iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ata-000538

Ensembl Protein ID

EMT31528

UniProt Accession

M8CBK2; M8CBK2_AEGTA

Genbank Protein ID

EMT31528.1

Protein Name

E3 ubiquitin-protein ligase UPL4

Genbank Nucleotide ID

KD503347

Gene Name

F775_21994

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
F775_21994	EMT31528	EMT31528

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-86	290.6	872	1221

Active Site

Position(s)	Description	Evidence
1207	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 5    lkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp...............ehlklFeflGrllgkalqdgr 86
            +k +ev f+gE g++  G+t ef++ + +elq+  +g+++ ++     et +++++ gl ++               ++ k F++lG +++ al dgr
   Q: 872  STKTIEVVFEGEVGTGR-GPTFEFYSTVGHELQKLGIGMWRGDNArkAGETGFVRSSFGLFPQpwssvgtstrgielsDVVKKFKLLGHVVARALLDGR 969
           56789************.**********************6555543444555555555544467777778**************************** PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaes.....................dieelgldltfsvseeilgetkeeeLkpgGenip 164
           +ld+plsk+fyk +l ++l++ d++++dpel k++ e ++++++                     ++  ++l+l f+     l+   e+eL+pgG++  
   Q: 970  ILDIPLSKAFYKIMLCQELDIYDIPSFDPELGKTVLEFQALVKRkkfletssektpnpntdlsykNVRLEDLCLDFT-----LPGNPEYELVPGGSDKI 1063
           **********************************9999999843445555666677777777788888888999998.....99*************** PP
   S: 165  VtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           Vt +N+eeYv+l+v+++lk gi++qveaf++  nev+ l+ l++F+eee+e ++cGe +++ +++l++++++++gy ++sp i++F+e+l+ef++e+++
   Q: 1064 VTLDNLEEYVNLIVDATLKGGIAKQVEAFKSAVNEVFALQTLRMFNEEEMERILCGEqDSWASSKLEDHIEFEHGYDASSPPIKNFLEILREFEREDQR 1162
           *********************************************************999*************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk..dasd.drlPssnTCfnyLkLPeYsskei 318
           afLqF+Tg ++lPlgG+a+l p+l+v+rk  d++  ++lPs+nTC + +kLP+Yssk++
   Q: 1163 AFLQFTTGAPQLPLGGLASLDPKLTVVRKqcDGNVdNELPSVNTCRHFIKLPPYSSKQQ 1221
           *******************************55555********************985 PP

Organism

Aegilops tauschii

Protein Sequence
(Fasta)

MPPRGPAGPW PHEPGPMLTL VPCLRALDKI SEECPDQCLR LGVAAAALHL FDFLSASKQK 60
VALKIVAELV QECDDADVPK AMEAAPALCN LLQSADNTIL ESALSCLGML AADAHGKAEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCCCAC GAGGCCCAGC AGGCCCCTGG CCGCACGAAC CGGGACCAAT GCTCACATTA 60
GTCCCGGTTC GTGACTGAAC CGGGACTAAT GTGAATATTG CCCTATGACC AAAGCCCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0436--Ligase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ats:F775_21994

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004521	Anolis carolinensis	39.48	1.00e-41	166.00
IUUC-Bdi-014726	Brachypodium distachyon	74.53	0.00e+00	1799.00
IUUC-Dno-029954	Dasypus novemcinctus	38.38	2.00e-40	161.00
IUUC-Hvu-047700	Hordeum vulgare	91.06	0.00e+00	2149.00
IUUC-Lpe-051372	Leersia perrieri	63.57	0.00e+00	1567.00
IUUC-Mga-059409	Meleagris gallopavo	39.85	2.00e-42	168.00
IUUC-Oba-075424	Oryza barthii	64.40	0.00e+00	1558.00
IUUC-Obr-076607	Oryza brachyantha	63.82	0.00e+00	1504.00
IUUC-Ogl-077414	Oryza glaberrima	64.35	0.00e+00	1547.00
IUUC-Ogu-078341	Oryza glumaepatula	64.48	0.00e+00	1559.00
IUUC-Oin-079282	Oryza indica	61.72	0.00e+00	1446.00
IUUC-Olo-080303	Oryza longistaminata	64.40	0.00e+00	1558.00
IUUC-Ome-081638	Oryza meridionalis	64.07	0.00e+00	1546.00
IUUC-Oni-082977	Oryza nivara	64.40	0.00e+00	1558.00
IUUC-Opu-083574	Oryza punctata	65.29	0.00e+00	1583.00
IUUC-Oru-084742	Oryza rufipogon	64.64	0.00e+00	1558.00
IUUC-Osa-085605	Oryza sativa	64.64	0.00e+00	1558.00
IUUC-Sit-110218	Setaria italica	63.47	0.00e+00	1512.00
IUUC-Sbi-114373	Sorghum bicolor	61.38	0.00e+00	1448.00
IUUC-Tgu-117167	Taeniopygia guttata	39.85	6.00e-42	166.00
IUUC-Tae-123024	Triticum aestivum	99.08	0.00e+00	2387.00
IUUC-Tur-126730	Triticum urartu	95.87	0.00e+00	2255.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence