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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046090
UUCD1 version UUC-HoS-00836
Ensembl Protein ID ENSP00000378328.3
UniProt Accession Q86YJ7; Q8N7S9; AN13B_HUMAN
Genbank Protein ID BAC05148.1; AAH32554.3
Protein Name Ankyrin repeat domain-containing protein 13B
Genbank Nucleotide ID AK097716; AC104564
Gene Name ANKRD13B
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198720.12 ENST00000394859.7 ENSP00000378328.3
ENSG00000198720.12 ENST00000579719.1 ENSP00000465708.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanmiRecords
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 22298428
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UIM 0.0001 23.6 586 604
UBD/Alpha-Helix/UIM 0.00018 13.6 503 520
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 2    EdeeLqlAlalSlqEeees 20
            de+L+lA++lS qE+ee+
   Q: 586  YDEQLRLAMELSAQEQEER 604
           69**************986 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEee 18
           d+d++Lq A+++Sl E++
   Q: 503  DDDDLLQFAIQQSLLEAG 520
           79**************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
 Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Protein Sequence
(Fasta)
MIPANASARK GPEGKYPLHY LVWHNRHREL EKEVRAGQVD IEQLDPRGRT PLHLATTLGH 60
LECARVLLAH GADVGRENRS GWTVLQEAVS TRDLELVQLV LRYRDYQRVV KRLAGIPVLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046090|UBD,UIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTTAAAGGG GCCGCGGCAG ATGCCCGGCC CCGGCGGGCA GCGTGGCCTG CGGCCCTGGC 60
CTCCGCTGCA GCGCTCGCCT GGCCCGGAGG CAATGTGAGT CACCCTCACA GCCCCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046090|UBD,UIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR021832--ANKRD13
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR003903--UIM_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM
Pfam

PF12796--Ank_2
PF11904--GPCR_chapero_1
SMART

SM00248--ANK
SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane
KEGG hsa:124930
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000665 Aegilops tauschii 30.10 1.00e-14 74.30
IUUC-Aml-002227 Ailuropoda melanoleuca 98.65 0.00e+00 1010.00
IUUC-Atr-002910 Amborella trichopoda 33.60 1.00e-30 128.00
IUUC-Aca-004536 Anolis carolinensis 75.13 0.00e+00 831.00
IUUC-Aly-006347 Arabidopsis lyrata 27.20 1.00e-33 138.00
IUUC-Ath-007312 Arabidopsis thaliana 27.96 9.00e-37 148.00
IUUC-Ame-011280 Astyanax mexicanus 70.98 0.00e+00 799.00
IUUC-Bta-012633 Bos taurus 97.49 0.00e+00 1109.00
IUUC-Bdi-015044 Brachypodium distachyon 32.84 7.00e-27 115.00
IUUC-Bol-016226 Brassica oleracea 28.17 2.00e-34 140.00
IUUC-Bra-017598 Brassica rapa 29.54 1.00e-37 150.00
IUUC-Cja-019421 Callithrix jacchus 98.48 0.00e+00 836.00
IUUC-Cfa-020114 Canis familiaris 96.15 0.00e+00 1088.00
IUUC-Cpo-022470 Cavia porcellus 98.56 0.00e+00 1048.00
IUUC-Csa-023354 Chlorocebus sabaeus 99.33 0.00e+00 1105.00
IUUC-Dre-027443 Danio rerio 70.05 0.00e+00 801.00
IUUC-Dno-029392 Dasypus novemcinctus 94.60 0.00e+00 968.00
IUUC-Dor-030806 Dipodomys ordii 92.68 0.00e+00 782.00
IUUC-Eca-033903 Equus caballus 98.28 0.00e+00 1002.00
IUUC-Eeu-034577 Erinaceus europaeus 96.88 0.00e+00 888.00
IUUC-Fca-035836 Felis catus 96.65 0.00e+00 1095.00
IUUC-Fal-037542 Ficedula albicollis 85.69 0.00e+00 991.00
IUUC-Gmo-039247 Gadus morhua 68.68 0.00e+00 796.00
IUUC-Gga-040451 Gallus gallus 89.42 0.00e+00 976.00
IUUC-Gac-041465 Gasterosteus aculeatus 68.17 0.00e+00 779.00
IUUC-Gma-043893 Glycine max 32.40 4.00e-38 152.00
IUUC-Ggo-044843 Gorilla gorilla 99.82 0.00e+00 1024.00
IUUC-Hvu-047841 Hordeum vulgare 31.79 4.00e-31 129.00
IUUC-Itr-048446 Ictidomys tridecemlineatus 98.55 0.00e+00 1066.00
IUUC-Lch-049984 Latimeria chalumnae 82.45 0.00e+00 872.00
IUUC-Lpe-051217 Leersia perrieri 32.94 9.00e-27 115.00
IUUC-Laf-054198 Loxodonta africana 92.10 0.00e+00 1051.00
IUUC-Mcc-055437 Macaca mulatta 99.49 0.00e+00 1105.00
IUUC-Meu-056403 Macropus eugenii 88.93 0.00e+00 936.00
IUUC-Mtr-058522 Medicago truncatula 29.03 2.00e-32 134.00
IUUC-Mga-059949 Meleagris gallopavo 84.72 0.00e+00 840.00
IUUC-Mmr-061704 Microcebus murinus 98.65 0.00e+00 1099.00
IUUC-Mdo-062800 Monodelphis domestica 90.24 0.00e+00 1043.00
IUUC-Mmu-064320 Mus musculus 96.99 0.00e+00 1089.00
IUUC-Mac-065460 Musa acuminata 29.71 5.00e-38 152.00
IUUC-Mpu-065892 Mustela putorius furo 97.86 0.00e+00 1021.00
IUUC-Mlu-067964 Myotis lucifugus 82.45 0.00e+00 826.00
IUUC-Nle-069652 Nomascus leucogenys 93.36 0.00e+00 904.00
IUUC-Opr-071009 Ochotona princeps 90.43 0.00e+00 896.00
IUUC-Ont-072518 Oreochromis niloticus 71.38 0.00e+00 777.00
IUUC-Oan-072815 Ornithorhynchus anatinus 86.75 0.00e+00 819.00
IUUC-Ocu-074278 Oryctolagus cuniculus 99.55 0.00e+00 928.00
IUUC-Oba-075972 Oryza barthii 30.51 2.00e-26 114.00
IUUC-Obr-076237 Oryza brachyantha 31.01 2.00e-26 113.00
IUUC-Ogl-077611 Oryza glaberrima 31.86 5.00e-32 132.00
IUUC-Ogu-078651 Oryza glumaepatula 31.86 5.00e-32 132.00
IUUC-Oin-079479 Oryza indica 31.86 5.00e-32 132.00
IUUC-Olo-080761 Oryza longistaminata 30.51 2.00e-26 114.00
IUUC-Ome-081427 Oryza meridionalis 31.86 6.00e-32 132.00
IUUC-Oni-082794 Oryza nivara 31.86 5.00e-32 132.00
IUUC-Opu-084158 Oryza punctata 31.55 1.00e-31 131.00
IUUC-Oru-084489 Oryza rufipogon 31.86 5.00e-32 132.00
IUUC-Osa-085430 Oryza sativa 31.86 5.00e-32 132.00
IUUC-Ola-087114 Oryzias latipes 69.52 0.00e+00 804.00
IUUC-Oga-089031 Otolemur garnettii 98.48 0.00e+00 1110.00
IUUC-Oar-089561 Ovis aries 94.48 0.00e+00 1063.00
IUUC-Ptr-091401 Pan troglodytes 99.49 0.00e+00 1095.00
IUUC-Pan-092615 Papio anubis 99.33 0.00e+00 1107.00
IUUC-Ppa-096001 Physcomitrella patens 33.98 2.00e-28 120.00
IUUC-Pfo-096300 Poecilia formosa 65.16 0.00e+00 773.00
IUUC-Pab-098006 Pongo abelii 99.28 0.00e+00 1016.00
IUUC-Pop-099831 Populus trichocarpa 28.71 5.00e-32 132.00
IUUC-Pca-101055 Procavia capensis 92.29 0.00e+00 1044.00
IUUC-Ppe-101713 Prunus persica 35.07 2.00e-34 140.00
IUUC-Pva-102501 Pteropus vampyrus 98.88 0.00e+00 920.00
IUUC-Rno-104986 Rattus norvegicus 97.14 0.00e+00 1088.00
IUUC-Smo-109402 Selaginella moellendorffii 34.66 1.00e-33 137.00
IUUC-Sit-110746 Setaria italica 33.75 6.00e-28 119.00
IUUC-Sly-111817 Solanum lycopersicum 30.37 1.00e-35 144.00
IUUC-Stu-112735 Solanum tuberosum 34.10 2.00e-30 127.00
IUUC-Sar-113707 Sorex araneus 94.06 0.00e+00 1020.00
IUUC-Sbi-114285 Sorghum bicolor 31.65 1.00e-31 131.00
IUUC-Ssc-116209 Sus scrofa 97.32 0.00e+00 1031.00
IUUC-Tgu-117342 Taeniopygia guttata 86.13 0.00e+00 920.00
IUUC-Tru-117882 Takifugu rubripes 63.37 0.00e+00 766.00
IUUC-Tni-119972 Tetraodon nigroviridis 66.18 0.00e+00 694.00
IUUC-Tca-121256 Theobroma cacao 34.13 3.00e-34 140.00
IUUC-Tae-123916 Triticum aestivum 37.04 4.00e-19 89.70
IUUC-Tur-126871 Triticum urartu 30.77 5.00e-24 106.00
IUUC-Tbe-127904 Tupaia belangeri 96.52 0.00e+00 790.00
IUUC-Ttr-128724 Tursiops truncatus 98.91 0.00e+00 1075.00
IUUC-Vvi-131403 Vitis vinifera 29.05 4.00e-30 126.00
IUUC-Xtr-132340 Xenopus tropicalis 75.22 0.00e+00 791.00
IUUC-Xma-133401 Xiphophorus maculatus 70.12 0.00e+00 763.00
Created Date 25-Jun-2017

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