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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105168
UUCD1 version UUC-RaN-00448
Ensembl Protein ID ENSRNOP00000014478.2
UniProt Accession D4ABP9; FBX3_RAT
Genbank Protein ID EDL79684.1
Protein Name F-box only protein 3
Genbank Nucleotide ID CH473949
Gene Name Fbxo3; Fbx3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009549.4 ENSRNOT00000014478.4 ENSRNOP00000014478.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 96.16 0.00e+00 793.00 IUUC-Hsa-047002
E3 adaptor/Cullin RING/SCF/F-box 36.36 6.00e-04 40.40 IUUC-Sce-106220
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).
 Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).
Protein Sequence
(Fasta)
MAAVEAETGL LTLESLPTDP LLLILSFVDY RDLINCCYVS RRLSQLSTHD PLWRRHCKKY 60
WLITEEEKAR KNQCWKSLFI ATYSDVGRYI NHYAAIKKAW DDLKKYLEPR CPRMVLSLKE 120
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Protein Fasta Sequence


>IUUC-Rno-105168|E3,F-box|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
AGGCTGCAGC GGGCTGGGCA AGATGGCTGC CGTAGAGGCC GAGACAGGGT TGCTGACCCT 60
GGAGTCGCTA CCCACCGACC CTCTGCTCCT CATCTTATCC TTCGTGGACT ACAGGGACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105168|E3,F-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007474--ApaG_domain
IPR001810--F-box_dom
IPR018958--SMI1/KNR4-like_dom
PROSITE

PS51087--APAG
PS50181--FBOX
Pfam

PF04379--DUF525
PF12937--F-box-like
PF09346--SMI1_KNR4
SMART

SM00256--FBOX
SM00860--SMI1_KNR4
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
KEGG rno:690634
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001541 Ailuropoda melanoleuca 97.26 0.00e+00 774.00
IUUC-Afl-008734 Aspergillus flavus 29.69 4.00e-03 36.20
IUUC-Ani-009404 Aspergillus nidulans 29.69 3.00e-03 36.60
IUUC-Ang-009604 Aspergillus niger 31.03 9.00e-04 38.50
IUUC-Aor-009932 Aspergillus oryzae 29.69 3.00e-03 36.60
IUUC-Bta-013260 Bos taurus 95.44 0.00e+00 789.00
IUUC-Bdi-014986 Brachypodium distachyon 24.62 5.00e-15 75.50
IUUC-Bol-015263 Brassica oleracea 26.09 6.00e-20 91.70
IUUC-Cja-019627 Callithrix jacchus 96.16 0.00e+00 795.00
IUUC-Cfa-020598 Canis familiaris 95.92 0.00e+00 794.00
IUUC-Cpo-021355 Cavia porcellus 96.77 0.00e+00 769.00
IUUC-Csa-023967 Chlorocebus sabaeus 95.92 0.00e+00 792.00
IUUC-Cin-025228 Ciona intestinalis 33.25 1.00e-46 180.00
IUUC-Csv-026017 Ciona savignyi 30.86 2.00e-49 189.00
IUUC-Dno-029157 Dasypus novemcinctus 98.68 2.00e-166 578.00
IUUC-Dor-030275 Dipodomys ordii 96.08 0.00e+00 726.00
IUUC-Ete-032638 Echinops telfairi 92.94 2.00e-152 531.00
IUUC-Eca-034324 Equus caballus 94.70 0.00e+00 739.00
IUUC-Eeu-034676 Erinaceus europaeus 82.08 0.00e+00 642.00
IUUC-Fca-035703 Felis catus 95.92 0.00e+00 794.00
IUUC-Fso-038271 Fusarium solani 34.48 5.00e-05 42.70
IUUC-Ggo-044501 Gorilla gorilla 96.16 0.00e+00 793.00
IUUC-Hsa-047002 Homo sapiens 96.16 0.00e+00 793.00
IUUC-Itr-048749 Ictidomys tridecemlineatus 98.68 2.00e-166 578.00
IUUC-Laf-054310 Loxodonta africana 96.16 0.00e+00 794.00
IUUC-Mcc-055406 Macaca mulatta 95.92 0.00e+00 793.00
IUUC-Mmr-061614 Microcebus murinus 95.64 0.00e+00 783.00
IUUC-Mmu-063540 Mus musculus 98.32 0.00e+00 803.00
IUUC-Mpu-066040 Mustela putorius furo 95.92 0.00e+00 794.00
IUUC-Mlu-067763 Myotis lucifugus 88.59 0.00e+00 788.00
IUUC-Nfi-068290 Neosartorya fischeri 31.25 7.00e-04 38.90
IUUC-Nle-069186 Nomascus leucogenys 96.16 0.00e+00 793.00
IUUC-Opr-070860 Ochotona princeps 82.91 3.00e-79 289.00
IUUC-Ocu-074378 Oryctolagus cuniculus 71.88 4.00e-61 227.00
IUUC-Oba-075362 Oryza barthii 24.71 8.00e-13 67.80
IUUC-Ogl-077469 Oryza glaberrima 23.37 1.00e-12 68.20
IUUC-Oin-079080 Oryza indica 23.37 7.00e-12 65.10
IUUC-Ome-081119 Oryza meridionalis 24.18 3.00e-13 69.70
IUUC-Opu-084117 Oryza punctata 23.28 3.00e-12 66.20
IUUC-Osa-085783 Oryza sativa 23.37 6.00e-12 65.50
IUUC-Oga-088925 Otolemur garnettii 95.68 0.00e+00 788.00
IUUC-Oar-090074 Ovis aries 95.68 0.00e+00 791.00
IUUC-Ptr-091462 Pan troglodytes 96.16 0.00e+00 793.00
IUUC-Pan-092326 Papio anubis 95.92 0.00e+00 793.00
IUUC-Psi-093898 Pelodiscus sinensis 86.71 2.00e-146 511.00
IUUC-Pab-097597 Pongo abelii 96.16 0.00e+00 793.00
IUUC-Pva-102622 Pteropus vampyrus 96.40 0.00e+00 796.00
IUUC-Sce-106220 Saccharomyces cerevisiae 36.36 2.00e-04 40.80
IUUC-Sit-110738 Setaria italica 23.43 2.00e-09 57.00
IUUC-Stu-112725 Solanum tuberosum 33.33 3.00e-05 43.10
IUUC-Ssc-115881 Sus scrofa 95.17 4.00e-156 543.00
IUUC-Tca-121476 Theobroma cacao 26.11 2.00e-18 86.70
IUUC-Tur-126848 Triticum urartu 24.72 2.00e-13 70.10
IUUC-Ttr-128934 Tursiops truncatus 95.87 0.00e+00 686.00
IUUC-Uma-129413 Ustilago maydis 39.47 2.30e-01 31.60
IUUC-Vda-129904 Verticillium dahliae 30.85 2.00e-05 43.90
IUUC-Vpa-130081 Vicugna pacos 97.38 0.00e+00 736.00
Created Date 25-Jun-2017

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