genbank Protein ID BAB84667.1; CAA19375.1
Protein Name E3 ubiquitin-protein ligase ubr1; N-end-recognizing protein; N-recognin-1; RING-type E3 ubiquitin transferase ubr1
Genbank Nucleotide ID AB079542; CU329671
Gene Name ubr1; SPBC19C7.02; SPBC32F12.14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC19C7.02 SPBC19C7.02.1 SPBC19C7.02.1:pep
Annotation
mRNA Expression
GEO
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21410566
E3 activity/N-recognin/UBR-box UBR 21410566
E3 activity/N-recognin/N-domain N-domain 21410566
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.50e-10 39.5 1182 1334
E3 activity/N-recognin/UBR-box 1.50e-24 84.4 94 165
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkd................................................................................ 10
           C++C+e++kd                                                                                
   Q: 1182 CLLCQEELKDkrpygtlvfvlrssvlrlfpaddanyvsevldipdsldheiqerpfglagkrkkvldsteaydydnyyyekkgnelhqlk 1271
           777744443344444444444444444444444444444444444444444444444444444444444444444444444444444444 PP
   S: 11   .............gplvlpCgHvfhadClqkw..............pglknssskefrCPlCr 46
                        g++ ++CgH++h dC+++               ++++n+s+kef+CPlC+
   Q: 1272 dsfngfppdqldrGLHATGCGHFMHIDCFKNHiatvtlatranpyrNHPHNLSMKEFLCPLCK 1334
           44444444444449***************5555*****************************7 PP
   

   E3 activity/N-recognin/UBR-box
   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksgg.ggfCdCGdteAwedgskCkkll 71
           s+Cg++f++ge +y+C+tCsvd++++lC++Cf++++HkdHe+++++s+g gg+CdCG+++Aw  +++Ck ++
   Q: 94   SKCGHIFRKGEVFYRCKTCSVDSNSALCVKCFRATSHKDHETSFTVSAGsGGCCDCGNAAAWIGDVSCKIHS 165
           58*********************************************9989******************997 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
 Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Protein Sequence
(Fasta)
MLQDESSRSL PRSALIRRRL SLFLQSHALM YSFLWSESAK KSLLNEVFSA LLGYDHTLWN 60
TLLPERPTID ASFLLRRAQG HSEGDEYRHG TCESKCGHIF RKGEVFYRCK TCSVDSNSAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Spo-108183|E3,RING;E3,UBR-box;E3,N-domain|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAAAATTTA ATAAGCCATA CCCTGAAAAA CTTCCATTGG TTTCCATAAA TTAGTATATA 60
CTCTACTAAC ACGCTGGAAG TTCAAGTTTG GTTTTCGAAG TACTTATACT ATTCCTACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108183|E3,RING;E3,UBR-box;E3,N-domain|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071455--P:cellular response to hyperoxia
GO:1901487--P:negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels
GO:0010620--P:negative regulation of transcription by transcription factor catabolism
GO:1990920--P:proteasome localization to nuclear periphery
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901044--P:protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway
KEGG spo:SPBC19C7.02
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001354 Ailuropoda melanoleuca 23.73 1.00e-39 157.00
IUUC-Apl-003828 Anas platyrhynchos 24.47 2.00e-47 183.00
IUUC-Aca-004982 Anolis carolinensis 23.54 1.00e-53 203.00
IUUC-Ath-007148 Arabidopsis thaliana 27.07 3.00e-16 79.70
IUUC-Ago-007946 Ashbya gossypii 20.32 7.00e-43 168.00
IUUC-Acl-008055 Aspergillus clavatus 30.20 0.00e+00 660.00
IUUC-Afl-008479 Aspergillus flavus 30.40 0.00e+00 673.00
IUUC-Afu-008929 Aspergillus fumigatus 30.94 0.00e+00 687.00
IUUC-Ani-009334 Aspergillus nidulans 30.45 2.00e-180 625.00
IUUC-Ang-009550 Aspergillus niger 31.03 0.00e+00 667.00
IUUC-Aor-010124 Aspergillus oryzae 30.49 0.00e+00 675.00
IUUC-Ate-010550 Aspergillus terreus 30.57 0.00e+00 671.00
IUUC-Ame-011917 Astyanax mexicanus 23.56 1.00e-43 170.00
IUUC-Bgr-011999 Blumeria graminis 26.35 1.00e-164 572.00
IUUC-Bta-012768 Bos taurus 24.65 3.00e-46 179.00
IUUC-Bdi-014635 Brachypodium distachyon 31.97 4.00e-21 96.30
IUUC-Bol-016004 Brassica oleracea 25.93 3.00e-18 86.70
IUUC-Bra-017621 Brassica rapa 26.40 9.00e-18 84.70
IUUC-Cel-018476 Caenorhabditis elegans 35.71 6.00e-20 92.40
IUUC-Cja-019797 Callithrix jacchus 24.41 1.00e-41 163.00
IUUC-Cfa-020950 Canis familiaris 24.31 7.00e-47 181.00
IUUC-Cpo-022385 Cavia porcellus 24.28 2.00e-44 173.00
IUUC-Cre-022936 Chlamydomonas reinhardtii 28.75 3.00e-03 33.90
IUUC-Csa-024082 Chlorocebus sabaeus 24.60 8.00e-46 177.00
IUUC-Cin-025148 Ciona intestinalis 23.95 1.00e-30 126.00
IUUC-Cgl-026605 Colletotrichum gloeosporioides 29.25 0.00e+00 637.00
IUUC-Cne-026823 Cryptococcus neoformans 25.49 8.00e-68 251.00
IUUC-Dre-028343 Danio rerio 25.16 2.00e-46 179.00
IUUC-Dor-030207 Dipodomys ordii 23.11 1.00e-23 104.00
IUUC-Dse-031531 Dothistroma septosporum 29.19 8.00e-131 460.00
IUUC-Dme-031910 Drosophila melanogaster 23.62 2.00e-27 116.00
IUUC-Ete-033162 Echinops telfairi 24.37 1.00e-24 107.00
IUUC-Eca-033454 Equus caballus 24.93 1.00e-47 183.00
IUUC-Eeu-034664 Erinaceus europaeus 22.61 2.00e-29 123.00
IUUC-Fca-036588 Felis catus 24.83 2.00e-47 183.00
IUUC-Fal-036919 Ficedula albicollis 23.37 9.00e-45 174.00
IUUC-Fox-037984 Fusarium oxysporum 28.48 1.00e-170 593.00
IUUC-Fso-038463 Fusarium solani 28.66 8.00e-173 600.00
IUUC-Ggr-040070 Gaeumannomyces graminis 29.19 4.00e-178 617.00
IUUC-Gga-041123 Gallus gallus 24.84 4.00e-48 185.00
IUUC-Gac-042622 Gasterosteus aculeatus 23.75 5.00e-41 162.00
IUUC-Ggo-045583 Gorilla gorilla 24.73 7.00e-45 174.00
IUUC-Hsa-046343 Homo sapiens 24.53 1.00e-44 174.00
IUUC-Hvu-047101 Hordeum vulgare 37.66 1.00e-18 83.60
IUUC-Itr-048410 Ictidomys tridecemlineatus 24.15 9.00e-43 167.00
IUUC-Kpa-049088 Komagataella pastoris 25.36 4.00e-96 345.00
IUUC-Lch-049904 Latimeria chalumnae 22.95 2.00e-52 199.00
IUUC-Lpe-051516 Leersia perrieri 30.51 7.00e-21 95.50
IUUC-Loc-052624 Lepisosteus oculatus 24.05 4.00e-50 192.00
IUUC-Lma-053059 Leptosphaeria maculans 29.58 0.00e+00 661.00
IUUC-Laf-054142 Loxodonta africana 24.47 3.00e-44 172.00
IUUC-Mcc-055677 Macaca mulatta 24.60 6.00e-46 178.00
IUUC-Meu-056858 Macropus eugenii 36.64 1.00e-18 87.80
IUUC-Mor-057051 Magnaporthe oryzae 28.71 2.00e-180 625.00
IUUC-Mpo-057372 Magnaporthe poae 30.81 3.00e-122 431.00
IUUC-Mla-058963 Melampsora laricipopulina 28.99 1.00e-97 350.00
IUUC-Mga-059698 Meleagris gallopavo 24.88 2.00e-48 186.00
IUUC-Mvi-060535 Microbotryum violaceum 29.32 3.00e-92 332.00
IUUC-Mmr-060901 Microcebus murinus 24.33 7.00e-47 181.00
IUUC-Mdo-062014 Monodelphis domestica 24.97 8.00e-49 187.00
IUUC-Mmu-063699 Mus musculus 23.58 2.00e-41 163.00
IUUC-Mpu-066153 Mustela putorius furo 24.33 1.00e-45 177.00
IUUC-Mlu-068151 Myotis lucifugus 24.79 5.00e-42 165.00
IUUC-Nfi-068403 Neosartorya fischeri 30.72 0.00e+00 683.00
IUUC-Ncr-068864 Neurospora crassa 28.88 2.00e-165 575.00
IUUC-Nle-069529 Nomascus leucogenys 24.70 6.00e-46 178.00
IUUC-Opr-071107 Ochotona princeps 30.04 1.00e-22 100.00
IUUC-Ont-072189 Oreochromis niloticus 24.21 1.00e-42 167.00
IUUC-Oan-072893 Ornithorhynchus anatinus 24.76 3.00e-48 186.00
IUUC-Ocu-074082 Oryctolagus cuniculus 25.22 3.00e-47 182.00
IUUC-Oba-075295 Oryza barthii 25.97 8.00e-13 68.60
IUUC-Obr-076117 Oryza brachyantha 31.65 2.00e-22 100.00
IUUC-Ogl-077571 Oryza glaberrima 32.07 9.00e-23 101.00
IUUC-Ogu-078497 Oryza glumaepatula 25.97 7.00e-13 68.60
IUUC-Oin-079343 Oryza indica 25.97 7.00e-13 68.60
IUUC-Oni-083099 Oryza nivara 25.97 8.00e-13 68.60
IUUC-Opu-083202 Oryza punctata 32.07 7.00e-23 102.00
IUUC-Oru-084471 Oryza rufipogon 25.97 1.00e-12 67.80
IUUC-Osa-085336 Oryza sativa 32.07 7.00e-23 100.00
IUUC-Ola-087460 Oryzias latipes 23.45 2.00e-44 172.00
IUUC-Olu-087865 Ostreococcus lucimarinus 26.61 9.00e-03 33.10
IUUC-Oga-088432 Otolemur garnettii 24.28 8.00e-47 181.00
IUUC-Oar-090206 Ovis aries 24.80 9.00e-45 174.00
IUUC-Ptr-091180 Pan troglodytes 24.63 6.00e-44 171.00
IUUC-Pan-092375 Papio anubis 24.70 3.00e-46 179.00
IUUC-Psi-093049 Pelodiscus sinensis 24.40 4.00e-44 172.00
IUUC-Pno-094877 Phaeosphaeria nodorum 29.84 3.00e-118 418.00
IUUC-Ppa-095715 Physcomitrella patens 36.67 1.00e-27 118.00
IUUC-Pfo-097124 Poecilia formosa 24.24 2.00e-50 192.00
IUUC-Pab-097989 Pongo abelii 24.83 1.00e-46 181.00
IUUC-Pgr-103372 Puccinia graminis 28.52 2.00e-93 336.00
IUUC-Ptt-103878 Puccinia triticina 29.64 5.00e-95 341.00
IUUC-Pte-104174 Pyrenophora teres 29.74 0.00e+00 666.00
IUUC-Pyt-104431 Pyrenophora triticirepentis 29.19 0.00e+00 660.00
IUUC-Rno-105567 Rattus norvegicus 23.62 6.00e-44 171.00
IUUC-Sce-106272 Saccharomyces cerevisiae 21.51 9.00e-53 201.00
IUUC-Sha-106980 Sarcophilus harrisii 24.63 6.00e-47 181.00
IUUC-Sja-107980 Schizosaccharomyces japonicus 49.56 0.00e+00 1838.00
IUUC-Ssl-108568 Sclerotinia sclerotiorum 35.82 2.20e-02 30.40
IUUC-Sit-110716 Setaria italica 30.99 7.00e-22 98.60
IUUC-Stu-112005 Solanum tuberosum 30.51 2.00e-03 31.60
IUUC-Sar-113447 Sorex araneus 23.96 2.00e-38 153.00
IUUC-Sre-115045 Sporisorium reilianum 27.92 9.00e-102 364.00
IUUC-Ssc-115525 Sus scrofa 24.61 2.00e-46 179.00
IUUC-Tgu-116943 Taeniopygia guttata 23.84 2.00e-47 183.00
IUUC-Tru-117782 Takifugu rubripes 22.54 1.00e-42 167.00
IUUC-Tni-119987 Tetraodon nigroviridis 23.41 6.00e-37 148.00
IUUC-Tre-122137 Trichoderma reesei 28.08 1.00e-167 583.00
IUUC-Tvi-122272 Trichoderma virens 28.35 8.00e-174 603.00
IUUC-Tae-125358 Triticum aestivum 29.55 2.00e-20 93.60
IUUC-Tme-127156 Tuber melanosporum 30.57 0.00e+00 652.00
IUUC-Tbe-128103 Tupaia belangeri 40.16 8.00e-22 98.20
IUUC-Ttr-128253 Tursiops truncatus 24.05 5.00e-38 152.00
IUUC-Uma-129344 Ustilago maydis 27.89 3.00e-104 372.00
IUUC-Vda-129778 Verticillium dahliae 28.37 5.00e-178 617.00
IUUC-Vpa-130540 Vicugna pacos 24.36 2.00e-43 170.00
IUUC-Vvi-131290 Vitis vinifera 23.87 7.00e-20 91.70
IUUC-Xtr-132690 Xenopus tropicalis 23.55 2.00e-43 170.00
IUUC-Xma-134112 Xiphophorus maculatus 24.74 2.00e-50 193.00
Created Date 25-Jun-2017

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