iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.50e-07	31.8	125	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  +v  CgH+f+  Cl++w        ++ +CP+C+
   Q: 125  CNICLDTAKD-AVVSMCGHLFCWPCLHQW---LLTRPNRKLCPVCK 166
           99********.77799*************...44599999*****7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEEPKSVSTA ELPSTSTGAS SSSSTLSNNV SYDKIAWTRD ITEPLAEESS TSQLRPLGTS 60
IPTNSTASEL KKSNTSYSFT GDYLSGGNKA DLKGGYPFGG TDTDTKANEK DKEKEHTADD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTATCGTC AGTGCAATTG TTTTGAGGTG CTAAGACGTC AATTGATTGA CTTGTCCACA 60
CAATCAATTT AGCAACATTC TCTGATTCGG TTTAACAATA CTTAGCACGG CAAGTAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG32581

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bgr-012018	Blumeria graminis	42.37	3.00e-10	58.50
IUUC-Hvu-047148	Hordeum vulgare	36.24	2.00e-23	103.00
IUUC-Ncr-068628	Neurospora crassa	45.10	3.00e-11	62.40
IUUC-Oba-075500	Oryza barthii	44.55	2.00e-23	102.00
IUUC-Obr-076049	Oryza brachyantha	49.54	4.00e-25	108.00
IUUC-Osa-086198	Oryza sativa	51.14	6.00e-25	107.00
IUUC-Sbi-114164	Sorghum bicolor	40.18	3.00e-23	102.00
IUUC-Tca-121264	Theobroma cacao	42.50	1.00e-24	106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence