iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	21421380

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-35	120.3	140	178
UBD/Beta-Prp	6.10e-55	187.4	12	252

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ +++ ++f +d + +vsG+ D+++kvWDl+ g+ll+
   Q: 140  GHSRGISTIRFtPDgRWVVSGGLDNVVKVWDLTAGKLLH 178
           8***********99999******************9987 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            +h++ ++c+ + ++ ++l++tg++d ++ +w + +++ l sl gh+++v +v f++ + + + g++ ++ik+wd++  k+v++++gh ++  +++f+
   Q: 12   LAHSANVNCLSIgKKTSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFH 109
           57899999999999*********************************************9999*********************************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsld 201
           p g++l+sGs+d  +++wd++++ c++ t +gh++ ++++++ pdg+ +vsG+lD++v++Wdl  gkll++++  h+++++sl+f++  + l++gs d
   Q: 110  PFGEFLASGSSDANLKIWDIRKKGCIQ-TYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKF-HEGPIRSLDFHPLEFLLATGSAD 205
           ***************************.*********************************************9.*********************** PP
   S: 202  gtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +tvk+wdl+t e + + +   + v+s++f+p++  l +g  D s++++
   Q: 206  RTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCG-LDDSLKVY 252
           ******************************999999998.57777775 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May participate in a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.

Protein Sequence
(Fasta)

MAKRGYKLQE FLAHSANVNC LSIGKKTSRL FITGGDDYKV NLWAIGKPTS LMSLCGHTSA 60
VDSVAFDSAE VLVLAGASSG VIKLWDVEEA KMVRAFTGHR SNCSAVEFHP FGEFLASGSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTCGTGTC ACTATTTGAA TCTGATTTCG TCTCGTTTCT TTCAATCTTC TTCCCCGAAT 60
CTGATTCTCT CTCACGTTTT TTGGATTTCA AATCTCAACG GAAAGCGATC TCTTCTCATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0051013--P:microtubule severing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bol-015355	Brassica oleracea	76.39	0.00e+00	1712.00
IUUC-Bra-017265	Brassica rapa	76.62	0.00e+00	1753.00
IUUC-Gma-043323	Glycine max	63.25	0.00e+00	667.00
IUUC-Mtr-057706	Medicago truncatula	60.15	0.00e+00	629.00
IUUC-Mac-065245	Musa acuminata	67.04	2.00e-153	536.00
IUUC-Ogl-077401	Oryza glaberrima	68.19	6.00e-153	534.00
IUUC-Ogu-078062	Oryza glumaepatula	67.76	1.00e-150	526.00
IUUC-Osa-085801	Oryza sativa	68.19	7.00e-153	533.00
IUUC-Pop-100006	Populus trichocarpa	65.36	0.00e+00	723.00
IUUC-Ppe-101697	Prunus persica	63.06	0.00e+00	654.00
IUUC-Sbi-114389	Sorghum bicolor	63.34	7.00e-149	520.00
IUUC-Tca-121590	Theobroma cacao	66.54	0.00e+00	729.00
IUUC-Tae-125438	Triticum aestivum	71.43	7.00e-149	520.00
IUUC-Tur-126181	Triticum urartu	70.72	3.00e-146	511.00
IUUC-Tme-127141	Tuber melanosporum	30.58	6.00e-30	124.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence