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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046445
UUCD1 version UUC-HoS-01020
Ensembl Protein ID ENSP00000244426.6
UniProt Accession Q9UK97; A6NFW3; B3KMM6; O75986; Q59EH8; Q6PKH7; Q9NT57; Q9Y593; FBX9_HUMAN
Genbank Protein ID AAF03704.1; AAW51115.1; CAB70786.2; BAG51038.1; BAD93070.1; CAI20262.1; CAI20263.1; AAH00650.2; AAF04518.1
Protein Name F-box only protein 9; Cross-immune reaction antigen 1; Renal carcinoma antigen NY-REN-57
Genbank Nucleotide ID AF176704; AY858798; AL137520; AK021559; AB209833; AL031178; AL031178; BC000650; AF174597
Gene Name FBXO9; FBX9; VCIA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000112146.16 ENST00000323557.11 ENSP00000326968.7
ENSG00000112146.16 ENST00000244426.10 ENSP00000244426.6
ENSG00000112146.16 ENST00000484436.7 ENSP00000477487.1
ENSG00000112146.16 ENST00000473318.1 ENSP00000417349.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 23263282
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00056 21.6 178 236
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 93   tpeegpdaglldrlpeeilveilkll.....dkeellraarvcrrwqelasqkalwktv 146
            pe ++ + +++ lp e+l+ i++ +     d ++l ++++vcr ++ +a+++++w+ +
   Q: 178  QPELESSQIHISVLPMEVLMYIFRWVvssdlDLRSLEQLSLVCRGFYICARDPEIWRLA 236
           58999999*****************8888889999*********************865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Protein Sequence
(Fasta)
MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS 60
SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046445|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATACGTATGC CATGGAGGTT TGCTGCACCT ATTGACCCGT CCTGTAAGTT CCCTCCCCTC 60
GTCCCACCTA CCCCACAACA GGCCCTGGTG TGTGTTGTTC CCCTCCCTGT GTCCATGTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046445|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR007330--MIT
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0032006--P:regulation of TOR signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:26268
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000378 Aegilops tauschii 35.54 5.00e-15 74.30
IUUC-Aml-001660 Ailuropoda melanoleuca 95.41 0.00e+00 863.00
IUUC-Atr-003042 Amborella trichopoda 35.03 7.00e-24 104.00
IUUC-Apl-004118 Anas platyrhynchos 84.25 0.00e+00 723.00
IUUC-Aca-005282 Anolis carolinensis 84.25 0.00e+00 737.00
IUUC-Aly-005616 Arabidopsis lyrata 32.39 5.00e-20 91.70
IUUC-Ath-007590 Arabidopsis thaliana 32.95 3.00e-20 92.40
IUUC-Acl-008135 Aspergillus clavatus 26.57 8.00e-18 85.50
IUUC-Afl-008699 Aspergillus flavus 26.04 2.00e-20 94.40
IUUC-Afu-008824 Aspergillus fumigatus 25.07 5.00e-17 82.80
IUUC-Ani-009388 Aspergillus nidulans 25.68 2.00e-17 84.00
IUUC-Ang-009815 Aspergillus niger 26.12 1.00e-16 81.60
IUUC-Aor-010113 Aspergillus oryzae 51.43 6.00e-06 44.70
IUUC-Ate-010365 Aspergillus terreus 28.37 5.00e-15 76.30
IUUC-Ame-011406 Astyanax mexicanus 70.73 5.00e-178 617.00
IUUC-Bgr-012145 Blumeria graminis 26.86 4.00e-18 86.30
IUUC-Bta-012354 Bos taurus 93.36 0.00e+00 851.00
IUUC-Bci-013686 Botrytis cinerea 25.75 2.00e-19 90.90
IUUC-Bdi-014609 Brachypodium distachyon 36.02 2.00e-24 106.00
IUUC-Bol-016149 Brassica oleracea 32.77 1.00e-20 94.00
IUUC-Bra-017126 Brassica rapa 32.77 7.00e-21 94.70
IUUC-Cfa-020387 Canis familiaris 95.64 0.00e+00 867.00
IUUC-Cpo-021298 Cavia porcellus 91.97 0.00e+00 819.00
IUUC-Cre-022803 Chlamydomonas reinhardtii 34.50 4.00e-20 92.40
IUUC-Csa-024074 Chlorocebus sabaeus 99.08 0.00e+00 880.00
IUUC-Cho-024705 Choloepus hoffmanni 96.11 2.00e-146 512.00
IUUC-Cin-025508 Ciona intestinalis 35.68 5.00e-65 241.00
IUUC-Csv-026173 Ciona savignyi 33.25 7.00e-59 221.00
IUUC-Cgl-026681 Colletotrichum gloeosporioides 25.62 1.00e-18 88.20
IUUC-Cne-026854 Cryptococcus neoformans 26.48 8.00e-24 105.00
IUUC-Cme-027201 Cyanidioschyzon merolae 35.50 1.00e-22 100.00
IUUC-Dre-027811 Danio rerio 67.59 2.00e-171 595.00
IUUC-Dno-029907 Dasypus novemcinctus 95.87 0.00e+00 873.00
IUUC-Dor-030126 Dipodomys ordii 89.86 0.00e+00 812.00
IUUC-Dse-031460 Dothistroma septosporum 43.21 3.00e-13 70.50
IUUC-Dme-031882 Drosophila melanogaster 35.48 4.00e-68 251.00
IUUC-Ete-032852 Echinops telfairi 80.72 0.00e+00 708.00
IUUC-Eca-033835 Equus caballus 95.68 0.00e+00 870.00
IUUC-Eeu-034960 Erinaceus europaeus 81.78 0.00e+00 710.00
IUUC-Fca-035547 Felis catus 94.59 0.00e+00 867.00
IUUC-Fal-037181 Ficedula albicollis 81.46 0.00e+00 680.00
IUUC-Fox-038043 Fusarium oxysporum 24.52 5.00e-14 72.80
IUUC-Fso-038242 Fusarium solani 27.25 2.00e-17 84.30
IUUC-Gmo-039658 Gadus morhua 61.58 4.00e-147 514.00
IUUC-Ggr-040039 Gaeumannomyces graminis 45.00 1.00e-13 71.60
IUUC-Gga-040387 Gallus gallus 83.98 0.00e+00 723.00
IUUC-Gac-042247 Gasterosteus aculeatus 66.51 3.00e-170 591.00
IUUC-Gma-043457 Glycine max 35.63 2.00e-23 103.00
IUUC-Ggo-045216 Gorilla gorilla 99.54 0.00e+00 883.00
IUUC-Hvu-047506 Hordeum vulgare 35.40 3.00e-24 105.00
IUUC-Itr-048990 Ictidomys tridecemlineatus 94.06 5.00e-119 419.00
IUUC-Kpa-049180 Komagataella pastoris 25.53 6.00e-18 85.10
IUUC-Lch-049659 Latimeria chalumnae 73.23 0.00e+00 683.00
IUUC-Lpe-051160 Leersia perrieri 35.06 4.00e-09 55.10
IUUC-Loc-051734 Lepisosteus oculatus 75.71 0.00e+00 650.00
IUUC-Lma-053018 Leptosphaeria maculans 38.68 1.00e-13 72.00
IUUC-Laf-053937 Loxodonta africana 95.42 0.00e+00 862.00
IUUC-Mcc-055178 Macaca mulatta 99.31 0.00e+00 884.00
IUUC-Mor-056938 Magnaporthe oryzae 44.74 1.00e-12 68.60
IUUC-Mpo-057448 Magnaporthe poae 45.00 5.00e-14 72.40
IUUC-Mtr-058008 Medicago truncatula 37.36 5.00e-25 108.00
IUUC-Mla-058994 Melampsora laricipopulina 30.56 1.00e-14 74.70
IUUC-Mga-059979 Meleagris gallopavo 83.52 0.00e+00 720.00
IUUC-Mvi-060524 Microbotryum violaceum 29.15 3.00e-21 97.10
IUUC-Mmr-061163 Microcebus murinus 76.06 5.00e-177 613.00
IUUC-Mdo-062767 Monodelphis domestica 90.97 0.00e+00 804.00
IUUC-Mmu-064355 Mus musculus 91.28 0.00e+00 833.00
IUUC-Mac-064946 Musa acuminata 33.53 4.00e-22 98.60
IUUC-Mpu-066278 Mustela putorius furo 93.89 0.00e+00 791.00
IUUC-Mlu-068028 Myotis lucifugus 93.74 0.00e+00 869.00
IUUC-Nfi-068607 Neosartorya fischeri 24.92 5.00e-18 85.90
IUUC-Ncr-068733 Neurospora crassa 29.82 5.00e-14 72.80
IUUC-Nle-070061 Nomascus leucogenys 98.85 0.00e+00 881.00
IUUC-Opr-071040 Ochotona princeps 56.85 2.00e-131 462.00
IUUC-Ont-071715 Oreochromis niloticus 70.86 4.00e-177 614.00
IUUC-Oan-073385 Ornithorhynchus anatinus 89.27 0.00e+00 800.00
IUUC-Ocu-074608 Oryctolagus cuniculus 94.81 0.00e+00 849.00
IUUC-Oba-075531 Oryza barthii 31.71 4.00e-09 55.10
IUUC-Obr-076891 Oryza brachyantha 34.71 1.00e-23 103.00
IUUC-Ogl-077925 Oryza glaberrima 34.48 7.00e-24 104.00
IUUC-Ogu-078352 Oryza glumaepatula 31.71 4.00e-09 55.10
IUUC-Oin-080025 Oryza indica 34.48 6.00e-24 104.00
IUUC-Olo-080624 Oryza longistaminata 29.94 4.00e-16 78.60
IUUC-Ome-081745 Oryza meridionalis 34.48 6.00e-24 104.00
IUUC-Oni-082992 Oryza nivara 35.06 4.00e-24 105.00
IUUC-Opu-083594 Oryza punctata 30.86 5.00e-16 78.60
IUUC-Oru-084792 Oryza rufipogon 31.71 4.00e-09 55.50
IUUC-Osa-086272 Oryza sativa 35.35 6.00e-10 56.60
IUUC-Ola-086443 Oryzias latipes 67.64 3.00e-172 597.00
IUUC-Olu-087849 Ostreococcus lucimarinus 27.17 5.00e-15 75.10
IUUC-Oga-087973 Otolemur garnettii 88.41 0.00e+00 789.00
IUUC-Oar-089479 Ovis aries 92.68 0.00e+00 844.00
IUUC-Ptr-091217 Pan troglodytes 99.77 0.00e+00 887.00
IUUC-Pan-092809 Papio anubis 99.31 0.00e+00 884.00
IUUC-Psi-093838 Pelodiscus sinensis 85.13 0.00e+00 774.00
IUUC-Pma-094194 Petromyzon marinus 49.12 1.00e-109 390.00
IUUC-Pno-094974 Phaeosphaeria nodorum 30.24 1.00e-14 74.70
IUUC-Ppa-095612 Physcomitrella patens 37.21 2.00e-22 99.80
IUUC-Pfo-097152 Poecilia formosa 64.83 2.00e-170 591.00
IUUC-Pab-098181 Pongo abelii 99.08 0.00e+00 884.00
IUUC-Pop-098903 Populus trichocarpa 34.44 4.00e-21 95.50
IUUC-Pca-100097 Procavia capensis 88.07 0.00e+00 782.00
IUUC-Ppe-101770 Prunus persica 34.29 5.00e-23 101.00
IUUC-Pva-103016 Pteropus vampyrus 95.08 0.00e+00 885.00
IUUC-Pgr-103565 Puccinia graminis 47.06 7.00e-13 69.30
IUUC-Ptt-103963 Puccinia triticina 24.44 3.90e-02 33.10
IUUC-Pte-104397 Pyrenophora teres 27.57 6.00e-13 69.30
IUUC-Pyt-104618 Pyrenophora triticirepentis 55.56 1.10e-02 34.70
IUUC-Rno-104872 Rattus norvegicus 91.97 0.00e+00 837.00
IUUC-Sce-106426 Saccharomyces cerevisiae 27.14 1.00e-15 77.00
IUUC-Sha-106487 Sarcophilus harrisii 89.50 0.00e+00 633.00
IUUC-Sja-107695 Schizosaccharomyces japonicus 30.80 2.00e-20 93.20
IUUC-Spo-108193 Schizosaccharomyces pombe 28.91 2.00e-19 89.70
IUUC-Ssl-108468 Sclerotinia sclerotiorum 28.09 2.00e-20 94.40
IUUC-Smo-109062 Selaginella moellendorffii 37.36 1.00e-21 97.40
IUUC-Sit-110175 Setaria italica 36.00 6.00e-26 111.00
IUUC-Sly-111632 Solanum lycopersicum 31.36 1.00e-22 100.00
IUUC-Stu-112393 Solanum tuberosum 32.73 1.00e-22 100.00
IUUC-Sar-113758 Sorex araneus 90.20 0.00e+00 789.00
IUUC-Sbi-114191 Sorghum bicolor 36.02 1.00e-24 107.00
IUUC-Sre-115169 Sporisorium reilianum 35.88 1.00e-15 79.00
IUUC-Ssc-116249 Sus scrofa 92.69 0.00e+00 829.00
IUUC-Tgu-117421 Taeniopygia guttata 81.05 0.00e+00 681.00
IUUC-Tru-118114 Takifugu rubripes 64.20 2.00e-161 561.00
IUUC-Tsy-119305 Tarsius syrichta 83.00 0.00e+00 741.00
IUUC-Tni-120491 Tetraodon nigroviridis 63.10 2.00e-162 565.00
IUUC-Tca-120948 Theobroma cacao 37.27 2.00e-22 99.80
IUUC-Tre-121934 Trichoderma reesei 26.86 3.00e-18 87.00
IUUC-Tvi-122432 Trichoderma virens 26.56 3.00e-18 86.70
IUUC-Tae-123129 Triticum aestivum 36.02 4.00e-24 105.00
IUUC-Tur-126459 Triticum urartu 35.06 2.00e-09 55.50
IUUC-Tme-127190 Tuber melanosporum 26.07 7.00e-16 79.00
IUUC-Tbe-127313 Tupaia belangeri 69.18 8.00e-124 436.00
IUUC-Ttr-128471 Tursiops truncatus 92.15 0.00e+00 851.00
IUUC-Uma-129486 Ustilago maydis 32.85 3.00e-14 74.30
IUUC-Vda-129897 Verticillium dahliae 25.11 7.00e-20 92.00
IUUC-Vpa-130277 Vicugna pacos 69.28 2.00e-128 452.00
IUUC-Vvi-130912 Vitis vinifera 35.63 1.00e-23 103.00
IUUC-Xtr-132405 Xenopus tropicalis 79.00 0.00e+00 682.00
IUUC-Xma-133338 Xiphophorus maculatus 65.06 1.00e-171 595.00
IUUC-Yli-134647 Yarrowia lipolytica 31.55 7.00e-15 75.10
IUUC-Zma-135447 Zea mays 36.02 8.00e-25 107.00
Created Date 25-Jun-2017

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