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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045821
Ensembl Protein ID ENSP00000382688.2
UniProt Accession P29375; A8MV76; Q4LE72; Q86XZ1; KDM5A_HUMAN
Genbank Protein ID AAB28544.1; BAE06081.1; AAH48307.1; AAH53893.1; AAI10917.1
Protein Name Lysine-specific demethylase 5A; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2
Genbank Nucleotide ID S66431; AB209999; AC005844; BC053893; BC110916
Gene Name KDM5A; JARID1A; RBBP2; RBP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000073614.12 ENST00000399788.6 ENSP00000382688.2
ENSG00000073614.12 ENST00000544760.1 ENSP00000440622.1
ENSG00000073614.12 ENST00000535014.5 ENSP00000443854.1
ENSG00000073614.12 ENST00000536014.5 ENSP00000438203.1
ENSG00000073614.12 ENST00000543507.1 ENSP00000444251.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 7.40e-18 66.1 295 342
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           vC +Cg+g +++ +l+ C+ C++ +H  Cl ++  +++p+ + w CpkC +
   Q: 295  VCMFCGRGNNED-KLLLCDGCDDSYHTFCLIPP-LPDVPKGD-WRCPKCVA 342
           8*********88.6*******************.*******7.******75 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
Protein Sequence
(Fasta)
MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK IRPPKDWQPP 60
FACEVKSFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL QGSTLKIPVV ERKILDLYAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045821|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCAGAACTTT GGCGGGCAAG GAGACAAACA GCCACACTGT GCTGCCGGGG AAGAGAAGAA 60
GAAGGAAAGG CCAGACACAC AGGCGTCGTG CAGCTGCGGA AGGATTCCGT TTCCTGCAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045821|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0032993--C:protein-DNA complex
GO:0031490--F:chromatin DNA binding
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0034720--P:histone H3-K4 demethylation
GO:0008584--P:male gonad development
GO:1901726--P:negative regulation of histone deacetylase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0007283--P:spermatogenesis
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:5927
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002061 Ailuropoda melanoleuca 98.64 0.00e+00 2974.00
IUUC-Atr-002595 Amborella trichopoda 30.67 2.00e-124 441.00
IUUC-Apl-004141 Anas platyrhynchos 92.37 0.00e+00 2811.00
IUUC-Aca-004952 Anolis carolinensis 90.48 0.00e+00 2811.00
IUUC-Ate-010453 Aspergillus terreus 29.33 2.00e-116 414.00
IUUC-Ame-011323 Astyanax mexicanus 76.74 0.00e+00 2067.00
IUUC-Bgr-012241 Blumeria graminis 29.46 2.00e-107 385.00
IUUC-Bta-012902 Bos taurus 97.64 0.00e+00 2997.00
IUUC-Bdi-014050 Brachypodium distachyon 29.84 5.00e-119 423.00
IUUC-Cja-018988 Callithrix jacchus 96.81 0.00e+00 2790.00
IUUC-Cfa-020212 Canis familiaris 97.63 0.00e+00 2933.00
IUUC-Cpo-022221 Cavia porcellus 97.84 0.00e+00 2081.00
IUUC-Csa-023575 Chlorocebus sabaeus 99.51 0.00e+00 2900.00
IUUC-Cho-024280 Choloepus hoffmanni 93.02 0.00e+00 2731.00
IUUC-Cin-025321 Ciona intestinalis 49.10 0.00e+00 1078.00
IUUC-Csv-026185 Ciona savignyi 48.09 0.00e+00 1173.00
IUUC-Dre-027909 Danio rerio 76.07 0.00e+00 1650.00
IUUC-Dno-029473 Dasypus novemcinctus 97.92 0.00e+00 2704.00
IUUC-Dor-030281 Dipodomys ordii 96.19 0.00e+00 1224.00
IUUC-Dme-032021 Drosophila melanogaster 47.13 0.00e+00 1123.00
IUUC-Eca-034265 Equus caballus 96.87 0.00e+00 2955.00
IUUC-Fca-035476 Felis catus 97.57 0.00e+00 2966.00
IUUC-Fal-037078 Ficedula albicollis 91.87 0.00e+00 2494.00
IUUC-Ggr-039929 Gaeumannomyces graminis 30.14 1.00e-108 389.00
IUUC-Gga-040466 Gallus gallus 91.15 0.00e+00 2894.00
IUUC-Gac-042566 Gasterosteus aculeatus 75.66 0.00e+00 2112.00
IUUC-Ggo-044524 Gorilla gorilla 92.99 0.00e+00 2551.00
IUUC-Kpa-049245 Komagataella pastoris 23.29 1.00e-40 162.00
IUUC-Lch-050630 Latimeria chalumnae 74.67 0.00e+00 2114.00
IUUC-Loc-051963 Lepisosteus oculatus 76.62 0.00e+00 2070.00
IUUC-Laf-053918 Loxodonta africana 91.27 0.00e+00 2589.00
IUUC-Mcc-055672 Macaca mulatta 98.02 0.00e+00 3001.00
IUUC-Mor-057198 Magnaporthe oryzae 30.80 1.00e-119 425.00
IUUC-Mga-059192 Meleagris gallopavo 83.30 0.00e+00 2437.00
IUUC-Mmr-060968 Microcebus murinus 96.50 0.00e+00 2989.00
IUUC-Mdo-062945 Monodelphis domestica 95.69 0.00e+00 2798.00
IUUC-Mmu-063614 Mus musculus 96.69 0.00e+00 2943.00
IUUC-Mpu-066349 Mustela putorius furo 98.47 0.00e+00 2875.00
IUUC-Mlu-067363 Myotis lucifugus 98.05 0.00e+00 3027.00
IUUC-Nle-070142 Nomascus leucogenys 99.53 0.00e+00 3020.00
IUUC-Opr-071002 Ochotona princeps 91.69 0.00e+00 1406.00
IUUC-Ont-072471 Oreochromis niloticus 78.23 0.00e+00 1881.00
IUUC-Oan-072797 Ornithorhynchus anatinus 80.09 0.00e+00 2027.00
IUUC-Ocu-074164 Oryctolagus cuniculus 97.10 0.00e+00 3021.00
IUUC-Oba-075388 Oryza barthii 27.95 2.00e-83 305.00
IUUC-Obr-076296 Oryza brachyantha 34.43 3.00e-97 351.00
IUUC-Ogu-079040 Oryza glumaepatula 28.00 1.00e-83 305.00
IUUC-Ome-081764 Oryza meridionalis 29.91 1.00e-101 365.00
IUUC-Oni-083012 Oryza nivara 27.91 5.00e-83 303.00
IUUC-Opu-083164 Oryza punctata 29.03 4.00e-93 337.00
IUUC-Oru-084630 Oryza rufipogon 27.60 2.00e-82 301.00
IUUC-Ola-087076 Oryzias latipes 75.22 0.00e+00 2101.00
IUUC-Oga-088350 Otolemur garnettii 96.09 0.00e+00 2891.00
IUUC-Oar-090045 Ovis aries 97.45 0.00e+00 2978.00
IUUC-Ptr-091199 Pan troglodytes 99.23 0.00e+00 3011.00
IUUC-Pan-092094 Papio anubis 95.61 0.00e+00 2742.00
IUUC-Psi-093550 Pelodiscus sinensis 91.52 0.00e+00 2588.00
IUUC-Ppa-095839 Physcomitrella patens 35.20 7.00e-16 80.90
IUUC-Pfo-097266 Poecilia formosa 75.12 0.00e+00 2107.00
IUUC-Pab-098576 Pongo abelii 99.70 0.00e+00 3019.00
IUUC-Pca-100123 Procavia capensis 94.64 0.00e+00 1655.00
IUUC-Pva-103109 Pteropus vampyrus 92.31 0.00e+00 2810.00
IUUC-Pgr-103434 Puccinia graminis 28.15 9.00e-38 150.00
IUUC-Pte-104195 Pyrenophora teres 30.14 5.00e-122 433.00
IUUC-Pyt-104566 Pyrenophora triticirepentis 30.24 4.00e-124 440.00
IUUC-Rno-105664 Rattus norvegicus 96.69 0.00e+00 2942.00
IUUC-Sha-107506 Sarcophilus harrisii 93.87 0.00e+00 2546.00
IUUC-Sja-107734 Schizosaccharomyces japonicus 21.09 3.00e-35 144.00
IUUC-Spo-108283 Schizosaccharomyces pombe 23.48 1.00e-52 202.00
IUUC-Smo-108843 Selaginella moellendorffii 52.08 1.00e-10 62.40
IUUC-Sit-110534 Setaria italica 29.71 1.00e-121 432.00
IUUC-Sar-113052 Sorex araneus 97.04 0.00e+00 2962.00
IUUC-Sbi-114173 Sorghum bicolor 58.14 1.00e-11 64.30
IUUC-Tgu-116613 Taeniopygia guttata 91.19 0.00e+00 2803.00
IUUC-Tru-118604 Takifugu rubripes 75.10 0.00e+00 2149.00
IUUC-Tsy-119237 Tarsius syrichta 98.79 0.00e+00 1316.00
IUUC-Tni-120779 Tetraodon nigroviridis 74.95 0.00e+00 2129.00
IUUC-Tvi-122263 Trichoderma virens 29.19 2.00e-108 387.00
IUUC-Tae-125894 Triticum aestivum 29.54 1.00e-111 399.00
IUUC-Tme-127087 Tuber melanosporum 30.87 1.00e-131 464.00
IUUC-Tbe-127627 Tupaia belangeri 98.99 0.00e+00 807.00
IUUC-Ttr-129242 Tursiops truncatus 95.86 0.00e+00 2891.00
IUUC-Uma-129590 Ustilago maydis 30.44 6.00e-134 473.00
IUUC-Vda-129733 Verticillium dahliae 29.75 3.00e-105 377.00
IUUC-Vpa-130429 Vicugna pacos 90.20 0.00e+00 1464.00
IUUC-Xtr-131762 Xenopus tropicalis 76.94 0.00e+00 2262.00
IUUC-Xma-133693 Xiphophorus maculatus 75.15 0.00e+00 2126.00
Created Date 25-Jun-2017

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