iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-08	34.7	1515	1643

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC.........................................................................ledf.....kdgplvlpCg 18
           C+iC                                                                         l        ++g++v +Cg
   Q: 1515 CIICncttpstesnpiglvvlvessgivghrrriaerlplpinaedesrlahttrlaaefnrrtellslkfgdeswyL--SnnmayDNGVHVQSCG 1608
           666666666666666666666666666666555555555555555555555555555554444444444433333330..033344789******* PP
   S: 19   HvfhadClqkw.......pglknssskefrCPlCr 46
           H+ h++Cl+++       + ++ + ++ef+CP+Cr
   Q: 1609 HHVHLSCLEAYlktlyttQRQPVQDRGEFYCPVCR 1643
           ******************999999**********8 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MDEDDNLSNA DISIDDEEVV REQTHHPPMQ EDQELDNEDG SSDVDLSSVY VVPPIVSAPS 60
PASVRIAGGS TIGGGGVAAG AVPTTTDNSH SPFHDWDSSV AAAAAPPPPP PRTGPTTTTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTGTAGA GCGGTCACAC TGGATGAAAT TCAAGACCTA TCGATATCCT GATATACACG 60
CCAACGAAGA CCGTGTGTGG ATTCGTGGAG CAAATCGAAG TTGGCAGGAT TAAAGGCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043066--P:negative regulation of apoptotic process
GO:0034126--P:positive regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

dme:Dmel_CG42593

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002071	Ailuropoda melanoleuca	42.63	3.00e-55	208.00
IUUC-Apl-003859	Anas platyrhynchos	44.36	2.00e-59	223.00
IUUC-Aca-004832	Anolis carolinensis	45.60	1.00e-59	223.00
IUUC-Bdi-014635	Brachypodium distachyon	42.86	9.00e-26	112.00
IUUC-Bol-016004	Brassica oleracea	31.62	2.00e-21	98.60
IUUC-Cel-018255	Caenorhabditis elegans	25.49	1.00e-56	215.00
IUUC-Cja-019761	Callithrix jacchus	40.77	7.00e-56	211.00
IUUC-Cpo-021462	Cavia porcellus	34.76	3.00e-56	212.00
IUUC-Cin-025110	Ciona intestinalis	32.57	1.00e-121	431.00
IUUC-Csv-026296	Ciona savignyi	36.78	3.00e-40	158.00
IUUC-Dno-029345	Dasypus novemcinctus	35.26	3.00e-58	219.00
IUUC-Gmo-038976	Gadus morhua	34.28	1.00e-54	207.00
IUUC-Itr-048464	Ictidomys tridecemlineatus	39.82	0.00e+00	634.00
IUUC-Lch-050205	Latimeria chalumnae	40.24	5.00e-135	475.00
IUUC-Lpe-051516	Leersia perrieri	44.63	2.00e-24	108.00
IUUC-Mga-060032	Meleagris gallopavo	44.75	9.00e-60	224.00
IUUC-Mdo-062136	Monodelphis domestica	44.05	2.00e-56	213.00
IUUC-Mac-064773	Musa acuminata	47.66	7.00e-30	126.00
IUUC-Oba-075295	Oryza barthii	26.56	3.00e-16	81.30
IUUC-Obr-076117	Oryza brachyantha	42.86	9.00e-25	109.00
IUUC-Ogl-077571	Oryza glaberrima	42.86	5.00e-25	110.00
IUUC-Ogu-078497	Oryza glumaepatula	26.56	3.00e-16	81.30
IUUC-Oin-079343	Oryza indica	25.46	9.00e-16	79.30
IUUC-Olo-081056	Oryza longistaminata	26.56	3.00e-16	81.30
IUUC-Ome-081738	Oryza meridionalis	26.56	4.00e-16	80.90
IUUC-Oni-083099	Oryza nivara	26.33	6.00e-16	80.10
IUUC-Opu-083202	Oryza punctata	42.86	7.00e-25	110.00
IUUC-Oru-084471	Oryza rufipogon	26.33	8.00e-16	79.70
IUUC-Osa-085336	Oryza sativa	42.86	4.00e-25	109.00
IUUC-Ola-086515	Oryzias latipes	32.80	4.00e-105	374.00
IUUC-Ppa-095715	Physcomitrella patens	25.16	3.00e-30	127.00
IUUC-Pab-098783	Pongo abelii	41.29	9.00e-56	210.00
IUUC-Pop-099496	Populus trichocarpa	37.86	8.00e-23	102.00
IUUC-Pca-101009	Procavia capensis	42.47	2.00e-136	480.00
IUUC-Sha-107406	Sarcophilus harrisii	42.11	8.00e-136	478.00
IUUC-Sit-110716	Setaria italica	41.35	2.00e-24	108.00
IUUC-Sar-112948	Sorex araneus	34.92	1.00e-54	207.00
IUUC-Sbi-114577	Sorghum bicolor	26.48	2.00e-25	111.00
IUUC-Tni-120560	Tetraodon nigroviridis	33.70	9.00e-55	207.00
IUUC-Tca-121077	Theobroma cacao	23.25	1.00e-20	95.50
IUUC-Tbe-127964	Tupaia belangeri	40.53	1.00e-54	206.00
IUUC-Vvi-131290	Vitis vinifera	40.62	9.00e-23	102.00
IUUC-Xtr-132335	Xenopus tropicalis	42.86	9.00e-56	211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence