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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031734
UUCD1 version UUC-DrM-00449
Ensembl Protein ID FBpp0074330
UniProt Accession Q9VWV8; NOSIP_DROME
Genbank Protein ID AAF48829.1
Protein Name Nitric oxide synthase-interacting protein homolog
Genbank Nucleotide ID AE014298
Gene Name CG6179
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0030915 FBtr0074558 FBpp0074330
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
iRefIndexMentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.80e-13 50.4 40 79
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C+++l++ r Pv++++G+ +d+++I +++ ++++
   Q: 40   VKSFDCCSLTLQPCRRPVITKDGYLFDKEAILQYIVTKKN 79
           567789*****************************76655 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
 Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
Protein Sequence
(Fasta)
MTRHARNCTA GAVYTYNEKK RDAAESGYGT NAQRLGKDSV KSFDCCSLTL QPCRRPVITK 60
DGYLFDKEAI LQYIVTKKNE YSRRLKEYER LRRAEEDKLS QEANSKQQAR MERFVNAEKP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031734|E3,U-box|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTATTTAGT GATCAAGATA CGGTCACACC GTATCTAGCA GTAAATAAAC TATTTTAAGC 60
AGTTTATTCA AATTTTTCGC TGCCAAATCC AGGAAACTCT ATTGAAATGA CTCGCCACGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031734|E3,U-box|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF15906--zf-NOSIP
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0000398--P:mRNA splicing, via spliceosome
GO:0043086--P:negative regulation of catalytic activity
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination
KEGG dme:Dmel_CG6179
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000769 Aegilops tauschii 41.98 3.00e-12 66.20
IUUC-Aml-002069 Ailuropoda melanoleuca 49.68 3.00e-78 284.00
IUUC-Atr-002661 Amborella trichopoda 28.85 3.00e-29 121.00
IUUC-Aca-004630 Anolis carolinensis 46.15 2.00e-82 297.00
IUUC-Aly-006316 Arabidopsis lyrata 27.95 6.00e-32 130.00
IUUC-Ath-007000 Arabidopsis thaliana 27.02 7.00e-31 126.00
IUUC-Ame-011874 Astyanax mexicanus 47.73 5.00e-75 273.00
IUUC-Bgr-012090 Blumeria graminis 25.00 1.00e-04 39.70
IUUC-Bta-012956 Bos taurus 49.04 3.00e-80 290.00
IUUC-Bci-013897 Botrytis cinerea 36.25 2.00e-08 52.40
IUUC-Bdi-014968 Brachypodium distachyon 28.67 1.00e-32 132.00
IUUC-Bol-015578 Brassica oleracea 28.99 2.00e-34 138.00
IUUC-Bra-017234 Brassica rapa 28.99 2.00e-34 138.00
IUUC-Cel-018637 Caenorhabditis elegans 41.19 6.00e-56 209.00
IUUC-Cja-019632 Callithrix jacchus 46.62 4.00e-80 290.00
IUUC-Cfa-020192 Canis familiaris 48.87 3.00e-79 288.00
IUUC-Cpo-021939 Cavia porcellus 48.55 4.00e-79 286.00
IUUC-Cre-023005 Chlamydomonas reinhardtii 29.84 2.00e-35 142.00
IUUC-Csa-023802 Chlorocebus sabaeus 48.55 8.00e-81 292.00
IUUC-Cho-024637 Choloepus hoffmanni 54.65 1.00e-21 95.50
IUUC-Cin-025180 Ciona intestinalis 47.73 2.00e-81 294.00
IUUC-Csv-026206 Ciona savignyi 58.11 9.00e-51 191.00
IUUC-Cgl-026696 Colletotrichum gloeosporioides 22.95 3.00e-09 55.50
IUUC-Cne-026827 Cryptococcus neoformans 32.93 2.00e-05 42.70
IUUC-Dre-028092 Danio rerio 49.52 1.00e-81 295.00
IUUC-Dno-029501 Dasypus novemcinctus 43.67 1.00e-64 239.00
IUUC-Dor-030542 Dipodomys ordii 49.20 5.00e-82 296.00
IUUC-Dse-031188 Dothistroma septosporum 23.79 8.00e-10 57.00
IUUC-Eca-033577 Equus caballus 49.22 4.00e-81 293.00
IUUC-Fca-035761 Felis catus 49.20 5.00e-81 293.00
IUUC-Fox-037703 Fusarium oxysporum 32.50 2.00e-06 45.80
IUUC-Fso-038208 Fusarium solani 34.78 4.00e-05 41.20
IUUC-Gmo-038523 Gadus morhua 43.75 1.00e-40 158.00
IUUC-Ggr-040087 Gaeumannomyces graminis 33.77 5.00e-07 47.80
IUUC-Gac-042621 Gasterosteus aculeatus 42.77 6.00e-72 263.00
IUUC-Gma-042698 Glycine max 29.19 1.00e-32 132.00
IUUC-Ggo-045357 Gorilla gorilla 48.55 7.00e-81 292.00
IUUC-Hsa-046195 Homo sapiens 48.55 7.00e-81 292.00
IUUC-Hvu-047174 Hordeum vulgare 27.95 2.00e-32 131.00
IUUC-Itr-048487 Ictidomys tridecemlineatus 48.55 2.00e-80 291.00
IUUC-Lch-050569 Latimeria chalumnae 47.65 2.00e-78 284.00
IUUC-Lpe-050992 Leersia perrieri 30.43 2.00e-17 82.40
IUUC-Loc-052522 Lepisosteus oculatus 46.91 7.00e-76 276.00
IUUC-Lma-053254 Leptosphaeria maculans 32.18 9.00e-08 50.40
IUUC-Laf-053397 Loxodonta africana 48.43 2.00e-81 295.00
IUUC-Mcc-054681 Macaca mulatta 48.55 8.00e-81 293.00
IUUC-Meu-056723 Macropus eugenii 47.40 2.00e-79 287.00
IUUC-Mtr-058063 Medicago truncatula 28.12 1.00e-32 132.00
IUUC-Mla-059004 Melampsora laricipopulina 27.39 2.00e-18 85.10
IUUC-Mvi-060460 Microbotryum violaceum 26.67 8.00e-22 96.70
IUUC-Mmr-060847 Microcebus murinus 49.20 9.00e-82 295.00
IUUC-Mdo-062480 Monodelphis domestica 47.62 5.00e-80 290.00
IUUC-Mmu-063809 Mus musculus 48.73 6.00e-81 293.00
IUUC-Mac-064870 Musa acuminata 27.85 2.00e-31 128.00
IUUC-Mpu-066322 Mustela putorius furo 48.55 5.00e-81 293.00
IUUC-Mlu-067556 Myotis lucifugus 49.52 1.00e-80 291.00
IUUC-Ncr-068898 Neurospora crassa 30.91 5.00e-05 41.60
IUUC-Nle-070049 Nomascus leucogenys 48.55 1.00e-80 292.00
IUUC-Opr-070972 Ochotona princeps 50.96 2.00e-83 301.00
IUUC-Ont-071682 Oreochromis niloticus 48.39 1.00e-77 282.00
IUUC-Oan-073296 Ornithorhynchus anatinus 69.49 1.00e-21 94.70
IUUC-Ocu-074218 Oryctolagus cuniculus 48.28 7.00e-71 259.00
IUUC-Oba-075284 Oryza barthii 28.52 1.00e-32 132.00
IUUC-Obr-076651 Oryza brachyantha 27.81 4.00e-31 127.00
IUUC-Ogl-077899 Oryza glaberrima 28.52 1.00e-32 132.00
IUUC-Ogu-078477 Oryza glumaepatula 27.91 3.00e-32 131.00
IUUC-Oin-080011 Oryza indica 28.52 1.00e-32 132.00
IUUC-Olo-080545 Oryza longistaminata 28.03 4.00e-23 101.00
IUUC-Ome-081543 Oryza meridionalis 28.52 1.00e-32 132.00
IUUC-Oni-082955 Oryza nivara 28.52 1.00e-32 132.00
IUUC-Opu-083565 Oryza punctata 28.52 1.00e-32 132.00
IUUC-Oru-084474 Oryza rufipogon 28.52 1.00e-32 132.00
IUUC-Osa-085913 Oryza sativa 28.52 1.00e-32 132.00
IUUC-Ola-086851 Oryzias latipes 46.47 2.00e-81 294.00
IUUC-Olu-087724 Ostreococcus lucimarinus 29.58 1.00e-16 79.30
IUUC-Oga-087970 Otolemur garnettii 47.44 3.00e-79 287.00
IUUC-Oar-089756 Ovis aries 48.24 3.00e-77 280.00
IUUC-Ptr-091485 Pan troglodytes 47.91 7.00e-78 283.00
IUUC-Pan-091832 Papio anubis 48.55 7.00e-81 292.00
IUUC-Pma-094551 Petromyzon marinus 52.12 3.00e-85 307.00
IUUC-Pno-094830 Phaeosphaeria nodorum 33.33 5.00e-10 57.80
IUUC-Ppa-095255 Physcomitrella patens 27.33 2.00e-29 121.00
IUUC-Pfo-096373 Poecilia formosa 47.12 7.00e-81 292.00
IUUC-Pab-098247 Pongo abelii 48.55 1.00e-80 292.00
IUUC-Pop-099186 Populus trichocarpa 28.52 2.00e-29 122.00
IUUC-Pca-100677 Procavia capensis 46.29 2.00e-60 224.00
IUUC-Ppe-101403 Prunus persica 26.23 8.00e-28 116.00
IUUC-Pva-103000 Pteropus vampyrus 48.55 2.00e-81 294.00
IUUC-Pgr-103663 Puccinia graminis 26.33 2.00e-21 96.30
IUUC-Ptt-103712 Puccinia triticina 34.85 9.00e-08 49.70
IUUC-Pte-104287 Pyrenophora teres 24.83 6.00e-16 77.40
IUUC-Pyt-104579 Pyrenophora triticirepentis 24.38 9.00e-10 57.00
IUUC-Rno-106069 Rattus norvegicus 48.73 5.00e-81 293.00
IUUC-Sha-106553 Sarcophilus harrisii 46.62 7.00e-80 289.00
IUUC-Spo-108182 Schizosaccharomyces pombe 26.67 7.00e-03 33.50
IUUC-Smo-108874 Selaginella moellendorffii 29.04 1.00e-32 132.00
IUUC-Sit-110307 Setaria italica 29.24 1.00e-31 129.00
IUUC-Sly-111094 Solanum lycopersicum 26.84 1.00e-29 122.00
IUUC-Stu-112363 Solanum tuberosum 27.16 4.00e-30 124.00
IUUC-Sar-113480 Sorex araneus 48.87 2.00e-77 281.00
IUUC-Sbi-113939 Sorghum bicolor 28.24 1.00e-30 126.00
IUUC-Ssc-115644 Sus scrofa 48.55 2.00e-81 294.00
IUUC-Tru-118781 Takifugu rubripes 45.60 3.00e-81 293.00
IUUC-Tni-119672 Tetraodon nigroviridis 60.24 1.00e-26 109.00
IUUC-Tca-121795 Theobroma cacao 27.15 7.00e-32 130.00
IUUC-Tre-122037 Trichoderma reesei 33.33 7.00e-06 44.30
IUUC-Tvi-122524 Trichoderma virens 26.04 1.00e-14 72.80
IUUC-Tae-122828 Triticum aestivum 27.95 2.00e-32 131.00
IUUC-Tur-126387 Triticum urartu 25.95 3.00e-22 99.00
IUUC-Tme-127111 Tuber melanosporum 33.75 3.00e-06 45.10
IUUC-Ttr-128227 Tursiops truncatus 48.55 1.00e-80 292.00
IUUC-Vda-129924 Verticillium dahliae 24.56 3.00e-15 75.50
IUUC-Vpa-130802 Vicugna pacos 58.43 2.00e-27 115.00
IUUC-Vvi-131105 Vitis vinifera 26.85 2.00e-29 121.00
IUUC-Xtr-132830 Xenopus tropicalis 47.02 5.00e-82 296.00
IUUC-Xma-133618 Xiphophorus maculatus 45.19 3.00e-74 271.00
IUUC-Zma-135389 Zea mays 29.53 7.00e-32 130.00
Created Date 25-Jun-2017

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