iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048914

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01003149

Gene Name

Herc1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000016063.2	ENSSTOT00000016079.2	ENSSTOP00000014391.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-93	313.8	939	1273
E3 adaptor/Cullin RING/DCX/DWD	1.40e-09	37.9	176	215

Active Site

Position(s)	Description	Evidence
1242	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 939  PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 1025
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+ ++l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 1026 PLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 1112
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 1113 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 1197
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Ys++ ++ e+L+yAi++++++++
   Q: 1198 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSNQLVMAERLRYAINNCRSIDM 1273
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH  +v+ +af sd   lvsG+  g + +W+lr+g +l++
   Q: 176  GHITPVRTVAFsSDgLALVSGGLGGLMNIWSLRDGSVLQT 215
           78889******9995669*****************99985 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MHRRELEHCY RKDVSVTCIA WFSEDRPFAV GYFDGKLLLG TKEPLEKGGI VLIDAHKDTL 60
VSMKWDPTGH ILMTCAKEEN VKLWGLISGC WRCLHSLCHP SIVNGIAWCN LPGRGSKLQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACTAATGG CTGAAGAATA AATCAAGATG GCAACTATGG TTCCACCAGT GAAATTGAAA 60
TGGCTAGAAC ATCTGAACAG CTCCTGGATT ACAGAGGACA GTGAATCTAT TGCTACAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	97.45	0.00e+00	2564.00
IUUC-Atr-003065	Amborella trichopoda	32.74	3.00e-47	183.00
IUUC-Apl-003461	Anas platyrhynchos	93.22	0.00e+00	2487.00
IUUC-Aca-004452	Anolis carolinensis	85.77	0.00e+00	2229.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	2.00e-47	184.00
IUUC-Ame-011268	Astyanax mexicanus	67.67	0.00e+00	1790.00
IUUC-Bta-013213	Bos taurus	97.83	0.00e+00	2541.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	6.00e-52	197.00
IUUC-Bol-015203	Brassica oleracea	35.48	5.00e-49	189.00
IUUC-Bra-017584	Brassica rapa	33.94	5.00e-49	189.00
IUUC-Cja-019298	Callithrix jacchus	97.83	0.00e+00	2580.00
IUUC-Cfa-021213	Canis familiaris	97.91	0.00e+00	2574.00
IUUC-Cpo-021674	Cavia porcellus	97.37	0.00e+00	2521.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.76	3.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	97.76	0.00e+00	2577.00
IUUC-Cho-024567	Choloepus hoffmanni	86.61	0.00e+00	1321.00
IUUC-Cin-025709	Ciona intestinalis	36.52	6.00e-174	605.00
IUUC-Csv-026336	Ciona savignyi	37.08	3.00e-179	624.00
IUUC-Dre-028289	Danio rerio	84.57	0.00e+00	2262.00
IUUC-Dno-029988	Dasypus novemcinctus	96.68	0.00e+00	2521.00
IUUC-Dor-030636	Dipodomys ordii	94.80	0.00e+00	2124.00
IUUC-Dme-032171	Drosophila melanogaster	39.39	4.00e-161	564.00
IUUC-Ete-032598	Echinops telfairi	84.93	0.00e+00	1356.00
IUUC-Eca-033754	Equus caballus	97.45	0.00e+00	2565.00
IUUC-Eeu-034702	Erinaceus europaeus	98.52	3.00e-159	558.00
IUUC-Fca-035900	Felis catus	98.37	0.00e+00	2591.00
IUUC-Fal-037034	Ficedula albicollis	89.38	0.00e+00	1493.00
IUUC-Gmo-038634	Gadus morhua	91.02	0.00e+00	1211.00
IUUC-Gga-040321	Gallus gallus	93.51	0.00e+00	2519.00
IUUC-Gac-042444	Gasterosteus aculeatus	65.97	0.00e+00	1781.00
IUUC-Ggo-045134	Gorilla gorilla	97.68	0.00e+00	2575.00
IUUC-Hsa-046516	Homo sapiens	97.76	0.00e+00	2578.00
IUUC-Hvu-047529	Hordeum vulgare	35.38	1.00e-47	185.00
IUUC-Lch-049903	Latimeria chalumnae	89.21	0.00e+00	2383.00
IUUC-Lpe-051165	Leersia perrieri	34.08	2.00e-50	192.00
IUUC-Loc-052149	Lepisosteus oculatus	83.45	0.00e+00	2127.00
IUUC-Laf-053426	Loxodonta africana	97.99	0.00e+00	2580.00
IUUC-Mcc-055826	Macaca mulatta	97.76	0.00e+00	2576.00
IUUC-Mmr-061512	Microcebus murinus	97.91	0.00e+00	2578.00
IUUC-Mdo-062177	Monodelphis domestica	94.75	0.00e+00	2513.00
IUUC-Mmu-064373	Mus musculus	97.83	0.00e+00	2568.00
IUUC-Mpu-066148	Mustela putorius furo	97.60	0.00e+00	2573.00
IUUC-Mlu-067680	Myotis lucifugus	96.98	0.00e+00	2519.00
IUUC-Nle-069633	Nomascus leucogenys	96.75	0.00e+00	2529.00
IUUC-Opr-070609	Ochotona princeps	88.40	0.00e+00	1249.00
IUUC-Ont-071249	Oreochromis niloticus	84.23	0.00e+00	2229.00
IUUC-Oan-073157	Ornithorhynchus anatinus	94.00	0.00e+00	2496.00
IUUC-Ocu-074841	Oryctolagus cuniculus	98.07	0.00e+00	2584.00
IUUC-Oba-075262	Oryza barthii	33.50	2.00e-48	186.00
IUUC-Obr-076115	Oryza brachyantha	34.10	2.00e-48	186.00
IUUC-Ogl-077586	Oryza glaberrima	33.50	2.00e-48	186.00
IUUC-Ogu-078796	Oryza glumaepatula	33.25	9.00e-48	184.00
IUUC-Oin-079298	Oryza indica	33.25	9.00e-48	184.00
IUUC-Olo-080768	Oryza longistaminata	34.78	6.00e-53	201.00
IUUC-Ome-081908	Oryza meridionalis	34.29	2.00e-47	182.00
IUUC-Oni-082049	Oryza nivara	33.25	9.00e-48	184.00
IUUC-Opu-083608	Oryza punctata	33.17	4.00e-49	188.00
IUUC-Oru-084712	Oryza rufipogon	33.25	9.00e-48	184.00
IUUC-Osa-086078	Oryza sativa	33.25	9.00e-48	184.00
IUUC-Ola-086889	Oryzias latipes	84.52	0.00e+00	2236.00
IUUC-Oga-088459	Otolemur garnettii	98.22	0.00e+00	2583.00
IUUC-Oar-089888	Ovis aries	97.83	0.00e+00	2542.00
IUUC-Ptr-091114	Pan troglodytes	97.76	0.00e+00	2578.00
IUUC-Pan-092442	Papio anubis	97.76	0.00e+00	2576.00
IUUC-Psi-093833	Pelodiscus sinensis	93.13	0.00e+00	2499.00
IUUC-Pma-094275	Petromyzon marinus	47.43	3.00e-84	306.00
IUUC-Ppa-095790	Physcomitrella patens	35.80	2.00e-54	206.00
IUUC-Pfo-097262	Poecilia formosa	85.43	0.00e+00	2253.00
IUUC-Pab-097760	Pongo abelii	97.83	0.00e+00	2567.00
IUUC-Pop-099121	Populus trichocarpa	36.63	6.00e-51	196.00
IUUC-Pca-100465	Procavia capensis	96.44	0.00e+00	2529.00
IUUC-Ppe-101345	Prunus persica	33.92	4.00e-51	196.00
IUUC-Pva-102950	Pteropus vampyrus	97.37	0.00e+00	2554.00
IUUC-Rno-104892	Rattus norvegicus	97.68	0.00e+00	2529.00
IUUC-Sha-106633	Sarcophilus harrisii	93.21	0.00e+00	2439.00
IUUC-Smo-108827	Selaginella moellendorffii	35.40	1.00e-50	195.00
IUUC-Sit-110415	Setaria italica	34.42	2.00e-52	199.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	8.00e-52	198.00
IUUC-Stu-112166	Solanum tuberosum	31.71	1.00e-47	184.00
IUUC-Sar-113251	Sorex araneus	86.11	0.00e+00	1358.00
IUUC-Sbi-114352	Sorghum bicolor	31.99	1.00e-44	174.00
IUUC-Ssc-116391	Sus scrofa	97.99	0.00e+00	2581.00
IUUC-Tgu-116554	Taeniopygia guttata	93.06	0.00e+00	2490.00
IUUC-Tru-118695	Takifugu rubripes	85.11	0.00e+00	2242.00
IUUC-Tsy-119647	Tarsius syrichta	85.26	0.00e+00	1248.00
IUUC-Tni-120707	Tetraodon nigroviridis	84.49	0.00e+00	2269.00
IUUC-Tca-121094	Theobroma cacao	35.07	4.00e-50	193.00
IUUC-Tae-124157	Triticum aestivum	31.55	3.00e-44	173.00
IUUC-Tur-126300	Triticum urartu	35.38	4.00e-48	187.00
IUUC-Tbe-127346	Tupaia belangeri	89.24	0.00e+00	2291.00
IUUC-Ttr-128542	Tursiops truncatus	90.54	0.00e+00	1533.00
IUUC-Vpa-130611	Vicugna pacos	92.21	0.00e+00	996.00
IUUC-Xtr-131933	Xenopus tropicalis	87.36	0.00e+00	2222.00
IUUC-Xma-134216	Xiphophorus maculatus	85.12	0.00e+00	2247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence