iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068695

Ensembl Protein ID

ESA43429

UniProt Accession

Q7S304; U9W5C9; BRE1_NEUCR

Genbank Protein ID

ESA43429.1

Protein Name

E3 ubiquitin-protein ligase bre1; RING-type E3 ubiquitin transferase bre1

Genbank Nucleotide ID

CM002238

Gene Name

upl-1; bre1; NCU07544

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU07544	ESA43429	ESA43429

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-05	25.0	672	711

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C++ fk+ +++ +CgHvf+ +C+ +++      +++  +CP C+
   Q: 672  CSVCRSNFKN-TILKGCGHVFCNECVdNRL------ANRMRKCPSCN 711
           **********.999************8888......9*********7 PP

Organism

Neurospora crassa

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MPVATSPSAV PRPTTVKMED RKRPAANADD VAPPSKRQAV NGTSKSKDDS NDSREEAWIE 60
EYQKGAIYRQ MLEYKRSKVD LEHRLQEAEK SAAFHDDHLR VIKYWLSQLT QELELIVEGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCCATTG CTCCCGCCCT TCCTCGTCAC AGACAAACAG ATGGAAGACG CGGGACTAAC 60
CAGAGAACAG TAATTCATCG ACCCATTGTA TTCAATTACC CTACTTACCT AACCTCGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08647--BRE1

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination

KEGG

ncr:NCU07544

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001976	Ailuropoda melanoleuca	34.29	7.00e-12	64.30
IUUC-Apl-003407	Anas platyrhynchos	27.31	9.00e-13	67.40
IUUC-Aca-004850	Anolis carolinensis	27.19	1.00e-12	67.00
IUUC-Aly-006469	Arabidopsis lyrata	37.29	2.00e-10	60.10
IUUC-Ath-006615	Arabidopsis thaliana	37.29	2.00e-10	59.30
IUUC-Ago-007988	Ashbya gossypii	31.42	3.00e-35	141.00
IUUC-Acl-008319	Aspergillus clavatus	43.74	4.00e-151	526.00
IUUC-Afl-008679	Aspergillus flavus	40.90	1.00e-118	418.00
IUUC-Afu-008884	Aspergillus fumigatus	41.61	4.00e-122	430.00
IUUC-Ani-009487	Aspergillus nidulans	39.52	3.00e-110	390.00
IUUC-Ang-009601	Aspergillus niger	40.56	2.00e-140	491.00
IUUC-Aor-010142	Aspergillus oryzae	41.04	4.00e-140	490.00
IUUC-Ate-010547	Aspergillus terreus	41.73	2.00e-136	478.00
IUUC-Ame-011916	Astyanax mexicanus	51.06	5.00e-12	65.10
IUUC-Bgr-012245	Blumeria graminis	46.86	2.00e-171	593.00
IUUC-Bta-012357	Bos taurus	34.29	9.00e-12	64.30
IUUC-Bci-013926	Botrytis cinerea	51.61	0.00e+00	681.00
IUUC-Bdi-014799	Brachypodium distachyon	39.66	2.00e-12	66.20
IUUC-Bol-016588	Brassica oleracea	38.98	5.00e-11	61.60
IUUC-Bra-017335	Brassica rapa	38.98	6.00e-11	61.20
IUUC-Cel-018659	Caenorhabditis elegans	25.13	6.00e-12	64.30
IUUC-Cja-019042	Callithrix jacchus	25.81	2.00e-09	56.20
IUUC-Cfa-020320	Canis familiaris	34.29	9.00e-12	64.30
IUUC-Cpo-021617	Cavia porcellus	28.24	1.00e-13	70.50
IUUC-Cre-022940	Chlamydomonas reinhardtii	45.65	5.00e-08	50.80
IUUC-Csa-023509	Chlorocebus sabaeus	34.29	8.00e-12	64.30
IUUC-Cho-024616	Choloepus hoffmanni	34.29	2.00e-11	62.80
IUUC-Cin-025174	Ciona intestinalis	25.11	5.00e-11	62.00
IUUC-Csv-025830	Ciona savignyi	42.55	6.00e-10	58.20
IUUC-Cgl-026569	Colletotrichum gloeosporioides	50.99	0.00e+00	625.00
IUUC-Cne-026878	Cryptococcus neoformans	29.37	1.00e-20	93.60
IUUC-Cme-027134	Cyanidioschyzon merolae	42.37	3.00e-12	65.50
IUUC-Dre-028171	Danio rerio	26.70	4.00e-14	72.00
IUUC-Dno-029537	Dasypus novemcinctus	34.29	1.00e-11	63.90
IUUC-Dor-030250	Dipodomys ordii	34.29	9.00e-12	64.30
IUUC-Dse-031300	Dothistroma septosporum	38.81	1.00e-117	415.00
IUUC-Dme-032034	Drosophila melanogaster	41.51	2.00e-10	60.10
IUUC-Ete-033164	Echinops telfairi	34.29	8.00e-12	64.30
IUUC-Eca-033347	Equus caballus	34.29	9.00e-12	64.30
IUUC-Eeu-034801	Erinaceus europaeus	41.54	1.00e-10	60.10
IUUC-Fca-036024	Felis catus	28.24	1.00e-13	70.90
IUUC-Fal-037622	Ficedula albicollis	48.94	3.00e-11	62.40
IUUC-Fox-038017	Fusarium oxysporum	55.79	0.00e+00	731.00
IUUC-Fso-038414	Fusarium solani	55.67	0.00e+00	634.00
IUUC-Gmo-039446	Gadus morhua	51.06	8.00e-12	64.30
IUUC-Ggr-040117	Gaeumannomyces graminis	54.75	0.00e+00	743.00
IUUC-Gga-040412	Gallus gallus	27.31	2.00e-12	66.60
IUUC-Gac-042205	Gasterosteus aculeatus	27.27	5.00e-12	65.10
IUUC-Gma-042797	Glycine max	26.70	1.00e-12	67.00
IUUC-Ggo-044703	Gorilla gorilla	34.29	8.00e-12	64.30
IUUC-Hsa-046462	Homo sapiens	34.29	8.00e-12	64.30
IUUC-Hvu-047689	Hordeum vulgare	39.66	1.00e-12	67.00
IUUC-Itr-048298	Ictidomys tridecemlineatus	34.29	9.00e-12	64.30
IUUC-Kpa-049345	Komagataella pastoris	29.43	7.00e-28	117.00
IUUC-Lch-049505	Latimeria chalumnae	29.17	1.00e-15	77.00
IUUC-Lpe-051253	Leersia perrieri	36.21	2.00e-12	66.60
IUUC-Loc-052847	Lepisosteus oculatus	48.94	1.00e-10	58.50
IUUC-Lma-053312	Leptosphaeria maculans	38.93	4.00e-129	453.00
IUUC-Laf-054122	Loxodonta africana	34.29	8.00e-12	64.30
IUUC-Mcc-054647	Macaca mulatta	34.29	8.00e-12	64.30
IUUC-Meu-056559	Macropus eugenii	34.29	8.00e-12	64.30
IUUC-Mor-057068	Magnaporthe oryzae	53.78	0.00e+00	679.00
IUUC-Mpo-057568	Magnaporthe poae	55.16	0.00e+00	744.00
IUUC-Mtr-057632	Medicago truncatula	39.66	3.00e-13	68.90
IUUC-Mla-059072	Melampsora laricipopulina	25.52	1.00e-14	73.60
IUUC-Mga-059731	Meleagris gallopavo	27.31	5.00e-12	65.10
IUUC-Mvi-060341	Microbotryum violaceum	26.07	4.00e-16	78.60
IUUC-Mmr-061495	Microcebus murinus	28.24	1.00e-13	70.50
IUUC-Mdo-062599	Monodelphis domestica	34.29	7.00e-12	64.70
IUUC-Mmu-063278	Mus musculus	34.29	1.00e-11	63.90
IUUC-Mac-065103	Musa acuminata	26.88	3.00e-11	62.40
IUUC-Mpu-065910	Mustela putorius furo	34.29	7.00e-12	64.30
IUUC-Mlu-067040	Myotis lucifugus	34.29	9.00e-12	64.30
IUUC-Nfi-068269	Neosartorya fischeri	41.19	3.00e-122	430.00
IUUC-Nle-069058	Nomascus leucogenys	34.29	8.00e-12	64.30
IUUC-Opr-071149	Ochotona princeps	34.29	1.00e-11	63.90
IUUC-Ont-072543	Oreochromis niloticus	50.98	5.00e-13	68.60
IUUC-Oan-072996	Ornithorhynchus anatinus	28.57	7.00e-14	70.90
IUUC-Ocu-074773	Oryctolagus cuniculus	34.29	8.00e-12	64.30
IUUC-Oba-075000	Oryza barthii	36.21	6.00e-13	67.80
IUUC-Obr-076532	Oryza brachyantha	36.21	7.00e-13	67.80
IUUC-Ogl-077200	Oryza glaberrima	36.21	6.00e-13	68.20
IUUC-Ogu-078279	Oryza glumaepatula	36.21	5.00e-13	68.20
IUUC-Oin-079097	Oryza indica	36.21	6.00e-13	68.20
IUUC-Olo-080612	Oryza longistaminata	39.58	4.00e-09	55.50
IUUC-Ome-081304	Oryza meridionalis	37.04	7.00e-12	64.30
IUUC-Oni-082162	Oryza nivara	36.21	7.00e-13	67.80
IUUC-Opu-083683	Oryza punctata	39.58	2.00e-09	56.60
IUUC-Oru-084382	Oryza rufipogon	36.21	7.00e-13	67.80
IUUC-Osa-085839	Oryza sativa	39.58	2.00e-09	56.20
IUUC-Ola-087287	Oryzias latipes	51.06	6.00e-12	64.70
IUUC-Olu-087683	Ostreococcus lucimarinus	37.93	6.00e-09	51.20
IUUC-Oga-088961	Otolemur garnettii	34.29	8.00e-12	64.30
IUUC-Oar-089755	Ovis aries	34.29	1.00e-11	63.90
IUUC-Ptr-091602	Pan troglodytes	34.29	8.00e-12	64.30
IUUC-Pan-092263	Papio anubis	34.29	8.00e-12	64.30
IUUC-Psi-093554	Pelodiscus sinensis	33.33	3.00e-11	62.80
IUUC-Pno-095079	Phaeosphaeria nodorum	39.52	1.00e-127	448.00
IUUC-Ppa-095651	Physcomitrella patens	26.70	3.00e-12	65.50
IUUC-Pfo-097527	Poecilia formosa	48.98	4.00e-12	65.50
IUUC-Pab-098598	Pongo abelii	34.29	8.00e-12	64.30
IUUC-Pop-099376	Populus trichocarpa	36.21	1.00e-11	63.50
IUUC-Pca-100544	Procavia capensis	26.73	7.00e-12	64.70
IUUC-Ppe-102065	Prunus persica	34.48	6.00e-10	58.20
IUUC-Pva-102720	Pteropus vampyrus	34.29	8.00e-12	64.30
IUUC-Pgr-103536	Puccinia graminis	23.63	1.00e-12	66.60
IUUC-Ptt-104014	Puccinia triticina	23.13	6.00e-07	47.80
IUUC-Pte-104415	Pyrenophora teres	35.91	4.00e-117	414.00
IUUC-Pyt-104762	Pyrenophora triticirepentis	37.02	8.00e-122	429.00
IUUC-Rno-104996	Rattus norvegicus	34.29	9.00e-12	64.30
IUUC-Sce-106384	Saccharomyces cerevisiae	32.75	2.00e-42	165.00
IUUC-Sha-107000	Sarcophilus harrisii	34.29	8.00e-12	64.30
IUUC-Sja-108010	Schizosaccharomyces japonicus	25.21	6.00e-27	114.00
IUUC-Spo-108304	Schizosaccharomyces pombe	28.41	3.00e-23	102.00
IUUC-Ssl-108546	Sclerotinia sclerotiorum	49.58	0.00e+00	648.00
IUUC-Smo-109550	Selaginella moellendorffii	29.94	4.00e-11	62.00
IUUC-Sit-110382	Setaria italica	28.93	4.00e-12	65.10
IUUC-Sly-111490	Solanum lycopersicum	35.85	1.00e-09	57.40
IUUC-Sar-113349	Sorex araneus	33.83	5.00e-13	68.60
IUUC-Sbi-114734	Sorghum bicolor	25.14	5.00e-12	62.80
IUUC-Sre-115087	Sporisorium reilianum	29.89	5.00e-26	111.00
IUUC-Ssc-115723	Sus scrofa	34.29	7.00e-12	64.30
IUUC-Tgu-116549	Taeniopygia guttata	48.94	4.00e-11	62.00
IUUC-Tru-118776	Takifugu rubripes	51.06	5.00e-12	65.10
IUUC-Tsy-118808	Tarsius syrichta	34.29	1.00e-11	63.50
IUUC-Tni-120790	Tetraodon nigroviridis	51.06	6.00e-12	64.70
IUUC-Tca-121060	Theobroma cacao	34.48	3.00e-10	59.30
IUUC-Tre-122150	Trichoderma reesei	52.72	0.00e+00	710.00
IUUC-Tvi-122431	Trichoderma virens	55.07	0.00e+00	770.00
IUUC-Tae-124308	Triticum aestivum	39.66	9.00e-13	67.40
IUUC-Tur-126160	Triticum urartu	37.50	8.00e-09	54.30
IUUC-Tme-127177	Tuber melanosporum	37.64	2.00e-119	421.00
IUUC-Tbe-127597	Tupaia belangeri	26.73	2.00e-11	63.20
IUUC-Ttr-128266	Tursiops truncatus	34.29	9.00e-12	64.30
IUUC-Uma-129488	Ustilago maydis	30.66	2.00e-24	106.00
IUUC-Vda-129815	Verticillium dahliae	48.48	0.00e+00	642.00
IUUC-Vpa-130237	Vicugna pacos	34.29	7.00e-12	64.70
IUUC-Vvi-131316	Vitis vinifera	34.48	1.00e-10	60.50
IUUC-Xtr-132906	Xenopus tropicalis	26.48	2.00e-12	66.20
IUUC-Xma-133365	Xiphophorus maculatus	51.06	5.00e-12	65.10
IUUC-Yli-134445	Yarrowia lipolytica	29.24	3.00e-56	211.00
IUUC-Zma-135598	Zea mays	25.47	2.00e-12	66.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence