iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000066427.21	ENST00000558190.5	ENSP00000478320.1
ENSG00000066427.21	ENST00000359366.9	ENSP00000352324.5
ENSG00000066427.21	ENST00000503767.5	ENSP00000426697.1
ENSG00000066427.21	ENST00000340660.10	ENSP00000339110.6
ENSG00000066427.21	ENST00000532032.5	ENSP00000437157.1
ENSG00000066427.21	ENST00000554592.5	ENSP00000451385.1
ENSG00000066427.21	ENST00000556315.5	ENSP00000451132.1
ENSG00000066427.21	ENST00000554672.5	ENSP00000451417.1
ENSG00000066427.21	ENST00000557030.5	ENSP00000452139.1
ENSG00000066427.21	ENST00000556958.5	ENSP00000452532.1
ENSG00000066427.21	ENST00000556374.5	ENSP00000451399.1
ENSG00000066427.21	ENST00000553570.5	ENSP00000451405.1
ENSG00000066427.21	ENST00000554994.5	ENSP00000451771.1
ENSG00000066427.21	ENST00000556671.5	ENSP00000451693.1
ENSG00000066427.21	ENST00000554350.5	ENSP00000451103.1
ENSG00000066427.21	ENST00000556220.5	ENSP00000450641.1
ENSG00000066427.21	ENST00000554673.5	ENSP00000452356.1
ENSG00000066427.21	ENST00000506466.5	ENSP00000435571.1
ENSG00000066427.21	ENST00000526872.2	ENSP00000474067.1
ENSG00000066427.21	ENST00000429774.6	ENSP00000389376.3
ENSG00000066427.21	ENST00000620536.4	ENSP00000484016.1
ENSG00000066427.21	ENST00000545170.5	ENSP00000445618.2
ENSG00000066427.21	ENST00000621269.4	ENSP00000481390.1
ENSG00000066427.21	ENST00000393287.9	ENSP00000376965.6
ENSG00000066427.21	ENST00000617719.4	ENSP00000481998.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	15265035; 16118278
UBD/Alpha-Helix/UIM	UIM	24063750
DUB/Josephin	Josephin	20940148; 21245847; 18599482

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	1.60e-05	26.0	224	242
UBD/Alpha-Helix/UIM	2.6e-05	16.2	244	260

Active Site

Position(s)	Description	Evidence
14	Nucleophile	{ECO:0000269\|PubMed:23625928}
119	Proton acceptor	{ECO:0000305\|PubMed:16020535, ECO:0000305\|PubMed:16118278}
134	N/A	{ECO:0000305\|PubMed:16020535, ECO:0000305\|PubMed:16118278}

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +++e+Lq+AlalS+qE ++
   Q: 224  EDEEDLQRALALSRQEIDM 242
           69**************886 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           dE+++L++A++lS+q  
   Q: 244  DEEADLRRAIQLSMQGS 260
           7*************976 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription.

Protein Sequence
(Fasta)

MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT 60
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGGGGCA GGGGGCGGAG CTGGAGGGGG TGGTTCGGCG TGGGGGCCGT TGGCTCCAGA 60
CAAATAAACA TGGAGTCCAT CTTCCACGAG AAAGTGAGTG TCCGCGTTCG GTGGGGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0950--Spinocerebellar ataxia
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0818--Triplet repeat expansion
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR011990--TPR-like_helical_dom
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN
PS50330--UIM

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005759--C:mitochondrial matrix
GO:0031966--C:mitochondrial membrane
GO:0042405--C:nuclear inclusion body
GO:0016363--C:nuclear matrix
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0051117--F:ATPase binding
GO:0042802--F:identical protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0030036--P:actin cytoskeleton organization
GO:0034605--P:cellular response to heat
GO:0071218--P:cellular response to misfolded protein
GO:0007268--P:chemical synaptic transmission
GO:0045104--P:intermediate filament cytoskeleton organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0007399--P:nervous system development
GO:0006289--P:nucleotide-excision repair
GO:1904294--P:positive regulation of ERAD pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:1904379--P:protein localization to cytosolic proteasome complex involved in ERAD pathway
GO:0010810--P:regulation of cell-substrate adhesion
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:4287

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	90.62	1.00e-172	598.00
IUUC-Apl-003210	Anas platyrhynchos	76.12	5.00e-134	470.00
IUUC-Aca-005171	Anolis carolinensis	78.60	4.00e-115	407.00
IUUC-Aly-005625	Arabidopsis lyrata	44.64	3.00e-40	158.00
IUUC-Ath-007088	Arabidopsis thaliana	44.64	3.00e-40	158.00
IUUC-Afu-009069	Aspergillus fumigatus	30.67	1.10e-01	30.00
IUUC-Ame-010715	Astyanax mexicanus	70.93	3.00e-121	427.00
IUUC-Bta-013538	Bos taurus	81.54	8.00e-166	576.00
IUUC-Bci-013745	Botrytis cinerea	34.85	1.80e-01	31.60
IUUC-Bdi-015000	Brachypodium distachyon	42.01	2.00e-35	143.00
IUUC-Bol-015894	Brassica oleracea	44.05	1.00e-40	160.00
IUUC-Bra-018020	Brassica rapa	44.31	4.00e-41	162.00
IUUC-Cel-018121	Caenorhabditis elegans	37.12	1.00e-43	169.00
IUUC-Cja-018840	Callithrix jacchus	89.89	0.00e+00	674.00
IUUC-Cfa-021035	Canis familiaris	91.67	1.00e-175	608.00
IUUC-Cpo-021776	Cavia porcellus	85.19	3.00e-168	584.00
IUUC-Cho-024878	Choloepus hoffmanni	89.71	4.00e-169	587.00
IUUC-Cgl-026754	Colletotrichum gloeosporioides	55.56	4.20e-01	30.80
IUUC-Dre-027506	Danio rerio	69.64	2.00e-89	322.00
IUUC-Dno-029172	Dasypus novemcinctus	89.71	4.00e-173	600.00
IUUC-Dor-030900	Dipodomys ordii	80.00	2.00e-149	521.00
IUUC-Ete-033000	Echinops telfairi	66.54	6.00e-84	304.00
IUUC-Eca-034338	Equus caballus	91.76	7.00e-172	596.00
IUUC-Eeu-034585	Erinaceus europaeus	98.10	7.00e-57	214.00
IUUC-Fca-035441	Felis catus	90.07	5.00e-71	259.00
IUUC-Fal-037525	Ficedula albicollis	86.04	1.00e-127	449.00
IUUC-Gmo-039718	Gadus morhua	72.41	2.00e-111	394.00
IUUC-Gga-040774	Gallus gallus	82.45	7.00e-141	493.00
IUUC-Gac-041671	Gasterosteus aculeatus	72.76	5.00e-108	384.00
IUUC-Gma-042801	Glycine max	41.32	8.00e-37	147.00
IUUC-Ggo-044759	Gorilla gorilla	83.57	4.00e-134	470.00
IUUC-Hvu-047492	Hordeum vulgare	43.20	3.00e-34	139.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	76.51	2.00e-130	457.00
IUUC-Lch-049519	Latimeria chalumnae	70.47	1.00e-109	389.00
IUUC-Lpe-050819	Leersia perrieri	43.27	3.00e-35	142.00
IUUC-Loc-051816	Lepisosteus oculatus	75.50	4.00e-129	454.00
IUUC-Laf-053784	Loxodonta africana	90.15	4.00e-173	600.00
IUUC-Mcc-055283	Macaca mulatta	94.54	0.00e+00	638.00
IUUC-Meu-056589	Macropus eugenii	87.20	4.00e-143	501.00
IUUC-Mtr-058233	Medicago truncatula	34.32	6.00e-37	148.00
IUUC-Mla-059013	Melampsora laricipopulina	39.90	1.00e-30	127.00
IUUC-Mga-059301	Meleagris gallopavo	81.13	6.00e-143	500.00
IUUC-Mmr-061038	Microcebus murinus	91.76	9.00e-177	612.00
IUUC-Mdo-062927	Monodelphis domestica	92.11	4.00e-150	524.00
IUUC-Mmu-063600	Mus musculus	87.23	2.00e-153	535.00
IUUC-Mpu-065897	Mustela putorius furo	96.11	1.00e-158	552.00
IUUC-Mlu-067543	Myotis lucifugus	95.05	1.00e-159	555.00
IUUC-Nle-069847	Nomascus leucogenys	88.51	9.00e-168	582.00
IUUC-Opr-070550	Ochotona princeps	81.47	1.00e-147	515.00
IUUC-Ont-071723	Oreochromis niloticus	69.68	2.00e-110	392.00
IUUC-Oan-073569	Ornithorhynchus anatinus	78.90	7.00e-149	520.00
IUUC-Ocu-074632	Oryctolagus cuniculus	89.81	1.00e-168	585.00
IUUC-Oba-075288	Oryza barthii	43.27	1.00e-37	150.00
IUUC-Obr-076050	Oryza brachyantha	42.69	2.00e-33	136.00
IUUC-Ogl-077174	Oryza glaberrima	43.27	1.00e-37	150.00
IUUC-Ogu-078006	Oryza glumaepatula	43.27	1.00e-37	150.00
IUUC-Oin-079278	Oryza indica	40.88	5.00e-35	141.00
IUUC-Olo-080941	Oryza longistaminata	43.27	1.00e-37	150.00
IUUC-Ome-081172	Oryza meridionalis	43.27	2.00e-37	150.00
IUUC-Oni-082239	Oryza nivara	43.27	1.00e-37	150.00
IUUC-Opu-083939	Oryza punctata	42.69	6.00e-37	147.00
IUUC-Oru-084393	Oryza rufipogon	43.27	1.00e-37	150.00
IUUC-Osa-086080	Oryza sativa	43.27	1.00e-37	150.00
IUUC-Ola-087566	Oryzias latipes	73.88	4.00e-111	394.00
IUUC-Oga-088617	Otolemur garnettii	75.00	2.00e-134	471.00
IUUC-Oar-090052	Ovis aries	84.18	2.00e-163	568.00
IUUC-Ptr-091435	Pan troglodytes	95.98	0.00e+00	647.00
IUUC-Psi-093313	Pelodiscus sinensis	88.72	4.00e-131	460.00
IUUC-Pma-094374	Petromyzon marinus	60.75	1.00e-84	306.00
IUUC-Ppa-095601	Physcomitrella patens	44.64	2.00e-44	173.00
IUUC-Pfo-097327	Poecilia formosa	70.37	1.00e-112	399.00
IUUC-Pab-098611	Pongo abelii	94.26	3.00e-152	530.00
IUUC-Pca-101022	Procavia capensis	99.11	5.00e-65	241.00
IUUC-Ppe-101545	Prunus persica	43.45	2.00e-38	152.00
IUUC-Pva-102844	Pteropus vampyrus	91.67	1.00e-175	608.00
IUUC-Rno-104896	Rattus norvegicus	84.24	3.00e-162	564.00
IUUC-Sha-107106	Sarcophilus harrisii	84.66	7.00e-158	549.00
IUUC-Sit-110477	Setaria italica	43.86	1.00e-36	147.00
IUUC-Sly-111416	Solanum lycopersicum	39.13	9.00e-18	83.60
IUUC-Stu-112227	Solanum tuberosum	32.93	3.00e-20	91.70
IUUC-Sar-113534	Sorex araneus	91.13	3.00e-145	508.00
IUUC-Sbi-114751	Sorghum bicolor	42.77	3.00e-35	142.00
IUUC-Ssc-115274	Sus scrofa	89.66	1.00e-175	608.00
IUUC-Tgu-117426	Taeniopygia guttata	84.27	4.00e-135	474.00
IUUC-Tru-118059	Takifugu rubripes	73.85	3.00e-109	387.00
IUUC-Tsy-119448	Tarsius syrichta	83.66	3.00e-88	318.00
IUUC-Tni-120681	Tetraodon nigroviridis	89.15	2.00e-61	227.00
IUUC-Tca-121442	Theobroma cacao	35.83	4.00e-40	158.00
IUUC-Tae-123969	Triticum aestivum	42.11	2.00e-32	132.00
IUUC-Tbe-127638	Tupaia belangeri	88.54	1.00e-156	545.00
IUUC-Ttr-129288	Tursiops truncatus	81.03	1.00e-149	522.00
IUUC-Vda-129976	Verticillium dahliae	42.11	9.00e-01	30.00
IUUC-Vpa-130788	Vicugna pacos	90.12	7.00e-171	593.00
IUUC-Vvi-131227	Vitis vinifera	42.51	7.00e-36	144.00
IUUC-Xtr-132147	Xenopus tropicalis	76.82	3.00e-124	437.00
IUUC-Xma-133144	Xiphophorus maculatus	70.03	3.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence